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Erschienen in: Pediatric Nephrology 3/2010

01.03.2010 | Original Article

Management in children of mild postnatal renal dilatation but without vesicoureteral reflux

verfasst von: Nigel G. Anderson, Jesse Fischer, Diane Leighton, James Hector-Taylor, Rachael L. McEwing

Erschienen in: Pediatric Nephrology | Ausgabe 3/2010

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Abstract

Infants with mild postnatal renal dilatation but without vesicoureteral reflux pose a challenge. For how long and in what way should they be followed? From May 1989 to December 2006, we prospectively followed 1,795 pregnancies in which the foetal renal pelvis measured 4 mm or greater. Voiding cystourethrography (VCUG) and renal ultrasound were performed on 1,315 infants at 6 weeks of age. Our study group comprised 208 (167 male) infants with normal VCUG findings who had a renal pelvis of 6–11 mm. We followed them for 1–17 years (mean 11 years). Medical and radiological records were reviewed to determine any urinary symptoms and final outcome. They underwent, on average, four further imaging tests. The renal dilatation had resolved by 24 months in approximately 70%. Urinary tract infection (UTI) developed in 16 (8%). Calyceal dilatation was more likely in those developing UTI (P = 0.02). Twenty-two (10.6%) had a radiologically demonstrated urinary tract abnormality. Of the five who had renal scarring or severe obstruction, four became symptomatic. Most infants with mild postnatal renal dilatation can be investigated with only one further sonogram at 24 months of age. Mild postnatal renal dilatation is associated with subsequent UTI or renal tract abnormality in 18%. Severe renal abnormality occurred in 2.4%.
Literatur
1.
Zurück zum Zitat Katzir Z, Witzling M, Nikolov G, Gvirtz G, Arbel E, Kohelet D, Boaz M, Smetana S, Lorberboym M (2005) Neonates with extra-renal pelvis: the first 2 years. Pediatr Nephrol 20:763–767CrossRefPubMed Katzir Z, Witzling M, Nikolov G, Gvirtz G, Arbel E, Kohelet D, Boaz M, Smetana S, Lorberboym M (2005) Neonates with extra-renal pelvis: the first 2 years. Pediatr Nephrol 20:763–767CrossRefPubMed
2.
Zurück zum Zitat Dremsek PA, Gindl K, Voitl P, Strobl R, Hafner E, Geissler W, Hruby W, Sacher M (1997) Renal pyelectasis in fetuses and neonates: diagnostic value of renal pelvis diameter in pre- and postnatal sonographic screening. AJR Am J Roentgenol 168:1017–1019PubMed Dremsek PA, Gindl K, Voitl P, Strobl R, Hafner E, Geissler W, Hruby W, Sacher M (1997) Renal pyelectasis in fetuses and neonates: diagnostic value of renal pelvis diameter in pre- and postnatal sonographic screening. AJR Am J Roentgenol 168:1017–1019PubMed
3.
Zurück zum Zitat Joseph VT (2006) The management of renal conditions in the perinatal period. Early Hum Dev 82:313–324CrossRefPubMed Joseph VT (2006) The management of renal conditions in the perinatal period. Early Hum Dev 82:313–324CrossRefPubMed
4.
Zurück zum Zitat Bouzada MC, Oliveira EA, Pereira AK, Leite HV, Rodrigues AM, Fagundes LA, Gonçalves RP, Parreiras R (2004) Diagnostic accuracy of postnatal renal pelvic diameter as a predictor of uropathy: a prospective study. Pediatr Radiol 34:798–804CrossRefPubMed Bouzada MC, Oliveira EA, Pereira AK, Leite HV, Rodrigues AM, Fagundes LA, Gonçalves RP, Parreiras R (2004) Diagnostic accuracy of postnatal renal pelvic diameter as a predictor of uropathy: a prospective study. Pediatr Radiol 34:798–804CrossRefPubMed
