Ausgabe 1/2006
Inhalt (76 Artikel)
Stable low-level expression of p21WAF1/CIP1 in A549 human bronchogenic carcinoma cell line-derived clones down-regulates E2F1 mRNA and restores cell proliferation control
Timothy G Graves, Michael W Harr, Erin L Crawford, James C Willey
BRAF mutations are associated with distinctive clinical, pathological and molecular features of colorectal cancer independently of microsatellite instability status
Wei Qi Li, Kazuyuki Kawakami, Andrew Ruszkiewicz, Graeme Bennett, James Moore, Barry Iacopetta
Hypoxia-inducible factor-1α polymorphisms and TSC1/2 mutations are complementary in head and neck cancers
Carla Hebert, Kathleen Norris, Pallavi Parashar, Robert A Ord, Nikolaos G Nikitakis, John J Sauk
The tumor suppressor DAL-1/4.1B and protein methylation cooperate in inducing apoptosis in MCF-7 breast cancer cells
Wei Jiang, Irene F Newsham
Rhodamine-RCA in vivo labeling guided laser capture microdissection of cancer functional angiogenic vessels in a murine squamous cell carcinoma mouse model
Finie Hunter, Jianwu Xie, Cameron Trimble, Monica Bur, King CP Li
The cancer stem cell: Evidence for its origin as an injured autoreactive T Cell
Peter Grandics
The cyclin D1 proto-oncogene is sequestered in the cytoplasm of mammalian cancer cell lines
John P Alao, Simon C Gamble, Alexandra V Stavropoulou, Karen M Pomeranz, Eric W-F Lam, R Charles Coombes, David M Vigushin
Histone deacetylase inhibitor, Trichostatin A induces ubiquitin-dependent cyclin D1 degradation in MCF-7 breast cancer cells
John P Alao, Alexandra V Stavropoulou, Eric W-F Lam, R Charles Coombes, David M Vigushin
Perlecan, a candidate gene for the CAPB locus, regulates prostate cancer cell growth via the Sonic Hedgehog pathway
Milton W Datta, Ana Maria Hernandez, Michael J Schlicht, Andrea J Kahler, Amy M DeGueme, Rajiv Dhir, Rajal B Shah, Cindy Farach-Carson, Andrea Barrett, Sumana Datta
Expression profile of mucins (MUC2, MUC5AC and MUC6) in Helicobacter pylori infected pre-neoplastic and neoplastic human gastric epithelium
Subramani Durai Babu, Venkataraman Jayanthi, Niranjali Devaraj, Celso A Reis, Halagowder Devaraj
Application of cytology and molecular biology in diagnosing premalignant or malignant oral lesions
Ravi Mehrotra, Anurag Gupta, Mamta Singh, Rahela Ibrahim
Dominant negative retinoic acid receptor initiates tumor formation in mice
Tara S Kupumbati, Giorgio Cattoretti, Christine Marzan, Eduardo F Farias, Reshma Taneja, Rafael Mira-y-Lopez
In vitro and in vivo effects of the PPAR-alpha agonists fenofibrate and retinoic acid in endometrial cancer
Samir A Saidi, Cathrine M Holland, D Stephen Charnock-Jones, Stephen K Smith
Mitochondrial aconitase and citrate metabolism in malignant and nonmalignant human prostate tissues
Keshav K Singh, Mohamed M Desouki, Renty B Franklin, Leslie C Costello
Active Stat3 is required for survival of human squamous cell carcinoma cells in serum-free conditions
Weihong Yin, Satish Cheepala, Jennifer N Roberts, Keith Syson-Chan, John DiGiovanni, John L Clifford
