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Seminars in Immunopathology

Erschienen in:

01.11.2014 | Review

Manipulation of host pathways by human cytomegalovirus: insights from genome-wide studies

verfasst von: Yifat Cohen, Noam Stern-Ginossar

Erschienen in: Seminars in Immunopathology | Ausgabe 6/2014

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Abstract

The herpesvirus human cytomegalovirus (HCMV) infects the majority of the world’s population, leading to severe diseases in millions of newborns and immunocompromised adults annually. During infection, HCMV extensively manipulates cellular gene expression to maintain conditions favorable for efficient viral propagation. Identifying the pathways that the virus relies on or subverts is of great interest as they have the potential to provide new therapeutic targets and to reveal novel principles in cell biology. Over the past years, high-throughput analyses have profoundly broadened our understanding of the processes that occur during HCMV infection. In this review, we will discuss these new findings and how they impact our understanding of the biology of HCMV.

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Titel: Manipulation of host pathways by human cytomegalovirus: insights from genome-wide studies
verfasst von: Yifat Cohen
Noam Stern-Ginossar
Publikationsdatum: 01.11.2014
Verlag: Springer Berlin Heidelberg
Erschienen in: Seminars in Immunopathology / Ausgabe 6/2014
Print ISSN: 1863-2297
Elektronische ISSN: 1863-2300
DOI: https://doi.org/10.1007/s00281-014-0443-7

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