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Erschienen in: International Journal of Legal Medicine 2/2017

21.09.2016 | Review

Medico-legal perspectives on sudden cardiac death in young athletes

verfasst von: Antonio Oliva, Vincenzo M. Grassi, Oscar Campuzano, Maria Brion, Vincenzo Arena, Sara Partemi, Monica Coll, Vincenzo L. Pascali, Josep Brugada, Angel Carracedo, Ramon Brugada

Erschienen in: International Journal of Legal Medicine | Ausgabe 2/2017

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Abstract

Sudden cardiac death (SCD) in a young athlete represents a dramatic event, and an increasing number of medico-legal cases have addressed this topic. In addition to representing an ethical and medico-legal responsibility, prevention of SCD is directly correlated with accurate eligibility/disqualification decisions, with an inappropriate pronouncement in either direction potentially leading to legal controversy. This review summarizes the common causes of SCD in young athletes, divided into structural (hypertrophic cardiomyopathy, arrhythmogenic cardiomyopathy, congenital coronary artery anomalies, etc.), electrical (Brugada, congenital LQT, Wolf-Parkinson-White syndrome, etc.), and acquired cardiac abnormalities (myocarditis, etc.). In addition, the roles of hereditary cardiac anomalies in SCD in athletes and the effects of a positive result on them and their families are discussed. The medico-legal relevance of pre-participation screening is analyzed, and recommendations from the American Heart Association and European Society of Cardiology are compared. Finally, the main issues concerning the differentiation between physiologic cardiac adaptation in athletes and pathologic findings and, thereby, definition of the so-called gray zone, which is based on exact knowledge of the mechanism of cardiac remodeling including structural or functional adaptions, will be addressed.
Literatur
1.
Zurück zum Zitat Maron BJ, Haas TS, Ahluwalia A, Murphy CJ, Garberich RF (2016) Demographics and epidemiology of sudden deaths in young competitive athletes: from the U.S. National registry. Am J Med. doi:10.1016/j.amjmed.2016.02.031 Maron BJ, Haas TS, Ahluwalia A, Murphy CJ, Garberich RF (2016) Demographics and epidemiology of sudden deaths in young competitive athletes: from the U.S. National registry. Am J Med. doi:10.​1016/​j.​amjmed.​2016.​02.​031
2.
Zurück zum Zitat Maron BJ, Haas TS, Duncanson ER, Garberich RF, Baker AM, Mackey-Bojack S (2016) Comparison of the frequency of sudden cardiovascular deaths in young competitive athletes versus nonathletes: should we really screen only athletes? Am J Cardiol 117:1339–1341. doi:10.1016/j.amjcard.2016.01.026 PubMedCrossRef Maron BJ, Haas TS, Duncanson ER, Garberich RF, Baker AM, Mackey-Bojack S (2016) Comparison of the frequency of sudden cardiovascular deaths in young competitive athletes versus nonathletes: should we really screen only athletes? Am J Cardiol 117:1339–1341. doi:10.​1016/​j.​amjcard.​2016.​01.​026 PubMedCrossRef
5.
Zurück zum Zitat Corrado D, Basso C, Rizzoli G, Schiavon M, Thiene G (2003) Does sports activity enhance the risk of sudden death in adolescents and young adults? J Am Coll Cardiol 42:1959–1963PubMedCrossRef Corrado D, Basso C, Rizzoli G, Schiavon M, Thiene G (2003) Does sports activity enhance the risk of sudden death in adolescents and young adults? J Am Coll Cardiol 42:1959–1963PubMedCrossRef
6.
Zurück zum Zitat Grazioli G, Merino B, Montserrat S, Vidal B, Azqueta M, Pare C, Sarquella-Brugada G, Yanguas X, Pi R, Til L, Escoda J, Brugada J, Sitges M (2014) Usefulness of echocardiography in preparticipation screening of competitive athletes. Rev Esp Cardiol (Engl Ed) 67:701–705. doi:10.1016/j.rec.2013.11.023 CrossRef Grazioli G, Merino B, Montserrat S, Vidal B, Azqueta M, Pare C, Sarquella-Brugada G, Yanguas X, Pi R, Til L, Escoda J, Brugada J, Sitges M (2014) Usefulness of echocardiography in preparticipation screening of competitive athletes. Rev Esp Cardiol (Engl Ed) 67:701–705. doi:10.​1016/​j.​rec.​2013.​11.​023 CrossRef
7.
Zurück zum Zitat Fletcher GF, Balady G, Blair SN, Blumenthal J, Caspersen C, Chaitman B, Epstein S, Sivarajan Froelicher ES, Froelicher VF, Pina IL, Pollock ML (1996) Statement on exercise: benefits and recommendations for physical activity programs for all Americans. A statement for health professionals by the Committee on Exercise and Cardiac Rehabilitation of the Council on Clinical Cardiology, American Heart Association. Circulation 94:857–862PubMedCrossRef Fletcher GF, Balady G, Blair SN, Blumenthal J, Caspersen C, Chaitman B, Epstein S, Sivarajan Froelicher ES, Froelicher VF, Pina IL, Pollock ML (1996) Statement on exercise: benefits and recommendations for physical activity programs for all Americans. A statement for health professionals by the Committee on Exercise and Cardiac Rehabilitation of the Council on Clinical Cardiology, American Heart Association. Circulation 94:857–862PubMedCrossRef
8.
Zurück zum Zitat Pate RR, Davis MG, Robinson TN, Stone EJ, McKenzie TL, Young JC (2006) Promoting physical activity in children and youth: a leadership role for schools: a scientific statement from the American Heart Association council on nutrition, physical activity, and metabolism (physical activity committee) in collaboration with the councils on cardiovascular disease in the young and cardiovascular nursing. Circulation 114:1214–1224. doi:10.1161/circulationaha.106.177052 PubMedCrossRef Pate RR, Davis MG, Robinson TN, Stone EJ, McKenzie TL, Young JC (2006) Promoting physical activity in children and youth: a leadership role for schools: a scientific statement from the American Heart Association council on nutrition, physical activity, and metabolism (physical activity committee) in collaboration with the councils on cardiovascular disease in the young and cardiovascular nursing. Circulation 114:1214–1224. doi:10.​1161/​circulationaha.​106.​177052 PubMedCrossRef
9.
Zurück zum Zitat Swift DL, Lavie CJ, Johannsen NM, Arena R, Earnest CP, O’Keefe JH, Milani RV, Blair SN, Church TS (2013) Physical activity, cardiorespiratory fitness, and exercise training in primary and secondary coronary prevention. Circ J 77:281–292PubMedCrossRef Swift DL, Lavie CJ, Johannsen NM, Arena R, Earnest CP, O’Keefe JH, Milani RV, Blair SN, Church TS (2013) Physical activity, cardiorespiratory fitness, and exercise training in primary and secondary coronary prevention. Circ J 77:281–292PubMedCrossRef
10.
Zurück zum Zitat Thompson PD, Franklin BA, Balady GJ, Blair SN, Corrado D, Estes NA 3rd, Fulton JE, Gordon NF, Haskell WL, Link MS, Maron BJ, Mittleman MA, Pelliccia A, Wenger NK, Willich SN, Costa F (2007) Exercise and acute cardiovascular events placing the risks into perspective: a scientific statement from the American Heart Association council on nutrition, physical activity, and metabolism and the council on clinical cardiology. Circulation 115:2358–2368. doi:10.1161/circulationaha.107.181485 PubMedCrossRef Thompson PD, Franklin BA, Balady GJ, Blair SN, Corrado D, Estes NA 3rd, Fulton JE, Gordon NF, Haskell WL, Link MS, Maron BJ, Mittleman MA, Pelliccia A, Wenger NK, Willich SN, Costa F (2007) Exercise and acute cardiovascular events placing the risks into perspective: a scientific statement from the American Heart Association council on nutrition, physical activity, and metabolism and the council on clinical cardiology. Circulation 115:2358–2368. doi:10.​1161/​circulationaha.​107.​181485 PubMedCrossRef
12.
Zurück zum Zitat Thompson PD, Funk EJ, Carleton RA, Sturner WQ (1982) Incidence of death during jogging in Rhode Island from 1975 through 1980. JAMA 247:2535–2538PubMedCrossRef Thompson PD, Funk EJ, Carleton RA, Sturner WQ (1982) Incidence of death during jogging in Rhode Island from 1975 through 1980. JAMA 247:2535–2538PubMedCrossRef
14.
Zurück zum Zitat Hatzaras I, Tranquilli M, Coady M, Barrett PM, Bible J, Elefteriades JA (2007) Weight lifting and aortic dissection: more evidence for a connection. Cardiology 107:103–106. doi:10.1159/000094530 PubMedCrossRef Hatzaras I, Tranquilli M, Coady M, Barrett PM, Bible J, Elefteriades JA (2007) Weight lifting and aortic dissection: more evidence for a connection. Cardiology 107:103–106. doi:10.​1159/​000094530 PubMedCrossRef
18.
Zurück zum Zitat Ofman P, Khawaja O, Rahilly-Tierney CR, Peralta A, Hoffmeister P, Reynolds MR, Gaziano JM, Djousse L (2013) Regular physical activity and risk of atrial fibrillation: a systematic review and meta-analysis. Circ Arrhythm Electrophysiol 6:252–256. doi:10.1161/circep.113.000147 PubMedCrossRef Ofman P, Khawaja O, Rahilly-Tierney CR, Peralta A, Hoffmeister P, Reynolds MR, Gaziano JM, Djousse L (2013) Regular physical activity and risk of atrial fibrillation: a systematic review and meta-analysis. Circ Arrhythm Electrophysiol 6:252–256. doi:10.​1161/​circep.​113.​000147 PubMedCrossRef
19.
Zurück zum Zitat Rosengren A, Hauptman PJ, Lappas G, Olsson L, Wilhelmsen L, Swedberg K (2009) Big men and atrial fibrillation: effects of body size and weight gain on risk of atrial fibrillation in men. Eur Heart J 30:1113–1120. doi:10.1093/eurheartj/ehp076 PubMedCrossRef Rosengren A, Hauptman PJ, Lappas G, Olsson L, Wilhelmsen L, Swedberg K (2009) Big men and atrial fibrillation: effects of body size and weight gain on risk of atrial fibrillation in men. Eur Heart J 30:1113–1120. doi:10.​1093/​eurheartj/​ehp076 PubMedCrossRef
22.
23.
Zurück zum Zitat Grani C, Chappex N, Fracasso T, Vital C, Kellerhals C, Schmied C, Saguner AM, Trachsel LD, Eser P, Michaud K, Wilhelm M (2016) Sports-related sudden cardiac death in Switzerland classified by static and dynamic components of exercise. Eur J Prev Cardiol. doi:10.1177/2047487316632967 PubMed Grani C, Chappex N, Fracasso T, Vital C, Kellerhals C, Schmied C, Saguner AM, Trachsel LD, Eser P, Michaud K, Wilhelm M (2016) Sports-related sudden cardiac death in Switzerland classified by static and dynamic components of exercise. Eur J Prev Cardiol. doi:10.​1177/​2047487316632967​ PubMed
24.
26.
