Review
Introduction
Neoadjuvant treatments
Neoadjuvant radiotherapy
Study | Histology | SCC (%) | Treatment |
n
| MS (months) | 5-year OS (%) | P value |
---|---|---|---|---|---|---|---|
Launois and colleagues [11] | SCC | 100 | NART 40 Gy | 77 | 10 | 10 | NS |
Surgery | 57 | 12 | 12 | ||||
Gignoux and colleagues [12] | SCC | 100 | NART 33 Gy | 106 | 11 | 11 | NS |
Surgery | 102 | 11 | 10 | ||||
Arnott and colleagues [13] | AC/SCC | 36 | NART 20 Gy | 90 | 8 | 9 | NS |
Surgery | 86 | 8 | 17 | ||||
Nygaard and colleagues [14] | SCC | 100 | NART 35 Gy | 48 | 21a | NS | |
Surgery | 41 | 9a | |||||
Wang and colleagues [15] | SCC | 100 | NART 40 Gy | 104 | 35 | NS | |
Surgery | 102 | 30 |
Neoadjuvant chemotherapy
Study | Histology | SCC (%) | Treatment |
n
| MS (months) | 3-year OS (%) | P value |
---|---|---|---|---|---|---|---|
Schlag [18] | SCC | 100 | CF | 22 | 7 | NS | |
Surgery | 24 | 6 | |||||
Nygaard and colleagues [14] | SCC | 100 | BC | 44 | 7 | 3 | NS |
Surgery | 41 | 7 | 9 | ||||
Maipang and colleagues [19] | SCC | 100 | BVC | 24 | 17 | 31 | NS |
Surgery | 22 | 17 | 36 | ||||
Law and colleagues [20] | SCC | 100 | CF | 74 | 17 | 40 | NS |
Surgery | 73 | 13 | 13 | ||||
Ancona and colleagues [21] | SCC | 100 | CF | 47 | 25 | 34a | NS |
Surgery | 47 | 24 | 22a | ||||
Kelsen and colleagues [22] | AC/SCC | 54 | CF | 213 | 15 | 19a | NS |
Surgery | 227 | 16 | 20a | ||||
Allum and colleagues [23] | AC/SCC | 31 | CF | 400 | 17 | 43 | <0.01 |
Surgery | 402 | 13 | 34 |
Neoadjuvant chemoradiotherapy
Study | Histology | SCC (%) | Treatment |
n
| MS (months) | 5-year OS (%) | P value |
---|---|---|---|---|---|---|---|
Bosset and colleagues [30] | SCC | 100 | C + 37 Gy | 143 | 19 | 7 | NS |
Surgery | 139 | 19 | 9 | ||||
Lee and colleagues [32] | SCC | 100 | CF + 45 Gy | 51 | 28 | 49a | NS |
Surgery | 50 | 27 | 41a | ||||
Burmeister and colleagues [34] | AC/SCC | 35 | CF + 35 Gy | 128 | 22 | 17 | NS |
Surgery | 128 | 19 | 13 | ||||
Natsugoe and colleagues [33] | SCC | 100 | CF + 40 Gy | 22 | 57 | 0.58 | |
Surgery | 23 | 41 | |||||
Tepper and colleagues [35] | AC/SCC | 25 | CF + 50.4 Gy | 30 | 54 | 39 | <0.01 |
Surgery | 26 | 21 | 16 | ||||
Mariette and colleagues [31] | AC/SCC | 66 | CF + 45 Gy | 97 | 32 | 49a | 0.68 |
Surgery | 98 | 44 | 55a | ||||
Gaast and colleagues [36] | AC/SCC | 24 | PC + 41.4 Gy | 175 | 49 | 59a | 0.011 |
Surgery | 188 | 26 | 48a |
Adjuvant treatments
Adjuvant radiotherapy
Studies | Histology | SCC (%) | Treatment |
n
| MS (months) | 5-year OS (%) | P value |
---|---|---|---|---|---|---|---|
Kunath and Fischer [39] | SCC | 100 | ART 50 to 55 Gy | 23 | 9 | NS | |
Surgery | 21 | 6 | |||||
Ténière and colleagues [40] | SCC | 100 | ART 45 to 55 Gy | 102 | 18 | 19 | NS |
Surgery | 119 | 18 | 19 | ||||
Fok and colleagues [41] | SCC | 100 | ART 43 to 53 Gy | 42 | 11 | 10 | NS |
Surgery | 39 | 22 | 16 | ||||
Zieren and colleagues [42] | SCC | 100 | ART 56 Gy | 33 | 23a | NS | |
Surgery | 35 | 22a | |||||
Xiao and colleagues [43] | SCC | 100 | ART 50 to 60 Gy | 220 | 41 | NS | |
Surgery | 275 | 32 |
Adjuvant chemotherapy
Study | Histology | SCC (%) | Treatment |
n
| MS (months) | 5-year OS (%) | P value |
---|---|---|---|---|---|---|---|
Pouliquen and colleagues [46] | SCC | 100 | CF | 52 | 13 | NS | |
Surgery | 68 | 14 | |||||
Ando and colleagues [47] | SCC | 100 | CV | 100 | 45 | NS | |
Surgery | 105 | 48 | |||||
Ando and colleagues [25] | SCC | 100 | CF | 120 | 61 | NS | |
Surgery | 122 | 52 |