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Erschienen in: Der Urologe 4/2014

01.04.2014 | Leitthema

Molekulare multimodale Hybridbildgebung des Prostata- und Blasenkarzinoms

verfasst von: PD Dr. T. Maurer, M. Eiber, B.J. Krause

Erschienen in: Die Urologie | Ausgabe 4/2014

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Zusammenfassung

Seit Einführung der kombinierten radiologisch-nuklearmedizinischen Bildgebung in Form der Positronenemissionstomographie/Computertomographie (PET/CT) und unlängst auch der PET/Magnetresonanztomographie (PET/MRT) stehen beim Blasen- und Prostatakarzinom neue und z. T. vielversprechende diagnostische Möglichkeiten zur Verfügung. Während beim Blasenkarzinom die PET-basierte Hybridbildgebung bisher nur in ausgewählten Fällen zur Anwendung kommt, zeichnet sich eine Zunahme der PET-Diagnostik beim Prostatakarzinom mit der Entwicklung karzinomspezifischer PET-Tracer ab. Besonders neuartige Liganden des prostataspezifischen Membranantigens (PSMA) besitzen hierbei das Potential, das zukünftige Staging des Prostatakarzinoms nachhaltig zu beeinflussen. Bevor jedoch ein breiter Einsatz in der Routine empfohlen werden kann, sollte eine Evaluierung im Rahmen von prospektiven multizentrischen klinischen Studien erfolgen.
Literatur
1.
Zurück zum Zitat Afshar-Oromieh A, Haberkorn U, Eder M et al (2012) [68Ga]Gallium-labelled PSMA ligand as superior PET tracer for the diagnosis of prostate cancer: comparison with 18F-FECH. Eur J Nucl Med Mol Imaging 39:1085–1086PubMedCrossRef Afshar-Oromieh A, Haberkorn U, Eder M et al (2012) [68Ga]Gallium-labelled PSMA ligand as superior PET tracer for the diagnosis of prostate cancer: comparison with 18F-FECH. Eur J Nucl Med Mol Imaging 39:1085–1086PubMedCrossRef
2.
Zurück zum Zitat Akduman EI, Momtahen AJ, Balci NC et al (2008) Comparison between malignant and benign abdominal lymph nodes on diffusion-weighted imaging. Acad Radiol 15:641–646PubMedCrossRef Akduman EI, Momtahen AJ, Balci NC et al (2008) Comparison between malignant and benign abdominal lymph nodes on diffusion-weighted imaging. Acad Radiol 15:641–646PubMedCrossRef
3.
Zurück zum Zitat AWMF (2011) Interdisziplinäre Leitlinie der Qualität S3 zur Früherkennung, Diagnose und Therapie der verschiedenen Stadien des Prostatakarzinoms. AWMF, Düsseldorf AWMF (2011) Interdisziplinäre Leitlinie der Qualität S3 zur Früherkennung, Diagnose und Therapie der verschiedenen Stadien des Prostatakarzinoms. AWMF, Düsseldorf
5.
Zurück zum Zitat Beer AJ, Eiber M, Souvatzoglou M et al (2011) Restricted water diffusibility as measured by diffusion-weighted MR imaging and choline uptake in (11)C-choline PET/CT are correlated in pelvic lymph nodes in patients with prostate cancer. Mol Imaging Biol 13:352–361PubMedCrossRef Beer AJ, Eiber M, Souvatzoglou M et al (2011) Restricted water diffusibility as measured by diffusion-weighted MR imaging and choline uptake in (11)C-choline PET/CT are correlated in pelvic lymph nodes in patients with prostate cancer. Mol Imaging Biol 13:352–361PubMedCrossRef
6.
Zurück zum Zitat Beheshti M, Haim S, Zakavi R et al (2013) Impact of 18F-choline PET/CT in prostate cancer patients with biochemical recurrence: influence of androgen deprivation therapy and correlation with PSA kinetics. J Nucl Med 54:833–840PubMedCrossRef Beheshti M, Haim S, Zakavi R et al (2013) Impact of 18F-choline PET/CT in prostate cancer patients with biochemical recurrence: influence of androgen deprivation therapy and correlation with PSA kinetics. J Nucl Med 54:833–840PubMedCrossRef
7.
Zurück zum Zitat Boonsirikamchai P, Choi S, Frank SJ et al (2013) MR imaging of prostate cancer in radiation oncology: what radiologists need to know. Radiographics 33:741–761PubMedCrossRef Boonsirikamchai P, Choi S, Frank SJ et al (2013) MR imaging of prostate cancer in radiation oncology: what radiologists need to know. Radiographics 33:741–761PubMedCrossRef
8.
Zurück zum Zitat Bouchelouche K, Turkbey B, Choyke PL (2012) PET/CT and MRI in Bladder Cancer. J Cancer Sci Ther S14, doi:10.4172/1948-5956 Bouchelouche K, Turkbey B, Choyke PL (2012) PET/CT and MRI in Bladder Cancer. J Cancer Sci Ther S14, doi:10.4172/1948-5956
9.
Zurück zum Zitat Breeuwsma AJ, Rybalov M, Leliveld AM et al (2012) Correlation of [11C]choline PET-CT with time to treatment and disease-specific survival in men with recurrent prostate cancer after radical prostatectomy. Q J Nucl Med Mol Imaging 56:440–446PubMed Breeuwsma AJ, Rybalov M, Leliveld AM et al (2012) Correlation of [11C]choline PET-CT with time to treatment and disease-specific survival in men with recurrent prostate cancer after radical prostatectomy. Q J Nucl Med Mol Imaging 56:440–446PubMed
10.
Zurück zum Zitat Brogsitter C, Zophel K, Kotzerke J (2013) 18F-Choline, 11C-choline and 11C-acetate PET/CT: comparative analysis for imaging prostate cancer patients. Eur J Nucl Med Mol Imaging 40(Suppl 1):18–27CrossRef Brogsitter C, Zophel K, Kotzerke J (2013) 18F-Choline, 11C-choline and 11C-acetate PET/CT: comparative analysis for imaging prostate cancer patients. Eur J Nucl Med Mol Imaging 40(Suppl 1):18–27CrossRef
11.
