Erschienen in:
01.10.2007 | Case Report
Necrotizing Granulomatous Hepatitis as an Unusual Manifestation of Lyme Disease
verfasst von:
Antonela C. Zanchi, Alan R. Gingold, Neil D. Theise, Albert D. Min
Erschienen in:
Digestive Diseases and Sciences
|
Ausgabe 10/2007
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Excerpt
Lyme disease is the most common vector-borne infection in the United States and is caused by
Borrelia burgdorferi, a spirochete that is transmitted from the ixodid tick. Abnormal liver chemistry is a rare, but well-described phenomenon in Lyme disease infection [
1]. There have been several postulated theories as to the cause of hepatitis with
B. burgdorferi infection. These include direct toxicity from the spirochete, systemic cytokine release, and, possibly, an immune-mediated event [
2]. Although elevated aminotransferase has been seen, there has been only one case reported of granulomatous hepatitis from Lyme infection [
3]. We describe here the first case of a patient with acute Lyme disease who was found to have necrotizing granulomatous hepatitis with eosinophilic infiltration of the liver. …