Zurück zum Zitat Holst AG, Winkel BG, Theilade J, Kristensen IB, Thomsen JL, Ottesen GL, Svendsen JH, Haunso S, Prescott E, Tfelt-Hansen J (2010) Incidence and etiology of sports-related sudden cardiac death in Denmark—implications for preparticipation screening. Heart Rhythm 7:1365–1371. doi:10.1016/j.hrthm.2010.05.021 PubMedCrossRef Holst AG, Winkel BG, Theilade J, Kristensen IB, Thomsen JL, Ottesen GL, Svendsen JH, Haunso S, Prescott E, Tfelt-Hansen J (2010) Incidence and etiology of sports-related sudden cardiac death in Denmark—implications for preparticipation screening. Heart Rhythm 7:1365–1371. doi:10.​1016/​j.​hrthm.​2010.​05.​021 PubMedCrossRef
27.
Zurück zum Zitat Sharma S (2003) Athlete’s heart—effect of age, sex, ethnicity and sporting discipline. Exp Physiol 88:665–669PubMedCrossRef Sharma S (2003) Athlete’s heart—effect of age, sex, ethnicity and sporting discipline. Exp Physiol 88:665–669PubMedCrossRef
28.
Zurück zum Zitat Risgaard B, Winkel BG, Jabbari R, Glinge C, Ingemann-Hansen O, Thomsen JL, Ottesen GL, Haunso S, Holst AG, Tfelt-Hansen J (2014) Sports-related sudden cardiac death in a competitive and a noncompetitive athlete population aged 12 to 49 years: data from an unselected nationwide study in Denmark. Heart Rhythm 11:1673–1681. doi:10.1016/j.hrthm.2014.05.026 PubMedCrossRef Risgaard B, Winkel BG, Jabbari R, Glinge C, Ingemann-Hansen O, Thomsen JL, Ottesen GL, Haunso S, Holst AG, Tfelt-Hansen J (2014) Sports-related sudden cardiac death in a competitive and a noncompetitive athlete population aged 12 to 49 years: data from an unselected nationwide study in Denmark. Heart Rhythm 11:1673–1681. doi:10.​1016/​j.​hrthm.​2014.​05.​026 PubMedCrossRef
31.
Zurück zum Zitat Corrado D, Basso C, Thiene G, McKenna WJ, Davies MJ, Fontaliran F, Nava A, Silvestri F, Blomstrom-Lundqvist C, Wlodarska EK, Fontaine G, Camerini F (1997) Spectrum of clinicopathologic manifestations of arrhythmogenic right ventricular cardiomyopathy/dysplasia: a multicenter study. J Am Coll Cardiol 30:1512–1520PubMedCrossRef Corrado D, Basso C, Thiene G, McKenna WJ, Davies MJ, Fontaliran F, Nava A, Silvestri F, Blomstrom-Lundqvist C, Wlodarska EK, Fontaine G, Camerini F (1997) Spectrum of clinicopathologic manifestations of arrhythmogenic right ventricular cardiomyopathy/dysplasia: a multicenter study. J Am Coll Cardiol 30:1512–1520PubMedCrossRef
32.
Zurück zum Zitat Maron BJ (2002) Hypertrophic cardiomyopathy: a systematic review. JAMA 287:1308–1320PubMed Maron BJ (2002) Hypertrophic cardiomyopathy: a systematic review. JAMA 287:1308–1320PubMed
33.
Zurück zum Zitat Maron BJ, Shirani J, Poliac LC, Mathenge R, Roberts WC, Mueller FO (1996) Sudden death in young competitive athletes. Clinical, demographic, and pathological profiles. JAMA 276:199–204PubMedCrossRef Maron BJ, Shirani J, Poliac LC, Mathenge R, Roberts WC, Mueller FO (1996) Sudden death in young competitive athletes. Clinical, demographic, and pathological profiles. JAMA 276:199–204PubMedCrossRef
34.
Zurück zum Zitat Maron BJ, Gardin JM, Flack JM, Gidding SS, Kurosaki TT, Bild DE (1995) Prevalence of hypertrophic cardiomyopathy in a general population of young adults. Echocardiographic analysis of 4111 subjects in the CARDIA study. Coronary artery risk development in (young) adults. Circulation 92:785–789PubMedCrossRef Maron BJ, Gardin JM, Flack JM, Gidding SS, Kurosaki TT, Bild DE (1995) Prevalence of hypertrophic cardiomyopathy in a general population of young adults. Echocardiographic analysis of 4111 subjects in the CARDIA study. Coronary artery risk development in (young) adults. Circulation 92:785–789PubMedCrossRef
35.
Zurück zum Zitat Maron BJ, Udelson JE, Bonow RO, Nishimura RA, Ackerman MJ, Estes NA III, Cooper LT Jr, Link MS, Maron MS (2015) Eligibility and disqualification recommendations for competitive athletes with cardiovascular abnormalities: task force 3: hypertrophic cardiomyopathy, arrhythmogenic right ventricular cardiomyopathy and other cardiomyopathies, and myocarditis: a scientific statement from the American Heart Association and American College of Cardiology. J Am Coll Cardiol 66:2362–2371. doi:10.1016/j.jacc.2015.09.035 PubMedCrossRef Maron BJ, Udelson JE, Bonow RO, Nishimura RA, Ackerman MJ, Estes NA III, Cooper LT Jr, Link MS, Maron MS (2015) Eligibility and disqualification recommendations for competitive athletes with cardiovascular abnormalities: task force 3: hypertrophic cardiomyopathy, arrhythmogenic right ventricular cardiomyopathy and other cardiomyopathies, and myocarditis: a scientific statement from the American Heart Association and American College of Cardiology. J Am Coll Cardiol 66:2362–2371. doi:10.​1016/​j.​jacc.​2015.​09.​035 PubMedCrossRef
37.
Zurück zum Zitat Corrado D, Wichter T, Link MS, Hauer RN, Marchlinski FE, Anastasakis A, Bauce B, Basso C, Brunckhorst C, Tsatsopoulou A, Tandri H, Paul M, Schmied C, Pelliccia A, Duru F, Protonotarios N, Estes NM 3rd, McKenna WJ, Thiene G, Marcus FI, Calkins H (2015) Treatment of arrhythmogenic right ventricular cardiomyopathy/dysplasia: an international task force consensus statement. Circulation 132:441–453. doi:10.1161/circulationaha.115.017944 PubMedPubMedCentralCrossRef Corrado D, Wichter T, Link MS, Hauer RN, Marchlinski FE, Anastasakis A, Bauce B, Basso C, Brunckhorst C, Tsatsopoulou A, Tandri H, Paul M, Schmied C, Pelliccia A, Duru F, Protonotarios N, Estes NM 3rd, McKenna WJ, Thiene G, Marcus FI, Calkins H (2015) Treatment of arrhythmogenic right ventricular cardiomyopathy/dysplasia: an international task force consensus statement. Circulation 132:441–453. doi:10.​1161/​circulationaha.​115.​017944 PubMedPubMedCentralCrossRef
38.
Zurück zum Zitat James CA, Bhonsale A, Tichnell C, Murray B, Russell SD, Tandri H, Tedford RJ, Judge DP, Calkins H (2013) Exercise increases age-related penetrance and arrhythmic risk in arrhythmogenic right ventricular dysplasia/cardiomyopathy-associated desmosomal mutation carriers. J Am Coll Cardiol 62:1290–1297. doi:10.1016/j.jacc.2013.06.033 PubMedCrossRef James CA, Bhonsale A, Tichnell C, Murray B, Russell SD, Tandri H, Tedford RJ, Judge DP, Calkins H (2013) Exercise increases age-related penetrance and arrhythmic risk in arrhythmogenic right ventricular dysplasia/cardiomyopathy-associated desmosomal mutation carriers. J Am Coll Cardiol 62:1290–1297. doi:10.​1016/​j.​jacc.​2013.​06.​033 PubMedCrossRef
39.
Zurück zum Zitat Campuzano O, Alcalde M, Allegue C, Iglesias A, Garcia-Pavia P, Partemi S, Oliva A, Pascali VL, Berne P, Sarquella-Brugada G, Brugada J, Brugada P, Brugada R (2013) Genetics of arrhythmogenic right ventricular cardiomyopathy. J Med Genet 50:280–289. doi:10.1136/jmedgenet-2013-101523 PubMedCrossRef Campuzano O, Alcalde M, Allegue C, Iglesias A, Garcia-Pavia P, Partemi S, Oliva A, Pascali VL, Berne P, Sarquella-Brugada G, Brugada J, Brugada P, Brugada R (2013) Genetics of arrhythmogenic right ventricular cardiomyopathy. J Med Genet 50:280–289. doi:10.​1136/​jmedgenet-2013-101523 PubMedCrossRef
40.
Zurück zum Zitat Ruwald AC, Marcus F, Estes NA 3rd, Link M, McNitt S, Polonsky B, Calkins H, Towbin JA, Moss AJ, Zareba W (2015) Association of competitive and recreational sport participation with cardiac events in patients with arrhythmogenic right ventricular cardiomyopathy: results from the North American multidisciplinary study of arrhythmogenic right ventricular cardiomyopathy. Eur Heart J 36:1735–1743. doi:10.1093/eurheartj/ehv110 PubMedPubMedCentralCrossRef Ruwald AC, Marcus F, Estes NA 3rd, Link M, McNitt S, Polonsky B, Calkins H, Towbin JA, Moss AJ, Zareba W (2015) Association of competitive and recreational sport participation with cardiac events in patients with arrhythmogenic right ventricular cardiomyopathy: results from the North American multidisciplinary study of arrhythmogenic right ventricular cardiomyopathy. Eur Heart J 36:1735–1743. doi:10.​1093/​eurheartj/​ehv110 PubMedPubMedCentralCrossRef
42.
Zurück zum Zitat Thompson PD, Myerburg RJ, Levine BD, Udelson JE, Kovacs RJ (2015) Eligibility and disqualification recommendations for competitive athletes with cardiovascular abnormalities: task force 8: coronary artery disease: a scientific statement from the American Heart Association and American College of Cardiology. J Am Coll Cardiol 66:2406–2411. doi:10.1016/j.jacc.2015.09.040 PubMedCrossRef Thompson PD, Myerburg RJ, Levine BD, Udelson JE, Kovacs RJ (2015) Eligibility and disqualification recommendations for competitive athletes with cardiovascular abnormalities: task force 8: coronary artery disease: a scientific statement from the American Heart Association and American College of Cardiology. J Am Coll Cardiol 66:2406–2411. doi:10.​1016/​j.​jacc.​2015.​09.​040 PubMedCrossRef
44.
Zurück zum Zitat Yetman AT, Bornemeier RA, McCrindle BW (2003) Long-term outcome in patients with Marfan syndrome: is aortic dissection the only cause of sudden death? J Am Coll Cardiol 41:329–332PubMedCrossRef Yetman AT, Bornemeier RA, McCrindle BW (2003) Long-term outcome in patients with Marfan syndrome: is aortic dissection the only cause of sudden death? J Am Coll Cardiol 41:329–332PubMedCrossRef
45.
