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26.12.2015 | Original Paper

Neuroanatomical Markers of Neurological Soft Signs in Recent-Onset Schizophrenia and Asperger-Syndrome

verfasst von: Dusan Hirjak, Robert C. Wolf, Isa Paternoga, Katharina M. Kubera, Anne K. Thomann, Bram Stieltjes, Klaus H. Maier-Hein, Philipp A. Thomann

Erschienen in: Brain Topography | Ausgabe 3/2016

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Abstract

Neurological soft signs (NSS) are frequently found in psychiatric disorders of significant neurodevelopmental origin. Previous MRI studies in schizophrenia have shown that NSS are associated with abnormal cortical, thalamic and cerebellar structure and function. So far, however, no neuroimaging studies investigated brain correlates of NSS in individuals with Asperger-Syndrome (AS) and the question whether the two disorders exhibit common or disease-specific cortical correlates of NSS remains unresolved. High-resolution MRI data at 3 T were obtained from 48 demographically matched individuals (16 schizophrenia patients, 16 subjects with AS and 16 healthy individuals). The surface-based analysis via Freesurfer enabled calculation of cortical thickness, area and folding (local gyrification index, LGI). NSS were examined on the Heidelberg Scale and related to cortical measures. In schizophrenia, higher NSS were associated with reduced cortical thickness and LGI in fronto-temporo-parietal brain areas. In AS, higher NSS were associated with increased frontotemporal cortical thickness. This study lends further support to the hypothesis that disorder-specific mechanisms contribute to NSS expression in schizophrenia and AS. Pointing towards dissociable neural patterns may help deconstruct the complex processes underlying NSS in these neurodevelopmental disorders.

Allen G, Muller RA, Courchesne E (2004) Cerebellar function in autism: functional magnetic resonance image activation during a simple motor task. Biol Psychiatry 56:269–278CrossRefPubMed

Andreasen NC (1983) The Scale for the Assessment of Negative Symptoms (SANS). University of Iowa, Iowa City, Iowa

Andreasen NC (1984) The Scale for the Assessment of Positive Symptoms (SAPS). University of Iowa, Iowa City, Iowa

Andreasen NC, Paradiso S, O DS (1998) “Cognitive dysmetria” as an integrative theory of schizophrenia: a dysfunction in cortical-subcortical-cerebellar circuitry? Schizophr Bull 24:203–218CrossRefPubMed

Bachmann S, Bottmer C, Schroder J (2005) Neurological soft signs in first-episode schizophrenia: a follow-up study. Am J Psychiatry 162:2337–2343CrossRefPubMed

Baron-Cohen S, Hoekstra RA, Knickmeyer R, Wheelwright S (2006) The Autism-Spectrum Quotient (AQ)—adolescent version. J Autism Dev Disord 36:343–350CrossRefPubMed

Bernard JA, Mittal VA (2015) Updating the research domain criteria: the utility of a motor dimension. Psychol Med. 45(13):2685–2689. doi:10.1017/S0033291715000872 CrossRefPubMedPubMedCentral

Bhojraj TS, Sweeney JA, Prasad KM, Eack S, Rajarethinam R, Francis AN et al (2011) Progressive alterations of the auditory association areas in young non-psychotic offspring of schizophrenia patients. J Psychiatr Res 45:205–212CrossRefPubMedPubMedCentral

Bombin I, Arango C, Buchanan RW (2005) Significance and meaning of neurological signs in schizophrenia: two decades later. Schizophr Bull 31:962–977CrossRefPubMed

Casanova MF, El-Baz A, Mott M, Mannheim G, Hassan H, Fahmi R et al (2009) Reduced gyral window and corpus callosum size in autism: possible macroscopic correlates of a minicolumnopathy. J Autism Dev Disord 39:751–764CrossRefPubMedPubMedCentral

Chan RC, Gottesman II (2008) Neurological soft signs as candidate endophenotypes for schizophrenia: a shooting star or a Northern star? Neurosci Biobehav Rev 32:957–971CrossRefPubMed

Cheung C, Yu K, Fung G, Leung M, Wong C, Li Q et al (2010) Autistic disorders and schizophrenia: related or remote? An anatomical likelihood estimation. PLoS One 5:e12233CrossRefPubMedPubMedCentral

Chung MK, Robbins SM, Dalton KM, Davidson RJ, Alexander AL, Evans AC (2005) Cortical thickness analysis in autism with heat kernel smoothing. Neuroimage 25:1256–1265CrossRefPubMed

Dale AM, Fischl B, Sereno MI (1999) Cortical surface-based analysis. I. Segmentation and surface reconstruction. NeuroImage 9:179–194CrossRefPubMed

DeRamus TP, Kana RK (2015) Anatomical likelihood estimation meta-analysis of grey and white matter anomalies in autism spectrum disorders. NeuroImage Clin 7:525–536CrossRefPubMedPubMedCentral

Desikan RS, Segonne F, Fischl B, Quinn BT, Dickerson BC, Blacker D et al (2006) An automated labeling system for subdividing the human cerebral cortex on MRI scans into gyral based regions of interest. Neuroimage 31:968–980CrossRefPubMed

Esposito G, Pasca SP (2013) Motor abnormalities as a putative endophenotype for Autism Spectrum Disorders. Front Integr Neurosci 7:43CrossRefPubMedPubMedCentral

Fischl B, Dale AM (2000) Measuring the thickness of the human cerebral cortex from magnetic resonance images. Proc Natl Acad Sci USA 97:11050–11055CrossRefPubMedPubMedCentral

Fischl B, Sereno MI, Dale AM (1999) Cortical surface-based analysis. II: Inflation, flattening, and a surface-based coordinate system. NeuroImage 9:195–207CrossRefPubMed

