PEEP and intracranial pressure
ARDS is not uncommon in aSAH. A retrospective, single-institution cohort study of 620 aSAH patients found that 27% had a PaO2:FiO
2 (fraction of inspired oxygen) ratio of ≤ 300 with 18% having a ratio ≤ 200 [
11]. The diagnosis of lung injury occurred a median of 3 days from admission [
11]. They found severity of illness, clinical grade of hemorrhage, red blood cell transfusions, and severe sepsis to be independently associated with developing ARDS [
11]. Higher tidal volumes were not found to be associated with the subsequent development of ARDS [
11]. ARDS was independently associated with mortality and longer hospital lengths of stay [
11].
Another retrospective, single-institution observational study found that the development of lung injury was correlated with HH score (
p < 0.001), with 30.4% of HH4 and 35.5% of HH5 patients experiencing severe lung injury (defined by the authors as a PaO
2 to FiO
2 ratio of ≤ 200) [
6]. An additional retrospective, observational study of 62 patients with aSAH requiring MV found 50% of their cohort developed ARDS. Forty-five percent of the patients were diagnosed with ARDS on the first day of MV—suggesting hypoxia, not solely the need for airway protection, may contribute to the requirement for MV [
12].
The hypothesized pathophysiology leading to the development of lung injury in aSAH patients is a “double-hit” model, with the first hit being an adrenergic surge and systemic inflammation incited by acute neurologic injury and the second from non-neurological stressors, such as infections, transfusions, and MV [
21‐
23]. The best evidence for MV strategies to improve survival in ARDS involves lung-protective ventilation parameters described in an ARDS Network trial (ARDSNet) which includes tidal volumes of 6–8 mL/kg of predicted body weight to achieve a plateau pressure ≤ 30 cmH
2O [
24]. However, it is important to recognize that patients with elevated ICPs were excluded from the ARDSNet trial, which likely excluded many aSAH patients. Such an exclusion may limit the generalizability of this ventilation strategy to patients with aSAH.
When examining the utilization rates of the ARDSNet lung-protective ventilator strategies in aSAH patients, a retrospective, single-institution cohort study found that 58% of patients were maintained within ARDSNet parameters, including tidal volumes of ≤ 8 mL/kg, yet there were no ventilator settings that predicted the development of ARDS [
12]. The presence of ARDS risk factors, defined as sepsis, shock, pneumonia, gastric aspiration, and transfusion, were the only findings associated with the development of ARDS. As opposed to other studies, the clinical severity of aSAH did not correlate with the development of ARDS [
12]. The development of ARDS was associated with increased duration of intensive care unit (ICU) stay, but not mortality [
12].
A prospective, single-center study of 499 patients with acute brain injury, including SAH, found that lower tidal volumes and higher positive end-expiratory pressure (PEEP) resulted in decreased duration of MV from 14.9 to 12.6 days and increased 90-day ICU days [
25]. In a multicenter study of all acute brain injury patients including SAH, a protocol of low tidal volume (≤ 7 mL/kg), moderate PEEP (6–8 cmH
2O), and early extubation was associated with a decrease in mortality and number of invasive ventilation-free days [
26].
Alveolar collapse is a key pathophysiologic characteristic of ARDS and results in hypoxemia from intrapulmonary shunt [
27]. By using PEEP to open collapsed lung units, alveolar recruitment is one strategy to maintain functional residual capacity and thereby improve oxygenation in ARDS [
28,
29]. However, lung recruitment remains controversial, and high PEEP ventilation was associated with higher mortality compared to low PEEP ventilation in a randomized control trial [
30]. The applicability of these trials to patients with aSAH is limited because they excluded patients with elevated ICP or acute brain injury.
