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03.05.2021 | Original Article

Mono-macrophage-Derived MANF Alleviates Bacterial Myocarditis by Inhibiting NF-kappaB Activation and Myocardial Inflammation

verfasst von: Changhui Wang, Qin Bao, Chao Hou, Minqiong Sun, Xuegang Song, Shiyu Cao, Xinyu Wang, Qiying Shen, Ye Zhao, Dong Wang

Erschienen in: Inflammation | Ausgabe 5/2021

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Abstract

Bacterial myocarditis is a key cause leading to myocardial damage and cardiac dysfunction. Mesencephalic astrocyte-derived neurotrophic factor (MANF) has been found to be an anti-inflammatory factor. This study is to explore the effect of MANF on LPS-induced myocardial inflammation and macrophage differentiation. The myocarditis mouse model was constructed by LPS treatment. Myocardial damage and serum inflammatory factors were evaluated by ELISA. RT-qPCR was used to detect mRNA of M1/M2 macrophage markers. Western blot, immunohistochemical, and immunofluorescent staining were used to examine myocardial M1/M2 macrophages and NF-κB activation. Mono-macrophage-derived MANF deficiency enhanced LPS-induced inflammatory response and increased M1 macrophages in myocardium tissues, further causing more severe myocardial injury and lower survival rate of mice. Also, LPS-induced myocardial NF-κB activation was strengthened after mono-macrophage-derived MANF knockout. Mono-macrophage-derived MANF inhibits bacterial myocarditis and myocardial M1 macrophage differentiation, which is potential to be used for bacterial myocarditis treatment clinically.

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Titel: Mono-macrophage-Derived MANF Alleviates Bacterial Myocarditis by Inhibiting NF-kappaB Activation and Myocardial Inflammation
verfasst von: Changhui Wang
Qin Bao
Chao Hou
Minqiong Sun
Xuegang Song
Shiyu Cao
Xinyu Wang
Qiying Shen
Ye Zhao
Dong Wang
Publikationsdatum: 03.05.2021
Verlag: Springer US
Erschienen in: Inflammation / Ausgabe 5/2021
Print ISSN: 0360-3997
Elektronische ISSN: 1573-2576
DOI: https://doi.org/10.1007/s10753-021-01469-0

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Mono-macrophage-Derived MANF Alleviates Bacterial Myocarditis by Inhibiting NF-kappaB Activation and Myocardial Inflammation

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