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01.05.2014 | Functional Neuroradiology

Motor function deficits in schizophrenia: an fMRI and VBM study

verfasst von: Sadhana Singh, Satnam Goyal, Shilpi Modi, Pawan Kumar, Namita Singh, Triptish Bhatia, Smita N. Deshpande, Subash Khushu

Erschienen in: Neuroradiology | Ausgabe 5/2014

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Abstract

Introduction

To investigate whether the motor functional alterations in schizophrenia (SZ) are also associated with structural changes in the related brain areas using functional magnetic resonance imaging (fMRI) and voxel-based morphometry (VBM).

Methods

A sample of 14 right-handed SZ patients and 14 right-handed healthy control subjects matched for age, sex, and education were examined with structural high-resolution T1-weighted MRI; fMRI images were obtained during right index finger-tapping task in the same session.

Results

fMRI results showed reduced functional activation in the motor areas (contralateral precentral and postcentral gyrus) and ipsilateral cerebellum in SZ subjects as compared to healthy controls (n = 14). VBM analysis also revealed reduced grey matter in motor areas and white matter reduction in cerebellum of SZ subjects as compared to controls.

Conclusion

The present study provides an evidence for a possible association between structural alterations in the motor cortex and disturbed functional activation in the motor areas in persons affected with SZ during a simple finger-tapping task.

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http://www.fil.ion.ucl.ac.uk/~john/misc/VBMclass10.pdf

http://www.jiscmail.ac.uk/cgi-bin/wa.exe?A2=ind0807&L=SPM&P=R7075&1

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Titel: Motor function deficits in schizophrenia: an fMRI and VBM study
verfasst von: Sadhana Singh
Satnam Goyal
Shilpi Modi
Pawan Kumar
Namita Singh
Triptish Bhatia
Smita N. Deshpande
Subash Khushu
Publikationsdatum: 01.05.2014
Verlag: Springer Berlin Heidelberg
Erschienen in: Neuroradiology / Ausgabe 5/2014
Print ISSN: 0028-3940
Elektronische ISSN: 1432-1920
DOI: https://doi.org/10.1007/s00234-014-1325-3

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