Ausgabe 1/2023
Inhalt (209 Artikel)
MicroRNA-1 attenuates the growth and metastasis of small cell lung cancer through CXCR4/FOXM1/RRM2 axis
Parvez Khan, Jawed Akhtar Siddiqui, Prakash G. Kshirsagar, Ramakanth Chirravuri Venkata, Shailendra Kumar Maurya, Tamara Mirzapoiazova, Naveenkumar Perumal, Sanjib Chaudhary, Ranjana Kumari Kanchan, Mahek Fatima, Md Arafat Khan, Asad Ur Rehman, Imayavaramban Lakshmanan, Sidharth Mahapatra, Geoffrey A. Talmon, Prakash Kulkarni, Apar K. Ganti, Maneesh Jain, Ravi Salgia, Surinder Kumar Batra, Mohd Wasim Nasser
An exosome-based liquid biopsy signature for pre-operative identification of lymph node metastasis in patients with pathological high-risk T1 colorectal cancer
Katsuki Miyazaki, Yuma Wada, Keisuke Okuno, Tatsuro Murano, Yuji Morine, Tetsuya Ikemoto, Yu Saito, Hiroaki Ikematsu, Yusuke Kinugasa, Mitsuo Shimada, Ajay Goel
Safety and antitumor activity of GD2-Specific 4SCAR-T cells in patients with glioblastoma
Zhuohao Liu, Jiayi Zhou, Xinzhi Yang, Yuchen Liu, Chang Zou, Wen Lv, Cheng Chen, Kenneth King-yip Cheng, Tao Chen, Lung-Ji Chang, Dinglan Wu, Jie Mao
Tumor-secreted exosomal miR-141 activates tumor-stroma interactions and controls premetastatic niche formation in ovarian cancer metastasis
Yulan Mo, Leanne L. Leung, Celia S. L. Mak, Xueyu Wang, Wai-Sun Chan, Lynn M. N. Hui, Hermit W. M. Tang, Michelle K. Y. Siu, Rakesh Sharma, Dakang Xu, Stephen K. W. Tsui, Hextan Y. S. Ngan, Mingo M. H. Yung, Karen K. L. Chan, David W. Chan
Crosstalk between 5-methylcytosine and N6-methyladenosine machinery defines disease progression, therapeutic response and pharmacogenomic landscape in hepatocellular carcinoma
Yu Tian, Haijuan Xiao, Yanhui Yang, Pingping Zhang, Jiahui Yuan, Wei Zhang, Lijie Chen, Yibao Fan, Jinze Zhang, Huan Cheng, Tingwei Deng, Lin Yang, Weiwei Wang, Guoyong Chen, Peiqin Wang, Peng Gong, Xing Niu, Xianbin Zhang
CMTM6 overexpression confers trastuzumab resistance in HER2-positive breast cancer
Fei Xing, Hongli Gao, Guanglei Chen, Lisha Sun, Jiayi Sun, Xinbo Qiao, Jinqi Xue, Caigang Liu
Clinical application and detection techniques of liquid biopsy in gastric cancer
Shuo Ma, Meiling Zhou, Yanhua Xu, Xinliang Gu, Mingyuan Zou, Gulinaizhaer Abudushalamu, Yuming Yao, Xiaobo Fan, Guoqiu Wu
Unravelling the enigma of siRNA and aptamer mediated therapies against pancreatic cancer
Zhe Liu, Neha Parveen, Urushi Rehman, Aisha Aziz, Afsana Sheikh, Mohammed A. S. Abourehab, Wei Guo, Junhao Huang, Zhenning Wang, Prashant Kesharwani
Correction: Mettl14 inhibits bladder TIC self-renewal and bladder tumorigenesis through N6 - methyladenosine of Notch1
Chaohui Gu, Zhiyu Wang, Naichun Zhou, Guanru Li, Yiping Kou, Yang Luo, Yidi Wang, Jinjian Yang, Fengyan Tian
Advancements in nanoparticle-based treatment approaches for skin cancer therapy
Leli Zeng, B. H. Jaswanth Gowda, Mohammed Gulzar Ahmed, Mohammed A. S. Abourehab, Zhe-Sheng Chen, Changhua Zhang, Jia Li, Prashant Kesharwani
Retraction Note: CircPSMC3 suppresses the proliferation and metastasis of gastric cancer by acting as a competitive endogenous RNA through sponging miR-296-5p
Dawei Rong, Chen Lu, Betty Zhang, Kai Fu, Shuli Zhao, Weiwei Tang, Hongyong Cao
Harnessing the MYB-dependent TAL1 5’super-enhancer for targeted therapy in T-ALL
Charlotte Smith, Aurore Touzart, Mathieu Simonin, Christine Tran-Quang, Guillaume Hypolite, Mehdi Latiri, Guillaume P. Andrieu, Estelle Balducci, Marie-Émilie Dourthe, Ashish Goyal, Françoise Huguet, Arnaud Petit, Norbert Ifrah, André Baruchel, Hervé Dombret, Elizabeth Macintyre, Christoph Plass, Jacques Ghysdael, Nicolas Boissel, Vahid Asnafi
A microRNA signature for risk-stratification and response prediction to FOLFOX-based adjuvant therapy in stage II and III colorectal cancer
Keisuke Okuno, Raju Kandimalla, Marta Mendiola, Francesc Balaguer, Luis Bujanda, Carlos Fernandez-Martos, Jorge Aparicio, Jaime Feliu, Masanori Tokunaga, Yusuke Kinugasa, Joan Maurel, Ajay Goel
Correction: CircNTNG1 inhibits renal cell carcinoma progression via HOXA5-mediated epigenetic silencing of Slug
Yanping Liang, Junjie Cen, Yong Huang, Yong Fang, Yunfei Wang, Guannan Shu, Yihui Pan, Kangbo Huang, Jiaqi Dong, Mi Zhou, Yi Xu, Junhang Luo, Min Liu, Jiaxing Zhang
Circulating tumor nucleic acids: biology, release mechanisms, and clinical relevance
Pavel Stejskal, Hani Goodarzi, Josef Srovnal, Marián Hajdúch, Laura J. van ’t Veer, Mark Jesus M. Magbanua
A novel polypeptide encoded by the circular RNA ZKSCAN1 suppresses HCC via degradation of mTOR
Runjie Song, Shuoqian Ma, Jiajia Xu, Xin Ren, Peilan Guo, Huijiao Liu, Peng Li, Fan Yin, Mei Liu, Qiang Wang, Lei Yu, Jiali Liu, Binwei Duan, Nafis A. Rahman, Sławomir Wołczyński, Guangming Li, Xiangdong Li
Molecular differences of angiogenic versus vessel co-opting colorectal cancer liver metastases at single-cell resolution
Johannes Robert Fleischer, Alexandra Maria Schmitt, Gwendolyn Haas, Xingbo Xu, Elisabeth Maria Zeisberg, Hanibal Bohnenberger, Stefan Küffer, Laure-Anne Teuwen, Philipp Johannes Karras, Tim Beißbarth, Annalen Bleckmann, Mélanie Planque, Sarah-Maria Fendt, Peter Vermeulen, Michael Ghadimi, Joanna Kalucka, Tiago De Oliveira, Lena-Christin Conradi
Targeting Pim kinases in hematological cancers: molecular and clinical review
Marcia Bellon, Christophe Nicot
Correction: circCYP24A1 facilitates esophageal squamous cell carcinoma progression through binding PKM2 to regulate NF-κB-induced CCL5 secretion
Lina Gu, Yang Sang, Xixi Nan, Yang Zheng, Fei Liu, Lingjiao Meng, Meixiang Sang, Baoen Shan
CAR-cell therapy in the era of solid tumor treatment: current challenges and emerging therapeutic advances
Karama Makni Maalej, Maysaloun Merhi, Varghese P. Inchakalody, Sarra Mestiri, Majid Alam, Cristina Maccalli, Honar Cherif, Shahab Uddin, Martin Steinhoff, Francesco M. Marincola, Said Dermime
Lysyl hydroxylase LH1 promotes confined migration and metastasis of cancer cells by stabilizing Septin2 to enhance actin network
Zihan Yang, Li Zhou, Tongxu Si, Siyuan Chen, Chengxi Liu, Kelvin Kaki Ng, Zesheng Wang, Zhiji Chen, Chan Qiu, Guopan Liu, Qingliang Wang, Xiaoyu Zhou, Liang Zhang, Zhongping Yao, Song He, Mengsu Yang, Zhihang Zhou
CAR T cells: engineered immune cells to treat brain cancers and beyond