5.
Zurück zum Zitat Clautice-Engle T, Anderson NG, Allan RB, Abbott GD (1995) Diagnosis of obstructive hydronephrosis in infants: comparison sonograms performed 6 days and 6 weeks after birth. AJR Am J Roentgenol 164:963–967PubMed Clautice-Engle T, Anderson NG, Allan RB, Abbott GD (1995) Diagnosis of obstructive hydronephrosis in infants: comparison sonograms performed 6 days and 6 weeks after birth. AJR Am J Roentgenol 164:963–967PubMed
6.
Zurück zum Zitat Avni FE, Hall M, Rypens F (2001) The postnatal work-up of congenital uronephropathies. In: Baert AL, Sartor K (eds) Pediatric uroradiology. Springer, Berlin Heidelberg New York, pp 321–336 Avni FE, Hall M, Rypens F (2001) The postnatal work-up of congenital uronephropathies. In: Baert AL, Sartor K (eds) Pediatric uroradiology. Springer, Berlin Heidelberg New York, pp 321–336
7.
Zurück zum Zitat Acton C, Pahuja M, Opie G, Woodward A (2003) A 5-year audit of 778 neonatal renal scans (part 1): perplexing pyelectasis and suggested protocol for investigation. Australas Radiol 47:349–353CrossRefPubMed Acton C, Pahuja M, Opie G, Woodward A (2003) A 5-year audit of 778 neonatal renal scans (part 1): perplexing pyelectasis and suggested protocol for investigation. Australas Radiol 47:349–353CrossRefPubMed
8.
Zurück zum Zitat Ismaili K, Avni FE, Piepsz A, Wissing KM, Cochat P, Aubert D, Hall M (2004) Current management of infants with fetal renal pelvis dilation: a survey by French-speaking pediatric nephrologists and urologists. Pediatr Nephrol 19:966–971CrossRefPubMed Ismaili K, Avni FE, Piepsz A, Wissing KM, Cochat P, Aubert D, Hall M (2004) Current management of infants with fetal renal pelvis dilation: a survey by French-speaking pediatric nephrologists and urologists. Pediatr Nephrol 19:966–971CrossRefPubMed
9.
Zurück zum Zitat Ismaili K, Avni FE, Wissing KM, Hall M, Brussels Free University Perinatal Nephrology Study Group (2004) Long-term clinical outcome of infants with mild and moderate fetal pyelectasis: validation of neonatal ultrasound as a screening tool to detect significant nephrouropathies. J Pediatr 144:759–765 Ismaili K, Avni FE, Wissing KM, Hall M, Brussels Free University Perinatal Nephrology Study Group (2004) Long-term clinical outcome of infants with mild and moderate fetal pyelectasis: validation of neonatal ultrasound as a screening tool to detect significant nephrouropathies. J Pediatr 144:759–765
10.
Zurück zum Zitat Anderson NG, Abbott GD, Mogridge N, Allan RB, Maling TM, Wells JE (1997) Vesicoureteric reflux in the newborn: relationship to fetal renal pelvic diameter. Pediatr Nephrol 11:610–616CrossRefPubMed Anderson NG, Abbott GD, Mogridge N, Allan RB, Maling TM, Wells JE (1997) Vesicoureteric reflux in the newborn: relationship to fetal renal pelvic diameter. Pediatr Nephrol 11:610–616CrossRefPubMed
11.
Zurück zum Zitat de Bruyn R, Marks SD (2008) Postnatal investigation of fetal renal disease. Semin Fetal Neonatal Med 13:133–141CrossRefPubMed de Bruyn R, Marks SD (2008) Postnatal investigation of fetal renal disease. Semin Fetal Neonatal Med 13:133–141CrossRefPubMed
12.