Zurück zum Zitat Braverman AC, Harris KM, Kovacs RJ, Maron BJ (2015) Eligibility and disqualification recommendations for competitive athletes with cardiovascular abnormalities: task force 7: aortic diseases, including Marfan syndrome: a scientific statement from the American Heart Association and American College of Cardiology. J Am Coll Cardiol 66:2398–2405. doi:10.1016/j.jacc.2015.09.039 PubMedCrossRef Braverman AC, Harris KM, Kovacs RJ, Maron BJ (2015) Eligibility and disqualification recommendations for competitive athletes with cardiovascular abnormalities: task force 7: aortic diseases, including Marfan syndrome: a scientific statement from the American Heart Association and American College of Cardiology. J Am Coll Cardiol 66:2398–2405. doi:10.​1016/​j.​jacc.​2015.​09.​039 PubMedCrossRef
47.
Zurück zum Zitat Jeresaty RM (1986) Mitral valve prolapse: definition and implications in athletes. J Am Coll Cardiol 7:231–236PubMedCrossRef Jeresaty RM (1986) Mitral valve prolapse: definition and implications in athletes. J Am Coll Cardiol 7:231–236PubMedCrossRef
48.
Zurück zum Zitat Kligfield P, Levy D, Devereux RB, Savage DD (1987) Arrhythmias and sudden death in mitral valve prolapse. Am Heart J 113:1298–1307PubMedCrossRef Kligfield P, Levy D, Devereux RB, Savage DD (1987) Arrhythmias and sudden death in mitral valve prolapse. Am Heart J 113:1298–1307PubMedCrossRef
49.
Zurück zum Zitat Nordhues BD, Siontis KC, Scott CG, Nkomo VT, Ackerman MJ, Asirvatham SJ, Noseworthy PA (2016) Bileaflet mitral valve prolapse and risk of ventricular dysrhythmias and death. J Cardiovasc Electrophysiol 27:463–468. doi:10.1111/jce.12914 PubMedCrossRef Nordhues BD, Siontis KC, Scott CG, Nkomo VT, Ackerman MJ, Asirvatham SJ, Noseworthy PA (2016) Bileaflet mitral valve prolapse and risk of ventricular dysrhythmias and death. J Cardiovasc Electrophysiol 27:463–468. doi:10.​1111/​jce.​12914 PubMedCrossRef
50.
Zurück zum Zitat Basso C, Perazzolo Marra M, Rizzo S, De Lazzari M, Giorgi B, Cipriani A, Frigo AC, Rigato I, Migliore F, Pilichou K, Bertaglia E, Cacciavillani L, Bauce B, Corrado D, Thiene G, Iliceto S (2015) Arrhythmic mitral valve prolapse and sudden cardiac death. Circulation 132:556–566. doi:10.1161/circulationaha.115.016291 PubMedCrossRef Basso C, Perazzolo Marra M, Rizzo S, De Lazzari M, Giorgi B, Cipriani A, Frigo AC, Rigato I, Migliore F, Pilichou K, Bertaglia E, Cacciavillani L, Bauce B, Corrado D, Thiene G, Iliceto S (2015) Arrhythmic mitral valve prolapse and sudden cardiac death. Circulation 132:556–566. doi:10.​1161/​circulationaha.​115.​016291 PubMedCrossRef
51.
Zurück zum Zitat Bonow RO, Nishimura RA, Thompson PD, Udelson JE (2015) Eligibility and disqualification recommendations for competitive athletes with cardiovascular abnormalities: task force 5: valvular heart disease: a scientific statement from the American Heart Association and American College of Cardiology. J Am Coll Cardiol 66:2385–2392. doi:10.1016/j.jacc.2015.09.037 PubMedCrossRef Bonow RO, Nishimura RA, Thompson PD, Udelson JE (2015) Eligibility and disqualification recommendations for competitive athletes with cardiovascular abnormalities: task force 5: valvular heart disease: a scientific statement from the American Heart Association and American College of Cardiology. J Am Coll Cardiol 66:2385–2392. doi:10.​1016/​j.​jacc.​2015.​09.​037 PubMedCrossRef
52.
Zurück zum Zitat Kulbertus HE (1988) Ventricular arrhythmias, syncope and sudden death in aortic stenosis. Eur Heart J 9(Suppl E):51–52PubMedCrossRef Kulbertus HE (1988) Ventricular arrhythmias, syncope and sudden death in aortic stenosis. Eur Heart J 9(Suppl E):51–52PubMedCrossRef
53.
Zurück zum Zitat Vahanian A, Alfieri O, Andreotti F, Antunes MJ, Baron-Esquivias G, Baumgartner H, Borger MA, Carrel TP, De Bonis M, Evangelista A, Falk V, Iung B, Lancellotti P, Pierard L, Price S, Schafers HJ, Schuler G, Stepinska J, Swedberg K, Takkenberg J, Von Oppell UO, Windecker S, Zamorano JL, Zembala M (2012) Guidelines on the management of valvular heart disease (version 2012). Eur Heart J 33:2451–2496. doi:10.1093/eurheartj/ehs109 PubMedCrossRef Vahanian A, Alfieri O, Andreotti F, Antunes MJ, Baron-Esquivias G, Baumgartner H, Borger MA, Carrel TP, De Bonis M, Evangelista A, Falk V, Iung B, Lancellotti P, Pierard L, Price S, Schafers HJ, Schuler G, Stepinska J, Swedberg K, Takkenberg J, Von Oppell UO, Windecker S, Zamorano JL, Zembala M (2012) Guidelines on the management of valvular heart disease (version 2012). Eur Heart J 33:2451–2496. doi:10.​1093/​eurheartj/​ehs109 PubMedCrossRef
54.
Zurück zum Zitat Brugada P, Brugada J (1992) Right bundle branch block, persistent ST segment elevation and sudden cardiac death: a distinct clinical and electrocardiographic syndrome. A multicenter report. J Am Coll Cardiol 20:1391–1396PubMedCrossRef Brugada P, Brugada J (1992) Right bundle branch block, persistent ST segment elevation and sudden cardiac death: a distinct clinical and electrocardiographic syndrome. A multicenter report. J Am Coll Cardiol 20:1391–1396PubMedCrossRef
55.
Zurück zum Zitat Jellins J, Milanovic M, Taitz DJ, Wan SH, Yam PW (2013) Brugada syndrome. Hong Kong Med J 19:159–167PubMed Jellins J, Milanovic M, Taitz DJ, Wan SH, Yam PW (2013) Brugada syndrome. Hong Kong Med J 19:159–167PubMed
59.
Zurück zum Zitat Ackerman MJ, Zipes DP, Kovacs RJ, Maron BJ (2015) Eligibility and disqualification recommendations for competitive athletes with cardiovascular abnormalities: task force 10: the cardiac channelopathies: a scientific statement from the American Heart Association and American College of Cardiology. J Am Coll Cardiol 66:2424–2428. doi:10.1016/j.jacc.2015.09.042 PubMedCrossRef Ackerman MJ, Zipes DP, Kovacs RJ, Maron BJ (2015) Eligibility and disqualification recommendations for competitive athletes with cardiovascular abnormalities: task force 10: the cardiac channelopathies: a scientific statement from the American Heart Association and American College of Cardiology. J Am Coll Cardiol 66:2424–2428. doi:10.​1016/​j.​jacc.​2015.​09.​042 PubMedCrossRef
63.
Zurück zum Zitat Corrado D, Basso C, Pavei A, Michieli P, Schiavon M, Thiene G (2006) Trends in sudden cardiovascular death in young competitive athletes after implementation of a preparticipation screening program. JAMA 296:1593–1601. doi:10.1001/jama.296.13.1593 PubMedCrossRef Corrado D, Basso C, Pavei A, Michieli P, Schiavon M, Thiene G (2006) Trends in sudden cardiovascular death in young competitive athletes after implementation of a preparticipation screening program. JAMA 296:1593–1601. doi:10.​1001/​jama.​296.​13.​1593 PubMedCrossRef
64.
Zurück zum Zitat Maron BJ, Doerer JJ, Haas TS, Tierney DM, Mueller FO (2006) Profile and frequency of sudden death in 1463 young competitive athletes: from a 25 year U.S: national registry: 1980–2005. Circulation. 114 Maron BJ, Doerer JJ, Haas TS, Tierney DM, Mueller FO (2006) Profile and frequency of sudden death in 1463 young competitive athletes: from a 25 year U.S: national registry: 1980–2005. Circulation. 114
65.
Zurück zum Zitat Crotti L, Hu D, Barajas-Martinez H, De Ferrari GM, Oliva A, Insolia R, Pollevick GD, Dagradi F, Guerchicoff A, Greco F, Schwartz PJ, Viskin S, Antzelevitch C (2012) Torsades de pointes following acute myocardial infarction: evidence for a deadly link with a common genetic variant. Heart Rhythm 9:1104–1112. doi:10.1016/j.hrthm.2012.02.014 PubMedPubMedCentralCrossRef Crotti L, Hu D, Barajas-Martinez H, De Ferrari GM, Oliva A, Insolia R, Pollevick GD, Dagradi F, Guerchicoff A, Greco F, Schwartz PJ, Viskin S, Antzelevitch C (2012) Torsades de pointes following acute myocardial infarction: evidence for a deadly link with a common genetic variant. Heart Rhythm 9:1104–1112. doi:10.​1016/​j.​hrthm.​2012.​02.​014 PubMedPubMedCentralCrossRef
67.
Zurück zum Zitat Neuspiel DR, Kuller LH (1985) Sudden and unexpected natural death in childhood and adolescence. JAMA 254:1321–1325PubMedCrossRef Neuspiel DR, Kuller LH (1985) Sudden and unexpected natural death in childhood and adolescence. JAMA 254:1321–1325PubMedCrossRef
68.
Zurück zum Zitat Heidbuchel H, Panhuyzen-Goedkoop N, Corrado D, Hoffmann E, Biffi A, Delise P, Blomstrom-Lundqvist C, Vanhees L, Ivarhoff P, Dorwarth U, Pelliccia A (2006) Recommendations for participation in leisure-time physical activity and competitive sports in patients with arrhythmias and potentially arrhythmogenic conditions Part I: Supraventricular arrhythmias and pacemakers. Eur J Cardiovasc Prev Rehabil 13:475–484. doi:10.1097/01.hjr.0000216543.54066.72 PubMedCrossRef Heidbuchel H, Panhuyzen-Goedkoop N, Corrado D, Hoffmann E, Biffi A, Delise P, Blomstrom-Lundqvist C, Vanhees L, Ivarhoff P, Dorwarth U, Pelliccia A (2006) Recommendations for participation in leisure-time physical activity and competitive sports in patients with arrhythmias and potentially arrhythmogenic conditions Part I: Supraventricular arrhythmias and pacemakers. Eur J Cardiovasc Prev Rehabil 13:475–484. doi:10.​1097/​01.​hjr.​0000216543.​54066.​72 PubMedCrossRef
69.
Zurück zum Zitat Pappone C, Santinelli V, Rosanio S, Vicedomini G, Nardi S, Pappone A, Tortoriello V, Manguso F, Mazzone P, Gulletta S, Oreto G, Alfieri O (2003) Usefulness of invasive electrophysiologic testing to stratify the risk of arrhythmic events in asymptomatic patients with Wolff-Parkinson-White pattern: results from a large prospective long-term follow-up study. J Am Coll Cardiol 41:239–244PubMedCrossRef Pappone C, Santinelli V, Rosanio S, Vicedomini G, Nardi S, Pappone A, Tortoriello V, Manguso F, Mazzone P, Gulletta S, Oreto G, Alfieri O (2003) Usefulness of invasive electrophysiologic testing to stratify the risk of arrhythmic events in asymptomatic patients with Wolff-Parkinson-White pattern: results from a large prospective long-term follow-up study. J Am Coll Cardiol 41:239–244PubMedCrossRef
70.