Zoufang Huang, Saikat Dewanjee, Pratik Chakraborty, Niraj Kumar Jha, Abhijit Dey, Moumita Gangopadhyay, Xuan-Yu Chen, Jian Wang, Saurabh Kumar Jha
Immunotherapies in rare cancers
Sneha Vivekanandhan, Deborah Bahr, Ashish Kothari, Mohammed Ali Ashary, Mizba Baksh, Emmanuel Gabriel
Retraction Note: Tumour-originated exosomal miR-155 triggers cancer-associated cachexia to promote tumour progression
Qi Wu, Si Sun, Zhiyu Li, Qian Yang, Bei Li, Shan Zhu, Lijun Wang, Juan Wu, Jingping Yuan, Changhua Yang, Juanjuan Li, Shengrong Sun
Letter to the Editor: clinical utility of urine DNA for noninvasive detection and minimal residual disease monitoring in urothelial carcinoma
Kaiwei Yang, Hailong Hu, Junlong Wu, Huina Wang, Zhaoxia Guo, Wei Yu, Lin Yao, Feng Ding, Tao Zhou, Wang Wang, Yunkai Wang, Lei Liu, Jing Guo, Shuaipeng Zhu, Xinhao Zhang, Shanbo Cao, Feng Lou, Yuanjie Niu, Dingwei Ye, Zhisong He
Regulatory cells and the effect of cancer immunotherapy
María Iglesias-Escudero, Noelia Arias-González, Eva Martínez-Cáceres
The chromatin-associated RNAs in gene regulation and cancer
Jun Tang, Xiang Wang, Desheng Xiao, Shuang Liu, Yongguang Tao
Adoptive cellular immunotherapy for solid neoplasms beyond CAR-T
Qiaofei Liu, Jiayi Li, Huaijin Zheng, Sen Yang, Yuze Hua, Nan Huang, Jorg Kleeff, Quan Liao, Wenming Wu
Roles of cancer-associated fibroblasts (CAFs) in anti- PD-1/PD-L1 immunotherapy for solid cancers
Liping Pei, Yang Liu, Lin Liu, Shuochen Gao, Xueyan Gao, Yudi Feng, Zhenqiang Sun, Yan Zhang, Chengzeng Wang
Emerging roles of tRNA-derived fragments in cancer
Min Fu, Jianmei Gu, Maoye Wang, Jiahui Zhang, Yanke Chen, Pengcheng Jiang, Taofeng Zhu, Xu Zhang
Gamma delta T-cell-based immune checkpoint therapy: attractive candidate for antitumor treatment
Zhifei Gao, Yifeng Bai, Anqi Lin, Aimin Jiang, Chaozheng Zhou, Quan Cheng, Zaoqu Liu, Xin Chen, Jian Zhang, Peng Luo
Transfer RNA-derived small RNAs in tumor microenvironment
Mei Yang, Yongzhen Mo, Daixi Ren, Shun Liu, Zhaoyang Zeng, Wei Xiong
Recent advances of small extracellular vesicle biomarkers in breast cancer diagnosis and prognosis
Yujin Lee, Jie Ni, Julia Beretov, Valerie C. Wasinger, Peter Graham, Yong Li
NK cells are never alone: crosstalk and communication in tumour microenvironments
Yongqiang Zhou, Lu Cheng, Lu Liu, Xun Li
Recent advances and applications of CRISPR-Cas9 in cancer immunotherapy
Zaoqu Liu, Meixin Shi, Yuqing Ren, Hui Xu, Siyuan Weng, Wenjing Ning, Xiaoyong Ge, Long Liu, Chunguang Guo, Mengjie Duo, Lifeng Li, Jing Li, Xinwei Han
Targeting RNA N6-methyladenosine to synergize with immune checkpoint therapy
Xianyong Zhou, Chen Li, Tong Chen, Wenhao Li, Xiaolong Wang, Qifeng Yang
Liquid biopsy at the frontier in renal cell carcinoma: recent analysis of techniques and clinical application
Mingyang Li, Lei Li, Jianyi Zheng, Zeyu Li, Shijie Li, Kefeng Wang, Xiaonan Chen
Cross-talk between cancer stem cells and immune cells: potential therapeutic targets in the tumor immune microenvironment
Bo Wu, Xiang Shi, Meixi Jiang, Hongxu Liu
SWI/SNF complexes in hematological malignancies: biological implications and therapeutic opportunities
Alvaro Andrades, Paola Peinado, Juan Carlos Alvarez-Perez, Juan Sanjuan-Hidalgo, Daniel J. García, Alberto M. Arenas, Ana M. Matia-González, Pedro P. Medina
Lung cancer immunotherapy: progress, pitfalls, and promises
Aritraa Lahiri, Avik Maji, Pravin D. Potdar, Navneet Singh, Purvish Parikh, Bharti Bisht, Anubhab Mukherjee, Manash K. Paul
LncRNA-BC069792 suppresses tumor progression by targeting KCNQ4 in breast cancer
Yunxiang Zhang, Xiaotong Dong, Xiangyu Guo, Chunsen Li, Yanping Fan, Pengju Liu, Dawei Yuan, Xialin Ma, Jingru Wang, Jie Zheng, Hongli Li, Peng Gao
m6A methylation: a process reshaping the tumour immune microenvironment and regulating immune evasion
Xiaoxue Cao, Qishun Geng, Danping Fan, Qiong Wang, Xing Wang, Mengxiao Zhang, Lu Zhao, Yi Jiao, Tingting Deng, Honglin Liu, Jing Zhou, Liqun Jia, Cheng Xiao
New frontiers in immune checkpoint B7-H3 (CD276) research and drug development
Ayechew Adera Getu, Abiye Tigabu, Ming Zhou, Jianrong Lu, Øystein Fodstad, Ming Tan
CD39/CD73/A2AR pathway and cancer immunotherapy
Chenglai Xia, Shuanghong Yin, Kenneth K. W. To, Liwu Fu
The epigenetic regulatory mechanism of PIWI/piRNAs in human cancers
Qun Zhang, Yazhi Zhu, Xinyu Cao, Wenhui Tan, Jianglong Yu, Yaqiong Lu, Ran Kang, Xiaolan Wang, Ermao Li
Cuproptosis: mechanisms and links with cancers
Jiaming Xie, Yannan Yang, Yibo Gao, Jie He
Correction: Development of a 4-aminopyrazolo[3,4-d]pyrimidine-based dual IGF1R/Src inhibitor as a novel anticancer agent with minimal toxicity
Ho Jin Lee, Phuong Chi Pham, Seung Yeob Hyun, Byungyeob Baek, Byungjin Kim, Yunha Kim, Hye-Young Min, Jeeyeon Lee, Ho-Young Lee
Extracellular matrix remodeling in tumor progression and immune escape: from mechanisms to treatments
Zhennan Yuan, Yingpu Li, Sifan Zhang, Xueying Wang, He Dou, Xi Yu, Zhiren Zhang, Shanshan Yang, Min Xiao
Hypoxia and HIFs in Ewing sarcoma: new perspectives on a multi-facetted relationship
A. Katharina Ceranski, Martha J. Carreño-Gonzalez, Anna C. Ehlers, Maria Vittoria Colombo, Florencia Cidre-Aranaz, Thomas G. P. Grünewald
Correction: Identification of lymphocyte cell-specific protein-tyrosine kinase (LCK) as a driver for invasion and migration of oral cancer by tumor heterogeneity exploitation
Jonas Weiße, Julia Rosemann, Lisa Müller, Matthias Kappler, Alexander W. Eckert, Markus Glaß, Danny Misiak, Stefan Hüttelmaier, Wolfgang G. Ballhausen, Mechthild Hatzfeld, Monika Haemmerle, Tony Gutschner
Correction: Circular RNA circCORO1C promotes laryngeal squamous cell carcinoma progression by modulating the let-7c-5p/PBX3 axis
Yongyan Wu, Yuliang Zhang, Xiwang Zheng, Fengsheng Dai, Yan Lu, Li Dai, Min Niu, Huina Guo, Wenqi Li, Xuting Xue, Yunfeng Bo, Yujia Guo, Jiangbo Qin, Yixiao Qin, Hongliang Liu, Yu Zhang, Tao Yang, Li Li, Linshi Zhang, Rui Hou, Shuxin Wen, Changming An, Huizheng Li, Wei Xu, Wei Gao
SOX2 dosage sustains tumor-promoting inflammation to drive disease aggressiveness by modulating the FOSL2/IL6 axis
Abdel Jelil Njouendou, Tibor Szarvas, Arnol Auvaker Zebaze Tiofack, Rovaldo Nguims Kenfack, Pamela Derliche Tonouo, Sidonie Noa Ananga, Esther H. M. Dina Bell, Gustave Simo, Jörg D. Hoheisel, Jens T. Siveke, Smiths S. Lueong