Zurück zum Zitat Ransley PG, Dhillon HK, Gordon I, Duffy PG, Dillon MJ, Barratt TM (1990) The postnatal management of hydronephrosis diagnosed by prenatal ultrasound. J Urol 144:584–587; discussion 593–594PubMed Ransley PG, Dhillon HK, Gordon I, Duffy PG, Dillon MJ, Barratt TM (1990) The postnatal management of hydronephrosis diagnosed by prenatal ultrasound. J Urol 144:584–587; discussion 593–594PubMed
13.
Zurück zum Zitat Riccabona M (2004) Assessment and management of newborn hydronephrosis. World J Urol 22:73–78PubMed Riccabona M (2004) Assessment and management of newborn hydronephrosis. World J Urol 22:73–78PubMed
14.
Zurück zum Zitat Merlini L, Parvex P, Anooshiravani-Dumont M, Girardin E, Hanquinet S (2007) Postnatal management of isolated mild pelvic dilatation detected in antenatal period. Acta Paediatr 96:1131–1134CrossRefPubMed Merlini L, Parvex P, Anooshiravani-Dumont M, Girardin E, Hanquinet S (2007) Postnatal management of isolated mild pelvic dilatation detected in antenatal period. Acta Paediatr 96:1131–1134CrossRefPubMed
15.
Zurück zum Zitat Anderson NG, Allan RB, Abbott GD (2004) Fluctuating size of fetal or neonatal renal pelvis: marker of high grade vesicoureteral reflux. Pediatr Nephrol 19:749–753CrossRefPubMed Anderson NG, Allan RB, Abbott GD (2004) Fluctuating size of fetal or neonatal renal pelvis: marker of high grade vesicoureteral reflux. Pediatr Nephrol 19:749–753CrossRefPubMed
16.
Zurück zum Zitat McIlroy PJ, Abbott GD, Anderson NG, Turner JG, Mogridge N, Wells JE (2000) Outcome of primary vesicoureteric reflux detected following fetal renal pelvic dilatation. J Paediatr Child Health 36:569–573CrossRefPubMed McIlroy PJ, Abbott GD, Anderson NG, Turner JG, Mogridge N, Wells JE (2000) Outcome of primary vesicoureteric reflux detected following fetal renal pelvic dilatation. J Paediatr Child Health 36:569–573CrossRefPubMed
17.
Zurück zum Zitat Kaplan EL, Meier P (1958) Nonparametric estimation from incomplete observations. J Am Stat Assoc 53:457–481CrossRef Kaplan EL, Meier P (1958) Nonparametric estimation from incomplete observations. J Am Stat Assoc 53:457–481CrossRef
18.
Zurück zum Zitat Gramellini D, Fieni S, Caforio E, Benassi G, Bedocchi L, Beseghi U, Benassi L (2006) Diagnostic accuracy of fetal renal pelvis anteroposterior diameter as a predictor of significant postnatal nephrouropathy: second versus third trimester of pregnancy. Am J Obstet Gynecol 194:167–173CrossRefPubMed Gramellini D, Fieni S, Caforio E, Benassi G, Bedocchi L, Beseghi U, Benassi L (2006) Diagnostic accuracy of fetal renal pelvis anteroposterior diameter as a predictor of significant postnatal nephrouropathy: second versus third trimester of pregnancy. Am J Obstet Gynecol 194:167–173CrossRefPubMed
19.
Zurück zum Zitat Toiviainen-Salo S, Garel L, Grignon A, Dubois J, Rypens F, Boisvert J, Perreault G, Decarie JC, Filiatrault D, Lapierre C, Miron MC, Bechard N (2004) Fetal hydronephrosis: is there hope for consensus? Pediatr Radiol 34:519–529CrossRefPubMed Toiviainen-Salo S, Garel L, Grignon A, Dubois J, Rypens F, Boisvert J, Perreault G, Decarie JC, Filiatrault D, Lapierre C, Miron MC, Bechard N (2004) Fetal hydronephrosis: is there hope for consensus? Pediatr Radiol 34:519–529CrossRefPubMed
20.
