Given that there is no clear conclusion on the link between metal allergy and implant failure, it logically follows that there is a similar lack of consensus on the approach to the testing and management of patients. The crucial question at hand is whether there is a need to carry out screening prior to implanting metal devices. If screening is needed, what is the most effective determination of metal allergy: epicutaneous patch testing, a lymphocyte transformation test or a self-reported history of metal reactions? In addition, how should we tailor the pre-implantation management plan for those who test positive? Should hypoallergenic alloys, with which surgeons may be less familiar and are more expensive, be used? What about the management plan for patients with suspected metal hypersensitivity post-implantation? This paper aims to answer each question in turn.
Is there a need for pre-implant testing?
Routine pre-implant screening or testing prior to surgery is not indicated, and opinions regarding the appropriate patients to test prior to surgery are controversial. There are no scientific or expert agreements on whether metal hypersensitivity reactions cause joint morbidity or failure following implant, and thus there is also no agreement on which patients require pre-surgical allergy evaluation.
A cohort study of 127 patients with 161 TKA (56 patients with patch test positives) versus 161 matched control TKAs without known metal allergy history or positive patch testing were followed over a period of 5.3 years [
41]. Most interestingly, those with patch test positives had similar reoperation, revision or complication rates in comparison to those with a normal skin patch testing as well as matched controls. Post-operative pain was not different between any of the groups. In view of the findings of the study, skin patch testing showed little value for predicting the clinical outcomes and was not recommended as a guide for implant alloy choice. A recent review lends support to the stance that pre-implantation testing is not routinely needed: the review acknowledged the presence of an association between implant failure and metal hypersensitivity, but concludes that the absence of a casual relationship means that the use of “hypoallergenic” implants cannot be justified [
43]. Other studies advocate the view that pre-implantation testing is unhelpful and of minimal benefit. For instance, Lachiewicz et al. proposed that pre-implantation screening prior to TKA is not necessary and that metal allergy post-TKA should only be diagnosed after all other possibilities are excluded [
40].
A group of 18 patients with pre-implant confirmed nickel allergy were followed for 6.3 years following implantation of a nickel-containing device. None of these patients developed cutaneous or systemic signs of metal hypersensitivity [
45]. In another study of 50 patients following TKA, 32% had positive skin patch tests to the metal constituents of the device (
n = 16), but there was no correlation between allergy and loosening or other prosthesis morbidity [
42]. At this time, there are no definitive studies supporting any diagnostic test for routine pre-implant screening.
While these studies are not supportive of pre-implant metal allergy evaluation, it is also still important to consider patient history of possible metal allergy when making an implant choice prior to surgery. A patient’s psychological status has strong influences on their clinical outcomes [
46]. Patient reports of metal allergy prior to implantation were associated with poorer functional outcomes (TKA) and mental health scores (THA) [
44]. Similar findings have been reported, finding that patient-reported allergies are a surrogate for mental health factors that lead to increased postoperative morbidity, and poorer functional/psychosocial outcomes [
47‐
49]. In a study of 459 THA or TKA patients reporting ≥4 allergies, they had decreased improvement and functional outcomes following surgery when compared to those with fewer allergies [
50]. A strong predictor of post-operative satisfaction following TKA is whether or not the surgeon met the patient’s pre-operative expectations [
51]. Thus, clear communication and making an effort to define patient expectations is important. Defining metal allergy status is one of many factors necessary to building a unique management plan for the individual. In some cases, it may be beneficial and indicated to use an appropriate allergen-free implant to eliminate patient worry as a potential source of post-operative pain in those reporting clinical metal reactions [
44].
The Danish experience as reported by Thyssen advises against routine pre-surgery patch testing unless there is a patient or clinical history of metal reactions “of a magnitude sufficient to cause concern to the patient or the doctor” [
52]. In Sweden, “virtually no such patients are evaluated” [
53]. In the United Kingdom, a Delphi Analysis of orthopedic surgeons reported that standard cobalt chromium/stainless steel devices should be implanted regardless of the patient’s metal allergy status [
54]. In Germany, a consensus group pragmatically suggests using titanium alloys for any patient self-reporting metal allergy. No pre-implant testing was recommended [
55]. Earlier perspectives from the United States were from Granchi and Reed, both suggesting patch testing prior to surgery in patients reporting a clinical history or metal sensitivity [
56,
57]. Recently, the American Contact Dermatitis Society (ACDS) published a consensus opinion regarding metal hypersensitivity reactions to implanted devices. Routine pre-implant testing is not recommended. In those rare patients self-reporting metal reactions on the skin, evaluation is suggested but not mandatory [
58].
In a survey performed at the European Society of Contact Dermatitis (ESCD) and subsequently the ACDS meetings, 54% of respondents considered patch testing prior to surgery indicated for those individuals reporting moderate or severe rashes after metal contact. For those not agreeing with preoperative testing, 38% considered a titanium-based alloy an acceptable alternative [
59]. Schalock and colleagues recommend a thoughtful and custom approach to pre-implant metal allergy: when the patch test is positive, other factors must still be taken into account, such as choosing the device that will be the best functional and durable implant [
60]. Ultimately, it is up to the patient and surgeon to decide the ‘best’ and most appropriate device.
Which Test is Preferred Pre-Implantation?
If pre-implantation testing is needed, the question that follows is which test would be most appropriate? Determining delayed-type hypersensitivity to metals can be done via two routes: by skin patch testing or through a blood test such as the lymphocyte transformation test (LTT) or leukocyte migration inhibition test.