Minimally invasive approaches for the early detection of endometrial cancer
Yufei Shen, Wenqing Yang, Jiachen Liu, Yu Zhang
Correction: Long non-coding RNA GBCDRlnc1 induces chemoresistance of gallbladder cancer cells by activating autophagy
Qiang Cai, Shouhua Wang, Longyang Jin, Mingzhe Weng, Di Zhou, Jiandong Wang, Zhaohui Tang, Zhiwei Quan
Exosome-derived circCCAR1 promotes CD8 + T-cell dysfunction and anti-PD1 resistance in hepatocellular carcinoma
Zongqiang Hu, Gang Chen, Yingpeng Zhao, Hongqiang Gao, Laibang Li, Yanfeng Yin, Jie Jiang, Li Wang, Yuanyi Mang, Yang Gao, Shengning Zhang, Jianghua Ran, Li Li
Retraction Note: MicroRNA-30d promotes angiogenesis and tumor growth via MYPT1/c-JUN/VEGFA pathway and predicts aggressive outcome in prostate cancer
Zhuo-yuan Lin, Guo Chen, Yan-qiong Zhang, Hui-chan He, Yu-xiang Liang, Jian-heng Ye, Ying-ke Liang, Ru-jun Mo, Jian-ming Lu, Yang-jia Zhuo, Yu Zheng, Fu-neng Jiang, Zhao-dong Han, Shu-lin Wu, Wei-de Zhong, Chin-Lee Wu
Retraction Note: CircTLK1 promotes the proliferation and metastasis of renal cell carcinoma by sponging miR-136-5p
Jianfa Li, Chenchen Huang, Yifan Zou, Jing Ye, Jing Yu, Yaoting Gui
Roles of tumor-associated macrophages in anti-PD-1/PD-L1 immunotherapy for solid cancers
Hao Zhang, Lin Liu, Jinbo Liu, Pengyuan Dang, Shengyun Hu, Weitang Yuan, Zhenqiang Sun, Yang Liu, Chengzeng Wang
Cuproptosis correlates with immunosuppressive tumor microenvironment based on pan-cancer multiomics and single-cell sequencing analysis
Yan Qin, Yanling Liu, Xiaoyun Xiang, Xingqing Long, Zuyuan Chen, Xiaoliang Huang, Jianrong Yang, Wei Li
Unleashing the potential of combining FGFR inhibitor and immune checkpoint blockade for FGF/FGFR signaling in tumor microenvironment
Ruiwen Ruan, Li Li, Xuan Li, Chunye Huang, Zhanmin Zhang, Hongguang Zhong, Shaocheng Zeng, Qianqian Shi, Yang Xia, Qinru Zeng, Qin Wen, Jingyi Chen, Xiaofeng Dai, Jianping Xiong, Xiaojun Xiang, Wan Lei, Jun Deng
The function and mechanisms of action of circular RNAs in Urologic Cancer
Zi-hao Zhang, Yue Wang, Ya Zhang, Sheng-Feng Zheng, Tao Feng, Xi Tian, Mierxiati Abudurexiti, Zhen-Da Wang, Wen-Kai Zhu, Jia-Qi Su, Hai-Liang Zhang, Guo-Hai Shi, Zi-Liang Wang, Da-Long Cao, Ding-Wei Ye
PROTAC’ing oncoproteins: targeted protein degradation for cancer therapy
Jeremy M. Kelm, Deepti S. Pandey, Evan Malin, Hussein Kansou, Sahil Arora, Raj Kumar, Navnath S. Gavande
Reprogramming anchorage dependency by adherent-to-suspension transition promotes metastatic dissemination
Hyunbin D. Huh, Yujin Sub, Jongwook Oh, Ye Eun Kim, Ju Young Lee, Hwa-Ryeon Kim, Soyeon Lee, Hannah Lee, Sehyung Pak, Sebastian E. Amos, Danielle Vahala, Jae Hyung Park, Ji Eun Shin, So Yeon Park, Han Sang Kim, Young Hoon Roh, Han-Woong Lee, Kun-Liang Guan, Yu Suk Choi, Joon Jeong, Junjeong Choi, Jae-Seok Roe, Heon Yung Gee, Hyun Woo Park
CDK9 inhibition induces epigenetic reprogramming revealing strategies to circumvent resistance in lymphoma
Elana Thieme, Nur Bruss, Duanchen Sun, Edward C. Dominguez, Daniel Coleman, Tingting Liu, Carly Roleder, Melissa Martinez, Krystine Garcia-Mansfield, Brian Ball, Patrick Pirrotte, Lili Wang, Zheng Xia, Alexey V. Danilov
HOTAIR: a potential metastatic, drug-resistant and prognostic regulator of breast cancer
Ganji Seeta Rama Raju, Eluri Pavitra, Sai Samyuktha Bandaru, Ganji Lakshmi Varaprasad, Ganji Purnachandra Nagaraju, Rama Rao Malla, Yun Suk Huh, Young-Kyu Han
TGF-β signaling promotes cervical cancer metastasis via CDR1as
Guanglei Zhong, Qian Zhao, Zhiliao Chen, Tingting Yao
CAR T-Cell therapy for the management of mantle cell lymphoma
Zoufang Huang, Vivek P. Chavda, Rajashri Bezbaruah, Hemant Dhamne, Dong-Hua Yang, Hong-Bing Zhao
The tumor ecosystem in head and neck squamous cell carcinoma and advances in ecotherapy
Yingying Gong, Lisha Bao, Tong Xu, Xiaofen Yi, Jinming Chen, Shanshan Wang, Zongfu Pan, Ping Huang, Minghua Ge
Super-enhancer-driven TOX2 mediates oncogenesis in Natural Killer/T Cell Lymphoma
Jianbiao Zhou, Sabrina Hui-Min Toh, Tze King Tan, Kalpnaa Balan, Jing Quan Lim, Tuan Zea Tan, Sinan Xiong, Yunlu Jia, Siok-Bian Ng, Yanfen Peng, Anand D. Jeyasekharan, Shuangyi Fan, Soon Thye Lim, Chin-Ann Johnny Ong, Choon Kiat Ong, Takaomi Sanda, Wee-Joo Chng
Immunotherapy of thymic epithelial tumors: molecular understandings and clinical perspectives
Yong-Qiang Ao, Jian Gao, Shuai Wang, Jia-Hao Jiang, Jie Deng, Hai-Kun Wang, Bei Xu, Jian-Yong Ding
Advances in immunology and immunotherapy for mesenchymal gastrointestinal cancers
Bo Li, Hui Chen, Shaohua Yang, Feng Chen, Liangliang Xu, Yan Li, Mingzhe Li, Chengming Zhu, Fangyuan Shao, Xinhua Zhang, Chuxia Deng, Leli Zeng, Yulong He, Changhua Zhang
A novel protein encoded by circINSIG1 reprograms cholesterol metabolism by promoting the ubiquitin-dependent degradation of INSIG1 in colorectal cancer
Li Xiong, Hua-shan Liu, Chi Zhou, Xin Yang, Liang Huang, Hai-qing Jie, Zi-wei Zeng, Xiao-bin Zheng, Wen-xin Li, Zhan-zhen Liu, Liang Kang, Zhen-xing Liang
Correction to: The function and mechanisms of action of circular RNAs in Urologic Cancer
Zi-hao Zhang, Yue Wang, Ya Zhang, Sheng-Feng Zheng, Tao Feng, Xi Tian, Mierxiati Abudurexiti, Zhen-Da Wang, Wen-Kai Zhu, Jia-Qi Su, Hai-Liang Zhang, Guo-Hai Shi, Zi-Liang Wang, Da-Long Cao, Ding-Wei Ye
Editorial Expression of Concern: Let-7d suppresses growth, metastasis, and tumor macrophage infiltration in renal cell carcinoma by targeting COL3A1 and CCL7
Boxing Su, Wei Zhao, Bentao Shi, Zhongyuan Zhang, Xi Yu, Feng Xie, Zhongqiang Guo, Xiaoyu Zhang, Jin Liu, Qi Shen, Jinghua Wang, Xuesong Li, Zhiqian Zhang, Liqun Zhou
Molecular mimicry and cancer vaccine development
Maria Tagliamonte, Beatrice Cavalluzzo, Angela Mauriello, Concetta Ragone, Franco M. Buonaguro, Maria Lina Tornesello, Luigi Buonaguro
Correction: minimally invasive approaches for the early detection of endometrial cancer
Yufei Shen, Wenqing Yang, Jiachen Liu, Yu Zhang
CircZBTB44 promotes renal carcinoma progression by stabilizing HK3 mRNA structure
Tushuai Li, Yue Gu, Baocai Xu, Kamil Kuca, Jie Zhang, Wenda Wu
Retraction Note: Systematic analyses reveal long non-coding RNA (PTAF)-mediated promotion of EMT and invasion-metastasis in serous ovarian cancer
Haihai Liang, Xiaoguang Zhao, Chengyu Wang, Jian Sun, Yingzhun Chen, Guoyuan Wang, Lei Fang, Rui Yang, Mengxue Yu, Yunyan Gu, Hongli Shan