Zurück zum Zitat Biffi A, Pelliccia A, Verdile L, Fernando F, Spataro A, Caselli S, Santini M, Maron BJ (2002) Long-term clinical significance of frequent and complex ventricular tachyarrhythmias in trained athletes. J Am Coll Cardiol 40:446–452PubMedCrossRef Biffi A, Pelliccia A, Verdile L, Fernando F, Spataro A, Caselli S, Santini M, Maron BJ (2002) Long-term clinical significance of frequent and complex ventricular tachyarrhythmias in trained athletes. J Am Coll Cardiol 40:446–452PubMedCrossRef
71.
Zurück zum Zitat Al-Khatib SM, Arshad A, Balk EM, Das SR, Hsu JC, Joglar JA, Page RL (2016) Risk stratification for arrhythmic events in patients with asymptomatic pre-excitation: a systematic review for the 2015 ACC/AHA/HRS guideline for the management of adult patients with supraventricular tachycardia: a report of the American College of Cardiology/American Heart Association task force on clinical practice guidelines and the heart rhythm society. J Am Coll Cardiol 67:1624–1638. doi:10.1016/j.jacc.2015.09.018 PubMedCrossRef Al-Khatib SM, Arshad A, Balk EM, Das SR, Hsu JC, Joglar JA, Page RL (2016) Risk stratification for arrhythmic events in patients with asymptomatic pre-excitation: a systematic review for the 2015 ACC/AHA/HRS guideline for the management of adult patients with supraventricular tachycardia: a report of the American College of Cardiology/American Heart Association task force on clinical practice guidelines and the heart rhythm society. J Am Coll Cardiol 67:1624–1638. doi:10.​1016/​j.​jacc.​2015.​09.​018 PubMedCrossRef
72.
Zurück zum Zitat Timmermans C, Smeets JL, Rodriguez LM, Vrouchos G, van den Dool A, Wellens HJ (1995) Aborted sudden death in the Wolff-Parkinson-White syndrome. Am J Cardiol 76:492–494PubMedCrossRef Timmermans C, Smeets JL, Rodriguez LM, Vrouchos G, van den Dool A, Wellens HJ (1995) Aborted sudden death in the Wolff-Parkinson-White syndrome. Am J Cardiol 76:492–494PubMedCrossRef
74.
Zurück zum Zitat Cohen MI, Triedman JK, Cannon BC, Davis AM, Drago F, Janousek J, Klein GJ, Law IH, Morady FJ, Paul T, Perry JC, Sanatani S, Tanel RE (2012) PACES/HRS expert consensus statement on the management of the asymptomatic young patient with a Wolff-Parkinson-White (WPW, ventricular preexcitation) electrocardiographic pattern: developed in partnership between the Pediatric and Congenital Electrophysiology Society (PACES) and the Heart Rhythm Society (HRS). Endorsed by the governing bodies of PACES, HRS, the American College of Cardiology Foundation (ACCF), the American Heart Association (AHA), the American Academy of Pediatrics (AAP), and the Canadian Heart Rhythm Society (CHRS). Heart Rhythm 9:1006–1024. doi:10.1016/j.hrthm.2012.03.050 PubMedCrossRef Cohen MI, Triedman JK, Cannon BC, Davis AM, Drago F, Janousek J, Klein GJ, Law IH, Morady FJ, Paul T, Perry JC, Sanatani S, Tanel RE (2012) PACES/HRS expert consensus statement on the management of the asymptomatic young patient with a Wolff-Parkinson-White (WPW, ventricular preexcitation) electrocardiographic pattern: developed in partnership between the Pediatric and Congenital Electrophysiology Society (PACES) and the Heart Rhythm Society (HRS). Endorsed by the governing bodies of PACES, HRS, the American College of Cardiology Foundation (ACCF), the American Heart Association (AHA), the American Academy of Pediatrics (AAP), and the Canadian Heart Rhythm Society (CHRS). Heart Rhythm 9:1006–1024. doi:10.​1016/​j.​hrthm.​2012.​03.​050 PubMedCrossRef
75.
Zurück zum Zitat Zipes DP, Link MS, Ackerman MJ, Kovacs RJ, Myerburg RJ, Estes NA 3rd (2015) Eligibility and disqualification recommendations for competitive athletes with cardiovascular abnormalities: task force 9: arrhythmias and conduction defects: a scientific statement from the American Heart Association and American College of Cardiology. J Am Coll Cardiol 66:2412–2423. doi:10.1016/j.jacc.2015.09.041 PubMedCrossRef Zipes DP, Link MS, Ackerman MJ, Kovacs RJ, Myerburg RJ, Estes NA 3rd (2015) Eligibility and disqualification recommendations for competitive athletes with cardiovascular abnormalities: task force 9: arrhythmias and conduction defects: a scientific statement from the American Heart Association and American College of Cardiology. J Am Coll Cardiol 66:2412–2423. doi:10.​1016/​j.​jacc.​2015.​09.​041 PubMedCrossRef
76.
Zurück zum Zitat Priori SG, Napolitano C, Memmi M, Colombi B, Drago F, Gasparini M, DeSimone L, Coltorti F, Bloise R, Keegan R, Cruz Filho FE, Vignati G, Benatar A, DeLogu A (2002) Clinical and molecular characterization of patients with catecholaminergic polymorphic ventricular tachycardia. Circulation 106:69–74PubMedCrossRef Priori SG, Napolitano C, Memmi M, Colombi B, Drago F, Gasparini M, DeSimone L, Coltorti F, Bloise R, Keegan R, Cruz Filho FE, Vignati G, Benatar A, DeLogu A (2002) Clinical and molecular characterization of patients with catecholaminergic polymorphic ventricular tachycardia. Circulation 106:69–74PubMedCrossRef
77.
Zurück zum Zitat Priori SG, Napolitano C, Tiso N, Memmi M, Vignati G, Bloise R, Sorrentino V, Danieli GA (2001) Mutations in the cardiac ryanodine receptor gene (hRyR2) underlie catecholaminergic polymorphic ventricular tachycardia. Circulation 103:196–200PubMedCrossRef Priori SG, Napolitano C, Tiso N, Memmi M, Vignati G, Bloise R, Sorrentino V, Danieli GA (2001) Mutations in the cardiac ryanodine receptor gene (hRyR2) underlie catecholaminergic polymorphic ventricular tachycardia. Circulation 103:196–200PubMedCrossRef
78.
Zurück zum Zitat Trusty JM, Beinborn DS, Jahangir A (2004) Dysrhythmias and the athlete. AACN Clin Issues 15:432–448PubMedCrossRef Trusty JM, Beinborn DS, Jahangir A (2004) Dysrhythmias and the athlete. AACN Clin Issues 15:432–448PubMedCrossRef
79.
Zurück zum Zitat Maron BJ, Pelliccia A, Spirito P (1995) Cardiac disease in young trained athletes. Insights into methods for distinguishing athlete’s heart from structural heart disease, with particular emphasis on hypertrophic cardiomyopathy. Circulation 91:1596–1601PubMedCrossRef Maron BJ, Pelliccia A, Spirito P (1995) Cardiac disease in young trained athletes. Insights into methods for distinguishing athlete’s heart from structural heart disease, with particular emphasis on hypertrophic cardiomyopathy. Circulation 91:1596–1601PubMedCrossRef
80.
Zurück zum Zitat Eckart RE, Scoville SL, Campbell CL, Shry EA, Stajduhar KC, Potter RN, Pearse LA, Virmani R (2004) Sudden death in young adults: a 25-year review of autopsies in military recruits. Ann Intern Med 141:829–834PubMedCrossRef Eckart RE, Scoville SL, Campbell CL, Shry EA, Stajduhar KC, Potter RN, Pearse LA, Virmani R (2004) Sudden death in young adults: a 25-year review of autopsies in military recruits. Ann Intern Med 141:829–834PubMedCrossRef
82.
Zurück zum Zitat Corrado D, Basso C, Thiene G (2001) Sudden cardiac death in young people with apparently normal heart. Cardiovasc Res 50:399–408PubMedCrossRef Corrado D, Basso C, Thiene G (2001) Sudden cardiac death in young people with apparently normal heart. Cardiovasc Res 50:399–408PubMedCrossRef
85.
Zurück zum Zitat Shekelle PG, Hardy ML, Morton SC, Maglione M, Mojica WA, Suttorp MJ, Rhodes SL, Jungvig L, Gagne J (2003) Efficacy and safety of ephedra and ephedrine for weight loss and athletic performance: a meta-analysis. JAMA 289:1537–1545. doi:10.1001/jama.289.12.1537 PubMed Shekelle PG, Hardy ML, Morton SC, Maglione M, Mojica WA, Suttorp MJ, Rhodes SL, Jungvig L, Gagne J (2003) Efficacy and safety of ephedra and ephedrine for weight loss and athletic performance: a meta-analysis. JAMA 289:1537–1545. doi:10.​1001/​jama.​289.​12.​1537 PubMed
86.
Zurück zum Zitat Riebe D, Fernhall B, Thompson PD (1992) The blood pressure response to exercise in anabolic steroid users. Med Sci Sports Exerc 24:633–637PubMedCrossRef Riebe D, Fernhall B, Thompson PD (1992) The blood pressure response to exercise in anabolic steroid users. Med Sci Sports Exerc 24:633–637PubMedCrossRef
87.
Zurück zum Zitat Freed DL, Banks AJ, Longson D, Burley DM (1975) Anabolic steroids in athelics: crossover double-blind trial on weightlifters. Br Med J 2:471–473PubMedPubMedCentralCrossRef Freed DL, Banks AJ, Longson D, Burley DM (1975) Anabolic steroids in athelics: crossover double-blind trial on weightlifters. Br Med J 2:471–473PubMedPubMedCentralCrossRef
88.
Zurück zum Zitat Fineschi V, Riezzo I, Centini F, Silingardi E, Licata M, Beduschi G, Karch SB (2007) Sudden cardiac death during anabolic steroid abuse: morphologic and toxicologic findings in two fatal cases of bodybuilders. Int J Legal Med 121:48–53. doi:10.1007/s00414-005-0055-9 PubMedCrossRef Fineschi V, Riezzo I, Centini F, Silingardi E, Licata M, Beduschi G, Karch SB (2007) Sudden cardiac death during anabolic steroid abuse: morphologic and toxicologic findings in two fatal cases of bodybuilders. Int J Legal Med 121:48–53. doi:10.​1007/​s00414-005-0055-9 PubMedCrossRef
89.
Zurück zum Zitat To LB, Sangster JF, Rampling D, Cammens I (1980) Ephedrine-induced cardiomyopathy. Med J Aust 2:35–36PubMed To LB, Sangster JF, Rampling D, Cammens I (1980) Ephedrine-induced cardiomyopathy. Med J Aust 2:35–36PubMed
90.
Zurück zum Zitat Bruno A, Nolte KB, Chapin J (1993) Stroke associated with ephedrine use. Neurology 43:1313–1316PubMedCrossRef Bruno A, Nolte KB, Chapin J (1993) Stroke associated with ephedrine use. Neurology 43:1313–1316PubMedCrossRef
92.
