Skip to main content
Erschienen in: Pediatric Nephrology 4/2012

01.04.2012 | Original Article

Managing children under 36 months of age with febrile urinary tract infection: a new approach

verfasst von: Marco Pennesi, Ines L’Erario, Laura Travan, Alessandro Ventura

Erschienen in: Pediatric Nephrology | Ausgabe 4/2012

Einloggen, um Zugang zu erhalten

Abstract

Background

Recent guidelines on urinary tract infection (UTI) agree on reducing the number of invasive procedures. None of these has been validated by a long-term study. We describe our 11-years experience in the application of a diagnostic protocol that uses a reduced number of invasive procedures.

Methods

We reviewed retrospectively the records of 406 children aged between 1 and 36 months at their first UTI. All patients underwent renal ultrasound (RUS). Children with abnormal RUS and those with UTI recurrences underwent voiding cystourethrography (VCUG) and dimercaptosuccinic acid (DMSA) renal scans.

Results

RUS after the first UTI was pathological in 7.4% children; 4.4 % had a second UTI. We performed 48 VCUG: 14 patients (29%) had vesicoureteral reflux (VUR), 12 of which showed an abnormal RUS while 2 had recurrent UTI. After DMSA renal scan renal damage appeared in only 6 of them (12.5%); all these children showed grade IV VUR.