Circulating biosignatures in multiple myeloma and their role in multidrug resistance
S. Rajeev Krishnan, M. Bebawy
Deciphering and advancing CAR T-cell therapy with single-cell sequencing technologies
Shengkang Huang, Xinyu Wang, Yu Wang, Yajing Wang, Chenglong Fang, Yazhuo Wang, Sifei Chen, Runkai Chen, Tao Lei, Yuchen Zhang, Xinjie Xu, Yuhua Li
Aberrant m5C hypermethylation mediates intrinsic resistance to gefitinib through NSUN2/YBX1/QSOX1 axis in EGFR-mutant non-small-cell lung cancer
Yueqin Wang, Jingyao Wei, Luyao Feng, Ouwen Li, Lan Huang, Shaoxuan Zhou, Yingjie Xu, Ke An, Yu Zhang, Ruiying Chen, Lulu He, Qiming Wang, Han Wang, Yue Du, Ruijuan Liu, Chunmin Huang, Xiaojian Zhang, Yun-gui Yang, Quancheng Kan, Xin Tian
CAR T cell-based immunotherapy and radiation therapy: potential, promises and risks
Lusine Hovhannisyan, Carsten Riether, Daniel M. Aebersold, Michaela Medová, Yitzhak Zimmer
Epigenetic inactivation of the 5-methylcytosine RNA methyltransferase NSUN7 is associated with clinical outcome and therapeutic vulnerability in liver cancer
Vanessa Ortiz-Barahona, Marta Soler, Veronica Davalos, Carlos A. García-Prieto, Maxime Janin, Fernando Setien, Irene Fernández-Rebollo, Joan J. Bech-Serra, Carolina De La Torre, Sonia Guil, Alberto Villanueva, Pei-Hong Zhang, Li Yang, Marco Guarnacci, Ulrike Schumann, Thomas Preiss, Ugne Balaseviciute, Robert Montal, Josep M. Llovet, Manel Esteller
Epigenetic reprogramming of Runx3 reinforces CD8 + T-cell function and improves the clinical response to immunotherapy
Zongzhi Liu, Xiang Li, Yibo Gao, Jiejie Liu, Yating Feng, Yang Liu, Junyun Wang, Chunmeng Wang, Dongrui Wang, Jie He, Weidong Han, Qian Mei, Yingli Sun
EZH2 mediated metabolic rewiring promotes tumor growth independently of histone methyltransferase activity in ovarian cancer
Jianfeng Chen, Jing Han Hong, Yulin Huang, Shini Liu, Jiaxin Yin, Peng Deng, Yichen Sun, Zhaoliang Yu, Xian Zeng, Rong Xiao, Jason Yongsheng Chan, Peiyong Guan, Yali Wang, Peili Wang, Lizhen Liu, Shijun Wen, Qiang Yu, Choon Kiat Ong, Bin-Tean Teh, Ying Xiong, Jing Tan
The phospholipid transporter PITPNC1 links KRAS to MYC to prevent autophagy in lung and pancreatic cancer
Rodrigo Entrialgo-Cadierno, Cristina Cueto-Ureña, Connor Welch, Iker Feliu, Irati Macaya, Laura Vera, Xabier Morales, Sandra Vietti Michelina, Pietro Scaparone, Ines Lopez, Elodie Darbo, Oihane Erice, Adrian Vallejo, Haritz Moreno, Ainhoa Goñi-Salaverri, David Lara-Astiaso, Nils Halberg, Ivan Cortes-Dominguez, Elizabeth Guruceaga, Chiara Ambrogio, Fernando Lecanda, Silve Vicent
New opportunities for RGD-engineered metal nanoparticles in cancer
Wei Qin, Jyoti Chandra, Mohammed A.S. Abourehab, Neelima Gupta, Zhe-Sheng Chen, Prashant Kesharwani, Hui-Ling Cao
IGF2BP1 induces neuroblastoma via a druggable feedforward loop with MYCN promoting 17q oncogene expression
Sven Hagemann, Danny Misiak, Jessica L. Bell, Tommy Fuchs, Marcell I. Lederer, Nadine Bley, Monika Hämmerle, Ehab Ghazy, Wolfgang Sippl, Johannes H. Schulte, Stefan Hüttelmaier
A combined computational and functional approach identifies IGF2BP2 as a driver of chemoresistance in a wide array of pre-clinical models of colorectal cancer
Sandra Kendzia, Susanne Franke, Tarek Kröhler, Nicole Golob-Schwarzl, Caroline Schweiger, Anna M. Toeglhofer, Christina Skofler, Stefan Uranitsch, Amin El-Heliebi, Julia Fuchs, Andreas Punschart, Philipp Stiegler, Marlen Keil, Jens Hoffmann, David Henderson, Hans Lehrach, Marie-Laure Yaspo, Christoph Reinhard, Reinhold Schäfer, Ulrich Keilholz, Christian Regenbrecht, Rudolf Schicho, Peter Fickert, Sigurd F. Lax, Frank Erdmann, Marcel H. Schulz, Alexandra K. Kiemer, Johannes Haybaeck, Sonja M. Kessler
EMT/MET plasticity in cancer and Go-or-Grow decisions in quiescence: the two sides of the same coin?
Azamat Akhmetkaliyev, Noura Alibrahim, Darya Shafiee, Eugene Tulchinsky
The role of m6A methylation in therapy resistance in cancer
Hengzhao Zhuang, Bo Yu, Dan Tao, Xiaoyan Xu, Yijun Xu, Jian Wang, Yang Jiao, Lili Wang
CXCR2 expression during melanoma tumorigenesis controls transcriptional programs that facilitate tumor growth
J. Yang, K. Bergdorf, C. Yan, W. Luo, S. C. Chen, G.D. Ayers, Q. Liu, X. Liu, M. Boothby, V.L. Weiss, S. M. Groves, A. N. Oleskie, X. Zhang, D. Y. Maeda, J. A. Zebala, V. Quaranta, A. Richmond
Co-inhibition of TIGIT and PD-1/PD-L1 in Cancer Immunotherapy: Mechanisms and Clinical Trials
Xianjing Chu, Wentao Tian, Ziqi Wang, Jing Zhang, Rongrong Zhou
Nanomaterials in tumor immunotherapy: new strategies and challenges
Xudong Zhu, Shenglong Li
Metal-enriched HSP90 nanoinhibitor overcomes heat resistance in hyperthermic intraperitoneal chemotherapy used for peritoneal metastases
Qiang Wang, Peng Liu, Yingfei Wen, Kuan Li, Bo Bi, Bin-bin Li, Miaojuan Qiu, Shiqiang Zhang, You Li, Jia Li, Hengxing Chen, Yuan Yin, Leli Zeng, Changhua Zhang, Yulong He, Jing Zhao
Molecular mechanisms of tumor resistance to radiotherapy
Yu Wu, Yingqiu Song, Runze Wang, Tianlu Wang
Correction: The phospholipid transporter PITPNC1 links KRAS to MYC to prevent autophagy in lung and pancreatic cancer
Rodrigo Entrialgo‑Cadierno, Cristina Cueto‑Ureña, Connor Welch, Iker Feliu, Irati Macaya, Laura Vera, Xabier Morales, Sandra Vietti Michelina, Pietro Scaparone, Ines Lopez, Elodie Darbo, Oihane Erice, Adrian Vallejo, Haritz Moreno, Ainhoa Goñi‑Salaverri, David Lara‑Astiaso, Nils Halberg, Ivan Cortes‑Dominguez, Elizabeth Guruceaga, Chiara Ambrogio, Fernando Lecanda, Silve Vicent
Gold nanoparticles and gold nanorods in the landscape of cancer therapy
Prashant Kesharwani, Ruiyang Ma, Liang Sang, Mahak Fatima, Afsana Sheikh, Mohammed A. S. Abourehab, Neelima Gupta, Zhe-Sheng Chen, Yun Zhou
m6A methylation reader IGF2BP2 activates endothelial cells to promote angiogenesis and metastasis of lung adenocarcinoma
Han Fang, Qi Sun, Jin Zhou, Huijuan Zhang, Qiong Song, Hua Zhang, Guohua Yu, Ying Guo, Chengyu Huang, Yakui Mou, Chuanliang Jia, Yingjian Song, Aina Liu, Kaiyu Song, Congxian Lu, Ruxian Tian, Shizhuang Wei, Dengfeng Yang, Yixuan Chen, Ting Li, Kejian Wang, Yilan Yu, Yufeng Lv, Ke Mo, Ping Sun, Xiaofeng Yu, Xicheng Song
Homology-independent targeted insertion (HITI) enables guided CAR knock-in and efficient clinical scale CAR-T cell manufacturing