Zurück zum Zitat Bücheler E, Lackner KL, Thelen M (2006) Einführung in die Radiologie, Diagnostik und Intervention, 11. Aufl. Thieme, Stuttgart, S 606 Bücheler E, Lackner KL, Thelen M (2006) Einführung in die Radiologie, Diagnostik und Intervention, 11. Aufl. Thieme, Stuttgart, S 606
12.
Zurück zum Zitat Bundschuh RA, Wendl CM, Weirich G et al (2013) Tumour volume delineation in prostate cancer assessed by [11C]choline PET/CT: validation with surgical specimens. Eur J Nucl Med Mol Imaging 40:824–831PubMedCrossRef Bundschuh RA, Wendl CM, Weirich G et al (2013) Tumour volume delineation in prostate cancer assessed by [11C]choline PET/CT: validation with surgical specimens. Eur J Nucl Med Mol Imaging 40:824–831PubMedCrossRef
13.
Zurück zum Zitat Ceci F, Castellucci P, Mamede M et al (2013) (11)C-Choline PET/CT in patients with hormone-resistant prostate cancer showing biochemical relapse after radical prostatectomy. Eur J Nucl Med Mol Imaging 40:149–155PubMedCrossRef Ceci F, Castellucci P, Mamede M et al (2013) (11)C-Choline PET/CT in patients with hormone-resistant prostate cancer showing biochemical relapse after radical prostatectomy. Eur J Nucl Med Mol Imaging 40:149–155PubMedCrossRef
14.
Zurück zum Zitat Daneshmand S, Ahmadi H, Huynh LN et al (2012) Preoperative staging of invasive bladder cancer with dynamic gadolinium-enhanced magnetic resonance imaging: results from a prospective study. Urology 80:1313–1318PubMedCrossRef Daneshmand S, Ahmadi H, Huynh LN et al (2012) Preoperative staging of invasive bladder cancer with dynamic gadolinium-enhanced magnetic resonance imaging: results from a prospective study. Urology 80:1313–1318PubMedCrossRef
15.
Zurück zum Zitat Eiber M, Beer AJ, Holzapfel K et al (2010) Preliminary results for characterization of pelvic lymph nodes in patients with prostate cancer by diffusion-weighted MR-imaging. Invest Radiol 45:15–23PubMedCrossRef Eiber M, Beer AJ, Holzapfel K et al (2010) Preliminary results for characterization of pelvic lymph nodes in patients with prostate cancer by diffusion-weighted MR-imaging. Invest Radiol 45:15–23PubMedCrossRef
16.
Zurück zum Zitat Eiber M, Holzapfel K, Ganter C et al (2011) Whole-body MRI including diffusion-weighted imaging (DWI) for patients with recurring prostate cancer: technical feasibility and assessment of lesion conspicuity in DWI. J Magn Reson Imaging 33:1160–1170PubMedCrossRef Eiber M, Holzapfel K, Ganter C et al (2011) Whole-body MRI including diffusion-weighted imaging (DWI) for patients with recurring prostate cancer: technical feasibility and assessment of lesion conspicuity in DWI. J Magn Reson Imaging 33:1160–1170PubMedCrossRef
17.
Zurück zum Zitat Eiber M, Souvatzoglou M, Maurer T et al (2013) Initial experience in restaging of patients with recurrent prostate cancer: comparison of 11C-Choline-PET/MR and 11C-Choline-PET/CT. Soc Nucl Med Annu Meet Abstr 5:343 Eiber M, Souvatzoglou M, Maurer T et al (2013) Initial experience in restaging of patients with recurrent prostate cancer: comparison of 11C-Choline-PET/MR and 11C-Choline-PET/CT. Soc Nucl Med Annu Meet Abstr 5:343
18.
Zurück zum Zitat Eschmann SM, Pfannenberg AC, Rieger A et al (2007) Comparison of 11C-choline-PET/CT and whole body-MRI for staging of prostate cancer. Nuklearmedizin 46:161–168PubMed Eschmann SM, Pfannenberg AC, Rieger A et al (2007) Comparison of 11C-choline-PET/CT and whole body-MRI for staging of prostate cancer. Nuklearmedizin 46:161–168PubMed
19.
Zurück zum Zitat Evangelista L, Guttilla A, Zattoni F et al (2013) Utility of choline positron emission tomography/computed tomography for lymph node involvement identification in intermediate- to high-risk prostate cancer: a systematic literature review and meta-analysis. Eur Urol 63:1040–1048PubMedCrossRef Evangelista L, Guttilla A, Zattoni F et al (2013) Utility of choline positron emission tomography/computed tomography for lymph node involvement identification in intermediate- to high-risk prostate cancer: a systematic literature review and meta-analysis. Eur Urol 63:1040–1048PubMedCrossRef
20.
Zurück zum Zitat Evangelista L, Zattoni F, Guttilla A et al (2013) Choline PET or PET/CT and biochemical relapse of prostate cancer: a systematic review and meta-analysis. Clin Nucl Med 38:305–314PubMedCrossRef Evangelista L, Zattoni F, Guttilla A et al (2013) Choline PET or PET/CT and biochemical relapse of prostate cancer: a systematic review and meta-analysis. Clin Nucl Med 38:305–314PubMedCrossRef
21.
Zurück zum Zitat Even-Sapir E, Metser U, Mishani E et al (2006) The detection of bone metastases in patients with high-risk prostate cancer: 99mTc-MDP Planar bone scintigraphy, single- and multi-field-of-view SPECT, 18F-fluoride PET, and 18F-fluoride PET/CT. J Nucl Med 47:287–297PubMed Even-Sapir E, Metser U, Mishani E et al (2006) The detection of bone metastases in patients with high-risk prostate cancer: 99mTc-MDP Planar bone scintigraphy, single- and multi-field-of-view SPECT, 18F-fluoride PET, and 18F-fluoride PET/CT. J Nucl Med 47:287–297PubMed
22.
Zurück zum Zitat Fuccio C, Castellucci P, Schiavina R et al (2012) Role of 11C-choline PET/CT in the re-staging of prostate cancer patients with biochemical relapse and negative results at bone scintigraphy. Eur J Radiol 81:893–896CrossRef Fuccio C, Castellucci P, Schiavina R et al (2012) Role of 11C-choline PET/CT in the re-staging of prostate cancer patients with biochemical relapse and negative results at bone scintigraphy. Eur J Radiol 81:893–896CrossRef
23.
