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Tumor Biology
Erschienen in: Tumor Biology 1/2016

04.11.2015 | Review

MicroRNAs as biomarkers and prospective therapeutic targets in colon and pancreatic cancers

verfasst von: Ganji Purnachandra Nagaraju, Appiya Santharam Madanraj, Sheik Aliya, Balney Rajitha, Olatunji Boladale Alese, Ekamber Kariali, Afroz Alam, Bassel F. El-Rayes

Erschienen in: Tumor Biology | Ausgabe 1/2016

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Abstract

Colon and pancreatic cancers have high mortality rates due to early metastasis prior to the onset of symptoms. Screening tests for colorectal cancer are invasive and expensive. No effective screening is available for pancreatic cancer. Identification of biomarkers for early detection in both of these cancers is being extensively researched. MicroRNAs (miRNA) are small non-coding molecule biomarkers that regulate cancers. Measurement of miRNAs in pancreatic fluid or blood could be a preferred non-invasive screening method. The regulation of colon and pancreatic cancers by miRNA is complex. miRNA play a central role in inflammation, invasiveness, and tumor progression in these two cancers, as well as regulation of the NF-κB pathway. miRNA’s evolving role in screening is also reviewed.
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Metadaten
Titel
MicroRNAs as biomarkers and prospective therapeutic targets in colon and pancreatic cancers
verfasst von
Ganji Purnachandra Nagaraju
Appiya Santharam Madanraj
Sheik Aliya
Balney Rajitha
Olatunji Boladale Alese
Ekamber Kariali
Afroz Alam
Bassel F. El-Rayes
Publikationsdatum
04.11.2015
Verlag
Springer Netherlands
Erschienen in
Tumor Biology / Ausgabe 1/2016
Print ISSN: 1010-4283
Elektronische ISSN: 1423-0380
DOI
https://doi.org/10.1007/s13277-015-4346-6

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