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Magnetic Resonance Materials in Physics, Biology and Medicine

Erschienen in:

01.08.2015 | Short Communication

Measurement reproducibility of magnetic resonance imaging-based finite element analysis of proximal femur microarchitecture for in vivo assessment of bone strength

verfasst von: Gregory Chang, Alexandra Hotca-Cho, Henry Rusinek, Stephen Honig, Artem Mikheev, Kenneth Egol, Ravinder R. Regatte, Chamith S. Rajapakse

Erschienen in: Magnetic Resonance Materials in Physics, Biology and Medicine | Ausgabe 4/2015

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Abstract

Introduction

Osteoporosis is a disease of weak bone. Our goal was to determine the measurement reproducibility of magnetic resonance assessment of proximal femur strength.

Methods

This study had institutional review board approval, and written informed consent was obtained from all subjects. We obtained images of proximal femur microarchitecture by scanning 12 subjects three times within 1 week at 3T using a high-resolution 3-D FLASH sequence. We applied finite element analysis to compute proximal femur stiffness and femoral neck elastic modulus.

Results

Within-day and between-day root-mean-square coefficients of variation and intraclass correlation coefficients ranged from 3.5 to 6.6 % and 0.96 to 0.98, respectively.

Conclusion

The measurement reproducibility of magnetic resonance assessment of proximal femur strength is suitable for clinical studies of disease progression or treatment response related to osteoporosis bone-strengthening interventions.

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Titel: Measurement reproducibility of magnetic resonance imaging-based finite element analysis of proximal femur microarchitecture for in vivo assessment of bone strength
verfasst von: Gregory Chang
Alexandra Hotca-Cho
Henry Rusinek
Stephen Honig
Artem Mikheev
Kenneth Egol
Ravinder R. Regatte
Chamith S. Rajapakse
Publikationsdatum: 01.08.2015
Verlag: Springer Berlin Heidelberg
Erschienen in: Magnetic Resonance Materials in Physics, Biology and Medicine / Ausgabe 4/2015
Print ISSN: 0968-5243
Elektronische ISSN: 1352-8661
DOI: https://doi.org/10.1007/s10334-014-0475-y

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Measurement reproducibility of magnetic resonance imaging-based finite element analysis of proximal femur microarchitecture for in vivo assessment of bone strength