To address this limitation, several small retrospective clinical studies have attempted to examine the relationship between lung-protective ventilation and ICP. One retrospective, single-institution review reported outcomes for 12 aSAH patients receiving lung-protective ventilation settings with resultant hypercapnia (defined as PaCO
2 50–60 mmHg) and found that these patients had no increase in their ICP compared to patients with a PaCO
2 of 40 mmHg [
31]. The authors hypothesized that while pial arteries vasodilate in response to hypercapnia, there is some evidence that the major cerebral arteries and intracortical arteries constrict instead, possibly accounting for the unchanged ICP they observed [
31,
32]. A randomized study of lung recruitment methods in aSAH patients with ARDS by Nemer et al. compared different alveolar recruitment maneuvers [
33]. One arm was subjected to 35 cmH
20 of continuous positive airway pressure for 40 s, termed continuous positive airway pressure recruitment maneuver (CRM), while the other underwent a pressure control recruitment maneuver (PCRM) of a PEEP of 15 cmH
20 with pressure control above PEEP of 35 cmH
20 for 2 min [
33]. Compared to baseline, they found CRM to be associated with a higher ICP (20.50 ± 4.75 vs 13.13 ± 3.56 mmHg) and a lower cerebral perfusion pressure (CPP) (62.38 ± 9.81 vs 79.60 ± 6.8 mmHg) with no significant improvement in PaO
2:FiO
2 ratio (110.9 ± 24.7 to 112.6 ± 26.7). PCRM on the other hand had no significant effect on ICP but increased CPP (84.25 ± 5.48 to 79 ± 6.80 mmHg) [
33]. PCRM was also associated with a clinically significant improvement in PaO
2:FiO
2 ratio (108.5 to 203.6) [
33].
One prospective, single-institution observational study evaluated the longitudinal effect of PEEP on ICP in aSAH patients [
34]. The authors found that, compared to a group with PEEP of 5 cmH
2O, patients with a PEEP of 20 cmH2O had no significant effect on ICP on post-bleed days 1 and 3, but did experience significantly higher ICP on post-bleed day 7 (19.5 vs 11 mmHg). Post-bleed day 7 is an important milestone in the natural history of aSAH because maximal vasospasm can occur between days 6 and 8 [
35]. Severe vasospasm may lead to reduced CBF and cause cerebral ischemia and edema. The elevated PEEP group also experienced a decrease in mean arterial pressure (MAP) from baseline and subsequently a decrease in cerebral blood flow, thought to be a result of ineffective cerebral autoregulation [
34]. The authors postulated that cerebral edema, in conjunction with elevated intracranial venous pressure and diminished intracranial venous outflow due to elevated PEEP, led to increased ICP [
34].
A retrospective, single-institution review of patients with severe neurologic injuries (GCS < 9, 37.5% with aSAH) who required MV and ICP monitoring found no significant association between PEEP and ICP or CPP, except in patients with severe lung injury (PaO
2/FiO
2 < 100) [
36]. On multivariate analysis of severe lung injury patients, every 1-cmH
2O increase in PEEP was associated with a 0.31-mmHg increase in ICP (
p = 0.04) and a 0.85-mmHg decrease in CPP (
p = 0.02) [
36]. The study did not report any subgroup analysis of the various pathologies included in their cohort or investigate if the mode of MV used had an effect on their results. On the other hand, a prospective study of 21 comatose patients with normal lung compliance and abnormal lung compliance were subjected to increases in PEEP while measuring central venous pressure (CVP), CPP, ICP, cerebral compliance, and mean middle cerebral artery velocity [
37]. In those with normal lung compliance, PEEP increases caused an increase in CVP but reduced MAP, CPP, and mean velocities while ICP and cerebral compliances stayed the same. In those with low compliance, there was no variation in any of the variables with increases in PEEP.
Recommendations
In summary, the literature suggests that an increase in PEEP decreases MAP and increases intracranial pressure. However, since ARDS can present early in these patients, higher PEEPs may be safe early in the course of a patient with aSAH without evidence of intracranial hypertension or mass effect from hematoma. It is reasonable to use ICPM with ability of CSF diversion as the patient approaches the peak of the DCI period, prior to increasing PEEP to treat lung pathology.