Hyatt Balke-Want, Vimal Keerthi, Nikolaos Gkitsas, Andrew G. Mancini, Gavin L. Kurgan, Carley Fowler, Peng Xu, Xikun Liu, Kyle Asano, Sunny Patel, Christopher J. Fisher, Annie K. Brown, Ramya H. Tunuguntla, Shabnum Patel, Elena Sotillo, Crystal L. Mackall, Steven A. Feldman
Correction: Co-inhibition of TIGIT and PD-1/PD-L1 in Cancer Immunotherapy: Mechanisms and Clinical Trials
Xianjing Chu, Wentao Tian, Ziqi Wang, Jing Zhang, Rongrong Zhou
Epigenetic modification of m6A regulator proteins in cancer
Yumin Wang, Yan Wang, Harsh Patel, Jichao Chen, Jinhua Wang, Zhe-Sheng Chen, Hongquan Wang
Enhancement of TKI sensitivity in lung adenocarcinoma through m6A-dependent translational repression of Wnt signaling by circ-FBXW7
Kai Li, Zi-Yang Peng, Rui Wang, Xiang Li, Ning Du, Da-Peng Liu, Jia Zhang, Yun-Feng Zhang, Lei Ma, Ye Sun, Shou-Ching Tang, Hong Ren, Yi-Ping Yang, Xin Sun
A novel polypeptide CAPG-171aa encoded by circCAPG plays a critical role in triple-negative breast cancer
Runjie Song, Peilan Guo, Xin Ren, Lijun Zhou, Peng Li, Nafis A Rahman, Sławomir Wołczyński, Xiru Li, Yanjun Zhang, Mei Liu, Jiali Liu, Xiangdong Li
Advancements in clinical aspects of targeted therapy and immunotherapy in breast cancer
Feng Ye, Saikat Dewanjee, Yuehua Li, Niraj Kumar Jha, Zhe-Sheng Chen, Ankush Kumar, Vishakha, Tapan Behl, Saurabh Kumar Jha, Hailin Tang
The use of RNA-based treatments in the field of cancer immunotherapy
Mohammad Chehelgerdi, Matin Chehelgerdi
Combined proteomics and CRISPR‒Cas9 screens in PDX identify ADAM10 as essential for leukemia in vivo
Ehsan Bahrami, Jan Philipp Schmid, Vindi Jurinovic, Martin Becker, Anna-Katharina Wirth, Romina Ludwig, Sophie Kreissig, Tania Vanessa Duque Angel, Diana Amend, Katharina Hunt, Rupert Öllinger, Roland Rad, Joris Maximilian Frenz, Maria Solovey, Frank Ziemann, Matthias Mann, Binje Vick, Christian Wichmann, Tobias Herold, Ashok Kumar Jayavelu, Irmela Jeremias
TREC mediated oncogenesis in human immature T lymphoid malignancies preferentially involves ZFP36L2
Estelle Balducci, Thomas Steimlé, Charlotte Smith, Patrick Villarese, Mélanie Feroul, Dominique Payet-Bornet, Sophie Kaltenbach, Lucile Couronné, Ludovic Lhermitte, Aurore Touzart, Marie-Emilie Dourthe, Mathieu Simonin, André Baruchel, Hervé Dombret, Norbert Ifrah, Nicolas Boissel, Bertrand Nadel, Elizabeth Macintyre, Agata Cieslak, Vahid Asnafi
Correction: Circular RNA circCORO1C promotes laryngeal squamous cell carcinoma progression by modulating the let-7c-5p/ PBX3 axis
Yongyan Wu, Yuliang Zhang, Xiwang Zheng, Fengsheng Dai, Yan Lu, Li Dai, Min Niu, Huina Guo, Wenqi Li, Xuting Xue, Yunfeng Bo, Yujia Guo, Jiangbo Qin, Yixiao Qin, Hongliang Liu, Yu Zhang, Tao Yang, Li Li, Linshi Zhang, Rui Hou, Shuxin Wen, Changming An, Huizheng Li, Wei Xu, Wei Gao
BID expression determines the apoptotic fate of cancer cells after abrogation of the spindle assembly checkpoint by AURKB or TTK inhibitors
Jordi Bertran-Alamillo, Ana Giménez-Capitán, Ruth Román, Sara Talbot, Rebecca Whiteley, Nicolas Floc’h, Elizabeth Martínez-Pérez, Matthew J. Martin, Paul D. Smith, Ivana Sullivan, Mikkel G. Terp, Jamal Saeh, Cristina Marino-Buslje, Giulia Fabbri, Grace Guo, Man Xu, Cristian Tornador, Andrés Aguilar-Hernández, Noemí Reguart, Henrik J. Ditzel, Alejandro Martínez-Bueno, Núria Nabau-Moretó, Amaya Gascó, Rafael Rosell, J. Elizabeth Pease, Urszula M. Polanska, Jon Travers, Jelena Urosevic, Miguel A. Molina-Vila
Immunotherapy: an emerging modality to checkmate brain metastasis
Aatiya Ahmad, Parvez Khan, Asad Ur Rehman, Surinder Kumar Batra, Mohd Wasim Nasser
Expression of mTOR in normal and pathological conditions
A Marques-Ramos, R Cervantes
Exosome-mediated miR-144-3p promotes ferroptosis to inhibit osteosarcoma proliferation, migration, and invasion through regulating ZEB1
Mingyang Jiang, Yiji Jike, Kaicheng Liu, Fu Gan, Ke Zhang, Mingjing Xie, Junlei Zhang, Chuanliang Chen, Xiaochong Zou, Xiaohong Jiang, Yongheng Dai, Weikui Chen, Yue Qiu, Zhandong Bo
Spatially resolved, high-dimensional transcriptomics sorts out the evolution of biphasic malignant pleural mesothelioma: new paradigms for immunotherapy
F Torricelli, B Donati, F Reggiani, V Manicardi, S Piana, R Valli, F Lococo, Alessia Ciarrocchi
Correction: Long non-coding RNA SOX2OT promotes the stemness phenotype of bladder cancer cells by modulating SOX2
Yonghao Zhan, Zhicong Chen, Shiming He, Yanqing Gong, Anbang He, Yifan Li, Lianghao Zhang, Xuepei Zhang, Dong Fang, Xuesong Li, Liqun Zhou
Correction: MIR22HG acts as a tumor suppressor via TGFβ/SMAD signaling and facilitates immunotherapy in colorectal cancer
Juan Xu, Tingting Shao, Mingxu Song, Yunjin Xie, Jialiang Zhou, Jiaqi Yin, Na Ding, Haozhe Zou, Yongsheng Li, Jiwei Zhang
Extracellular vesicle-circEHD2 promotes the progression of renal cell carcinoma by activating cancer-associated fibroblasts
Tao He, Qiansheng Zhang, Peng Xu, Wen Tao, Fuyang Lin, Renfei Liu, Mingzhao Li, Xiaolu Duan, Chao Cai, Di Gu, Guohua Zeng, Yongda Liu
Molecular and metabolic regulation of immunosuppression in metastatic pancreatic ductal adenocarcinoma
Shailendra K. Gautam, Surinder K. Batra, Maneesh Jain
METTL1 promotes tumorigenesis through tRNA-derived fragment biogenesis in prostate cancer
Raquel García-Vílchez, Ana M. Añazco-Guenkova, Sabine Dietmann, Judith López, Virginia Morón-Calvente, Silvia D’Ambrosi, Paz Nombela, Kepa Zamacola, Isabel Mendizabal, Saioa García-Longarte, Amaia Zabala-Letona, Ianire Astobiza, Sonia Fernández, Alejandro Paniagua, Borja Miguel-López, Virginie Marchand, Diego Alonso-López, Angelika Merkel, Ignacio García-Tuñón, Aitziber Ugalde-Olano, Ana Loizaga-Iriarte, Isabel Lacasa-Viscasillas, Miguel Unda, Mikel Azkargorta, Félix Elortza, Laura Bárcena, Monika Gonzalez-Lopez, Ana M. Aransay, Tomás Di Domenico, Manuel A. Sánchez-Martín, Javier De Las Rivas, Sònia Guil, Yuri Motorin, Mark Helm, Pier Paolo Pandolfi, Arkaitz Carracedo, Sandra Blanco
Durable response of lung carcinoma patients to EGFR tyrosine kinase inhibitors is determined by germline polymorphisms in some immune-related genes
Lorraine Dalens, Julie Niogret, Corentin Richard, Sandy Chevrier, Pascal Foucher, Bruno Coudert, Aurélie Lagrange, Laure Favier, Virginie Westeel, Stefano Kim, Olivier Adotevi, Caroline Chapusot, Laurent Martin, Laurent Arnould, Courèche-Guillaume Kaderbhai, Romain Boidot