Zurück zum Zitat Fuccio C, Castellucci P, Schiavina R et al (2010) Role of 11C-choline PET/CT in the restaging of prostate cancer patients showing a single lesion on bone scintigraphy. Ann Nucl Med 24:485–492PubMedCrossRef Fuccio C, Castellucci P, Schiavina R et al (2010) Role of 11C-choline PET/CT in the restaging of prostate cancer patients showing a single lesion on bone scintigraphy. Ann Nucl Med 24:485–492PubMedCrossRef
24.
Zurück zum Zitat Fuccio C, Schiavina R, Castellucci P et al (2011) Androgen deprivation therapy influences the uptake of 11C-choline in patients with recurrent prostate cancer: the preliminary results of a sequential PET/CT study. Eur J Nucl Med Mol Imaging 38:1985–1989PubMedCrossRef Fuccio C, Schiavina R, Castellucci P et al (2011) Androgen deprivation therapy influences the uptake of 11C-choline in patients with recurrent prostate cancer: the preliminary results of a sequential PET/CT study. Eur J Nucl Med Mol Imaging 38:1985–1989PubMedCrossRef
25.
Zurück zum Zitat Giannarini G, Nguyen DP, Thalmann GN et al (2012) Diffusion-weighted magnetic resonance imaging detects local recurrence after radical prostatectomy: initial experience. Eur Urol 61:616–620PubMedCrossRef Giannarini G, Nguyen DP, Thalmann GN et al (2012) Diffusion-weighted magnetic resonance imaging detects local recurrence after radical prostatectomy: initial experience. Eur Urol 61:616–620PubMedCrossRef
26.
Zurück zum Zitat Giovacchini G, Picchio M, Garcia-Parra R et al (2014) 11C-Choline PET/CT predicts prostate cancer-specific survival in patients with biochemical failure during androgen-deprivation therapy. J Nucl Med (Epub ahead of print) Giovacchini G, Picchio M, Garcia-Parra R et al (2014) 11C-Choline PET/CT predicts prostate cancer-specific survival in patients with biochemical failure during androgen-deprivation therapy. J Nucl Med (Epub ahead of print)
27.
Zurück zum Zitat Giovacchini G, Picchio M, Parra RG et al (2012) Prostate-specific antigen velocity versus prostate-specific antigen doubling time for prediction of 11C choline PET/CT in prostate cancer patients with biochemical failure after radical prostatectomy. Clin Nucl Med 37:325–331PubMedCrossRef Giovacchini G, Picchio M, Parra RG et al (2012) Prostate-specific antigen velocity versus prostate-specific antigen doubling time for prediction of 11C choline PET/CT in prostate cancer patients with biochemical failure after radical prostatectomy. Clin Nucl Med 37:325–331PubMedCrossRef
28.
Zurück zum Zitat Gofrit ON, Mishani E, Orevi M et al (2006) Contribution of 11C-choline positron emission tomography/computerized tomography to preoperative staging of advanced transitional cell carcinoma. J Urol 176:940–944PubMedCrossRef Gofrit ON, Mishani E, Orevi M et al (2006) Contribution of 11C-choline positron emission tomography/computerized tomography to preoperative staging of advanced transitional cell carcinoma. J Urol 176:940–944PubMedCrossRef
29.
Zurück zum Zitat Golan S, Sopov V, Baniel J et al (2011) Comparison of 11C-choline with 18F-FDG in positron emission tomography/computerized tomography for staging urothelial carcinoma: a prospective study. J Urol 186:436–441PubMedCrossRef Golan S, Sopov V, Baniel J et al (2011) Comparison of 11C-choline with 18F-FDG in positron emission tomography/computerized tomography for staging urothelial carcinoma: a prospective study. J Urol 186:436–441PubMedCrossRef
30.
Zurück zum Zitat Goodfellow H, Viney Z, Hughes P et al (2013) Role of Fdg Pet-Ct in the staging of bladder cancer. BJU Int (Epub ahead of print). doi: 10.1111/bju.12608 Goodfellow H, Viney Z, Hughes P et al (2013) Role of Fdg Pet-Ct in the staging of bladder cancer. BJU Int (Epub ahead of print). doi: 10.1111/bju.12608
31.
Zurück zum Zitat Goodman OB Jr, Barwe SP, Ritter B et al (2007) Interaction of prostate specific membrane antigen with clathrin and the adaptor protein complex-2. Int J Oncol 31:1199–1203PubMed Goodman OB Jr, Barwe SP, Ritter B et al (2007) Interaction of prostate specific membrane antigen with clathrin and the adaptor protein complex-2. Int J Oncol 31:1199–1203PubMed
32.
Zurück zum Zitat Gutzeit A, Doert A, Froehlich JM et al (2010) Comparison of diffusion-weighted whole body MRI and skeletal scintigraphy for the detection of bone metastases in patients with prostate or breast carcinoma. Skeletal Radiol 39:333–343PubMedCrossRef Gutzeit A, Doert A, Froehlich JM et al (2010) Comparison of diffusion-weighted whole body MRI and skeletal scintigraphy for the detection of bone metastases in patients with prostate or breast carcinoma. Skeletal Radiol 39:333–343PubMedCrossRef
33.
Zurück zum Zitat Haseebuddin M, Dehdashti F, Siegel BA et al (2013) 11C-acetate PET/CT before radical prostatectomy: nodal staging and treatment failure prediction. J Nucl Med 54:699–706PubMedCentralPubMedCrossRef Haseebuddin M, Dehdashti F, Siegel BA et al (2013) 11C-acetate PET/CT before radical prostatectomy: nodal staging and treatment failure prediction. J Nucl Med 54:699–706PubMedCentralPubMedCrossRef
34.