Promoter hypermethylation-mediated inactivation of multiple Slit-Robo pathway genes in cervical cancer progression
Gopeshwar Narayan, Chandra Goparaju, Hugo Arias-Pulido, Andreas M Kaufmann, Achim Schneider, Matthias Dürst, Mahesh Mansukhani, Bhavana Pothuri, Vundavalli V Murty
The clinical relevance of the metabolism of prostate cancer; zinc and tumor suppression: connecting the dots
Leslie C Costello, Renty B Franklin
Functional studies of BCL11A: characterization of the conserved BCL11A-XL splice variant and its interaction with BCL6 in nuclear paraspeckles of germinal center B cells
Hui Liu, Gregory C Ippolito, Jason K Wall, Teresa Niu, Loren Probst, Baeck-Seung Lee, Karen Pulford, Alison H Banham, Luke Stockwin, Arthur L Shaffer, Louis M Staudt, Chhaya Das, Martin JS Dyer, Philip W Tucker
Downregulation of survivin expression and concomitant induction of apoptosis by celecoxib and its non-cyclooxygenase-2-inhibitory analog, dimethyl-celecoxib (DMC), in tumor cells in vitro and in vivo
Peter Pyrko, Nathaniel Soriano, Adel Kardosh, Yen-Ting Liu, Jasim Uddin, Nicos A Petasis, Florence M Hofman, Ching-Shih Chen, Thomas C Chen, Axel H Schönthal
Cellular response to 5-fluorouracil (5-FU) in 5-FU-resistant colon cancer cell lines during treatment and recovery
Paula M De Angelis, Debbie H Svendsrud, Katherine L Kravik, Trond Stokke
The superoxide scavenger TEMPOL induces urokinase receptor (uPAR) expression in human prostate cancer cells
Danielle Lejeune, Mohammad Hasanuzzaman, Amanda Pitcock, Joseph Francis, Inder Sehgal
CDDO-Imidazolide inhibits growth and survival of c-Myc-induced mouse B cell and plasma cell neoplasms
Seong-Su Han, Liangping Peng, Seung-Tae Chung, Wendy DuBois, Sung-Ho Maeng, Arthur L Shaffer, Michael B Sporn, Siegfried Janz
Early expression of the Helicase-Like Transcription Factor (HLTF/SMARCA3) in an experimental model of estrogen-induced renal carcinogenesis
Gaël Debauve, Denis Nonclercq, Fabrice Ribaucour, Murielle Wiedig, Cécile Gerbaux, Oberdan Leo, Guy Laurent, Fabrice Journé, Alexandra Belayew, Gérard Toubeau
Optimized high-throughput microRNA expression profiling provides novel biomarker assessment of clinical prostate and breast cancer biopsies
Michael D Mattie, Christopher C Benz, Jessica Bowers, Kelly Sensinger, Linda Wong, Gary K Scott, Vita Fedele, David Ginzinger, Robert Getts, Chris Haqq
The p53-targeting human phosphatase hCdc14A interacts with the Cdk1/cyclin B complex and is differentially expressed in human cancers
Michelle T Paulsen, Adrienne M Starks, Frederick A Derheimer, Sheela Hanasoge, Liwu Li, Jack E Dixon, Mats Ljungman
Identification and characterization of Smyd2: a split SET/MYND domain-containing histone H3 lysine 36-specific methyltransferase that interacts with the Sin3 histone deacetylase complex
Mark A Brown, Robert J Sims III, Paul D Gottlieb, Philip W Tucker
Can the state of cancer chemotherapy resistance be reverted by epigenetic therapy?