Reigniting hope in cancer treatment: the promise and pitfalls of IL-2 and IL-2R targeting strategies
Shan Muhammad, Tao Fan, Yang Hai, Yibo Gao, Jie He
LINC02159 promotes non-small cell lung cancer progression via ALYREF/YAP1 signaling
Qiurong Yang, Maoye Wang, Jing Xu, Dan Yu, Yixin Li, Yanke Chen, Xiaoxin Zhang, Jiahui Zhang, Jianmei Gu, Xu Zhang
Retraction Note: Quercetin-induced miR-200b-3p regulates the mode of self-renewing divisions in pancreatic cancer
Clifford C. Nwaeburu, Alia Abukiwan, Zhefu Zhao, Ingrid Herr
Anlotinib plus icotinib as a potential treatment option for EGFR-mutated advanced non-squamous non-small cell lung cancer with concurrent mutations: final analysis of the prospective phase 2, multicenter ALTER-L004 study
Linlin Zhang, Liuchun Wang, Jingya Wang, Jinliang Chen, Zhaoting Meng, Zhujun Liu, Xiangli Jiang, Xinyue Wang, Chun Huang, Peng Chen, Yan Liang, Richeng Jiang, Jing Wang, Diansheng Zhong, Yanhong Shang, Yan Zhang, Cuiying Zhang, Dingzhi Huang
BRAF(V600E) mutation together with loss of Trp53 or pTEN drives the origination of hairy cell leukemia from B-lymphocytes
Jiajun Yap, Jimin Yuan, Wan Hwa Ng, Gao Bin Chen, Yuen Rong M. Sim, Kah Chun Goh, Joey Teo, Trixie Y. H. Lim, Shee Min Goay, Jia Hao Jackie Teo, Zhentang Lao, Paula Lam, Kanaga Sabapathy, Jiancheng Hu
Genomic variants exclusively identified in children with birth defects and concurrent malignant tumors predispose to cancer development
Yichuan Liu, Hui-Qi Qu, Xiao Chang, Frank D Mentch, Haijun Qiu, Xiang Wang, Amir Hossein Saeidian, Deborah Watson, Joseph Glessner, Hakon Hakonarson
REGISTRI: Regorafenib in first-line of KIT/PDGFRA wild type metastatic GIST: a collaborative Spanish (GEIS), Italian (ISG) and French Sarcoma Group (FSG) phase II trial
Javier Martin-Broto, Claudia Valverde, Nadia Hindi, Bruno Vincenzi, Javier Martinez-Trufero, Giovanni Grignani, Antoine Italiano, Javier Lavernia, Ana Vallejo, Paolo Dei Tos, Francois Le Loarer, Ricardo Gonzalez-Campora, Rafael Ramos, Diana Hernández-Jover, Antonio Gutierrez, Cesar Serrano, Maria Monteagudo, Rocio Letón, Mercedes Robledo, David S. Moura, Marta Martin-Ruiz, Jose A. López-Guerrero, Julia Cruz, Antonio Fernandez-Serra, Jean-Yves Blay, Elena Fumagalli, Virginia Martinez-Marin
Protein regulator of cytokinesis 1: a potential oncogenic driver
Sijing Li, Omar Motiño, Flavia Lambertucci, Isabelle Martins, Li Sun, Guido Kroemer
Local delivery of hrBMP4 as an anticancer therapy in patients with recurrent glioblastoma: a first-in-human phase 1 dose escalation trial
Eelke M. Bos, Elena Binda, Iris S.C. Verploegh, Eva Wembacher, Daphna Hoefnagel, Rutger K. Balvers, Anne L. Korporaal, Andrea Conidi, Esther A. H. Warnert, Nadia Trivieri, Alberto Visioli, Paola Zaccarini, Laura Caiola, Rogier van Wijck, Peter van der Spek, Danny Huylebroeck, Sieger Leenstra, Martine L.M. Lamfers, Zvi Ram, Manfred Westphal, David Noske, Federico Legnani, Francesco DiMeco, Angelo Luigi Vescovi, Clemens M.F. Dirven
Multifaceted role of redox pattern in the tumor immune microenvironment regarding autophagy and apoptosis
Yuqing Ren, Ruizhi Wang, Siyuan Weng, Hui Xu, Yuyuan Zhang, Shuang Chen, Shutong Liu, Yuhao Ba, Zhaokai Zhou, Peng Luo, Quan Cheng, Qin Dang, Zaoqu Liu, Xinwei Han
Target delivery of a PD-1-TREM2 scFv by CAR-T cells enhances anti-tumor efficacy in colorectal cancer
Jian Chen, Tianchuan Zhu, Guanmin Jiang, Qi Zeng, Zhijian Li, Xi Huang
Retraction Note: N6-methyladenosine induced mir-143-3p promotes the brain metastasis of lung cancer via regulation of VASH1
Hongsheng Wang, Qianqian Deng, Ziyan Lv, Yuyi Ling, Xue Hou, Zhuojia Chen, Xiaoxiao Dinglin, Shuxiang Ma, Delan Li, Yingmin Wu, Yanxi Peng, Hongbing Huang, Likun Chen
STAT3/LKB1 controls metastatic prostate cancer by regulating mTORC1/CREB pathway
Jan Pencik, Cecile Philippe, Michaela Schlederer, Emine Atas, Matteo Pecoraro, Sandra Grund-Gröschke, Wen (Jess) Li, Amanda Tracz, Isabel Heidegger, Sabine Lagger, Karolína Trachtová, Monika Oberhuber, Ellen Heitzer, Osman Aksoy, Heidi A. Neubauer, Bettina Wingelhofer, Anna Orlova, Nadine Witzeneder, Thomas Dillinger, Elisa Redl, Georg Greiner, David D’Andrea, Johnny R. Östman, Simone Tangermann, Ivana Hermanova, Georg Schäfer, Felix Sternberg, Elena E. Pohl, Christina Sternberg, Adam Varady, Jaqueline Horvath, Dagmar Stoiber, Tim I. Malcolm, Suzanne D. Turner, Eileen E. Parkes, Brigitte Hantusch, Gerda Egger, Stefan Rose-John, Valeria Poli, Suneil Jain, Chris W. D. Armstrong, Gregor Hoermann, Vincent Goffin, Fritz Aberger, Richard Moriggl, Arkaitz Carracedo, Cathal McKinney, Richard D. Kennedy, Helmut Klocker, Michael R. Speicher, Dean G. Tang, Ali A. Moazzami, David M. Heery, Marcus Hacker, Lukas Kenner
Correction: CircNFIB inhibits tumor growth and metastasis through suppressing MEK1/ERK signaling in intrahepatic cholangiocarcinoma
Jinpeng Du, Tian Lan, Haotian Liao, Xuping Feng, Xing Chen, Wenwei Liao, Guimin Hou, Lin Xu, Qingbo Feng, Kunlin Xie, Mingheng Liao, Xiangzheng Chen, Jiwei Huang, Kefei Yuan, Yong Zeng
Correction: Reprogramming anchorage dependency by adherent‑to‑suspension transition promotes metastatic dissemination
Hyunbin D. Huh, Yujin Sub, Jongwook Oh, Ye Eun Kim, Ju Young Lee, Hwa‑Ryeon Kim, Soyeon Lee, Hannah Lee, Sehyung Pak, Sebastian E. Amos, Danielle Vahala, Jae Hyung Park, Ji Eun Shin, So Yeon Park, Han Sang Kim, Young Hoon Roh, Han‑Woong Lee, Kun‑Liang Guan, Yu Suk Choi, Joon Jeong, Junjeong Choi, Jae‑Seok Roe, Heon Yung Gee, Hyun Woo Park
Unleashing T cell anti-tumor immunity: new potential for 5-Nonloxytryptamine as an agent mediating MHC-I upregulation in tumors
Paweł Stachura, Wei Liu, Haifeng C. Xu, Agnès Wlodarczyk, Olivia Stencel, Piyush Pandey, Melina Vogt, Sanil Bhatia, Daniel Picard, Marc Remke, Karl S. Lang, Dieter Häussinger, Bernhard Homey, Philipp A. Lang, Arndt Borkhardt, Aleksandra A. Pandyra
m6A-regulated tumor glycolysis: new advances in epigenetics and metabolism
Shi-Wei Yue, Hai-Ling Liu, Hong-Fei Su, Chu Luo, Hui-Fang Liang, Bi-Xiang Zhang, Wei Zhang
PI3K/AKT/mTOR signaling transduction pathway and targeted therapies in cancer