Zurück zum Zitat Cohen-Overbeek TE, Wijngaard-Boom P, Ursem NT, Hop WC, Wladimiroff JW, Wolffenbuttel KP (2005) Mild renal pyelectasis in the second trimester: determination of cut-off levels for postnatal referral. Ultrasound Obstet Gynecol 25:378–383CrossRefPubMed Cohen-Overbeek TE, Wijngaard-Boom P, Ursem NT, Hop WC, Wladimiroff JW, Wolffenbuttel KP (2005) Mild renal pyelectasis in the second trimester: determination of cut-off levels for postnatal referral. Ultrasound Obstet Gynecol 25:378–383CrossRefPubMed
21.
Zurück zum Zitat Plant ND, Hornung RJ, Coulthard MG, Keir MJ, Matthews JN, Robson SC (2005) Does antenatal pelvic dilation predict renal scarring? Arch Dis Child Fetal Neonatal Ed 90:F339–F340CrossRefPubMed Plant ND, Hornung RJ, Coulthard MG, Keir MJ, Matthews JN, Robson SC (2005) Does antenatal pelvic dilation predict renal scarring? Arch Dis Child Fetal Neonatal Ed 90:F339–F340CrossRefPubMed
22.
Zurück zum Zitat Mårild S, Jodal U (1998) Incidence rate of first-time symptomatic urinary tract infection in children under 6 years of age. Acta Paediatr 87:549–552CrossRefPubMed Mårild S, Jodal U (1998) Incidence rate of first-time symptomatic urinary tract infection in children under 6 years of age. Acta Paediatr 87:549–552CrossRefPubMed
23.
Zurück zum Zitat Harding LJ, Malone PS, Wellesley DG (1999) Antenatal minimal hydronephrosis: is its follow-up an unnecessary cause of concern? Prenat Diagn 19:701–705CrossRefPubMed Harding LJ, Malone PS, Wellesley DG (1999) Antenatal minimal hydronephrosis: is its follow-up an unnecessary cause of concern? Prenat Diagn 19:701–705CrossRefPubMed
24.
Zurück zum Zitat Dacher N, Mandell J, Lebowitz RL (1992) Urinary tract infections in infants in spite of prenatal diagnosis of hydronephrosis. Pediatr Radiol 22:401–405CrossRefPubMed Dacher N, Mandell J, Lebowitz RL (1992) Urinary tract infections in infants in spite of prenatal diagnosis of hydronephrosis. Pediatr Radiol 22:401–405CrossRefPubMed
25.
Zurück zum Zitat Fernbach SK, Maizels M, Conway JJ (1993) Ultrasound grading of hydronephrosis: introduction to the system used by the Society for Fetal Urology. Pediatr Radiol 23:478–480CrossRefPubMed Fernbach SK, Maizels M, Conway JJ (1993) Ultrasound grading of hydronephrosis: introduction to the system used by the Society for Fetal Urology. Pediatr Radiol 23:478–480CrossRefPubMed
26.
Zurück zum Zitat Darge K (2008) Voiding urosonography with US contrast agents for the diagnosis of vesicoureteric reflux in children. II. Comparison with radiological examinations. Pediatr Radiol 38:54–63CrossRefPubMed Darge K (2008) Voiding urosonography with US contrast agents for the diagnosis of vesicoureteric reflux in children. II. Comparison with radiological examinations. Pediatr Radiol 38:54–63CrossRefPubMed
27.
Zurück zum Zitat Lim R (2009) Vesicoureteral reflux and urinary tract infection: evolving practices and current controversies in pediatric imaging. AJR Am J Roentgenol 192:1197–208CrossRefPubMed Lim R (2009) Vesicoureteral reflux and urinary tract infection: evolving practices and current controversies in pediatric imaging. AJR Am J Roentgenol 192:1197–208CrossRefPubMed
Metadaten
Titel
Management in children of mild postnatal renal dilatation but without vesicoureteral reflux
verfasst von
Nigel G. Anderson
Jesse Fischer
Diane Leighton
James Hector-Taylor
Rachael L. McEwing
Publikationsdatum
01.03.2010
Verlag
Springer-Verlag
Erschienen in
Pediatric Nephrology / Ausgabe 3/2010
Print ISSN: 0931-041X
Elektronische ISSN: 1432-198X
DOI
https://doi.org/10.1007/s00467-009-1348-x

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