Carlos Perez-Plasencia, Alfonso Duenas-Gonzalez
Methylation mediated silencing of TMS1/ASC gene in prostate cancer
Partha M Das, Kavitha Ramachandran, Jane VanWert, Larry Ferdinand, Gopal Gopisetty, Isildinha M Reis, Rakesh Singal
Identification by Real-time PCR of 13 mature microRNAs differentially expressed in colorectal cancer and non-tumoral tissues
E Bandrés, E Cubedo, X Agirre, R Malumbres, R Zárate, N Ramirez, A Abajo, A Navarro, I Moreno, M Monzó, J García-Foncillas
Identification of differentially expressed genes in cutaneous squamous cell carcinoma by microarray expression profiling
Ingo Nindl, Chantip Dang, Tobias Forschner, Ralf J Kuban, Thomas Meyer, Wolfram Sterry, Eggert Stockfleth
Down-regulation of c-Myc following MEK/ERK inhibition halts the expression of malignant phenotype in rhabdomyosarcoma and in non muscle-derived human tumors
Francesco Marampon, Carmela Ciccarelli, Bianca M Zani
Intra-arterial adenoviral mediated tumor transfection in a novel model of cancer gene therapy
Gustavo Cabrera, Stacy L Porvasnik, Paul E DiCorleto, Maria Siemionow, Corey K Goldman
Comparison of chromosomal and array-based comparative genomic hybridization for the detection of genomic imbalances in primary prostate carcinomas
Franclim R Ribeiro, Rui Henrique, Merete Hektoen, Marianne Berg, Carmen Jerónimo, Manuel R Teixeira, Ragnhild A Lothe
Specific down-regulation of XIAP with RNA interference enhances the sensitivity of canine tumor cell-lines to TRAIL and doxorubicin
Bart Spee, Martijn DB Jonkers, Brigitte Arends, Gerard R Rutteman, Jan Rothuizen, Louis C Penning
Open access and beyond
Shawn Mathur, Christian Schmidt, Chhaya Das, Philip W Tucker
Somatic deletion of the NF1 gene in a neurofibromatosis type 1-associated malignant melanoma demonstrated by digital PCR
Albert Rübben, Birke Bausch, Arjen Nikkels
A genome-wide map of aberrantly expressed chromosomal islands in colorectal cancer
Eike Staub, Jörn Gröne, Detlev Mennerich, Stefan Röpcke, Irina Klamann, Bernd Hinzmann, Esmeralda Castanos-Velez, Benno Mann, Christian Pilarsky, Thomas Brümmendorf, Birgit Weber, Heinz-Johannes Buhr, André Rosenthal
RB acute loss induces centrosome amplification and aneuploidy in murine primary fibroblasts
Flora Iovino, Laura Lentini, Angela Amato, Aldo Di Leonardo
Identification of novel candidate target genes in amplicons of Glioblastoma multiforme tumors detected by expression and CGH microarray profiling
Yolanda Ruano, Manuela Mollejo, Teresa Ribalta, Concepción Fiaño, Francisca I Camacho, Elena Gómez, Angel Rodríguez de Lope, Jose-Luis Hernández-Moneo, Pedro Martínez, Bárbara Meléndez
Role of glycogen synthase kinase 3 beta (GSK3β) in mediating the cytotoxic effects of the histone deacetylase inhibitor trichostatin A (TSA) in MCF-7 breast cancer cells
John P Alao, Alexandra V Stavropoulou, Eric W-F Lam, R Charles Coombes
Overexpression of Eag1 potassium channels in clinical tumours
Bernhard Hemmerlein, Rüdiger M Weseloh, Fernanda Mello de Queiroz, Hendrik Knötgen, Araceli Sánchez, María E Rubio, Sabine Martin, Tessa Schliephacke, Marc Jenke, Heinz-Joachim-Radzun, Walter Stühmer, Luis A Pardo
Ether à go-go potassium channel expression in soft tissue sarcoma patients
Fernanda Mello de Queiroz, Guilherme Suarez-Kurtz, Walter Stühmer, Luis A Pardo