Zurück zum Zitat Heck MM, Souvatzoglou M, Retz M et al (2013) Prospective comparison of computed tomography, diffusion-weighted magnetic resonance imaging and [C]choline positron emission tomography/computed tomography for preoperative lymph node staging in prostate cancer patients. Eur J Nucl Med Mol Imaging 44(5):340–342 Heck MM, Souvatzoglou M, Retz M et al (2013) Prospective comparison of computed tomography, diffusion-weighted magnetic resonance imaging and [C]choline positron emission tomography/computed tomography for preoperative lymph node staging in prostate cancer patients. Eur J Nucl Med Mol Imaging 44(5):340–342
35.
Zurück zum Zitat Henry MD, Wen S, Silva MD et al (2004) A prostate-specific membrane antigen-targeted monoclonal antibody-chemotherapeutic conjugate designed for the treatment of prostate cancer. Cancer Res 64:7995–8001PubMedCrossRef Henry MD, Wen S, Silva MD et al (2004) A prostate-specific membrane antigen-targeted monoclonal antibody-chemotherapeutic conjugate designed for the treatment of prostate cancer. Cancer Res 64:7995–8001PubMedCrossRef
36.
Zurück zum Zitat Hitier-Berthault M, Ansquer C, Branchereau J et al (2013) 18 F-fluorodeoxyglucose positron emission tomography-computed tomography for preoperative lymph node staging in patients undergoing radical cystectomy for bladder cancer: a prospective study. Int J Urol 20:788–796PubMedCrossRef Hitier-Berthault M, Ansquer C, Branchereau J et al (2013) 18 F-fluorodeoxyglucose positron emission tomography-computed tomography for preoperative lymph node staging in patients undergoing radical cystectomy for bladder cancer: a prospective study. Int J Urol 20:788–796PubMedCrossRef
37.
Zurück zum Zitat Hovels AM, Heesakkers RA, Adang EM et al (2008) The diagnostic accuracy of CT and MRI in the staging of pelvic lymph nodes in patients with prostate cancer: a meta-analysis. Clin Radiol 63:387–395PubMedCrossRef Hovels AM, Heesakkers RA, Adang EM et al (2008) The diagnostic accuracy of CT and MRI in the staging of pelvic lymph nodes in patients with prostate cancer: a meta-analysis. Clin Radiol 63:387–395PubMedCrossRef
38.
Zurück zum Zitat Hricak H, Choyke PL, Eberhardt SC et al (2007) Imaging prostate cancer: a multidisciplinary perspective. Radiology 243:28–53PubMedCrossRef Hricak H, Choyke PL, Eberhardt SC et al (2007) Imaging prostate cancer: a multidisciplinary perspective. Radiology 243:28–53PubMedCrossRef
39.
Zurück zum Zitat Issa B (2002) In vivo measurement of the apparent diffusion coefficient in normal and malignant prostatic tissues using echo-planar imaging. J Magn Reson Imaging 16:196–200PubMedCrossRef Issa B (2002) In vivo measurement of the apparent diffusion coefficient in normal and malignant prostatic tissues using echo-planar imaging. J Magn Reson Imaging 16:196–200PubMedCrossRef
40.
Zurück zum Zitat Jacobs MA, Ouwerkerk R, Petrowski K et al (2008) Diffusion-weighted imaging with apparent diffusion coefficient mapping and spectroscopy in prostate cancer. Top Magn Reson Imaging 19:261–272PubMedCentralPubMedCrossRef Jacobs MA, Ouwerkerk R, Petrowski K et al (2008) Diffusion-weighted imaging with apparent diffusion coefficient mapping and spectroscopy in prostate cancer. Top Magn Reson Imaging 19:261–272PubMedCentralPubMedCrossRef
41.
Zurück zum Zitat Jadvar H (2013) Imaging evaluation of prostate cancer with 18F-fluorodeoxyglucose PET/CT: utility and limitations. Eur J Nucl Med Mol Imaging 40(Suppl 1):5–10CrossRef Jadvar H (2013) Imaging evaluation of prostate cancer with 18F-fluorodeoxyglucose PET/CT: utility and limitations. Eur J Nucl Med Mol Imaging 40(Suppl 1):5–10CrossRef
42.
Zurück zum Zitat Jadvar H, Desai B, Ji L et al (2013) Baseline 18F-FDG PET/CT parameters as imaging biomarkers of overall survival in castrate-resistant metastatic prostate cancer. J Nucl Med 54:1195–1201PubMedCentralPubMedCrossRef Jadvar H, Desai B, Ji L et al (2013) Baseline 18F-FDG PET/CT parameters as imaging biomarkers of overall survival in castrate-resistant metastatic prostate cancer. J Nucl Med 54:1195–1201PubMedCentralPubMedCrossRef
43.
Zurück zum Zitat Kahkonen E, Jambor I, Kemppainen J et al (2013) In vivo imaging of prostate cancer using [68Ga]-labeled bombesin analog BAY86-7548. Clin Cancer Res 19:5434–5443PubMedCrossRef Kahkonen E, Jambor I, Kemppainen J et al (2013) In vivo imaging of prostate cancer using [68Ga]-labeled bombesin analog BAY86-7548. Clin Cancer Res 19:5434–5443PubMedCrossRef
44.
Zurück zum Zitat Kibel AS, Dehdashti F, Katz MD et al (2009) Prospective study of [18F]fluorodeoxyglucose positron emission tomography/computed tomography for staging of muscle-invasive bladder carcinoma. J Clin Oncol 27:4314–4320PubMedCrossRef Kibel AS, Dehdashti F, Katz MD et al (2009) Prospective study of [18F]fluorodeoxyglucose positron emission tomography/computed tomography for staging of muscle-invasive bladder carcinoma. J Clin Oncol 27:4314–4320PubMedCrossRef
45.
Zurück zum Zitat Kim CK, Park BK, Park W et al (2010) Prostate MR imaging at 3T using a phased-arrayed coil in predicting locally recurrent prostate cancer after radiation therapy: preliminary experience. Abdom Imaging 35:246–252PubMedCrossRef Kim CK, Park BK, Park W et al (2010) Prostate MR imaging at 3T using a phased-arrayed coil in predicting locally recurrent prostate cancer after radiation therapy: preliminary experience. Abdom Imaging 35:246–252PubMedCrossRef
46.