Antonino Glaviano, Aaron S. C. Foo, Hiu Y. Lam, Kenneth C. H. Yap, William Jacot, Robert H. Jones, Huiyan Eng, Madhumathy G. Nair, Pooyan Makvandi, Birgit Geoerger, Matthew H. Kulke, Richard D. Baird, Jyothi S. Prabhu, Daniela Carbone, Camilla Pecoraro, Daniel B. L. Teh, Gautam Sethi, Vincenzo Cavalieri, Kevin H. Lin, Nathalie R. Javidi-Sharifi, Eneda Toska, Matthew S. Davids, Jennifer R. Brown, Patrizia Diana, Justin Stebbing, David A. Fruman, Alan P. Kumar
Correction: Discovery of a novel third-generation EGFR inhibitor and identification of a potential combination strategy to overcome resistance
Tao Zhang, Rong Qu, Shingpan Chan, Mengzhen Lai, Linjiang Tong, Fang Feng, Hongyu Chen, Tingting Song, Peiran Song, Gang Bai, Yingqiang Liu, Yanan Wang, Yan Li, Yi Su, Yanyan Shen, Yiming Sun, Yi Chen, Meiyu Geng, Ke Ding, Jian Ding, Hua Xie
Mechanisms of radiotherapy resistance and radiosensitization strategies for esophageal squamous cell carcinoma
Lingbo An, Mingyang Li, Qingge Jia
The screening, identification, design and clinical application of tumor-specific neoantigens for TCR-T cells
Jiangping Li, Zhiwen Xiao, Donghui Wang, Lei Jia, Shihong Nie, Xingda Zeng, Wei Hu
Beyond the anti-PD-1/PD-L1 era: promising role of the BTLA/HVEM axis as a future target for cancer immunotherapy
Christian Sordo-Bahamonde, Seila Lorenzo-Herrero, Rocío Granda-Díaz, Alejandra Martínez-Pérez, Candelaria Aguilar-García, Juan P. Rodrigo, Juana M. García-Pedrero, Segundo Gonzalez
BNIP3 as a potential biomarker for the identification of prognosis and diagnosis in solid tumours
Qin Yu, Wenhao Fu, Yutang Fu, Wenjing Ye, Huiqiong Yan, Zecheng Yu, Ruirui Li, Yili Cai, Yuxin Chen, Lingyun Wang, Xianqiao Wei, Yangkun Chen, Yuheng Zhang, Huazhong Ying, Furong Tang, Fangwei Dai, Wei Han
Correction: Gamabufotalin, a bufadienolide compound from toad venom, suppresses COX-2 expression through targeting IKKβ/NF-κB signaling pathway in lung cancer cells
Zhenlong Yu, Wei Guo, Xiaochi Ma, Baojing Zhang, Peipei Dong, Lin Huang, Xiuli Wang, Chao Wang, Xiaokui Huo, Wendan Yu, Canhui Yi, Yao Xiao, Wenjing Yang, Yu Qin, Yuhui Yuan, Songshu Meng, Quentin Liu, Wuguo Deng
Advances in immunotherapy for triple-negative breast cancer
Yang Liu, Yueting Hu, Jinqi Xue, Jingying Li, Jiang Yi, Jiawen Bu, Zhenyong Zhang, Peng Qiu, Xi Gu
Identification of multidrug chemoresistant genes in head and neck squamous cell carcinoma cells
Neha Khera, Asvika Soodhalaagunta Rajkumar, Khlood Abdulkader M Alkurdi, Zhiao Liu, Hong Ma, Ahmad Waseem, Muy-Teck Teh
Clinically conserved genomic subtypes of gastric adenocarcinoma
Yun Seong Jeong, Young-Gyu Eun, Sung Hwan Lee, Sang-Hee Kang, Sun Young Yim, Eui Hyun Kim, Joo Kyung Noh, Bo Hwa Sohn, Seon Rang Woo, Moonkyoo Kong, Deok Hwa Nam, Hee-Jin Jang, Hyun-Sung Lee, Shumei Song, Sang Cheul Oh, Jeeyun Lee, Jaffer A. Ajani, Ju-Seog Lee
The evolution and heterogeneity of neutrophils in cancers: origins, subsets, functions, orchestrations and clinical applications
Siyao Liu, Wenchuan Wu, Yueshan Du, Hanlin Yin, Qiangda Chen, Weisheng Yu, Wenquan Wang, Jun Yu, Liang Liu, Wenhui Lou, Ning Pu
Should I stay or should I go? Spatio-temporal control of cellular anchorage by hematopoietic factors orchestrates tumor metastatic cascade
Veronica Marabitti, Ignazio Caruana, Francesca Nazio
Structural and biological characterization of pAC65, a macrocyclic peptide that blocks PD-L1 with equivalent potency to the FDA-approved antibodies
Ismael Rodriguez, Justyna Kocik-Krol, Lukasz Skalniak, Bogdan Musielak, Aneta Wisniewska, Agnieszka Ciesiołkiewicz, Łukasz Berlicki, Jacek Plewka, Przemyslaw Grudnik, Malgorzata Stec, Maciej Siedlar, Tad A. Holak, Katarzyna Magiera-Mularz
CircXRN2 suppresses tumor progression driven by histone lactylation through activating the Hippo pathway in human bladder cancer
Bo Xie, Juntao Lin, Xianwu Chen, Xuejian Zhou, Yan Zhang, Mengjing Fan, Jiayong Xiang, Ning He, Zhenghui Hu, Feifan Wang
circEIF3I facilitates the recruitment of SMAD3 to early endosomes to promote TGF-β signalling pathway-mediated activation of MMPs in pancreatic cancer
Zhongjie Zhao, Wenbo Yang, Rui Kong, Yangyang Zhang, Le Li, Zengfu Song, Hongze Chen, Yan Luo, Tao Zhang, Chundong Cheng, Guanqun Li, Danxi Liu, Xinglong Geng, Hua Chen, Yongwei Wang, Shangha Pan, Jisheng Hu, Bei Sun
Retraction Note: HOXA7 plays a critical role in metastasis of liver cancer associated with activation of Snail
Bo Tang, Guangying Qi, Xiaoyu Sun, Fang Tang, Shengguang Yuan, Zhenran Wang, Xingsi Liang, Bo Li, Shuiping Yu, Jie Liu, Qi Huang, Yangchao Wei, Run Zhai, Biao Lei, Xinjin Guo, Songqing He
Correction: Advances in immunotherapy for triple-negative breast cancer
Yang Liu, Yueting Hu, Jinqi Xue, Jingying Li, Jiang Yi, Jiawen Bu, Zhenyong Zhang, Peng Qiu, Xi Gu
Correction: Circ-HuR suppresses HuR expression and gastric cancer progression by inhibiting CNBP transactivation
Feng Yang, Anpei Hu, Dan Li, Jianqun Wang, Yanhua Guo, Yang Liu, Hongjun Li, Yajun Chen, Xiaojing Wang, Kai Huang, Liduan Zheng, Qiangsong Tong
Combined inhibition of Bcl-2 family members and YAP induces synthetic lethality in metastatic gastric cancer with RASA1 and NF2 deficiency
Jong-Wan Kwon, Jeong-Seop Oh, Sang Hyeok Seok, Hyeok-Won An, Yu Jin Lee, Na Yun Lee, Taehun Ha, Hyeon Ah Kim, Gyeong Min Yoon, Sung Eun Kim, Pu-Reum Oh, Su-Hyung Lee, Dominic C. Voon, Dae-Yong Kim, Jun Won Park
Efficacy of cell-free DNA methylation-based blood test for colorectal cancer screening in high-risk population: a prospective cohort study
Fuqiang Zhao, Ping Bai, Jianfeng Xu, Zitong Li, Shan Muhammad, Diange Li, Zeyue Zhang, Yibo Gao, Qian Liu
EYA4 promotes breast cancer progression and metastasis through its role in replication stress avoidance
Bárbara de la Peña Avalos, Romain Tropée, Pascal H. G. Duijf, Eloïse Dray
Define cancer-associated fibroblasts (CAFs) in the tumor microenvironment: new opportunities in cancer immunotherapy and advances in clinical trials
Hao Zhang, Xinghai Yue, Zhe Chen, Chao Liu, Wantao Wu, Nan Zhang, Zaoqu Liu, Liping Yang, Qing Jiang, Quan Cheng, Peng Luo, Guodong Liu
Lipid polymer hybrid nanoparticles: a custom-tailored next-generation approach for cancer therapeutics
Kavita R. Gajbhiye, Rajesh Salve, Mahavir Narwade, Afsana Sheikh, Prashant Kesharwani, Virendra Gajbhiye
Profiling small RNAs in fecal immunochemical tests: is it possible?