The patch test is performed on the skin and is simple to perform, widely available and offers a wide variety of possible testing when compared to the LTT [
61]. Intradermal testing is rarely used due to false positive reactions with metal allergens [
59,
62‐
66]. The LTT is a measurement of lymphocyte proliferation in the presence and absence of a potential allergen. The patient’s lymphocytes are taken from peripheral blood and incubated for 7 days, with and without the allergen presence. The result is reported as a stimulation index, comparing the reactions. In the leukocyte migration inhibition test, mixed population leukocyte migration activity is measured in the presence of antigen. If the result is positive, migration is faster in non-allergic individuals [
30].
The patch test is considered the gold standard for detecting systemic type IV hypersensitivity reactions in the opinion of dermatologists. In a survey of the ACDS and EACD members, 83% of respondents considered the patch test to be the diagnostic test of choice for evaluation of metal allergy. Only 12% of dermatologist commonly used the LTT [
59,
67]. Orthopedic surgeons have different views of metal allergy and the necessity of testing. Their general opinion is that there is not a relevant correlation between patch testing on the skin and the immunologic responses in and around the bone–implant interface [
68]. This reluctance may in fact be correct, since the relationship between actual skin reactions in response to implanted metal allergy as well as peri-implant morbidity continues to be unclear [
69]. Skin exposure is not the same as the constant exposure experienced in the closed subcutaneous environment adjacent to the metallic implant. The dendritic cells present similar, but not the same. It is possible that the patch test only partially reproduces this peri-implant environment [
70,
71]. In the skin, the Langerhans cells are the primary antigen-presenting cell, while other similar dendritic cells and macrophages take on this role adjacent to the bone–implant interface. Langerhans cells seem to have a greater antigen-presenting ability when compared to macrophages in the blood [
30,
72]. Due to this, some believe that the LTT is more useful for prognosis and diagnosis of metal reactions when compared to patch testing [
73,
74].
Despite this, it is unlikely that the LTT will replace the patch test as the gold standard and most commonly clinically used test. Unfortunately, the LTT is not widely available for clinical use, is not standardized, has inter-laboratory variability and is often not covered by insurance (leading to higher patient costs). Also, the LTT may produce false negative results if the test is not transported and processed in a timely manner. Due to rapid T cell decay, even short delays can lead to false negative results [
60].
At this time, the scientific literature and these authors thus favor the skin patch test as the best available test to evaluate potential metal hypersensitivity reactions, both prior to and following implantation. The role of the LTT remains unclear, but seems to be gaining support for use in conjunction with the patch test and potentially coupled with peri-implant histopathology [
60,
67,
75,
76]. Protocols for patch testing have been proposed based on implant type and surgical location [
60,
77,
78].
One suggested use for the LTT is for further evaluation of those patients with negative patch testing and a residual strong clinical suspicion for metal allergy. In an evaluation of 56 patients with titanium alloy implants with systemic symptoms and negative skin patch testing, 54/56 had positive LTT. These 54 had complete symptom resolution after implant replacement with a non-titanium device [
79]. Another study combined three in vitro assays, measuring different aspects of lymphocyte activation in the hope of improving diagnosis [
80]. At this time, more research is needed to definitively determine the validity and appropriate clinical use of the LTT [
81].
Post-Implantation Testing
Surprisingly, there is unanimous consensus on how patients with asymptomatic, well-functioning devices should be managed: there is no indication for metal allergy testing.
Management of patients who suffer from residual post-implantation pain is not as well defined. It is difficult to ascertain, using patch testing alone, if a patient truly does suffer from metal hypersensitivity, and idetermining which patient would benefit from implant removal/revision is also challenging. Granchi et al. concluded that testing is indicated in failed metal-on-metal temporomandibular joint replacements with unclear diagnosis [
82]. The assumption is that there exist numerous more common causes for pain, loosening and/or failure and that these should be explored prior to considering metal hypersensitivity as the cause. These include component malalignment, complex regional pain syndrome, crepitation, early aseptic loosening, infection, instability, patellofemoral symptoms or patellar clunk syndrome [
83]. For patients who experience residual pain after TKA, metal hypersensitivity should only be suspected if the patient had a normal physical exam and radiographs/CT scans or MARS MRI, and normal laboratory work-up [
83]. An alternative approach uses clinical findings to identify those with a high suspicion of metal allergy who may benefit from metal allergy evaluation [
77].
Major diagnostic criteria for post-implantation metal hypersensitivity reactions include [
78]:
-
Eruption overlying the metal implant.
-
Positive patch test reaction to a metal used in the implant.
-
Complete recovery after removal of the offending implant.
-
Chronic dermatitis beginning weeks to months after metallic implantation.
While reactions considered to be less important are:
-
Dermatitis is therapy-resistant.
-
Morphology consistent with dermatitis (erythema, induration, papules, vesicles).
-
Systemic allergic dermatitis reaction.
-
Histology consistent with allergic contact dermatitis.
-
Positive in vitro test to metals, e.g., the lymphocyte transformation test.
Paradoxically, to arrive at a definitive diagnosis of metal allergy, it is necessary for the patient to undergo complete resolution of symptoms after device replacement with a non-allergenic implant. In a similar vein, Middleton suggests that reaching a definitive diagnosis of allergy-related implant is near-impossible, as not only does it require a show of improvement of clinical symptoms after implant replacement with an immunologically inert device but there should also technically be evidence of typical T-lymphocyte-rich immunohistopathology and a positive implant-relevant epicutaneous patch test [
44].
While it is promising that the academic discussion surrounding metal hypersensitivity is thriving, the conflicting conclusions in the literature shed insufficient light on pertinent issues, including but not limited to how patients who suffer from chronic post-surgical pain should be managed and the extent to which symptoms may be caused by metal allergy. More studies are needed before a definitive, evidence-based algorithm for diagnosis and management can be generated to tackle the existing dilemma.