Clinicopathological significance of stromal variables: angiogenesis, lymphangiogenesis, inflammatory infiltration, MMP and PINCH in colorectal carcinomas
Xiao-Feng Sun, Hong Zhang
Tumor suppressor gene methylation in follicular lymphoma: a comprehensive review
John Hayslip, Alberto Montero
Resveratrol interferes with AKT activity and triggers apoptosis in human uterine cancer cells
Émilie Sexton, Céline Van Themsche, Kim Leblanc, Sophie Parent, Pascal Lemoine, Eric Asselin
The stem cell factor/c-kit receptor pathway enhances proliferation and invasion of pancreatic cancer cells
Akira Yasuda, Hirozumi Sawai, Hiroki Takahashi, Nobuo Ochi, Yoichi Matsuo, Hitoshi Funahashi, Mikinori Sato, Yuji Okada, Hiromitsu Takeyama, Tadao Manabe
Expression of full-length p53 and its isoform Δp53 in breast carcinomas in relation to mutation status and clinical parameters
Lars O Baumbusch, Simen Myhre, Anita Langerød, Anna Bergamaschi, Stephanie B Geisler, Per E Lønning, Wolfgang Deppert, Irene Dornreiter, Anne-Lise Børresen-Dale
Expression of the bile acid receptor FXR in Barrett's esophagus and enhancement of apoptosis by guggulsterone in vitro
Andrea De Gottardi, Jean-Marc Dumonceau, Fabien Bruttin, Alain Vonlaufen, Isabelle Morard, Laurent Spahr, Laura Rubbia-Brandt, Jean-Louis Frossard, Winand NM Dinjens, Peter S Rabinovitch, Antoine Hadengue
Sensitive detection of human papillomavirus type 16 E7-specific T cells by ELISPOT after multiple in vitro stimulations of CD8+ T cells with peptide-pulsed autologous dendritic cells
Nathalie Cools, Peter Ponsaerts, Marc Lenjou, Griet Nijs, Dirk R Van Bockstaele, Viggo FI Van Tendeloo, Zwi N Berneman
Mesothelin-MUC16 binding is a high affinity, N-glycan dependent interaction that facilitates peritoneal metastasis of ovarian tumors
Jennifer AA Gubbels, Jennifer Belisle, Masanori Onda, Claudine Rancourt, Martine Migneault, Mitchell Ho, Tapan K Bera, Joseph Connor, Bangalore K Sathyanarayana, Byungkook Lee, Ira Pastan, Manish S Patankar
Calcium insensitivity of FA-6, a cell line derived from a pancreatic cancer associated with humoral hypercalcemia, is mediated by the significantly reduced expression of the Calcium Sensitive Receptor transduction component p38 MAPK
Richard Morgan, Benjamin Fairfax, Hardev S Pandha
SMC3 knockdown triggers genomic instability and p53-dependent apoptosis in human and zebrafish cells
Giancarlo Ghiselli
Differential cooperation of oncogenes with p53 and Bax to induce apoptosis in rhabdomyosarcoma
Alan C Taylor, Katja Schuster, Pamela P McKenzie, Linda C Harris
Myb proteins inhibit fibroblast transformation by v-Rel
Shu-ling Fu, Brigitte Ganter, Joseph S Lipsick
Pathway-specific differences between tumor cell lines and normal and tumor tissue cells
Adam Ertel, Arun Verghese, Stephen W Byers, Michael Ochs, Aydin Tozeren
Stromal Derived Factor-1 (SDF-1/CXCL12) and CXCR4 in renal cell carcinoma metastasis
Judong Pan, Javier Mestas, Marie D Burdick, Roderick J Phillips, George V Thomas, Karen Reckamp, John A Belperio, Robert M Strieter
MUC1 gene overexpressed in breast cancer: structure and transcriptional activity of the MUC1 promoter and role of estrogen receptor alpha (ERα) in regulation of the MUC1 gene expression
Joseph Z Zaretsky, Itay Barnea, Yael Aylon, Marat Gorivodsky, Daniel H Wreschner, Iafa Keydar
Tumor cell metabolism: the marriage of molecular genetics and proteomics with cellular intermediary metabolism; proceed with caution!
