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11.01.2018 | Brief Report

MicroRNA expression in SMARCB1/INI1-deficient sinonasal carcinoma: a clinicopathological and molecular genetic study

verfasst von: Jan Laco, Helena Kovaříková, Marcela Chmelařová, Hana Vošmiková, Kateřina Sieglová, Ivana Baranová, Pavel Dundr, Kristýna Němejcová, Jaroslav Michálek, Jana Šatanková, Milan Vošmik, Aleš Ryška

Erschienen in: Virchows Archiv | Ausgabe 5/2018

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Carcinomas of the sinonasal tract comprise of a heterogenous group of rare malignant tumors, of which the etiopathogenesis is largely unknown. In about 20–30% of sinonasal squamous cell carcinomas, high-risk human papillomavirus (HPV) has been identified, making the sinonasal area the second hot spot for HPV-associated carcinomas of the head and neck, after the oropharynx [1‐3]. …

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Laco J, Sieglová K, Vošmiková H, Dundr P, Němejcová K, Michálek J, Čelakovský P, Chrobok V, Mottl R, Mottlová A, Tuček L, Slezák R, Chmelařová M, Sirák I, Vošmik M, Ryška A (2015) The presence of high-risk human papillomavirus (HPV) E6/E7 mRNA transcripts in a subset of sinonasal carcinomas is evidence of involvement of HPV in its etiopathogenesis. Virchows Arch 467(4):405–415. https://doi.org/10.1007/s00428-015-1812-x CrossRefPubMed

Laco J, Vosmikova H, Novakova V, Celakovsky P, Dolezalova H, Tucek L, Nekvindova J, Vosmik M, Cermakova E, Ryska A (2011) The role of high risk human papillomavirus infection in oral and oropharyngeal squamous cell carcinoma in non-smoking and non-drinking patients: a clinicopathological and molecular study of 46 cases. Virchows Arch 458(2):179–187. https://doi.org/10.1007/s00428-010-1037-y CrossRefPubMed

Laco J, Nekvindova J, Novakova V, Celakovsky P, Dolezalova H, Tucek L, Vosmikova H, Vosmik M, Neskudlova T, Cermakova E, Hacova M, Ryska A (2012) Biologic importance and prognostic significance of selected clinicopathological parameters in patients with oral and oropharyngeal squamous cell carcinoma, with emphasis on smoking, protein p16^INK4a expression, and HPV status. Neoplasma 59(04):398–408. https://doi.org/10.4149/neo_2012_052 CrossRefPubMed

Laco J, Kovaříková H, Chmelařová M, Vošmiková H, Sieglová K, Bubancová I, Dundr P, Němejcová K, Michálek J, Čelakovský P, Mottl R, Sirák I, Vošmik M, Marek I, Geryk T, Mejzlík J, Šatanková J, Ryška A (2018) Analysis of DNA methylation and microRNA expression in NUT (nuclear protein in testis) midline carcinoma of the sinonasal tract: a clinicopathological, immunohistochemical and molecular genetic study. Neoplasma 65:101–111. https://doi.org/10.4149/neo_2018_161122N581 CrossRef

Agaimy A, Koch M, Lell M, Semrau S, Dudek W, Wachter DL, Knöll A, Iro H, Haller F, Hartmann A (2014) SMARCB1(INI1)-deficient sinonasal basaloid carcinoma: a novel member of the expanding family of SMARCB1-deficient neoplasms. Am J Surg Pathol 38(9):1274–1281. https://doi.org/10.1097/PAS.0000000000000236 CrossRefPubMedPubMedCentral

Bishop JA, Antonescu CR, Westra WH (2014) SMARCB1 (INI-1)-deficient carcinoma of the sinonasal tract. Am J Surg Pathol 38(9):1282–1289. https://doi.org/10.1097/PAS.0000000000000285 CrossRefPubMedPubMedCentral

Bell D, Hanna EY, Agaimy A, Weissferdt A (2015) Reappraisal of sinonasal undifferentiated carcinoma: SMARCB1 (INI1)-deficient sinonasal carcinoma: a single-institution experience. Virchows Arch 467(6):649–656. https://doi.org/10.1007/s00428-015-1853-1 CrossRefPubMed

Allison DB, Bishop JA, Ali SZ (2016) Cytopathologic characteristics of SMARCB1 (INI-1) deficient sinonasal carcinoma: a potential diagnostic pitfall. Diagn Cytopathol 44(8):700–703. https://doi.org/10.1002/dc.23503 CrossRefPubMed

Wasserman JK, Dickson BC, Perez-Ordonez B, de Almeida JR, Irish JC, Weinreb I (2017) INI1 (SMARCB1)-deficient sinonasal carcinoma: a clinicopathologic report of 2 cases. Head Neck Pathol 11(2):256–261. https://doi.org/10.1007/s12105-016-0752-3 CrossRefPubMed

10.

Agaimy A, Hartmann A, Antonescu CR, Chiosea SI, El-Mofty SK, Geddert H, Iro H, Lewis JS Jr, Märkl B, Mills SE, Riener MO, Robertson T, Sandison A, Semrau S, Simpson RH, Stelow E, Westra WH, Bishop JA (2017) SMARCB1 (INI-1)-deficient sinonasal carcinoma: a series of 39 cases expanding the morphologic and clinicopathologic spectrum of a recently described entity. Am J Surg Pathol 41(4):458–471. https://doi.org/10.1097/PAS.0000000000000797 CrossRefPubMedPubMedCentral

11.