Zurück zum Zitat Wiener I, Tilkian AG, Palazzolo M (1990) Coronary artery spasm and myocardial infarction in a patient with normal coronary arteries: temporal relationship to pseudoephedrine ingestion. Catheter Cardiovasc Diagn 20:51–53CrossRef Wiener I, Tilkian AG, Palazzolo M (1990) Coronary artery spasm and myocardial infarction in a patient with normal coronary arteries: temporal relationship to pseudoephedrine ingestion. Catheter Cardiovasc Diagn 20:51–53CrossRef
93.
94.
Zurück zum Zitat Chappex N, Schlaepfer J, Fellmann F, Bhuiyan ZA, Wilhelm M, Michaud K (2015) Sudden cardiac death among general population and sport related population in forensic experience. J Forensic Legal Med 35:62–68. doi:10.1016/j.jflm.2015.07.004 CrossRef Chappex N, Schlaepfer J, Fellmann F, Bhuiyan ZA, Wilhelm M, Michaud K (2015) Sudden cardiac death among general population and sport related population in forensic experience. J Forensic Legal Med 35:62–68. doi:10.​1016/​j.​jflm.​2015.​07.​004 CrossRef
95.
Zurück zum Zitat Hertz CL, Christiansen SL, Ferrero-Miliani L, Fordyce SL, Dahl M, Holst AG, Ottesen GL, Frank-Hansen R, Bundgaard H, Morling N (2015) Next-generation sequencing of 34 genes in sudden unexplained death victims in forensics and in patients with channelopathic cardiac diseases. Int J Legal Med 129:793–800. doi:10.1007/s00414-014-1105-y PubMedCrossRef Hertz CL, Christiansen SL, Ferrero-Miliani L, Fordyce SL, Dahl M, Holst AG, Ottesen GL, Frank-Hansen R, Bundgaard H, Morling N (2015) Next-generation sequencing of 34 genes in sudden unexplained death victims in forensics and in patients with channelopathic cardiac diseases. Int J Legal Med 129:793–800. doi:10.​1007/​s00414-014-1105-y PubMedCrossRef
97.
98.
Zurück zum Zitat Maron BJ, Thompson PD, Ackerman MJ, Balady G, Berger S, Cohen D, Dimeff R, Douglas PS, Glover DW, Hutter AM Jr, Krauss MD, Maron MS, Mitten MJ, Roberts WO, Puffer JC (2007) Recommendations and considerations related to preparticipation screening for cardiovascular abnormalities in competitive athletes: 2007 update: a scientific statement from the American Heart Association council on nutrition, physical activity, and metabolism: endorsed by the American College of Cardiology Foundation. Circulation 115:1643–1455. doi:10.1161/circulationaha.107.181423 PubMedCrossRef Maron BJ, Thompson PD, Ackerman MJ, Balady G, Berger S, Cohen D, Dimeff R, Douglas PS, Glover DW, Hutter AM Jr, Krauss MD, Maron MS, Mitten MJ, Roberts WO, Puffer JC (2007) Recommendations and considerations related to preparticipation screening for cardiovascular abnormalities in competitive athletes: 2007 update: a scientific statement from the American Heart Association council on nutrition, physical activity, and metabolism: endorsed by the American College of Cardiology Foundation. Circulation 115:1643–1455. doi:10.​1161/​circulationaha.​107.​181423 PubMedCrossRef
99.
Zurück zum Zitat Corrado D, Pelliccia A, Bjornstad HH, Vanhees L, Biffi A, Borjesson M, Panhuyzen-Goedkoop N, Deligiannis A, Solberg E, Dugmore D, Mellwig KP, Assanelli D, Delise P, Van-Buuren F, Anastasakis A, Heidbuchel H, Hoffmann E, Fagard R, Priori SG, Basso C, Arbustini E, Blomstrom-Lundqvist C, McKenna WJ, Thiene G (2005) Cardiovascular pre-participation screening of young competitive athletes for prevention of sudden death: proposal for a common European protocol. Consensus statement of the study group of sport cardiology of the working group of cardiac rehabilitation and exercise physiology and the working group of myocardial and pericardial diseases of the European Society of Cardiology. Eur Heart J 26:516–524. doi:10.1093/eurheartj/ehi108 PubMedCrossRef Corrado D, Pelliccia A, Bjornstad HH, Vanhees L, Biffi A, Borjesson M, Panhuyzen-Goedkoop N, Deligiannis A, Solberg E, Dugmore D, Mellwig KP, Assanelli D, Delise P, Van-Buuren F, Anastasakis A, Heidbuchel H, Hoffmann E, Fagard R, Priori SG, Basso C, Arbustini E, Blomstrom-Lundqvist C, McKenna WJ, Thiene G (2005) Cardiovascular pre-participation screening of young competitive athletes for prevention of sudden death: proposal for a common European protocol. Consensus statement of the study group of sport cardiology of the working group of cardiac rehabilitation and exercise physiology and the working group of myocardial and pericardial diseases of the European Society of Cardiology. Eur Heart J 26:516–524. doi:10.​1093/​eurheartj/​ehi108 PubMedCrossRef
100.
Zurück zum Zitat Richard P, Denjoy I, Fressart V, Wilson MG, Carre F, Charron P (2012) Advising a cardiac disease gene positive yet phenotype negative or borderline abnormal athlete: is sporting disqualification really necessary? Br J Sports Med 46(Suppl 1):i59–i68. doi:10.1136/bjsports-2012-091318 PubMedCrossRef Richard P, Denjoy I, Fressart V, Wilson MG, Carre F, Charron P (2012) Advising a cardiac disease gene positive yet phenotype negative or borderline abnormal athlete: is sporting disqualification really necessary? Br J Sports Med 46(Suppl 1):i59–i68. doi:10.​1136/​bjsports-2012-091318 PubMedCrossRef
101.
Zurück zum Zitat Priori SG, Wilde AA, Horie M, Cho Y, Behr ER, Berul C, Blom N, Brugada J, Chiang CE, Huikuri H, Kannankeril P, Krahn A, Leenhardt A, Moss A, Schwartz PJ, Shimizu W, Tomaselli G, Tracy C (2013) HRS/EHRA/APHRS expert consensus statement on the diagnosis and management of patients with inherited primary arrhythmia syndromes: document endorsed by HRS, EHRA, and APHRS in May 2013 and by ACCF, AHA, PACES, and AEPC in June 2013. Heart Rhythm 10:1932–1963. doi:10.1016/j.hrthm.2013.05.014 PubMedCrossRef Priori SG, Wilde AA, Horie M, Cho Y, Behr ER, Berul C, Blom N, Brugada J, Chiang CE, Huikuri H, Kannankeril P, Krahn A, Leenhardt A, Moss A, Schwartz PJ, Shimizu W, Tomaselli G, Tracy C (2013) HRS/EHRA/APHRS expert consensus statement on the diagnosis and management of patients with inherited primary arrhythmia syndromes: document endorsed by HRS, EHRA, and APHRS in May 2013 and by ACCF, AHA, PACES, and AEPC in June 2013. Heart Rhythm 10:1932–1963. doi:10.​1016/​j.​hrthm.​2013.​05.​014 PubMedCrossRef
103.
Zurück zum Zitat Kaltman JR, Thompson PD, Lantos J, Berul CI, Botkin J, Cohen JT, Cook NR, Corrado D, Drezner J, Frick KD, Goldman S, Hlatky M, Kannankeril PJ, Leslie L, Priori S, Saul JP, Shapiro-Mendoza CK, Siscovick D, Vetter VL, Boineau R, Burns KM, Friedman RA (2011) Screening for sudden cardiac death in the young: report from a national heart, lung, and blood institute working group. Circulation 123:1911–1918. doi:10.1161/circulationaha.110.017228 PubMedCrossRef Kaltman JR, Thompson PD, Lantos J, Berul CI, Botkin J, Cohen JT, Cook NR, Corrado D, Drezner J, Frick KD, Goldman S, Hlatky M, Kannankeril PJ, Leslie L, Priori S, Saul JP, Shapiro-Mendoza CK, Siscovick D, Vetter VL, Boineau R, Burns KM, Friedman RA (2011) Screening for sudden cardiac death in the young: report from a national heart, lung, and blood institute working group. Circulation 123:1911–1918. doi:10.​1161/​circulationaha.​110.​017228 PubMedCrossRef
106.
Zurück zum Zitat Panhuyzen-Goedkoop NM, Smeets JL (2014) Legal responsibilities of physicians when making participation decisions in athletes with cardiac disorders: do guidelines provide a solid legal footing? Br J Sports Med 48:1193–1195. doi:10.1136/bjsports-2013-093023 PubMedCrossRef Panhuyzen-Goedkoop NM, Smeets JL (2014) Legal responsibilities of physicians when making participation decisions in athletes with cardiac disorders: do guidelines provide a solid legal footing? Br J Sports Med 48:1193–1195. doi:10.​1136/​bjsports-2013-093023 PubMedCrossRef
109.
Zurück zum Zitat Mitten MJ, Zipes DP, Maron BJ, Bryant WJ (2015) Eligibility and disqualification recommendations for competitive athletes with cardiovascular abnormalities: task force 15: legal aspects of medical eligibility and disqualification recommendations: a scientific statement from the American Heart Association and American College of Cardiology. J Am Coll Cardiol 66:2447–2450. doi:10.1016/j.jacc.2015.09.047 PubMedCrossRef Mitten MJ, Zipes DP, Maron BJ, Bryant WJ (2015) Eligibility and disqualification recommendations for competitive athletes with cardiovascular abnormalities: task force 15: legal aspects of medical eligibility and disqualification recommendations: a scientific statement from the American Heart Association and American College of Cardiology. J Am Coll Cardiol 66:2447–2450. doi:10.​1016/​j.​jacc.​2015.​09.​047 PubMedCrossRef
111.
112.
Zurück zum Zitat Basso C, Maron BJ, Corrado D, Thiene G (2000) Clinical profile of congenital coronary artery anomalies with origin from the wrong aortic sinus leading to sudden death in young competitive athletes. J Am Coll Cardiol 35:1493–1501PubMedCrossRef Basso C, Maron BJ, Corrado D, Thiene G (2000) Clinical profile of congenital coronary artery anomalies with origin from the wrong aortic sinus leading to sudden death in young competitive athletes. J Am Coll Cardiol 35:1493–1501PubMedCrossRef
113.
Zurück zum Zitat Corrado D, Basso C, Fontaine G, McKenna WJ, Marcus FI, Nava A, Thiene G (2002) Clinical profile of young competitive athletes who died suddenly of arrhythmogenic right ventricular cardiomyopathy/dysplasia: a multicenter study. Pacing Clin Electrophysiol 25:544. doi:10.1111/j.1540-8159.2002.tb00021.x Corrado D, Basso C, Fontaine G, McKenna WJ, Marcus FI, Nava A, Thiene G (2002) Clinical profile of young competitive athletes who died suddenly of arrhythmogenic right ventricular cardiomyopathy/dysplasia: a multicenter study. Pacing Clin Electrophysiol 25:544. doi:10.​1111/​j.​1540-8159.​2002.​tb00021.​x
114.
