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Head and Neck Pathology

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01.09.2008 | Case Report

Mucoepidermoid Carcinoma with Spindle Cell Change: A Low-grade Lesion Potentially Mistaken for Sarcomatoid Dedifferentiation

verfasst von: Fumio Ide, Kenji Mishima, Ichiro Saito

Erschienen in: Head and Neck Pathology | Ausgabe 3/2008

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Abstract

An unusual case of mucoepidermoid carcinoma (MEC) of intraoral minor salivary gland origin with spindled morphology was presented. A fascicular stream of bland spindle cells from typical MEC areas amounted to more than 70% of the tumor. Spindle population had features consistent with immunohistochemical and ultrastructural profiles of intermediate cells and lacked overexpression of p53 and cyclin D1. There was no difference in the Ki-67 index between two distinct components. Awareness of extensive spindle cell change replacing a significant portion of low-grade MEC is crucial to avoid an erroneous interpretation of dedifferentiated sarcomatoid transformation.

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Titel: Mucoepidermoid Carcinoma with Spindle Cell Change: A Low-grade Lesion Potentially Mistaken for Sarcomatoid Dedifferentiation
verfasst von: Fumio Ide
Kenji Mishima
Ichiro Saito
Publikationsdatum: 01.09.2008
Verlag: Humana Press Inc
Erschienen in: Head and Neck Pathology / Ausgabe 3/2008
Elektronische ISSN: 1936-0568
DOI: https://doi.org/10.1007/s12105-008-0067-0

Springer Medizin

Mucoepidermoid Carcinoma with Spindle Cell Change: A Low-grade Lesion Potentially Mistaken for Sarcomatoid Dedifferentiation

Abstract

Neu im Fachgebiet Pathologie

Molekularpathologische Untersuchungen im Wandel der Zeit

Vergleichende Pathologie in der onkologischen Forschung

Gastrointestinale Stromatumoren

Personalisierte Medizin in der Onkologie

Springer Medizin

Abstract

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