Laco J, Chmelařová M, Vošmiková H, Sieglová K, Bubancová I, Dundr P, Němejcová K, Michálek J, Čelakovský P, Mottl R, Sirák I, Vošmik M, Ryška A (2017) SMARCB1/INI1-deficient sinonasal carcinoma shows methylation of RASSF1 gene: a clinicopathological, immunohistochemical and molecular genetic study of a recently described entity. Pathol Res Pract 213(2):133–142. https://doi.org/10.1016/j.prp.2016.10.012 CrossRefPubMed

12.

Chmelařová M, Sirák I, Mžik M, Sieglová K, Vošmiková H, Dundr P, Němejcová K, Michálek J, Vošmik M, Palička V, Laco J (2016) Importance of tumour suppressor gene methylation in sinonasal carcinomas. Folia Biol (Praha) 62(3):110–119

13.

Kovarikova H, Bubancova I, Laco J, Sieglova K, Vosmikova H, Dundr P, Nemejcova K, Michalek J, Vosmik M, Palicka V, Chmelarova M (2017) Deregulation of selected microRNAs in sinonasal carcinoma: value of miR-21 as prognostic biomarker in sinonasal squamous cell carcinoma. Head Neck 39(12):2528–2536. https://doi.org/10.1002/hed.24930 CrossRefPubMed

14.

Jamali Z, Asl Aminabadi N, Attaran R, Pournagiazar F, Ghertasi Oskouei S, Ahmadpour F (2015) MicroRNAs as prognostic molecular signatures in human head and neck squamous cell carcinoma: a systematic review and meta-analysis. Oral Oncol 51(4):321–331. https://doi.org/10.1016/j.oraloncology.2015.01.008 CrossRefPubMed

15.

Sredni ST, Bonaldo Mde F, Costa FF, Huang CC, Hamm CA, Rajaram V, Tomita T, Goldman S, Bischof JM, Soares MB (2010) Upregulation of mir-221 and mir-222 in atypical teratoid/rhabdoid tumors: potential therapeutic targets. Childs Nerv Syst 26(3):279–283. https://doi.org/10.1007/s00381-009-1028-y CrossRefPubMed

16.

Grupenmacher AT, Halpern AL, Bonaldo Mde F, Huang CC, Hamm CA, de Andrade A, Tomita T, Sredni ST (2013) Study of the gene expression and microRNA expression profiles of malignant rhabdoid tumors originated in the brain (AT/RT) and in the kidney (RTK). Childs Nerv Syst 29(11):1977–1983. https://doi.org/10.1007/s00381-013-2268-4 CrossRefPubMed

17.

Kohashi K, Yamamoto H, Kumagai R, Yamada Y, Hotokebuchi Y, Taguchi T, Iwamoto Y, Oda Y (2014) Differential microRNA expression profiles between malignant rhabdoid tumor and epithelioid sarcoma: miR193a-5p is suggested to downregulated SMARCB1 mRNA expression. Mod Pathol 27(6):832–839. https://doi.org/10.1038/modpathol.2013.213 CrossRefPubMed

18.

Sápi Z, Papp G, Szendröi PZ, Plótár V, Krausz T, Fletcher CD (2016) Epigenetic regulation of SMARCB1 by miR-2016, -381 and -671-5p is evident in a variety of SMARCB1 immunonegative soft tissue sarcomas, while miR-765 appears specific for epithelioid sarcoma. A miRNA study of 223 soft tissue sarcomas. Genes Chromosomes Cancer 55(10):786–802. https://doi.org/10.1002/gcc.22379 CrossRefPubMed

19.

Rupaimoole R, Slack FJ (2017) MicroRNA therapeutics: towards a new era for the management of cancer and other diseases. Nat Rev Drug Discov 16(3):203–222. https://doi.org/10.1038/nrd.2016.246 CrossRefPubMed

Titel: MicroRNA expression in SMARCB1/INI1-deficient sinonasal carcinoma: a clinicopathological and molecular genetic study
verfasst von: Jan Laco
Helena Kovaříková
Marcela Chmelařová
Hana Vošmiková
Kateřina Sieglová
Ivana Baranová
Pavel Dundr
Kristýna Němejcová
Jaroslav Michálek
Jana Šatanková
Milan Vošmik
Aleš Ryška
Publikationsdatum: 11.01.2018
Verlag: Springer Berlin Heidelberg
Erschienen in: Virchows Archiv / Ausgabe 5/2018
Print ISSN: 0945-6317
Elektronische ISSN: 1432-2307
DOI: https://doi.org/10.1007/s00428-018-2293-5

Springer Medizin

MicroRNA expression in SMARCB1/INI1-deficient sinonasal carcinoma: a clinicopathological and molecular genetic study

Excerpt

Neu im Fachgebiet Pathologie

Molekularpathologische Untersuchungen im Wandel der Zeit

Vergleichende Pathologie in der onkologischen Forschung

Gastrointestinale Stromatumoren

Personalisierte Medizin in der Onkologie

Springer Medizin

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