Conclusions

The application of our guidelines leads to a decrease in invasive examinations without missing any useful diagnoses or compromising the child’s health.
Literatur
1.
Zurück zum Zitat Mori R, Lakhanpaul M, Verrier-Jones K (2007) Diagnosis and management of urinary tract infection in children: summary of NICE guidance. BMJ 35:395–397CrossRef Mori R, Lakhanpaul M, Verrier-Jones K (2007) Diagnosis and management of urinary tract infection in children: summary of NICE guidance. BMJ 35:395–397CrossRef
2.
Zurück zum Zitat Subcommittee on Urinary Tract Infection and Steering Commitee on Quality Improvement and Management (2011) Urinary tract infection: clinical practice guideline for diagnosis and management of the initial UTI in febrile infants and children 2 to 24 months. Pediatrics 128:595–609CrossRef Subcommittee on Urinary Tract Infection and Steering Commitee on Quality Improvement and Management (2011) Urinary tract infection: clinical practice guideline for diagnosis and management of the initial UTI in febrile infants and children 2 to 24 months. Pediatrics 128:595–609CrossRef
3.
Zurück zum Zitat Coulthard MG (2007) NICE on childhood UTI: nasty processes produce nasty guidelines. BMJ 335:463–469PubMedCrossRef Coulthard MG (2007) NICE on childhood UTI: nasty processes produce nasty guidelines. BMJ 335:463–469PubMedCrossRef
4.
Zurück zum Zitat Coulthard MG (2008) Is reflux nephropathy preventable, and will the NICE childhood UTI guidelines help? Arch Dis Child 93:196–199PubMedCrossRef Coulthard MG (2008) Is reflux nephropathy preventable, and will the NICE childhood UTI guidelines help? Arch Dis Child 93:196–199PubMedCrossRef
5.
Zurück zum Zitat Pennesi M, Salvatore CM, Peratoner L (1998) Different clinical presentations of pyelonephritis in children with and without vesicoureteral reflux: an Italian Multicenter Study. Pediatrics 102:1493–1494PubMedCrossRef Pennesi M, Salvatore CM, Peratoner L (1998) Different clinical presentations of pyelonephritis in children with and without vesicoureteral reflux: an Italian Multicenter Study. Pediatrics 102:1493–1494PubMedCrossRef
7.
Zurück zum Zitat Montini G, Rigon L, Zucchetta P, Fregonese F, Toffolo A, Gobber D, Cecchin D, Pavanello L, Molinari PP, Maschio F, Zanchetta S, Cassar W, Casadio L, Crivellaro C, Fortunati P, Corsini A, Calderan A, Comacchio S, Tommasi L, Hewitt IK, Da Dalt L, Zacchello G, Dall'Amico R, IRIS Group (2008) Prophylaxis after first febrile urinary tract infection in children? A multicenter, randomized, controlled, noninferiority trial. Pediatrics 122:1064–1071PubMedCrossRef Montini G, Rigon L, Zucchetta P, Fregonese F, Toffolo A, Gobber D, Cecchin D, Pavanello L, Molinari PP, Maschio F, Zanchetta S, Cassar W, Casadio L, Crivellaro C, Fortunati P, Corsini A, Calderan A, Comacchio S, Tommasi L, Hewitt IK, Da Dalt L, Zacchello G, Dall'Amico R, IRIS Group (2008) Prophylaxis after first febrile urinary tract infection in children? A multicenter, randomized, controlled, noninferiority trial. Pediatrics 122:1064–1071PubMedCrossRef
8.
Zurück zum Zitat Fanos V, Cataldi L (2004) Antibiotics or surgery for vesicoureteric reflux in children. Lancet 364:1720–1722PubMedCrossRef Fanos V, Cataldi L (2004) Antibiotics or surgery for vesicoureteric reflux in children. Lancet 364:1720–1722PubMedCrossRef
9.
Zurück zum Zitat Wennerström M, Hansson S, Jodal U, Stokland E (1998) Disappearing of vesico-ureteral reflux in children. Arch Pediatr Adolesc Med 152:879–883PubMed Wennerström M, Hansson S, Jodal U, Stokland E (1998) Disappearing of vesico-ureteral reflux in children. Arch Pediatr Adolesc Med 152:879–883PubMed
10.
Zurück zum Zitat Pennesi M, Travan L, Peratoner L, Bordugo A, Cattaneo A, Ronfani L, Minisini S, Ventura A, North East Italy Prophylaxis in VUR study group (2008) Is antibiotic prophylaxis in children with vesicoureteral reflux effective in preventing pyelonephritis and renal scars? A randomized, controlled trial. Pediatrics 121:e1489–e1494PubMedCrossRef Pennesi M, Travan L, Peratoner L, Bordugo A, Cattaneo A, Ronfani L, Minisini S, Ventura A, North East Italy Prophylaxis in VUR study group (2008) Is antibiotic prophylaxis in children with vesicoureteral reflux effective in preventing pyelonephritis and renal scars? A randomized, controlled trial. Pediatrics 121:e1489–e1494PubMedCrossRef
11.
Zurück zum Zitat Marra G, Oppezzo C, Ardissino G, Daccò V, Testa S, Avolio L, Taioli E, Sereni F, ItalKid Project (2004) Severe vesicoureteral reflux and chronic renal failure: a condition peculiar to male gender? Data from the ItalKid Project. J Pediatr 144:677–681PubMedCrossRef Marra G, Oppezzo C, Ardissino G, Daccò V, Testa S, Avolio L, Taioli E, Sereni F, ItalKid Project (2004) Severe vesicoureteral reflux and chronic renal failure: a condition peculiar to male gender? Data from the ItalKid Project. J Pediatr 144:677–681PubMedCrossRef
12.
Zurück zum Zitat Assael BM, Guez S, Marra G, Secco E, Manzoni G, Bosio M, Pelegatta A, Acerbi L, delli Agnola CA, Selvaggio G, Vegni M, Cecchetti V, Cucchi L (1998) Congenital reflux nephropathy: a follow-up of 108 cases diagnosed perinatally. Br J Urol 82:252–257PubMedCrossRef Assael BM, Guez S, Marra G, Secco E, Manzoni G, Bosio M, Pelegatta A, Acerbi L, delli Agnola CA, Selvaggio G, Vegni M, Cecchetti V, Cucchi L (1998) Congenital reflux nephropathy: a follow-up of 108 cases diagnosed perinatally. Br J Urol 82:252–257PubMedCrossRef
13.
Zurück zum Zitat Yeung CK, Godley ML, Dhillon HK, Gordon I, Duffy PG, Ransley PG (1997) The characteristics of primary vesico-ureteric reflux in male and female infants with pre-natal hydronephrosis. Br J Urol 80:319–327PubMedCrossRef Yeung CK, Godley ML, Dhillon HK, Gordon I, Duffy PG, Ransley PG (1997) The characteristics of primary vesico-ureteric reflux in male and female infants with pre-natal hydronephrosis. Br J Urol 80:319–327PubMedCrossRef
14.
Zurück zum Zitat Craig JC, Irwing LM, Knight JF (2000) Does treatment of vesicouretal reflux in childhood prevent end-stage renal disease attributable to reflux nephropathy? Pediatrics 105:1236–1241PubMedCrossRef Craig JC, Irwing LM, Knight JF (2000) Does treatment of vesicouretal reflux in childhood prevent end-stage renal disease attributable to reflux nephropathy? Pediatrics 105:1236–1241PubMedCrossRef
15.
Zurück zum Zitat Coulthard MG, Lambert HJ, Keir MJ (2009) Do systemic symptoms predict the risk of kidney scarring after urinary tract infection? Arch Dis Child 94:278–281PubMedCrossRef Coulthard MG, Lambert HJ, Keir MJ (2009) Do systemic symptoms predict the risk of kidney scarring after urinary tract infection? Arch Dis Child 94:278–281PubMedCrossRef
16.
Zurück zum Zitat Montini G, Toffolo A, Zucchetta P, Dall'Amico R, Gobber D, Calderan A, Maschio F, Pavanello L, Molinari PP, Scorrano D, Zanchetta S, Cassar W, Brisotto P, Corsini A, Sartori S, Da Dalt L, Murer L, Zacchello G (2007) Antibiotic treatment for pyelonephritis in children: multicentre randomised controlled non-inferiority trial. BMJ 335:386PubMedCrossRef Montini G, Toffolo A, Zucchetta P, Dall'Amico R, Gobber D, Calderan A, Maschio F, Pavanello L, Molinari PP, Scorrano D, Zanchetta S, Cassar W, Brisotto P, Corsini A, Sartori S, Da Dalt L, Murer L, Zacchello G (2007) Antibiotic treatment for pyelonephritis in children: multicentre randomised controlled non-inferiority trial. BMJ 335:386PubMedCrossRef
17.
Zurück zum Zitat Coulthard MG, Verber I, Jani JC, Lawson GR, Stuart CA, Sharma V, Lamb WH, Keir MJ (2009) Can prompt treatment of childhood UTI prevent kidney scarring? Pediatr Nephrol 24:2059–2063PubMedCrossRef Coulthard MG, Verber I, Jani JC, Lawson GR, Stuart CA, Sharma V, Lamb WH, Keir MJ (2009) Can prompt treatment of childhood UTI prevent kidney scarring? Pediatr Nephrol 24:2059–2063PubMedCrossRef
19.
Zurück zum Zitat Coulthard MG (2009) Vesicoureteral reflux is not a benign condition. Pediatr Nephrol 24:227–232PubMedCrossRef Coulthard MG (2009) Vesicoureteral reflux is not a benign condition. Pediatr Nephrol 24:227–232PubMedCrossRef
20.
Zurück zum Zitat Venhola M, Uhari M (2009) Vesicoureteral reflux, a benign condition. Pediatr Nephrol 24:223–226PubMedCrossRef Venhola M, Uhari M (2009) Vesicoureteral reflux, a benign condition. Pediatr Nephrol 24:223–226PubMedCrossRef
Metadaten
Titel
Managing children under 36 months of age with febrile urinary tract infection: a new approach
verfasst von
Marco Pennesi
Ines L’Erario
Laura Travan
Alessandro Ventura
Publikationsdatum
01.04.2012
Verlag
Springer-Verlag
Erschienen in
Pediatric Nephrology / Ausgabe 4/2012
Print ISSN: 0931-041X
Elektronische ISSN: 1432-198X
DOI
https://doi.org/10.1007/s00467-011-2087-3

