Background
Methods
Study Design and Study Population
Data Collection
λ Liver involvement without underlying diseaseAST or ALT > 40 IU/L with or without right upper quadrant or epigastric abdominal pain |
λ Acute kidney injury Serum creatine level ≥ 90 umol/L; 1.0 mg/dL |
λ Neurological complications Eclampsia, altered mental status, blindness, stroke, clonus, severe headache, or persistent visual scotoma |
λ Blood coagulation disorders Thrombocytopenia: platelet count < 150 × 109/L, disseminated intravascular coagulation, or hemolysis |
λ Utero-placental dysfunction Fetal growth restrictiona, abnormal umbilical artery doppler waveformb, or stillbirthc |
Statistical Analyse
Results
Normal (n = 189) | Mild (n = 51) | Severe (n = 24) | P1 | P2 | P3 | |
---|---|---|---|---|---|---|
Maternal Age (y.o)a | 33.9 ± 5.2 | 34.5 ± 5.1 | 35.7 ± 4.8 | 1.000 | 0.333 | 1.000 |
Primiparab | 115 (61.2) | 33 (64.7) | 15 (62.5) | 1.000 | 1.000 | 1.000 |
Previous history of pre-eclampsiab | 19 (10.1) | 3 (5.9) | 1 (4.2) | 1.000 | 1.000 | 1.000 |
Low-dose aspirin for preventionb | 2 (1.1) | 2 (3.9) | 1 (4.2) | 0.597 | 0.605 | 1.000 |
Cesarean deliveryb | 146 (77.3) | 41 (82.0) | 22 (91.7) | 0.565 | 0.355 | 0.565 |
Normal (n = 189) | Mild (n = 51) | Severe (n = 24) | P1 | P2 | P3 | |
---|---|---|---|---|---|---|
GW at the onset of pre-eclampsia (weeks) a | 34.1 ± 4.4 | 33.7 ± 3.8 | 29.7 ± 5.5 | 1.000 | < 0.001 | 0.001 |
GW at the day of delivery (weeks) a | 35.1 ± 3.9 | 34.9 ± 3.6 | 31.4 ± 5.2 | 1.000 | < 0.001 | 0.001 |
Preterm delivery < 34 GWb | 66 (34.9) | 18 (35.3) | 16 (66.7) | 1.000 | 0.011 | 0.028 |
NICU admissionb | 101 (53.4) | 29 (56.9) | 21 (87.5) | 0.752 | 0.005 | 0.019 |
Severe hypertensionb | 126 (66.7) | 36 (70.6) | 13 (54.2) | 0.736 | 0.516 | 0.516 |
Utero-placental dysfunctionb | 54 (28.6) | 17 (33.3) | 7 (29.2) | 1.000 | 1.000 | 1.000 |
Maternal organ damage except thrombocytopeniab | 23 (12.2) | 6 (11.8) | 13 (54.2) | 1.000 | < 0.001 | < 0.001 |
eRR | 95 % CI | p value | |
---|---|---|---|
Severe hypertension | |||
Agea | 1.02 | 0.93–1.11 | 0.689 |
Mild thrombocytopeniab | 1.06 | 0.86–1.30 | 0.597 |
Severe thrombocytopeniab | 0.81 | 0.55–1.18 | 0.273 |
Utero-placental dysfunction | |||
Agea | 1.03 | 0.86–1.23 | 0.734 |
Mild thrombocytopeniab | 1.16 | 0.74–1.82 | 0.512 |
Severe thrombocytopeniab | 1.01 | 0.52–1.96 | 0.977 |
Maternal organ damage except thrombocytopenia | |||
Agea | 0.99 | 0.79–1.25 | 0.949 |
Mild thrombocytopeniab | 0.97 | 0.41–2.26 | 0.939 |
Severe thrombocytopeniab | 4.46 | 2.59–7.68 | < 0.001 |
eRR | 95 % CI | p value | |
---|---|---|---|
Preterm delivery < 34 GW | |||
Agea | 1.07 | 0.92–1.25 | 0.359 |
Mild thrombocytopeniab | 0.91 | 0.62–1.35 | 0.649 |
Severe thrombocytopeniab | 1.61 | 1.06–2.45 | 0.026 |
Severe hypertension | 1.30 | 0.93–1.82 | 0.121 |
utero-placental dysfunction | 2.22 | 1.66–2.96 | < 0.001 |
maternal organ damage except thrombocytopenia | 1.49 | 1.05–2.12 | 0.025 |
NICU admission | |||
Agea | 1.09 | 0.99–1.20 | 0.071 |
Mild thrombocytopeniab | 0.97 | 0.76–1.24 | 0.814 |
Severe thrombocytopeniab | 1.35 | 1.06–1.73 | 0.016 |
Severe hypertension | 1.17 | 0.94–1.44 | 0.158 |
utero-placental dysfunction | 2.23 | 1.87–2.67 | < 0.001 |
maternal organ damage except thrombocytopenia | 1.50 | 1.22–1.84 | < 0.001 |