Zurück zum Zitat Kim JK, Kim KA, Park BW et al (2008) Feasibility of diffusion-weighted imaging in the differentiation of metastatic from nonmetastatic lymph nodes: early experience. J Magn Reson Imaging 28:714–719PubMedCrossRef Kim JK, Kim KA, Park BW et al (2008) Feasibility of diffusion-weighted imaging in the differentiation of metastatic from nonmetastatic lymph nodes: early experience. J Magn Reson Imaging 28:714–719PubMedCrossRef
47.
Zurück zum Zitat Krause BJ, Souvatzoglou M, Treiber U (2013) Imaging of prostate cancer with PET/CT and radioactively labeled choline derivates. Urol Oncol 31:427–435PubMedCrossRef Krause BJ, Souvatzoglou M, Treiber U (2013) Imaging of prostate cancer with PET/CT and radioactively labeled choline derivates. Urol Oncol 31:427–435PubMedCrossRef
48.
Zurück zum Zitat Krause BJ, Souvatzoglou M, Tuncel M et al (2008) The detection rate of [11C]choline-PET/CT depends on the serum PSA-value in patients with biochemical recurrence of prostate cancer. Eur J Nucl Med Mol Imaging 35:18–23PubMedCrossRef Krause BJ, Souvatzoglou M, Tuncel M et al (2008) The detection rate of [11C]choline-PET/CT depends on the serum PSA-value in patients with biochemical recurrence of prostate cancer. Eur J Nucl Med Mol Imaging 35:18–23PubMedCrossRef
49.
Zurück zum Zitat Lecouvet FE, El Mouedden J, Collette L et al (2012) Can whole-body magnetic resonance imaging with diffusion-weighted imaging replace Tc 99m bone scanning and computed tomography for single-step detection of metastases in patients with high-risk prostate cancer? Eur Urol 62:68–75PubMedCrossRef Lecouvet FE, El Mouedden J, Collette L et al (2012) Can whole-body magnetic resonance imaging with diffusion-weighted imaging replace Tc 99m bone scanning and computed tomography for single-step detection of metastases in patients with high-risk prostate cancer? Eur Urol 62:68–75PubMedCrossRef
50.
Zurück zum Zitat Liedberg F, Bendahl PO, Davidsson T et al (2013) Preoperative staging of locally advanced bladder cancer before radical cystectomy using 3 tesla magnetic resonance imaging with a standardized protocol. Scand J Urol 47:108–112PubMedCrossRef Liedberg F, Bendahl PO, Davidsson T et al (2013) Preoperative staging of locally advanced bladder cancer before radical cystectomy using 3 tesla magnetic resonance imaging with a standardized protocol. Scand J Urol 47:108–112PubMedCrossRef
51.
Zurück zum Zitat Liu Y, Hu X, Liu H et al (2013) A comparative study of radiolabeled bombesin analogs for the PET imaging of prostate cancer. J Nucl Med 54:2132–2138PubMedCrossRef Liu Y, Hu X, Liu H et al (2013) A comparative study of radiolabeled bombesin analogs for the PET imaging of prostate cancer. J Nucl Med 54:2132–2138PubMedCrossRef
52.
Zurück zum Zitat Lu YY, Chen JH, Liang JA et al (2012) Clinical value of FDG PET or PET/CT in urinary bladder cancer: a systemic review and meta-analysis. Eur J Radiol 81:2411–2416PubMedCrossRef Lu YY, Chen JH, Liang JA et al (2012) Clinical value of FDG PET or PET/CT in urinary bladder cancer: a systemic review and meta-analysis. Eur J Radiol 81:2411–2416PubMedCrossRef
53.
Zurück zum Zitat Mamede M, Ceci F, Castellucci P et al (2013) The role of 11C-choline PET imaging in the early detection of recurrence in surgically treated prostate cancer patients with very low PSA level < 0.5 ng/mL. Clin Nucl Med 38:342–345CrossRef Mamede M, Ceci F, Castellucci P et al (2013) The role of 11C-choline PET imaging in the early detection of recurrence in surgically treated prostate cancer patients with very low PSA level < 0.5 ng/mL. Clin Nucl Med 38:342–345CrossRef
54.
Zurück zum Zitat Manenti G, Squillaci E, Di Roma M et al (2006) In vivo measurement of the apparent diffusion coefficient in normal and malignant prostatic tissue using thin-slice echo-planar imaging. Radiol Med 111:1124–1133PubMedCrossRef Manenti G, Squillaci E, Di Roma M et al (2006) In vivo measurement of the apparent diffusion coefficient in normal and malignant prostatic tissue using thin-slice echo-planar imaging. Radiol Med 111:1124–1133PubMedCrossRef
55.
Zurück zum Zitat Marzola MC, Chondrogiannis S, Ferretti A et al (2013) Role of 18F-choline PET/CT in biochemically relapsed prostate cancer after radical prostatectomy: correlation with trigger PSA, PSA velocity, PSA doubling time, and metastatic distribution. Clin Nucl Med 38:26–32CrossRef Marzola MC, Chondrogiannis S, Ferretti A et al (2013) Role of 18F-choline PET/CT in biochemically relapsed prostate cancer after radical prostatectomy: correlation with trigger PSA, PSA velocity, PSA doubling time, and metastatic distribution. Clin Nucl Med 38:26–32CrossRef
56.
Zurück zum Zitat Maurer T, Beer AJ, Souvatzoglou M et al (2014) 68Gallium-labelled ligand of prostate-specific membrane antigen (PSMA) for the evaluation of recurrent prostate cancer using PET/CT and PET/MR imaging. Eur Urol (Suppl) (Epub ahead of print) Maurer T, Beer AJ, Souvatzoglou M et al (2014) 68Gallium-labelled ligand of prostate-specific membrane antigen (PSMA) for the evaluation of recurrent prostate cancer using PET/CT and PET/MR imaging. Eur Urol (Suppl) (Epub ahead of print)
57.
Zurück zum Zitat Maurer T, Beer AJ, Souvatzoglou M et al (2014) Staging of intermediate and high-risk prostate cancer using whole body 68Gallium-labelled ligand of prostate-specific membrane antigen PET/MRI. J Urol (Suppl) (Epub ahead of print) Maurer T, Beer AJ, Souvatzoglou M et al (2014) Staging of intermediate and high-risk prostate cancer using whole body 68Gallium-labelled ligand of prostate-specific membrane antigen PET/MRI. J Urol (Suppl) (Epub ahead of print)
58.