Zurück zum Zitat Tester DJ, Spoon DB, Valdivia HH, Makielski JC, Ackerman MJ (2004) Targeted mutational analysis of the RyR2-encoded cardiac ryanodine receptor in sudden unexplained death: a molecular autopsy of 49 medical examiner/coroner’s cases. Mayo Clin Proc 79:1380–1384. doi:10.4065/79.11.1380 PubMedCrossRef Tester DJ, Spoon DB, Valdivia HH, Makielski JC, Ackerman MJ (2004) Targeted mutational analysis of the RyR2-encoded cardiac ryanodine receptor in sudden unexplained death: a molecular autopsy of 49 medical examiner/coroner’s cases. Mayo Clin Proc 79:1380–1384. doi:10.​4065/​79.​11.​1380 PubMedCrossRef
115.
Zurück zum Zitat Goldberger JJ, Cain ME, Hohnloser SH, Kadish AH, Knight BP, Lauer MS, Maron BJ, Page RL, Passman RS, Siscovick D, Stevenson WG, Zipes DP (2008) American Heart Association/American College of Cardiology Foundation/heart rhythm society scientific statement on noninvasive risk stratification techniques for identifying patients at risk for sudden cardiac death: a scientific statement from the American Heart Association council on clinical cardiology committee on electrocardiography and arrhythmias and council on epidemiology and prevention. Heart Rhythm 5:e1–e21. doi:10.1016/j.hrthm.2008.05.031 PubMedCrossRef Goldberger JJ, Cain ME, Hohnloser SH, Kadish AH, Knight BP, Lauer MS, Maron BJ, Page RL, Passman RS, Siscovick D, Stevenson WG, Zipes DP (2008) American Heart Association/American College of Cardiology Foundation/heart rhythm society scientific statement on noninvasive risk stratification techniques for identifying patients at risk for sudden cardiac death: a scientific statement from the American Heart Association council on clinical cardiology committee on electrocardiography and arrhythmias and council on epidemiology and prevention. Heart Rhythm 5:e1–e21. doi:10.​1016/​j.​hrthm.​2008.​05.​031 PubMedCrossRef
116.
Zurück zum Zitat Maron BJ, Friedman RA, Kligfield P, Levine BD, Viskin S, Chaitman BR, Okin PM, Saul JP, Salberg L, Van Hare GF, Soliman EZ, Chen J, Matherne GP, Bolling SF, Mitten MJ, Caplan A, Balady GJ, Thompson PD (2014) Assessment of the 12-lead electrocardiogram as a screening test for detection of cardiovascular disease in healthy general populations of young people (12–25 years of age): a scientific statement from the American Heart Association and the American College of Cardiology. J Am Coll Cardiol 64:1479–1514. doi:10.1016/j.jacc.2014.05.006 PubMedCrossRef Maron BJ, Friedman RA, Kligfield P, Levine BD, Viskin S, Chaitman BR, Okin PM, Saul JP, Salberg L, Van Hare GF, Soliman EZ, Chen J, Matherne GP, Bolling SF, Mitten MJ, Caplan A, Balady GJ, Thompson PD (2014) Assessment of the 12-lead electrocardiogram as a screening test for detection of cardiovascular disease in healthy general populations of young people (12–25 years of age): a scientific statement from the American Heart Association and the American College of Cardiology. J Am Coll Cardiol 64:1479–1514. doi:10.​1016/​j.​jacc.​2014.​05.​006 PubMedCrossRef
117.
Zurück zum Zitat Maron BJ, Levine BD, Washington RL, Baggish AL, Kovacs RJ, Maron MS (2015) Eligibility and disqualification recommendations for competitive athletes with cardiovascular abnormalities: task force 2: preparticipation screening for cardiovascular disease in competitive athletes: a scientific statement from the American Heart Association and American College of Cardiology. J Am Coll Cardiol 66:2356–2361. doi:10.1016/j.jacc.2015.09.034 PubMedCrossRef Maron BJ, Levine BD, Washington RL, Baggish AL, Kovacs RJ, Maron MS (2015) Eligibility and disqualification recommendations for competitive athletes with cardiovascular abnormalities: task force 2: preparticipation screening for cardiovascular disease in competitive athletes: a scientific statement from the American Heart Association and American College of Cardiology. J Am Coll Cardiol 66:2356–2361. doi:10.​1016/​j.​jacc.​2015.​09.​034 PubMedCrossRef
118.
Zurück zum Zitat Migliore F, Zorzi A, Michieli P, Perazzolo Marra M, Siciliano M, Rigato I, Bauce B, Basso C, Toazza D, Schiavon M, Iliceto S, Thiene G, Corrado D (2012) Prevalence of cardiomyopathy in Italian asymptomatic children with electrocardiographic T-wave inversion at preparticipation screening. Circulation 125:529–538. doi:10.1161/circulationaha.111.055673 PubMedCrossRef Migliore F, Zorzi A, Michieli P, Perazzolo Marra M, Siciliano M, Rigato I, Bauce B, Basso C, Toazza D, Schiavon M, Iliceto S, Thiene G, Corrado D (2012) Prevalence of cardiomyopathy in Italian asymptomatic children with electrocardiographic T-wave inversion at preparticipation screening. Circulation 125:529–538. doi:10.​1161/​circulationaha.​111.​055673 PubMedCrossRef
119.
Zurück zum Zitat Marcus FI (2000) Electrocardiographic features of inherited diseases that predispose to the development of cardiac arrhythmias, long QT syndrome, arrhythmogenic right ventricular cardiomyopathy/dysplasia, and Brugada syndrome. J Electrocardiol 33(Suppl):1–10PubMedCrossRef Marcus FI (2000) Electrocardiographic features of inherited diseases that predispose to the development of cardiac arrhythmias, long QT syndrome, arrhythmogenic right ventricular cardiomyopathy/dysplasia, and Brugada syndrome. J Electrocardiol 33(Suppl):1–10PubMedCrossRef
122.
Zurück zum Zitat Pelliccia A, Maron BJ (1995) Preparticipation cardiovascular evaluation of the competitive athlete: perspectives from the 30-year Italian experience. Am J Cardiol 75:827–829PubMedCrossRef Pelliccia A, Maron BJ (1995) Preparticipation cardiovascular evaluation of the competitive athlete: perspectives from the 30-year Italian experience. Am J Cardiol 75:827–829PubMedCrossRef
125.
Zurück zum Zitat Pelliccia A, Zipes DP, Maron BJ (2008) Bethesda conference #36 and the European society of cardiology consensus recommendations revisited a comparison of U.S. and European criteria for eligibility and disqualification of competitive athletes with cardiovascular abnormalities. J Am Coll Cardiol 52:1990–1996. doi:10.1016/j.jacc.2008.08.055 PubMedCrossRef Pelliccia A, Zipes DP, Maron BJ (2008) Bethesda conference #36 and the European society of cardiology consensus recommendations revisited a comparison of U.S. and European criteria for eligibility and disqualification of competitive athletes with cardiovascular abnormalities. J Am Coll Cardiol 52:1990–1996. doi:10.​1016/​j.​jacc.​2008.​08.​055 PubMedCrossRef
126.
Zurück zum Zitat Corrado D, Pelliccia A, Heidbuchel H, Sharma S, Link M, Basso C, Biffi A, Buja G, Delise P, Gussac I, Anastasakis A, Borjesson M, Bjornstad HH, Carre F, Deligiannis A, Dugmore D, Fagard R, Hoogsteen J, Mellwig KP, Panhuyzen-Goedkoop N, Solberg E, Vanhees L, Drezner J, Estes NA III, Iliceto S, Maron BJ, Peidro R, Schwartz PJ, Stein R, Thiene G, Zeppilli P, McKenna WJ (2010) Recommendations for interpretation of 12-lead electrocardiogram in the athlete. Eur Heart J 31:243–259. doi:10.1093/eurheartj/ehp473 PubMedCrossRef Corrado D, Pelliccia A, Heidbuchel H, Sharma S, Link M, Basso C, Biffi A, Buja G, Delise P, Gussac I, Anastasakis A, Borjesson M, Bjornstad HH, Carre F, Deligiannis A, Dugmore D, Fagard R, Hoogsteen J, Mellwig KP, Panhuyzen-Goedkoop N, Solberg E, Vanhees L, Drezner J, Estes NA III, Iliceto S, Maron BJ, Peidro R, Schwartz PJ, Stein R, Thiene G, Zeppilli P, McKenna WJ (2010) Recommendations for interpretation of 12-lead electrocardiogram in the athlete. Eur Heart J 31:243–259. doi:10.​1093/​eurheartj/​ehp473 PubMedCrossRef
132.
Zurück zum Zitat Maron BJ, Haas TS, Doerer JJ, Thompson PD, Hodges JS (2009) Comparison of U.S. and Italian experiences with sudden cardiac deaths in young competitive athletes and implications for preparticipation screening strategies. Am J Cardiol 104:276–280. doi:10.1016/j.amjcard.2009.03.037 PubMedCrossRef Maron BJ, Haas TS, Doerer JJ, Thompson PD, Hodges JS (2009) Comparison of U.S. and Italian experiences with sudden cardiac deaths in young competitive athletes and implications for preparticipation screening strategies. Am J Cardiol 104:276–280. doi:10.​1016/​j.​amjcard.​2009.​03.​037 PubMedCrossRef
133.
Zurück zum Zitat Steinvil A, Chundadze T, Zeltser D, Rogowski O, Halkin A, Galily Y, Perluk H, Viskin S (2011) Mandatory electrocardiographic screening of athletes to reduce their risk for sudden death proven fact or wishful thinking? J Am Coll Cardiol 57:1291–1296. doi:10.1016/j.jacc.2010.10.037 PubMedCrossRef Steinvil A, Chundadze T, Zeltser D, Rogowski O, Halkin A, Galily Y, Perluk H, Viskin S (2011) Mandatory electrocardiographic screening of athletes to reduce their risk for sudden death proven fact or wishful thinking? J Am Coll Cardiol 57:1291–1296. doi:10.​1016/​j.​jacc.​2010.​10.​037 PubMedCrossRef
135.
Zurück zum Zitat Pelliccia A, Culasso F, Di Paolo FM, Accettura D, Cantore R, Castagna W, Ciacciarelli A, Costini G, Cuffari B, Drago E, Federici V, Gribaudo CG, Iacovelli G, Landolfi L, Menichetti G, Atzeni UO, Parisi A, Pizzi AR, Rosa M, Santelli F, Santilio F, Vagnini A, Casasco M, Di Luigi L (2007) Prevalence of abnormal electrocardiograms in a large, unselected population undergoing pre-participation cardiovascular screening. Eur Heart J 28:2006–2010. doi:10.1093/eurheartj/ehm219 PubMedCrossRef Pelliccia A, Culasso F, Di Paolo FM, Accettura D, Cantore R, Castagna W, Ciacciarelli A, Costini G, Cuffari B, Drago E, Federici V, Gribaudo CG, Iacovelli G, Landolfi L, Menichetti G, Atzeni UO, Parisi A, Pizzi AR, Rosa M, Santelli F, Santilio F, Vagnini A, Casasco M, Di Luigi L (2007) Prevalence of abnormal electrocardiograms in a large, unselected population undergoing pre-participation cardiovascular screening. Eur Heart J 28:2006–2010. doi:10.​1093/​eurheartj/​ehm219 PubMedCrossRef
136.
