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Erschienen in: Strahlentherapie und Onkologie 3/2017

07.11.2016 | Muskuloskelettale Radiologie | Case Study

Successful treatment of chronic recurrent multifocal osteomyelitis using low-dose radiotherapy

A case report

verfasst von: Dr. Christian T. Dietzel, Christoph Schäfer, Dirk Vordermark

Erschienen in: Strahlentherapie und Onkologie | Ausgabe 3/2017

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Abstract

Background

Chronic recurrent multifocal osteomyelitis (CRMO) is a rare autoinflammatory disease, which lacks an infectious genesis and predominantly involves the metaphysis of long bones. Common treatments range from nonsteroidal anti-inflammatory drugs (NSAIDs) and corticosteroids at first onset of disease, to immunosuppressive drugs and bisphosphonates in cases of insufficient remission. The therapeutic use of low-dose radiotherapy for CRMO constitutes a novelty.

Case report

A 67-year-old female patient presented with radiologically proven CRMO affecting the right tibia/talus and no response to immunosuppressive therapy. Two treatment series of radiation therapy were applied with an interval of 6 weeks. Each series contained six fractions (three fractions per week) with single doses of 0.5 Gy, thus the total applied dose was 6 Gy. Ten months later, pain and symptoms of osteomyelitis had completely vanished.

Conclusion

Radiotherapy seems to be an efficient and feasible complementary treatment option for conventional treatment refractory CRMO in adulthood. The application of low doses per fraction is justified by the inflammatory pathomechanism of disease.
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Metadaten
Titel
Successful treatment of chronic recurrent multifocal osteomyelitis using low-dose radiotherapy
A case report
verfasst von
Dr. Christian T. Dietzel
Christoph Schäfer
Dirk Vordermark
Publikationsdatum
07.11.2016