Zurück zum Zitat Maurer T, Horn T, Beer AJ et al (2013) Functional imaging in bladder cancer. Urologe A 52:509–514PubMedCrossRef Maurer T, Horn T, Beer AJ et al (2013) Functional imaging in bladder cancer. Urologe A 52:509–514PubMedCrossRef
59.
Zurück zum Zitat Maurer T, Souvatzoglou M, Kubler H et al (2012) Diagnostic efficacy of [11C]choline positron emission tomography/computed tomography compared with conventional computed tomography in lymph node staging of patients with bladder cancer prior to radical cystectomy. Eur Urol 61:1031–1038PubMedCrossRef Maurer T, Souvatzoglou M, Kubler H et al (2012) Diagnostic efficacy of [11C]choline positron emission tomography/computed tomography compared with conventional computed tomography in lymph node staging of patients with bladder cancer prior to radical cystectomy. Eur Urol 61:1031–1038PubMedCrossRef
60.
Zurück zum Zitat Mease RC, Foss CA, Pomper MG (2013) PET imaging in prostate cancer: focus on prostate-specific membrane antigen. Curr Top Med Chem 13:951–962PubMedCrossRef Mease RC, Foss CA, Pomper MG (2013) PET imaging in prostate cancer: focus on prostate-specific membrane antigen. Curr Top Med Chem 13:951–962PubMedCrossRef
61.
Zurück zum Zitat Mertens LS, Bruin NM, Vegt E et al (2012) Catheter-assisted 18F-FDG-PET/CT imaging of primary bladder cancer: a prospective study. Nucl Med Commun 33:1195–1201PubMedCrossRef Mertens LS, Bruin NM, Vegt E et al (2012) Catheter-assisted 18F-FDG-PET/CT imaging of primary bladder cancer: a prospective study. Nucl Med Commun 33:1195–1201PubMedCrossRef
62.
Zurück zum Zitat Mertens LS, Fioole-Bruining A, Vegt E et al (2013) Impact of (18) F-fluorodeoxyglucose (FDG)-positron-emission tomography/computed tomography (PET/CT) on management of patients with carcinoma invading bladder muscle. BJU Int 112:729–734PubMedCrossRef Mertens LS, Fioole-Bruining A, Vegt E et al (2013) Impact of (18) F-fluorodeoxyglucose (FDG)-positron-emission tomography/computed tomography (PET/CT) on management of patients with carcinoma invading bladder muscle. BJU Int 112:729–734PubMedCrossRef
63.
Zurück zum Zitat Mohsen B, Giorgio T, Rasoul ZS et al (2013) Application of (11) C-acetate positron-emission tomography (PET) imaging in prostate cancer: systematic review and meta-analysis of the literature. BJU Int 112:1062–1072PubMedCrossRef Mohsen B, Giorgio T, Rasoul ZS et al (2013) Application of (11) C-acetate positron-emission tomography (PET) imaging in prostate cancer: systematic review and meta-analysis of the literature. BJU Int 112:1062–1072PubMedCrossRef
64.
Zurück zum Zitat Murphy GP, Elgamal AA, Su SL et al (1998) Current evaluation of the tissue localization and diagnostic utility of prostate specific membrane antigen. Cancer 83:2259–2269PubMedCrossRef Murphy GP, Elgamal AA, Su SL et al (1998) Current evaluation of the tissue localization and diagnostic utility of prostate specific membrane antigen. Cancer 83:2259–2269PubMedCrossRef
65.
Zurück zum Zitat Nanni C, Schiavina R, Boschi S et al (2013) Comparison of 18F-FACBC and 11C-choline PET/CT in patients with radically treated prostate cancer and biochemical relapse: preliminary results. Eur J Nucl Med Mol Imaging 40(Suppl 1):11–17CrossRef Nanni C, Schiavina R, Boschi S et al (2013) Comparison of 18F-FACBC and 11C-choline PET/CT in patients with radically treated prostate cancer and biochemical relapse: preliminary results. Eur J Nucl Med Mol Imaging 40(Suppl 1):11–17CrossRef
66.
Zurück zum Zitat Nayak B, Dogra PN, Naswa N et al (2013) Diuretic 18F-FDG PET/CT imaging for detection and locoregional staging of urinary bladder cancer: prospective evaluation of a novel technique. Eur J Nucl Med Mol Imaging 40:386–393PubMedCrossRef Nayak B, Dogra PN, Naswa N et al (2013) Diuretic 18F-FDG PET/CT imaging for detection and locoregional staging of urinary bladder cancer: prospective evaluation of a novel technique. Eur J Nucl Med Mol Imaging 40:386–393PubMedCrossRef
67.
Zurück zum Zitat Orevi M, Klein M, Mishani E et al (2012) 11C-acetate PET/CT in bladder urothelial carcinoma: intraindividual comparison with 11C-choline. Clin Nucl Med 37:67–72CrossRef Orevi M, Klein M, Mishani E et al (2012) 11C-acetate PET/CT in bladder urothelial carcinoma: intraindividual comparison with 11C-choline. Clin Nucl Med 37:67–72CrossRef
69.
Zurück zum Zitat Panebianco V, Barchetti F, Sciarra A et al (2013) Prostate cancer recurrence after radical prostatectomy: the role of 3-T diffusion imaging in multi-parametric magnetic resonance imaging. Eur Radiol 23:1745–1752PubMedCrossRef Panebianco V, Barchetti F, Sciarra A et al (2013) Prostate cancer recurrence after radical prostatectomy: the role of 3-T diffusion imaging in multi-parametric magnetic resonance imaging. Eur Radiol 23:1745–1752PubMedCrossRef
70.
Zurück zum Zitat Puech P, Potiron E, Lemaitre L et al (2009) Dynamic contrast-enhanced-magnetic resonance imaging evaluation of intraprostatic prostate cancer: correlation with radical prostatectomy specimens. Urology 74:1094–1099PubMedCrossRef Puech P, Potiron E, Lemaitre L et al (2009) Dynamic contrast-enhanced-magnetic resonance imaging evaluation of intraprostatic prostate cancer: correlation with radical prostatectomy specimens. Urology 74:1094–1099PubMedCrossRef
71.