Weitere Artikel der Ausgabe 4/2012

Pediatric Nephrology 4/2012 Zur Ausgabe

Neuer Typ-1-Diabetes bei Kindern am Wochenende eher übersehen

23.04.2024 Typ-1-Diabetes Nachrichten

Wenn Kinder an Werktagen zum Arzt gehen, werden neu auftretender Typ-1-Diabetes und diabetische Ketoazidosen häufiger erkannt als bei Arztbesuchen an Wochenenden oder Feiertagen.

Neue Studienergebnisse zur Myopiekontrolle mit Atropin

22.04.2024 Fehlsichtigkeit Nachrichten

Augentropfen mit niedrig dosiertem Atropin können helfen, das Fortschreiten einer Kurzsichtigkeit bei Kindern zumindest zu verlangsamen, wie die Ergebnisse einer aktuellen Studie mit verschiedenen Dosierungen zeigen.

Spinale Muskelatrophie: Neugeborenen-Screening lohnt sich

18.04.2024 Spinale Muskelatrophien Nachrichten

Seit 2021 ist die Untersuchung auf spinale Muskelatrophie Teil des Neugeborenen-Screenings in Deutschland. Eine Studie liefert weitere Evidenz für den Nutzen der Maßnahme.

Fünf Dinge, die im Kindernotfall besser zu unterlassen sind

18.04.2024 Pädiatrische Notfallmedizin Nachrichten

Im Choosing-Wisely-Programm, das für die deutsche Initiative „Klug entscheiden“ Pate gestanden hat, sind erstmals Empfehlungen zum Umgang mit Notfällen von Kindern erschienen. Fünf Dinge gilt es demnach zu vermeiden.

Update Pädiatrie

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.