Zurück zum Zitat Pelliccia A, Maron BJ, Culasso F, Di Paolo FM, Spataro A, Biffi A, Caselli G, Piovano P (2000) Clinical significance of abnormal electrocardiographic patterns in trained athletes. Circulation 102:278–284PubMedCrossRef Pelliccia A, Maron BJ, Culasso F, Di Paolo FM, Spataro A, Biffi A, Caselli G, Piovano P (2000) Clinical significance of abnormal electrocardiographic patterns in trained athletes. Circulation 102:278–284PubMedCrossRef
137.
Zurück zum Zitat Rowin EJ, Maron BJ, Appelbaum E, Link MS, Gibson CM, Lesser JR, Haas TS, Udelson JE, Manning WJ, Maron MS (2012) Significance of false negative electrocardiograms in preparticipation screening of athletes for hypertrophic cardiomyopathy. Am J Cardiol 110:1027–1032. doi:10.1016/j.amjcard.2012.05.035 PubMedCrossRef Rowin EJ, Maron BJ, Appelbaum E, Link MS, Gibson CM, Lesser JR, Haas TS, Udelson JE, Manning WJ, Maron MS (2012) Significance of false negative electrocardiograms in preparticipation screening of athletes for hypertrophic cardiomyopathy. Am J Cardiol 110:1027–1032. doi:10.​1016/​j.​amjcard.​2012.​05.​035 PubMedCrossRef
140.
Zurück zum Zitat Uberoi A, Stein R, Perez MV, Freeman J, Wheeler M, Dewey F, Peidro R, Hadley D, Drezner J, Sharma S, Pelliccia A, Corrado D, Niebauer J, Estes NA 3rd, Ashley E, Froelicher V (2011) Interpretation of the electrocardiogram of young athletes. Circulation 124:746–757. doi:10.1161/circulationaha.110.013078 PubMedCrossRef Uberoi A, Stein R, Perez MV, Freeman J, Wheeler M, Dewey F, Peidro R, Hadley D, Drezner J, Sharma S, Pelliccia A, Corrado D, Niebauer J, Estes NA 3rd, Ashley E, Froelicher V (2011) Interpretation of the electrocardiogram of young athletes. Circulation 124:746–757. doi:10.​1161/​circulationaha.​110.​013078 PubMedCrossRef
141.
Zurück zum Zitat Sheikh N, Papadakis M, Ghani S, Zaidi A, Gati S, Adami PE, Carre F, Schnell F, Wilson M, Avila P, McKenna W, Sharma S (2014) Comparison of electrocardiographic criteria for the detection of cardiac abnormalities in elite black and white athletes. Circulation 129:1637–1649. doi:10.1161/circulationaha.113.006179 PubMedCrossRef Sheikh N, Papadakis M, Ghani S, Zaidi A, Gati S, Adami PE, Carre F, Schnell F, Wilson M, Avila P, McKenna W, Sharma S (2014) Comparison of electrocardiographic criteria for the detection of cardiac abnormalities in elite black and white athletes. Circulation 129:1637–1649. doi:10.​1161/​circulationaha.​113.​006179 PubMedCrossRef
142.
Zurück zum Zitat Koester MC (2001) A review of sudden cardiac death in young athletes and strategies for preparticipation cardiovascular screening. J Athl Train 36:197–204PubMedPubMedCentral Koester MC (2001) A review of sudden cardiac death in young athletes and strategies for preparticipation cardiovascular screening. J Athl Train 36:197–204PubMedPubMedCentral
145.
Zurück zum Zitat Elger B, Michaud K, Mangin P (2010) When information can save lives: the duty to warn relatives about sudden cardiac death and environmental risks. Hastings Cent Rep 40:39–45PubMedCrossRef Elger B, Michaud K, Mangin P (2010) When information can save lives: the duty to warn relatives about sudden cardiac death and environmental risks. Hastings Cent Rep 40:39–45PubMedCrossRef
146.
Zurück zum Zitat Campuzano O, Allegue C, Partemi S, Iglesias A, Oliva A, Brugada R (2014) Negative autopsy and sudden cardiac death. Int J Legal Med 128:599–606. doi:10.1007/s00414-014-0966-4 Campuzano O, Allegue C, Partemi S, Iglesias A, Oliva A, Brugada R (2014) Negative autopsy and sudden cardiac death. Int J Legal Med 128:599–606. doi:10.​1007/​s00414-014-0966-4
150.
Zurück zum Zitat Harmon KG, Asif IM, Maleszewski JJ, Owens DS, Prutkin JM, Salerno JC, Zigman ML, Ellenbogen R, Rao AL, Ackerman MJ, Drezner JA (2015) Incidence, cause, and comparative frequency of sudden cardiac death in National Collegiate Athletic Association athletes: a decade in review. Circulation 132:10–19. doi:10.1161/circulationaha.115.015431 PubMedPubMedCentralCrossRef Harmon KG, Asif IM, Maleszewski JJ, Owens DS, Prutkin JM, Salerno JC, Zigman ML, Ellenbogen R, Rao AL, Ackerman MJ, Drezner JA (2015) Incidence, cause, and comparative frequency of sudden cardiac death in National Collegiate Athletic Association athletes: a decade in review. Circulation 132:10–19. doi:10.​1161/​circulationaha.​115.​015431 PubMedPubMedCentralCrossRef
152.
Zurück zum Zitat Maron BJ (1998) Cardiovascular risks to young persons on the athletic field. Ann Intern Med 129:379–386PubMedCrossRef Maron BJ (1998) Cardiovascular risks to young persons on the athletic field. Ann Intern Med 129:379–386PubMedCrossRef
153.
Zurück zum Zitat Van Camp SP, Bloor CM, Mueller FO, Cantu RC, Olson HG (1995) Nontraumatic sports death in high school and college athletes. Med Sci Sports Exerc 27:641–647PubMed Van Camp SP, Bloor CM, Mueller FO, Cantu RC, Olson HG (1995) Nontraumatic sports death in high school and college athletes. Med Sci Sports Exerc 27:641–647PubMed
154.
156.
Zurück zum Zitat Breuckmann F, Mohlenkamp S, Nassenstein K, Lehmann N, Ladd S, Schmermund A, Sievers B, Schlosser T, Jockel KH, Heusch G, Erbel R, Barkhausen J (2009) Myocardial late gadolinium enhancement: prevalence, pattern, and prognostic relevance in marathon runners. Radiology 251:50–57. doi:10.1148/radiol.2511081118 PubMedCrossRef Breuckmann F, Mohlenkamp S, Nassenstein K, Lehmann N, Ladd S, Schmermund A, Sievers B, Schlosser T, Jockel KH, Heusch G, Erbel R, Barkhausen J (2009) Myocardial late gadolinium enhancement: prevalence, pattern, and prognostic relevance in marathon runners. Radiology 251:50–57. doi:10.​1148/​radiol.​2511081118 PubMedCrossRef
157.
160.
Zurück zum Zitat Martinez-Diaz F, Bernal-Gilar M, Gomez-Zapata M, Luna A (2004) Expression and significance of cell immunohistochemical markers (HHF-35, CD-31, Bcl-2, P-53 and apopDETEC) in hypertrophic cardiomyopathy. Histol Histopathol 19:9–14PubMed Martinez-Diaz F, Bernal-Gilar M, Gomez-Zapata M, Luna A (2004) Expression and significance of cell immunohistochemical markers (HHF-35, CD-31, Bcl-2, P-53 and apopDETEC) in hypertrophic cardiomyopathy. Histol Histopathol 19:9–14PubMed
162.
163.
Zurück zum Zitat La Gerche A, Robberecht C, Kuiperi C, Nuyens D, Willems R, de Ravel T, Matthijs G, Heidbuchel H (2010) Lower than expected desmosomal gene mutation prevalence in endurance athletes with complex ventricular arrhythmias of right ventricular origin. Heart 96:1268–1274. doi:10.1136/hrt.2009.189621 PubMedCrossRef La Gerche A, Robberecht C, Kuiperi C, Nuyens D, Willems R, de Ravel T, Matthijs G, Heidbuchel H (2010) Lower than expected desmosomal gene mutation prevalence in endurance athletes with complex ventricular arrhythmias of right ventricular origin. Heart 96:1268–1274. doi:10.​1136/​hrt.​2009.​189621 PubMedCrossRef
164.
166.
Zurück zum Zitat Asimaki A, Tandri H, Huang H, Halushka MK, Gautam S, Basso C, Thiene G, Tsatsopoulou A, Protonotarios N, McKenna WJ, Calkins H, Saffitz JE (2009) A new diagnostic test for arrhythmogenic right ventricular cardiomyopathy. N Engl J Med 360:1075–1084. doi:10.1056/NEJMoa0808138 PubMedCrossRef Asimaki A, Tandri H, Huang H, Halushka MK, Gautam S, Basso C, Thiene G, Tsatsopoulou A, Protonotarios N, McKenna WJ, Calkins H, Saffitz JE (2009) A new diagnostic test for arrhythmogenic right ventricular cardiomyopathy. N Engl J Med 360:1075–1084. doi:10.​1056/​NEJMoa0808138 PubMedCrossRef
167.
Zurück zum Zitat Yoshida T, Kawano H, Kusumoto S, Fukae S, Koga S, Ikeda S, Koide Y, Abe K, Hayashi T, Maemura K (2015) Relationships between clinical characteristics and decreased plakoglobin and connexin 43 expressions in myocardial biopsies from patients with arrhythmogenic right ventricular cardiomyopathy. Int Heart J 56:626–631. doi:10.1536/ihj.15-144 PubMedCrossRef Yoshida T, Kawano H, Kusumoto S, Fukae S, Koga S, Ikeda S, Koide Y, Abe K, Hayashi T, Maemura K (2015) Relationships between clinical characteristics and decreased plakoglobin and connexin 43 expressions in myocardial biopsies from patients with arrhythmogenic right ventricular cardiomyopathy. Int Heart J 56:626–631. doi:10.​1536/​ihj.​15-144 PubMedCrossRef
168.
Zurück zum Zitat Siragam V, Cui X, Masse S, Ackerley C, Aafaqi S, Strandberg L, Tropak M, Fridman MD, Nanthakumar K, Liu J, Sun Y, Su B, Wang C, Liu X, Yan Y, Mendlowitz A, Hamilton RM (2014) TMEM43 mutation p.S358L alters intercalated disc protein expression and reduces conduction velocity in arrhythmogenic right ventricular cardiomyopathy. PLoS One 9:e109128. doi:10.1371/journal.pone.0109128 PubMedPubMedCentralCrossRef Siragam V, Cui X, Masse S, Ackerley C, Aafaqi S, Strandberg L, Tropak M, Fridman MD, Nanthakumar K, Liu J, Sun Y, Su B, Wang C, Liu X, Yan Y, Mendlowitz A, Hamilton RM (2014) TMEM43 mutation p.S358L alters intercalated disc protein expression and reduces conduction velocity in arrhythmogenic right ventricular cardiomyopathy. PLoS One 9:e109128. doi:10.​1371/​journal.​pone.​0109128 PubMedPubMedCentralCrossRef
169.
Zurück zum Zitat Kwon YS, Park TI, Cho Y, Bae MH, Kim S (2013) Clinical usefulness of immunohistochemistry for plakoglobin, N-cadherin, and connexin-43 in the diagnosis of arrhythmogenic right ventricular cardiomyopathy. Int J Clin Exp Pathol 6:2928–2935PubMedPubMedCentral Kwon YS, Park TI, Cho Y, Bae MH, Kim S (2013) Clinical usefulness of immunohistochemistry for plakoglobin, N-cadherin, and connexin-43 in the diagnosis of arrhythmogenic right ventricular cardiomyopathy. Int J Clin Exp Pathol 6:2928–2935PubMedPubMedCentral
170.