Zurück zum Zitat Reske SN, Blumstein NM, Neumaier B et al (2006) Imaging prostate cancer with 11C-choline PET/CT. J Nucl Med 47:1249–1254PubMed Reske SN, Blumstein NM, Neumaier B et al (2006) Imaging prostate cancer with 11C-choline PET/CT. J Nucl Med 47:1249–1254PubMed
72.
Zurück zum Zitat Richter S, Wuest M, Krieger SS et al (2013) Synthesis and radiopharmacological evaluation of a high-affinity and metabolically stabilized 18F-labeled bombesin analogue for molecular imaging of gastrin-releasing peptide receptor-expressing prostate cancer. Nucl Med Biol 40:1025–1034PubMedCrossRef Richter S, Wuest M, Krieger SS et al (2013) Synthesis and radiopharmacological evaluation of a high-affinity and metabolically stabilized 18F-labeled bombesin analogue for molecular imaging of gastrin-releasing peptide receptor-expressing prostate cancer. Nucl Med Biol 40:1025–1034PubMedCrossRef
73.
Zurück zum Zitat Rioja Zuazu J, Rodriguez M, Rincon Mayans A et al (2009) Usefulness of PET scans in diagnosing recurrent prostate cancer. Prostate with PSA level < 5 ng/ml. Actas Urol Esp 33:844–852CrossRef Rioja Zuazu J, Rodriguez M, Rincon Mayans A et al (2009) Usefulness of PET scans in diagnosing recurrent prostate cancer. Prostate with PSA level < 5 ng/ml. Actas Urol Esp 33:844–852CrossRef
74.
Zurück zum Zitat Saokar A, Islam T, Jantsch M et al (2010) Detection of lymph nodes in pelvic malignancies with computed tomography and magnetic resonance imaging. Clin Imaging 34:361–366PubMedCrossRef Saokar A, Islam T, Jantsch M et al (2010) Detection of lymph nodes in pelvic malignancies with computed tomography and magnetic resonance imaging. Clin Imaging 34:361–366PubMedCrossRef
75.
Zurück zum Zitat Schiavina R, Concetti S, Brunocilla E et al (2013) First case of F-FACBC PET/CT-guided salvage retroperitoneal lymph node dissection for disease relapse after radical prostatectomy for prostate cancer and negative C-Choline PET/CT: new imaging techniques may expand pioneering approaches. Urol Int 92:242–245PubMedCrossRef Schiavina R, Concetti S, Brunocilla E et al (2013) First case of F-FACBC PET/CT-guided salvage retroperitoneal lymph node dissection for disease relapse after radical prostatectomy for prostate cancer and negative C-Choline PET/CT: new imaging techniques may expand pioneering approaches. Urol Int 92:242–245PubMedCrossRef
76.
Zurück zum Zitat Schoder H, Ong SC, Reuter VE et al (2012) Initial results with (11)C-acetate positron emission tomography/computed tomography (PET/CT) in the staging of urinary bladder cancer. Mol Imaging Biol 14:245–251PubMedCrossRef Schoder H, Ong SC, Reuter VE et al (2012) Initial results with (11)C-acetate positron emission tomography/computed tomography (PET/CT) in the staging of urinary bladder cancer. Mol Imaging Biol 14:245–251PubMedCrossRef
77.
Zurück zum Zitat Shariat SF, Ehdaie B, Rink M et al (2012) Clinical nodal staging scores for bladder cancer: a proposal for preoperative risk assessment. Eur Urol 61:237–242PubMedCrossRef Shariat SF, Ehdaie B, Rink M et al (2012) Clinical nodal staging scores for bladder cancer: a proposal for preoperative risk assessment. Eur Urol 61:237–242PubMedCrossRef
78.
Zurück zum Zitat Silver DA, Pellicer I, Fair WR et al (1997) Prostate-specific membrane antigen expression in normal and malignant human tissues. Clin Cancer Res 3:81–85PubMed Silver DA, Pellicer I, Fair WR et al (1997) Prostate-specific membrane antigen expression in normal and malignant human tissues. Clin Cancer Res 3:81–85PubMed
79.
Zurück zum Zitat Souvatzoglou M, Eiber M, Martinez-Moeller A et al (2013) PET/MR in prostate cancer: technical aspects and potential diagnostic value. Eur J Nucl Med Mol Imaging 40(Suppl 1):79–88CrossRef Souvatzoglou M, Eiber M, Martinez-Moeller A et al (2013) PET/MR in prostate cancer: technical aspects and potential diagnostic value. Eur J Nucl Med Mol Imaging 40(Suppl 1):79–88CrossRef
80.
Zurück zum Zitat Souvatzoglou M, Eiber M, Takei T et al (2013) Comparison of integrated whole-body [11C]choline PET/MR with PET/CT in patients with prostate cancer. Eur J Nucl Med Mol Imaging 40:1486–1499PubMedCrossRef Souvatzoglou M, Eiber M, Takei T et al (2013) Comparison of integrated whole-body [11C]choline PET/MR with PET/CT in patients with prostate cancer. Eur J Nucl Med Mol Imaging 40:1486–1499PubMedCrossRef
81.
Zurück zum Zitat Souvatzoglou M, Weirich G, Schwarzenboeck S et al (2011) The sensitivity of [11C]choline PET/CT to localize prostate cancer depends on the tumor configuration. Clin Cancer Res 17:3751–3759PubMedCrossRef Souvatzoglou M, Weirich G, Schwarzenboeck S et al (2011) The sensitivity of [11C]choline PET/CT to localize prostate cancer depends on the tumor configuration. Clin Cancer Res 17:3751–3759PubMedCrossRef
82.
Zurück zum Zitat Stenzl A, Cowan NC, De Santis M et al (2011) Treatment of muscle-invasive and metastatic bladder cancer: update of the EAU guidelines. Eur Urol 59:1009–1018PubMedCrossRef Stenzl A, Cowan NC, De Santis M et al (2011) Treatment of muscle-invasive and metastatic bladder cancer: update of the EAU guidelines. Eur Urol 59:1009–1018PubMedCrossRef
83.