Leslie C Costello, Renty B Franklin
Regulation of angiogenesis and invasion by human Pituitary tumor transforming gene (PTTG) through increased expression and secretion of matrix metalloproteinase-2 (MMP-2)
Mohammad T Malik, Sham S Kakar
Ovarian epithelial cancer: a role for PGE2-synthesis and signalling in malignant transformation and progression
Katarina Rask, Yihong Zhu, Wanzhong Wang, Lars Hedin, Karin Sundfeldt
Gene expression profiling following constitutive activation of MEK1 and transformation of rat intestinal epithelial cells
Koga Komatsu, F Gregory Buchanan, Michiro Otaka, Mario Jin, Masaru Odashima, Yohei Horikawa, Sumio Watanabe, Raymond N DuBois
Pathway analysis of kidney cancer using proteomics and metabolic profiling
Bertrand Perroud, Jinoo Lee, Nelly Valkova, Amy Dhirapong, Pei-Yin Lin, Oliver Fiehn, Dietmar Kültz, Robert H Weiss
Altered Ca2+ homeostasis in polymorphonuclear leukocytes from chronic myeloid leukaemia patients
Chetana M Revankar, Suresh H Advani, Nishigandha R Naik
Tumor cell invasion of von Hippel Lindau renal cell carcinoma cells is mediated by membrane type-1 matrix metalloproteinase
Brenda L Petrella, Constance E Brinckerhoff
Analysis of gene expression and chemoresistance of CD133+ cancer stem cells in glioblastoma
Gentao Liu, Xiangpeng Yuan, Zhaohui Zeng, Patrizia Tunici, Hiushan Ng, Iman R Abdulkadir, Lizhi Lu, Dwain Irvin, Keith L Black, John S Yu
P53 and p73 differ in their ability to inhibit glucocorticoid receptor (GR) transcriptional activity
Lili Zhang, Linghu Nie, Carl G Maki
Tumor cell invasion of collagen matrices requires coordinate lipid agonist-induced G-protein and membrane-type matrix metalloproteinase-1-dependent signaling
Kevin E Fisher, Andreia Pop, Wonshill Koh, Nicholas J Anthis, W Brian Saunders, George E Davis
Effect of ret/PTC 1 rearrangement on transcription and post-transcriptional regulation in a papillary thyroid carcinoma model
Susanne Cahill, Paul Smyth, Stephen P Finn, Karen Denning, Richard Flavin, Esther M O'Regan, Jinghuan Li, Astrid Potratz, Simone M Guenther, Richard Henfrey, John J O'Leary, Orla Sheils
Valproic acid and butyrate induce apoptosis in human cancer cells through inhibition of gene expression of Akt/protein kinase B
Jihong Chen, Feras M Ghazawi, Wafae Bakkar, Qiao Li
Rb induces a proliferative arrest and curtails Brn-2 expression in retinoblastoma cells
David Cobrinik, Richard O Francis, David H Abramson, Thomas C Lee
Mitochondrial DNA mutations in preneoplastic lesions of the gastrointestinal tract: A biomarker for the early detection of cancer
Guoping Sui, Shaoyu Zhou, Jean Wang, Marcia Canto, Edward E Lee, James R Eshleman, Elizabeth A Montgomery, David Sidransky, Joseph A Califano, Anirban Maitra
Investigation of the molecular profile of basal cell carcinoma using whole genome microarrays
Lorraine O'Driscoll, Jason McMorrow, Padraig Doolan, Eadaoin McKiernan, Jai Prakash Mehta, Eoin Ryan, Patrick Gammell, Helena Joyce, Norma O'Donovan, Nicholas Walsh, Martin Clynes
Proteomic alteration in gastic adenocarcinomas from Japanese patients
Takahiro Yoshihara, Yoshito Kadota, Yoshiyuki Yoshimura, Yutaka Tatano, Naohiro Takeuchi, Hiroshi Okitsu, Atsushi Umemoto, Takashi Yamauchi, Kohji Itoh
Apigenin inhibits pancreatic cancer cell proliferation through G2/M cell cycle arrest
Michael B Ujiki, Xian-Zhong Ding, M Reza Salabat, David J Bentrem, Laleh Golkar, Ben Milam, Mark S Talamonti, Richard H Bell Jr, Takeshi Iwamura, Thomas E Adrian