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Graefe's Archive for Clinical and Experimental Ophthalmology
Erschienen in: Graefe's Archive for Clinical and Experimental Ophthalmology 4/2005

01.04.2005 | Clinical Investigation

May glutathione S-transferase M1 positive genotype afford protection against primary open-angle glaucoma?

verfasst von: Özlem Yildirim, Nurcan Aras Ateş, Lülüfer Tamer, Özay Öz, Ayça Yilmaz, Uĝur Atik, Handan Çamdeviren

Erschienen in: Graefe's Archive for Clinical and Experimental Ophthalmology | Ausgabe 4/2005

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Abstract

Purpose

To find out whether the polymorphism at GSTM1, GSTT1 and GSTP1 loci is associated with increased susceptibility to glaucoma.

Methods

We genotyped 153 primary open angle patients and 159 healthy controls. Genomic DNA from peripheral blood was examined using polymerase chain reaction and defined for the genetic polymorphisms of glutathione S-transferase.

Results

The frequency of the GSTM1 null genotype individuals among the glaucoma patients was significanlty higher than in controls (54.9 vs 40.9%) with odds ratio of 1.64 (95% CI: 1.10–2.59). The frequency of the GSTT1 and GSTP1 in both groups were not statistically different.

Conclusion

The present study suggests that the GSTM1 null genotype may be a genetic risk factor for development of primary open angle glaucoma. Further associations studies in other polymorphic genes for xenobiotic–metabolizing enzymes are needed to elucidate the environmental-genetic interaction in the underlying cause of primary open angle glaucoma.
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Metadaten
Titel
May glutathione S-transferase M1 positive genotype afford protection against primary open-angle glaucoma?
verfasst von
Özlem Yildirim
Nurcan Aras Ateş
Lülüfer Tamer
Özay Öz
Ayça Yilmaz
Uĝur Atik
Handan Çamdeviren
Publikationsdatum
01.04.2005
Erschienen in
Graefe's Archive for Clinical and Experimental Ophthalmology / Ausgabe 4/2005
Print ISSN: 0721-832X
Elektronische ISSN: 1435-702X
DOI
https://doi.org/10.1007/s00417-004-1013-9

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