Zurück zum Zitat Swinnen G, Maes A, Pottel H et al (2010) FDG-PET/CT for the preoperative lymph node staging of invasive bladder cancer. Eur Urol 57:641–647PubMedCrossRef Swinnen G, Maes A, Pottel H et al (2010) FDG-PET/CT for the preoperative lymph node staging of invasive bladder cancer. Eur Urol 57:641–647PubMedCrossRef
84.
Zurück zum Zitat Taoka T, Mayr NA, Lee HJ et al (2001) Factors influencing visualization of vertebral metastases on MR imaging versus bone scintigraphy. AJR Am J Roentgenol 176:1525–1530PubMedCrossRef Taoka T, Mayr NA, Lee HJ et al (2001) Factors influencing visualization of vertebral metastases on MR imaging versus bone scintigraphy. AJR Am J Roentgenol 176:1525–1530PubMedCrossRef
85.
Zurück zum Zitat Treglia G, Ceriani L, Sadeghi R et al (2013) Relationship between prostate-specific antigen kinetics and detection rate of radiolabelled choline PET/CT in restaging prostate cancer patients: a meta-analysis. Clin Chem Lab Med 1–9 Treglia G, Ceriani L, Sadeghi R et al (2013) Relationship between prostate-specific antigen kinetics and detection rate of radiolabelled choline PET/CT in restaging prostate cancer patients: a meta-analysis. Clin Chem Lab Med 1–9
86.
Zurück zum Zitat Umbehr MH, Muntener M, Hany T et al (2013) The role of 11C-choline and 18F-fluorocholine positron emission tomography (PET) and PET/CT in prostate cancer: a systematic review and meta-analysis. Eur Urol 64:106–117PubMedCrossRef Umbehr MH, Muntener M, Hany T et al (2013) The role of 11C-choline and 18F-fluorocholine positron emission tomography (PET) and PET/CT in prostate cancer: a systematic review and meta-analysis. Eur Urol 64:106–117PubMedCrossRef
87.
Zurück zum Zitat Vargas HA, Akin O, Schoder H et al (2012) Prospective evaluation of MRI, (1)(1)C-acetate PET/CT and contrast-enhanced CT for staging of bladder cancer. Eur J Radiol 81:4131–4137PubMedCrossRef Vargas HA, Akin O, Schoder H et al (2012) Prospective evaluation of MRI, (1)(1)C-acetate PET/CT and contrast-enhanced CT for staging of bladder cancer. Eur J Radiol 81:4131–4137PubMedCrossRef
88.
Zurück zum Zitat Vicente AM, Castrejon AS, Munoz AP et al (2010) Impact of 18F-FDG PET/CT with retrograde filling of the urinary bladder in patients with suspected pelvic malignancies. J Nucl Med Technol 38:128–137PubMedCrossRef Vicente AM, Castrejon AS, Munoz AP et al (2010) Impact of 18F-FDG PET/CT with retrograde filling of the urinary bladder in patients with suspected pelvic malignancies. J Nucl Med Technol 38:128–137PubMedCrossRef
89.
Zurück zum Zitat Von Eyben FE, Kairemo K (2013) Meta-analysis of 11C-choline and 18F-choline PET/CT for management of patients with prostate cancer. Nucl Med Commun 38(5):305–14CrossRef Von Eyben FE, Kairemo K (2013) Meta-analysis of 11C-choline and 18F-choline PET/CT for management of patients with prostate cancer. Nucl Med Commun 38(5):305–14CrossRef
90.
Zurück zum Zitat Wang L, Hricak H, Kattan MW et al (2006) Combined endorectal and phased-array MRI in the prediction of pelvic lymph node metastasis in prostate cancer. AJR Am J Roentgenol 186:743–748PubMedCrossRef Wang L, Hricak H, Kattan MW et al (2006) Combined endorectal and phased-array MRI in the prediction of pelvic lymph node metastasis in prostate cancer. AJR Am J Roentgenol 186:743–748PubMedCrossRef
91.
Zurück zum Zitat Watanabe H, Kanematsu M, Kondo H et al (2010) Preoperative detection of prostate cancer: a comparison with 11C-choline PET, 18F-fluorodeoxyglucose PET and MR imaging. J Magn Reson Imaging 31:1151–1156PubMedCrossRef Watanabe H, Kanematsu M, Kondo H et al (2010) Preoperative detection of prostate cancer: a comparison with 11C-choline PET, 18F-fluorodeoxyglucose PET and MR imaging. J Magn Reson Imaging 31:1151–1156PubMedCrossRef
92.
Zurück zum Zitat Wondergem M, Van Der Zant FM, Van Der Ploeg T et al (2013) A literature review of 18F-fluoride PET/CT and 18F-choline or 11C-choline PET/CT for detection of bone metastases in patients with prostate cancer. Nucl Med Commun 34:935–945PubMedCrossRef Wondergem M, Van Der Zant FM, Van Der Ploeg T et al (2013) A literature review of 18F-fluoride PET/CT and 18F-choline or 11C-choline PET/CT for detection of bone metastases in patients with prostate cancer. Nucl Med Commun 34:935–945PubMedCrossRef
93.
Zurück zum Zitat Yerram NK, Volkin D, Turkbey B et al (2012) Low suspicion lesions on multiparametric magnetic resonance imaging predict for the absence of high-risk prostate cancer. BJU Int 110:783–788CrossRef Yerram NK, Volkin D, Turkbey B et al (2012) Low suspicion lesions on multiparametric magnetic resonance imaging predict for the absence of high-risk prostate cancer. BJU Int 110:783–788CrossRef
Metadaten
Titel
Molekulare multimodale Hybridbildgebung des Prostata- und Blasenkarzinoms
verfasst von
PD Dr. T. Maurer
M. Eiber
B.J. Krause
Publikationsdatum
01.04.2014
Verlag
Springer Berlin Heidelberg
Erschienen in
Die Urologie / Ausgabe 4/2014
Print ISSN: 2731-7064
Elektronische ISSN: 2731-7072
DOI
https://doi.org/10.1007/s00120-014-3440-5

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