Prone positioning
Prone position ventilation improves gas exchange in patients with ARDS and other pathologic states with ventilation-perfusion mismatch such as NPE. One retrospective study of sixteen patients with aSAH, HH grade III or higher with ICPM described proning [
38]. With proning, there was a significant increase in PaO
2 (from 97.3 ± 20.7 to 126.6 ± 31.7 Torr) and PbtO
2 (from 26.8 ± 10.9 to 31.6 ± 12.2 Torr) along with ICP (from 9.3 ± 5.2 to 14.8 ± 6.7 mmHg) while CPP decreased (from 73.0 ± 10.5 to 67.7 ± 10.7 mmHg) [
38]. In a retrospective review of 29 patients with ICPM and acute brain injury, the mean baseline ICP in a supine position was 9.5 ± 5.9 mmHg which increased significantly during prone positioning to 15.4 ± 6.2 mmHg [
39]. They found no significant difference between CPP in a supine position (82 ± 14.5 mmHg) or a prone position (80.1 ± 14.1 mmHg) [
39]. Another prospective study of proning in 8 patients with TBI and SAH found similar results as the prior study with a statistically significant increase in PaO
2 (from 12.6 ± 1.4 to 15.7 ± 3.2 kPa) and ICP (from 12 ± 6 to 15 ± 4 mmHg) however with improvement in CPP (from 66 ± 7 to 73 ± 8 mmHg) [
40]. MAP improved in these patients (from 78 ± 8 to 88 ± 8 mmHg) [
40]. The authors postulate better venous return in the prone position improved MAP to a greater extent than ICP, resulting in improved CPP [
40]. Finally, another prospective trial in 11 patients with TBI and SAH found that proning had no significant effect on ICP, CPP, or MAP but significantly increased PaO
2 (from 13.2 ± 2.1 to 19.1 ± 6.1 kPa) [
41]. The authors comment on increasing sedation on a patient who had an immediate increase in ICP on proning which highlights that results in non-controlled studies may be confounded. It is important to note neither of these studies had patients with ARDS.
Recommendations
Based on these studies, proning can be expected to raise ICP significantly however dramatically improves oxygenation. Patients with aSAH with ICPM who have demonstrated stable ICPs, have no mass effect from intracranial hematoma or edema, and who are experiencing ARDS can be considered for proning.
Alternative modes of ventilation
Airway pressure release ventilation (APRV), a pressure-limited, time-cycled mode of MV that allows spontaneous breathing, is another treatment modality in the management of ARDS. APRV utilizes inverse ratio ventilation (IRV), whereby the inspiratory time is longer than the expiratory time. This increases alveolar recruitment and improves oxygenation [
42].
Our search yielded one single case report describing the use of APRV in aSAH, resulting in improvement in oxygenation, alveolar ventilation, and cerebral blood flow with a negligible increase in ICP [
43]. One study that examined IRV in a rabbit aSAH model compared to normal ratio ventilation did not find CPP to be significantly different, but did find significantly elevated mean airway pressures and slightly elevated ICP above baseline [
44]. In another study, 22 Yorkshire swine undergoing controlled lung injury to mimic ARDS and intracranial pathology with ICP elevation to 30–40 with intracranial balloon were randomized to ARDSNet, APRV, or sham, and blood gases, quantitative histopathology, and cerebral microdialysis were assessed [
45]. The investigators found no difference in FiO
2, CVP, end-tidal CO
2, MAP, CPP, and ICP between the groups, but statistically improved P/F ratio and higher mean airway pressures in the APRV group [
45]. They also found no differences in arterial pH, PaCO
2, PaO
2, and SaO
2 at the common carotid or venous pH, lactate, SvO
2, or PvO
2 at femoral and jugular sites with the only difference of APRV having lower PvCO
2 at the jugular site [
45]. Cerebral dialysis showed lower lactate in the APRV group but lactate pyruvate ratios insignificantly different [
45]. The two main limitations of this study are the dropout bias due to death of six animals not included and analysis for only 6.5 h.
Recommendations
Consider APRV in this population if there is concern for vent asynchrony or ARDS but need to maintain ICP.