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Investigational New Drugs

Erschienen in:

01.10.2009 | PRECLINICAL STUDIES

Mixed steroidal tetraoxanes induce apoptotic cell death in tumor cells

verfasst von: Željko Žižak, Zorica Juranić, Dejan Opsenica, Bogdan A. Šolaja

Erschienen in: Investigational New Drugs | Ausgabe 5/2009

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Summary

In this study we investigated the antiproliferative activity of six mixed steroidal tetraoxanes against various tumor cell lines, the toxicity against normal peripheral blood mononuclear cells (PBMC), and the mode of HeLa cell death induced by these compounds. Investigated tetraoxanes exerted a dose dependent antiproliferative action at micromolar concentrations toward target tumor cell lines. Treatment of HeLa cells for 24 h with all tetraoxanes induced apoptosis, as confirmed by morphological analysis and by the appearance of a typical ladder pattern in the DNA fragmentation assay.

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Titel: Mixed steroidal tetraoxanes induce apoptotic cell death in tumor cells
verfasst von: Željko Žižak
Zorica Juranić
Dejan Opsenica
Bogdan A. Šolaja
Publikationsdatum: 01.10.2009
Verlag: Springer US
Erschienen in: Investigational New Drugs / Ausgabe 5/2009
Print ISSN: 0167-6997
Elektronische ISSN: 1573-0646
DOI: https://doi.org/10.1007/s10637-008-9197-1

Die Highlights vom Kongress des American College of Cardiology 2024

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Mixed steroidal tetraoxanes induce apoptotic cell death in tumor cells

Summary

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Die Highlights vom Kongress des American College of Cardiology 2024

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Summary

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