Einar Birkeland, Giulio Ferrero, Barbara Pardini, Sinan U. Umu, Sonia Tarallo, Sara Bulfamante, Geir Hoff, Carlo Senore, Trine B Rounge, Alessio Naccarati
Spatial transcriptomic analysis of virtual prostate biopsy reveals confounding effect of tissue heterogeneity on genomic signatures
Sandy Figiel, Wencheng Yin, Dimitrios Doultsinos, Andrew Erickson, Ninu Poulose, Reema Singh, Anette Magnussen, Thineskrishna Anbarasan, Renuka Teague, Mengxiao He, Joakim Lundeberg, Massimo Loda, Clare Verrill, Richard Colling, Pelvender S. Gill, Richard J. Bryant, Freddie C. Hamdy, Dan J. Woodcock, Ian G. Mills, Olivier Cussenot, Alastair D. Lamb
LINC00922 decoys SIRT3 to facilitate the metastasis of colorectal cancer through up-regulation the H3K27 crotonylation of ETS1 promoter
Meijian Liao, Xiaolin Sun, Wendan Zheng, Mengdi Wu, Yifan Wang, Jia Yao, Yu Ma, Shoucui Gao, Dongsheng Pei
A circulating cell-free DNA methylation signature for the detection of hepatocellular carcinoma
Si-Cho Kim, Da-Won Kim, Eun Ju Cho, Jin-Young Lee, Jiwon Kim, Chaesun Kwon, Jeongsil Kim-Ha, Suk Kyun Hong, YoungRok Choi, Nam-Joon Yi, Kwang-Woong Lee, Kyung-Suk Suh, Won Kim, Woojin Kim, Hyunsoo Kim, Yoon Jun Kim, Jung-Hwan Yoon, Su Jong Yu, Young-Joon Kim
ERK mediates interferon gamma-induced melanoma cell death
Ameya Champhekar, Rachel Heymans, Justin Saco, Guillem Turon Font, Cynthia Gonzalez, Anne Gao, John Pham, June Lee, Ryan Maryoung, Egmidio Medina, Katie M. Campbell, Daniel Karin, David Austin, Robert Damioseaux, Antoni Ribas
Retraction Note: m6A modification-mediated CBX8 induction regulates stemness and chemosensitivity of colon cancer via upregulation of LGR5
Yi Zhang, Min Kang, Bin Zhang, Fanchao Meng, Jun Song, Hiroshi Kaneko, Fumio Shimamoto, Bo Tang
Liquid biopsy techniques and pancreatic cancer: diagnosis, monitoring, and evaluation
Kangchun Wang, Xin Wang, Qi Pan, Bei Zhao
Skin cancer: understanding the journey of transformation from conventional to advanced treatment approaches
Nazeer Hasan, Arif Nadaf, Mohammad Imran, Umme Jiba, Afsana Sheikh, Waleed H. Almalki, Salem Salman Almujri, Yousuf Hussain Mohammed, Prashant Kesharwani, Farhan Jalees Ahmad
Progressing nanotechnology to improve targeted cancer treatment: overcoming hurdles in its clinical implementation
Mohammad Chehelgerdi, Matin Chehelgerdi, Omer Qutaiba B. Allela, Renzon Daniel Cosme Pecho, Narayanan Jayasankar, Devendra Pratap Rao, Tamilanban Thamaraikani, Manimaran Vasanthan, Patrik Viktor, Natrayan Lakshmaiya, Mohamed J. Saadh, Ayesha Amajd, Mabrouk A. Abo-Zaid, Roxana Yolanda Castillo-Acobo, Ahmed H. Ismail, Ali H. Amin, Reza Akhavan-Sigari
Pan-cancer spatially resolved single-cell analysis reveals the crosstalk between cancer-associated fibroblasts and tumor microenvironment
Chenxi Ma, Chengzhe Yang, Ai Peng, Tianyong Sun, Xiaoli Ji, Jun Mi, Li Wei, Song Shen, Qiang Feng
The strategies to cure cancer patients by eradicating cancer stem-like cells
Yansui Mai, Jiyan Su, Chuan Yang, Chenglai Xia, Liwu Fu
Regulation and signaling pathways in cancer stem cells: implications for targeted therapy for cancer
Zhen Zeng, Minyang Fu, Yuan Hu, Yuquan Wei, Xiawei Wei, Min Luo
Correction: CircSMARCC1 facilitates tumor progression by disrupting the crosstalk between prostate cancer cells and tumor-associated macrophages via miR-1322/CCL20/CCR6 signaling
Tao Xie, Du-jiang Fu, Zhi-min Li, Dao-jun Lv, Xian-Lu Song, Yu-zhong Yu, Chong Wang, Kang-jin Li, Baoqian Zhai, Jiacheng Wu, Ning-Han Feng, Shan-Chao Zhao
circPSD3 is a promising inhibitor of uPA system to inhibit vascular invasion and metastasis in hepatocellular carcinoma
Liangliang Xu, Peng Wang, Li Li, Lian Li, Yang Huang, Yanfang Zhang, Xiaobo Zheng, Pengsheng Yi, Ming Zhang, Mingqing Xu
Correction: PP2A inhibition overcomes acquired resistance to HER2 targeted therapy
Martina S. J. McDermott, Brigid C. Browne, Neil T. Conlon, Neil A. O’Brien, Dennis J. Slamon, Michael Henry, Paula Meleady, Martin Clynes, Paul Dowling, John Crown, Norma O’Donovan
Circulating tumor DNA landscape and prognostic impact of acquired resistance to targeted therapies in cancer patients: a national center for precision medicine (PRISM) study
Arnaud Bayle, Laila Belcaid, Lola-Jade Palmieri, Diego Teysonneau, Sophie Cousin, Mariella Spalato-Ceruso, Mihaela Aldea, Damien Vasseur, Melissa Alame, Laura Blouin, Isabelle Soubeyran, Claudio Nicotra, Maud Ngocamus, Antoine Hollebecque, Yohann Loriot, Benjamin Besse, Ludovic Lacroix, Etienne Rouleau, Fabrice Barlesi, Fabrice Andre, Antoine Italiano
Targeting FLT3-TAZ signaling to suppress drug resistance in blast phase chronic myeloid leukemia
Ji Eun Shin, Soo-Hyun Kim, Mingyu Kong, Hwa-Ryeon Kim, Sungmin Yoon, Kyung-Mi Kee, Jung Ah Kim, Dong Hyeon Kim, So Yeon Park, Jae Hyung Park, Hongtae Kim, Kyoung Tai No, Han-Woong Lee, Heon Yung Gee, Seunghee Hong, Kun-Liang Guan, Jae-Seok Roe, Hyunbeom Lee, Dong-Wook Kim, Hyun Woo Park
Homologous recombination deficiency (HRD) testing on cell-free tumor DNA from peritoneal fluid
Cyril Roussel-Simonin, Felix Blanc-Durand, Roseline Tang, Damien Vasseur, Audrey Le Formal, Laure Chardin, Elisa Yaniz, Sébastien Gouy, Amandine Maulard, Stéphanie Scherier, Claire Sanson, Ludovic Lacroix, Sophie Cotteret, Lea Mauny, François Zaccarini, Etienne Rouleau, Alexandra Leary
CircHERC1 promotes non-small cell lung cancer cell progression by sequestering FOXO1 in the cytoplasm and regulating the miR-142-3p-HMGB1 axis
Yumeng Cui, Xiaojie Wu, Jie Jin, Weiling Man, Jie Li, Xiang Li, Yanghua Li, He Yao, Rongbin Zhong, Shiyun Chen, Jiahui Wu, Tianhao Zhu, Yanli Lin, Junjie Xu, Youliang Wang
Relapse of acute myeloid leukemia after allogeneic stem cell transplantation: immune escape mechanisms and current implications for therapy
Tatjana Sauerer, Giuliano Filippini Velázquez, Christoph Schmid
Ultra-sensitive CTC-based liquid biopsy for pancreatic cancer enabled by large blood volume analysis
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The Impact of FGFR3 Alterations on the Tumor Microenvironment and the Efficacy of Immune Checkpoint Inhibitors in Bladder Cancer
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The University of Kansas Cancer Center (KUCC), an NCI designated comprehensive cancer center
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Pere Llinàs-Arias, Miquel Ensenyat-Mendez, Sandra Íñiguez-Muñoz, Javier I. J. Orozco, Betsy Valdez, Matthew P. Salomon, Chikako Matsuba, Maria Solivellas-Pieras, Andrés F. Bedoya-López, Borja Sesé, Anja Mezger, Mattias Ormestad, Fernando Unzueta, Siri H. Strand, Alexander D. Boiko, E Shelley Hwang, Javier Cortés, Maggie L. DiNome, Manel Esteller, Mathieu Lupien, Diego M. Marzese
A bispecific Clec9A-PD-L1 targeted type I interferon profoundly reshapes the tumor microenvironment towards an antitumor state
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Andrea Sacconi, Paola Muti, Claudio Pulito, Giulia Urbani, Matteo Allegretti, Raul Pellini, Nikolay Mehterov, Uri Ben-David, Sabrina Strano, Paolo Bossi, Giovanni Blandino
The role of extracellular vesicles in circulating tumor cell-mediated distant metastasis
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Targeting MHC-I molecules for cancer: function, mechanism, and therapeutic prospects
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Effects of RNA methylation on Tumor angiogenesis and cancer progression
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A liquid biopsy signature of circulating extracellular vesicles-derived RNAs predicts response to first line chemotherapy in patients with metastatic colorectal cancer
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A positive feedback circuit driven by m6A-modified circular RNA facilitates colorectal cancer liver metastasis
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Extracellular vesicles remodel tumor environment for cancer immunotherapy
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USP13 drives lung squamous cell carcinoma by switching lung club cell lineage plasticity
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Hsa_circ_0136666 stimulates gastric cancer progression and tumor immune escape by regulating the miR-375/PRKDC Axis and PD-L1 phosphorylation
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Unveiling the hidden AP-1: revealing the crucial role of AP-1 in ccRCC at single-cell resolution
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