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Medical Molecular Morphology

Erschienen in:

08.10.2019 | Original Paper

Mechanism of atopic cataract caused by eosinophil granule major basic protein

verfasst von: Naoki Yamamoto, Noriko Hiramatsu, Sumito Isogai, Masashi Kondo, Kazuyoshi Imaizumi, Masayuki Horiguchi

Erschienen in: Medical Molecular Morphology | Ausgabe 2/2020

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Abstract

Atopic cataracts develop under the ages of 40 years, after which visual acuity rapidly declines. However, the mechanism underlying the development of atopic cataracts is not yet clear. We focused on the eosinophil granule major basic protein (MBP), which was detected in the aqueous humor of atopic cataracts previously, and which was cytotoxic. Specifically, we investigated its origin in this fluid and its effects on lens epithelial cells (LECs). MBP immunostaining was positive in atopic cataract-derived LECs, but negative in age-related cataract-derived LECs. MBP mRNA was not detected in either type of cataract, but protein was detected in the aqueous humor. Furthermore, the flare values associated with atopic cataracts were higher than those with age-related cataracts. When MBP was purified from eosinophils or recombinant MBP was added to LEC culture medium, cell viability decreased in a concentration-dependent manner, but an MBP antibody neutralized the cytotoxic effect of this protein towards these cells. These results were consistent with the flow of MBP into the aqueous humor from the blood due to a compromised blood–aqueous barrier. Thus, MBP could further penetrate the lens capsule and adhere to LECs, resulting in decreased cell viability and the development of atopic cataracts.

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Titel: Mechanism of atopic cataract caused by eosinophil granule major basic protein
verfasst von: Naoki Yamamoto
Noriko Hiramatsu
Sumito Isogai
Masashi Kondo
Kazuyoshi Imaizumi
Masayuki Horiguchi
Publikationsdatum: 08.10.2019
Verlag: Springer Singapore
Erschienen in: Medical Molecular Morphology / Ausgabe 2/2020
Print ISSN: 1860-1480
Elektronische ISSN: 1860-1499
DOI: https://doi.org/10.1007/s00795-019-00234-5

Neu im Fachgebiet Pathologie

Open Access 15.04.2024 | Biomarker | Schwerpunkt: Next Generation Pathology

Springer Medizin

Mechanism of atopic cataract caused by eosinophil granule major basic protein

Abstract

Neu im Fachgebiet Pathologie

Molekularpathologische Untersuchungen im Wandel der Zeit

Vergleichende Pathologie in der onkologischen Forschung

Gastrointestinale Stromatumoren

Personalisierte Medizin in der Onkologie

Springer Medizin

Abstract

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