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Virchows Archiv

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02.04.2018 | Brief Report

Molecular evidence of JAK2 p.V617F mutated pure erythroid leukemia arising from polycythemia vera

verfasst von: Alisha D. Ware, Jacqueline Birkness, Amy S. Duffield, Christopher D. Gocke

Erschienen in: Virchows Archiv | Ausgabe 1/2018

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Excerpt

Pure erythroid leukemia (PEL) is an uncommon subtype of acute myeloid leukemia (AML) [7, 8, 13, 15]. While AML is recognized as a complication of polycythemia vera (PV) [10‐12], there are few reports of PV transformation to PEL [1‐4, 6, 8, 9]. Five reported cases of PEL arising from PV, diagnosed between 1956 and 1962, followed therapy with radioactive phosphorus (³²P) [1, 4, 6, 9]. There were two case reports of transformation following therapy with hydroxyurea, in 1998 and 2012 [2, 3]. More recently, transformation to PEL and erythroid sarcoma in patients with long-standing PV treated with phlebotomy and hydroxyurea was described [5]. Here, we report molecular evidence of an unusual case of PEL with osseous involvement arising in a patient with known JAK2 V617F-positive PV. …

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Titel: Molecular evidence of JAK2 p.V617F mutated pure erythroid leukemia arising from polycythemia vera
verfasst von: Alisha D. Ware
Jacqueline Birkness
Amy S. Duffield
Christopher D. Gocke
Publikationsdatum: 02.04.2018
Verlag: Springer Berlin Heidelberg
Erschienen in: Virchows Archiv / Ausgabe 1/2018
Print ISSN: 0945-6317
Elektronische ISSN: 1432-2307
DOI: https://doi.org/10.1007/s00428-018-2347-8

Springer Medizin

Molecular evidence of JAK2 p.V617F mutated pure erythroid leukemia arising from polycythemia vera

Excerpt

Neu im Fachgebiet Pathologie

Molekularpathologische Untersuchungen im Wandel der Zeit

Vergleichende Pathologie in der onkologischen Forschung

Gastrointestinale Stromatumoren

Personalisierte Medizin in der Onkologie

Springer Medizin

Excerpt

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