171.
Zurück zum Zitat Rizzo S, Basso C, Lazzarini E, Celeghin R, Paolin A, Gerosa G, Valente M, Thiene G, Pilichou K (2015) TGF-beta1 pathway activation and adherens junction molecular pattern in nonsyndromic mitral valve prolapse. Cardiovasc Pathol 24:359–367. doi:10.1016/j.carpath.2015.07.009 PubMedCrossRef Rizzo S, Basso C, Lazzarini E, Celeghin R, Paolin A, Gerosa G, Valente M, Thiene G, Pilichou K (2015) TGF-beta1 pathway activation and adherens junction molecular pattern in nonsyndromic mitral valve prolapse. Cardiovasc Pathol 24:359–367. doi:10.​1016/​j.​carpath.​2015.​07.​009 PubMedCrossRef
172.
Zurück zum Zitat Corrado D, Nava A, Buja G, Martini B, Fasoli G, Oselladore L, Turrini P, Thiene G (1996) Familial cardiomyopathy underlies syndrome of right bundle branch block, ST segment elevation and sudden death. J Am Coll Cardiol 27:443–448PubMedCrossRef Corrado D, Nava A, Buja G, Martini B, Fasoli G, Oselladore L, Turrini P, Thiene G (1996) Familial cardiomyopathy underlies syndrome of right bundle branch block, ST segment elevation and sudden death. J Am Coll Cardiol 27:443–448PubMedCrossRef
173.
Zurück zum Zitat James TN, Zipes DP, Finegan RE, Eisele JW, Carter JE (1979) Cardiac ganglionitis associated with sudden unexpected death. Ann Intern Med 91:727–730PubMedCrossRef James TN, Zipes DP, Finegan RE, Eisele JW, Carter JE (1979) Cardiac ganglionitis associated with sudden unexpected death. Ann Intern Med 91:727–730PubMedCrossRef
174.
Zurück zum Zitat Rizzo S, Basso C, Troost D, Aronica E, Frigo AC, Driessen AH, Thiene G, Wilde AA, van der Wal AC (2014) T-cell-mediated inflammatory activity in the stellate ganglia of patients with ion-channel disease and severe ventricular arrhythmias. Circ Arrhythm Electrophysiol 7:224–229. doi:10.1161/circep.113.001184 PubMedCrossRef Rizzo S, Basso C, Troost D, Aronica E, Frigo AC, Driessen AH, Thiene G, Wilde AA, van der Wal AC (2014) T-cell-mediated inflammatory activity in the stellate ganglia of patients with ion-channel disease and severe ventricular arrhythmias. Circ Arrhythm Electrophysiol 7:224–229. doi:10.​1161/​circep.​113.​001184 PubMedCrossRef
176.
Zurück zum Zitat Angelini A, Crosato M, Boffa GM, Calabrese F, Calzolari V, Chioin R, Daliento L, Thiene G (2002) Active versus borderline myocarditis: clinicopathological correlates and prognostic implications. Heart 87:210–215PubMedPubMedCentralCrossRef Angelini A, Crosato M, Boffa GM, Calabrese F, Calzolari V, Chioin R, Daliento L, Thiene G (2002) Active versus borderline myocarditis: clinicopathological correlates and prognostic implications. Heart 87:210–215PubMedPubMedCentralCrossRef
177.
Zurück zum Zitat Angelini A, Calzolari V, Calabrese F, Boffa GM, Maddalena F, Chioin R, Thiene G (2000) Myocarditis mimicking acute myocardial infarction: role of endomyocardial biopsy in the differential diagnosis. Heart 84:245–250PubMedPubMedCentralCrossRef Angelini A, Calzolari V, Calabrese F, Boffa GM, Maddalena F, Chioin R, Thiene G (2000) Myocarditis mimicking acute myocardial infarction: role of endomyocardial biopsy in the differential diagnosis. Heart 84:245–250PubMedPubMedCentralCrossRef
179.
Zurück zum Zitat Pelliccia A, Maron BJ, De Luca R, Di Paolo FM, Spataro A, Culasso F (2002) Remodeling of left ventricular hypertrophy in elite athletes after long-term deconditioning. Circulation 105:944–949PubMedCrossRef Pelliccia A, Maron BJ, De Luca R, Di Paolo FM, Spataro A, Culasso F (2002) Remodeling of left ventricular hypertrophy in elite athletes after long-term deconditioning. Circulation 105:944–949PubMedCrossRef
180.
Zurück zum Zitat Pelliccia A, Culasso F, Di Paolo FM, Maron BJ (1999) Physiologic left ventricular cavity dilatation in elite athletes. Ann Intern Med 130:23–31PubMedCrossRef Pelliccia A, Culasso F, Di Paolo FM, Maron BJ (1999) Physiologic left ventricular cavity dilatation in elite athletes. Ann Intern Med 130:23–31PubMedCrossRef
181.
Zurück zum Zitat Abergel E, Chatellier G, Hagege AA, Oblak A, Linhart A, Ducardonnet A, Menard J (2004) Serial left ventricular adaptations in world-class professional cyclists: implications for disease screening and follow-up. J Am Coll Cardiol 44:144–149. doi:10.1016/j.jacc.2004.02.057 PubMedCrossRef Abergel E, Chatellier G, Hagege AA, Oblak A, Linhart A, Ducardonnet A, Menard J (2004) Serial left ventricular adaptations in world-class professional cyclists: implications for disease screening and follow-up. J Am Coll Cardiol 44:144–149. doi:10.​1016/​j.​jacc.​2004.​02.​057 PubMedCrossRef
182.
Zurück zum Zitat Mahon NG, Madden BP, Caforio AL, Elliott PM, Haven AJ, Keogh BE, Davies MJ, McKenna WJ (2002) Immunohistologic evidence of myocardial disease in apparently healthy relatives of patients with dilated cardiomyopathy. J Am Coll Cardiol 39:455–462PubMedCrossRef Mahon NG, Madden BP, Caforio AL, Elliott PM, Haven AJ, Keogh BE, Davies MJ, McKenna WJ (2002) Immunohistologic evidence of myocardial disease in apparently healthy relatives of patients with dilated cardiomyopathy. J Am Coll Cardiol 39:455–462PubMedCrossRef
185.
Zurück zum Zitat Gati S, Chandra N, Bennett RL, Reed M, Kervio G, Panoulas VF, Ghani S, Sheikh N, Zaidi A, Wilson M, Papadakis M, Carre F, Sharma S (2013) Increased left ventricular trabeculation in highly trained athletes: do we need more stringent criteria for the diagnosis of left ventricular non-compaction in athletes? Heart 99:401–408. doi:10.1136/heartjnl-2012-303418 PubMedCrossRef Gati S, Chandra N, Bennett RL, Reed M, Kervio G, Panoulas VF, Ghani S, Sheikh N, Zaidi A, Wilson M, Papadakis M, Carre F, Sharma S (2013) Increased left ventricular trabeculation in highly trained athletes: do we need more stringent criteria for the diagnosis of left ventricular non-compaction in athletes? Heart 99:401–408. doi:10.​1136/​heartjnl-2012-303418 PubMedCrossRef
188.
Zurück zum Zitat Hertz CL, Christiansen SL, Ferrero-Miliani L, Dahl M, Weeke PE, Ottesen GL, Frank-Hansen R, Bundgaard H, Morling N (2016) Next-generation sequencing of 100 candidate genes in young victims of suspected sudden cardiac death with structural abnormalities of the heart. Int J Legal Med 130:91–102. doi:10.1007/s00414-015-1261-8 PubMedCrossRef Hertz CL, Christiansen SL, Ferrero-Miliani L, Dahl M, Weeke PE, Ottesen GL, Frank-Hansen R, Bundgaard H, Morling N (2016) Next-generation sequencing of 100 candidate genes in young victims of suspected sudden cardiac death with structural abnormalities of the heart. Int J Legal Med 130:91–102. doi:10.​1007/​s00414-015-1261-8 PubMedCrossRef
189.
Zurück zum Zitat Papadakis M, Raju H, Behr ER, De Noronha SV, Spath N, Kouloubinis A, Sheppard MN, Sharma S (2013) Sudden cardiac death with autopsy findings of uncertain significance: potential for erroneous interpretation. Circ Arrhythm Electrophysiol 6:588–596. doi:10.1161/circep.113.000111 PubMedCrossRef Papadakis M, Raju H, Behr ER, De Noronha SV, Spath N, Kouloubinis A, Sheppard MN, Sharma S (2013) Sudden cardiac death with autopsy findings of uncertain significance: potential for erroneous interpretation. Circ Arrhythm Electrophysiol 6:588–596. doi:10.​1161/​circep.​113.​000111 PubMedCrossRef
191.
Zurück zum Zitat Stattin EL, Westin IM, Cederquist K, Jonasson J, Jonsson BA, Morner S, Norberg A, Krantz P, Wisten A (2016) Genetic screening in sudden cardiac death in the young can save future lives. Int J Legal Med 130:59–66. doi:10.1007/s00414-015-1237-8 PubMedCrossRef Stattin EL, Westin IM, Cederquist K, Jonasson J, Jonsson BA, Morner S, Norberg A, Krantz P, Wisten A (2016) Genetic screening in sudden cardiac death in the young can save future lives. Int J Legal Med 130:59–66. doi:10.​1007/​s00414-015-1237-8 PubMedCrossRef
193.
Zurück zum Zitat Wilhelm M, Bolliger SA, Bartsch C, Fokstuen S, Grani C, Martos V, Medeiros Domingo A, Osculati A, Rieubland C, Sabatasso S, Saguner AM, Schyma C, Tschui J, Wyler D, Bhuiyan ZA, Fellmann F, Michaud K (2015) Sudden cardiac death in forensic medicine—Swiss recommendations for a multidisciplinary approach. Swiss Med Wkly 145:w14129. doi:10.4414/smw.2015.14129 PubMed Wilhelm M, Bolliger SA, Bartsch C, Fokstuen S, Grani C, Martos V, Medeiros Domingo A, Osculati A, Rieubland C, Sabatasso S, Saguner AM, Schyma C, Tschui J, Wyler D, Bhuiyan ZA, Fellmann F, Michaud K (2015) Sudden cardiac death in forensic medicine—Swiss recommendations for a multidisciplinary approach. Swiss Med Wkly 145:w14129. doi:10.​4414/​smw.​2015.​14129 PubMed
Metadaten
Titel
Medico-legal perspectives on sudden cardiac death in young athletes
verfasst von
Antonio Oliva
Vincenzo M. Grassi
Oscar Campuzano
Maria Brion
Vincenzo Arena
Sara Partemi
Monica Coll
Vincenzo L. Pascali
Josep Brugada
Angel Carracedo
Ramon Brugada
Publikationsdatum
21.09.2016
Verlag
Springer Berlin Heidelberg
Erschienen in
International Journal of Legal Medicine / Ausgabe 2/2017
Print ISSN: 0937-9827
Elektronische ISSN: 1437-1596
DOI
https://doi.org/10.1007/s00414-016-1452-y

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