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Erschienen in: Clinical and Translational Oncology 12/2019

04.04.2019 | Review Article

miRNA signatures in childhood sarcomas and their clinical implications

verfasst von: G. M. Viera, K. B. Salomao, G. R. de Sousa, M. Baroni, L. E. A. Delsin, J. A. Pezuk, M. S. Brassesco

Erschienen in: Clinical and Translational Oncology | Ausgabe 12/2019

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Abstract

Progresses in multimodal treatments have significantly improved the outcomes for childhood cancer. Nonetheless, for about one-third of patients with Ewing sarcoma, rhabdomyosarcoma, or osteosarcoma steady remission has remained intangible. Thus, new biomarkers to improve early diagnosis and the development of precision-targeted medicine remain imperative. Over the last decade, remarkable progress has been made in the basic understanding of miRNAs function and in interpreting the contribution of their dysregulation to cancer development and progression. On this basis, this review focuses on what has been learned about the pivotal roles of miRNAs in the regulation of key genes implicated in childhood sarcomas.
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Metadaten
Titel
miRNA signatures in childhood sarcomas and their clinical implications
verfasst von
G. M. Viera
K. B. Salomao
G. R. de Sousa
M. Baroni
L. E. A. Delsin
J. A. Pezuk
M. S. Brassesco
Publikationsdatum
04.04.2019
Verlag
Springer International Publishing
Erschienen in
Clinical and Translational Oncology / Ausgabe 12/2019
Print ISSN: 1699-048X
Elektronische ISSN: 1699-3055
DOI
https://doi.org/10.1007/s12094-019-02104-z

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