Fischl B, Salat DH, Busa E, Albert M, Dieterich M, Haselgrove C et al (2002) Whole brain segmentation: automated labeling of neuroanatomical structures in the human brain. Neuron 33:341–355CrossRefPubMed

Fischl B, van der Kouwe A, Destrieux C, Halgren E, Segonne F, Salat DH et al (2004) Automatically parcellating the human cerebral cortex. Cereb Cortex 14:11–22CrossRefPubMed

Freitag CM (2014) Autism Spectrum Disorder in DSM-5—concept, validity, and reliability, impact on clinical care and future research. Z Kinder Jugendpsychiatr Psychother 42:185–192CrossRefPubMed

Friston K (2012) Ten ironic rules for non-statistical reviewers. Neuroimage. 61:1300–1310CrossRefPubMed

Gallese V, Keysers C, Rizzolatti G (2004) A unifying view of the basis of social cognition. Trends Cogn Sci 8:396–403CrossRefPubMed

Goch CJ, Stieltjes B, Henze R, Hering J, Poustka L, Meinzer HP et al (2014) Quantification of changes in language-related brain areas in autism spectrum disorders using large-scale network analysis. Int J Comput Assist Radiol Surg 9(3):357–365CrossRefPubMed

Guy E (1976) Abnormal involuntary movement scale. Rockwille, MD

Hadjikhani N, Joseph RM, Snyder J, Tager-Flusberg H (2006) Anatomical differences in the mirror neuron system and social cognition network in autism. Cereb Cortex 16:1276–1282CrossRefPubMed

Hall RC (1995) Global assessment of functioning. A modified scale. Psychosomatics. 36:267–275CrossRefPubMed

Hardan AY, Muddasani S, Vemulapalli M, Keshavan MS, Minshew NJ (2006) An MRI study of increased cortical thickness in autism. Am J Psychiatry 163:1290–1292CrossRefPubMedPubMedCentral

Haukvik UK, Schaer M, Nesvag R, McNeil T, Hartberg CB, Jonsson EG et al (2012) Cortical folding in Broca’s area relates to obstetric complications in schizophrenia patients and healthy controls. Psychol Med 42:1329–1337CrossRefPubMed

Heuser M, Thomann PA, Essig M, Bachmann S, Schroder J (2011) Neurological signs and morphological cerebral changes in schizophrenia: an analysis of NSS subscales in patients with first episode psychosis. Psychiatry Res 192:69–76CrossRefPubMed

Hirjak D, Wolf RC, Koch SC, Mehl L, Kelbel JK, Kubera KM et al (2014a) Neurological abnormalities in recent-onset schizophrenia and asperger-syndrome. Front Psychiatry 5:91CrossRefPubMedPubMedCentral

Hirjak D, Wolf RC, Kubera KM, Stieltjes B, Thomann PA (2014b) Multiparametric mapping of neurological soft signs in healthy adults. Brain Struct Funct. doi:10.1007/s00429-014-0964-9 PubMed

Hirjak D, Wolf RC, Stieltjes B, Hauser T, Seidl U, Schroder J et al (2014c) Cortical signature of neurological soft signs in recent onset schizophrenia. Brain Topogr 27:296–306CrossRefPubMed

Hirjak D, Kubera KM, Wolf RC, Thomann AK, Hell SK, Seidl U et al (2015a) Local brain gyrification as a marker of neurological soft signs in schizophrenia. Behav Brain Res 292:19–25CrossRefPubMed

Hirjak D, Thomann PA, Kubera KM, Wolf ND, Sambataro F, Wolf RC (2015b) Motor dysfunction within the schizophrenia-spectrum: a dimensional step towards an underappreciated domain. Schizophr Res. doi:10.1016/j.schres.2015.10.022 PubMed

Kates WR, Ikuta I, Burnette CP (2009) Gyrification patterns in monozygotic twin pairs varying in discordance for autism. Autism Res 2:267–278CrossRefPubMed

Khan AR, Wang L, Beg MF (2008) FreeSurfer-initiated fully-automated subcortical brain segmentation in MRI using Large Deformation Diffeomorphic Metric Mapping. Neuroimage 41:735–746CrossRefPubMedPubMedCentral

Klein D, Rotarska-Jagiela A, Genc E, Sritharan S, Mohr H, Roux F et al (2014) Adolescent brain maturation and cortical folding: evidence for reductions in gyrification. PLoS One 9:e84914CrossRefPubMedPubMedCentral

Kuperberg GR, Broome MR, McGuire PK, David AS, Eddy M, Ozawa F et al (2003) Regionally localized thinning of the cerebral cortex in schizophrenia. Arch Gen Psychiatry 60:878–888CrossRefPubMed

Lord C, Rutter M, Goode S, Heemsbergen J, Jordan H, Mawhood L et al (1989) Autism diagnostic observation schedule: a standardized observation of communicative and social behavior. J Autism Dev Disord 19:185–212CrossRefPubMed

Mayoral M, Merchan-Naranjo J, Rapado M, Leiva M, Moreno C, Giraldez M et al (2010) Neurological soft signs in juvenile patients with Asperger syndrome, early-onset psychosis, and healthy controls. Early Interv Psychiatry. 4:283–290CrossRefPubMed

Miller TJ, McGlashan TH, Rosen JL, Cadenhead K, Cannon T, Ventura J et al (2003) Prodromal assessment with the structured interview for prodromal syndromes and the scale of prodromal symptoms: predictive validity, interrater reliability, and training to reliability. Schizophr Bull 29:703–715CrossRefPubMed

Nanda P, Tandon N, Mathew IT, Giakoumatos CI, Abhishekh HA, Clementz BA et al (2014) Local gyrification index in probands with psychotic disorders and their first-degree relatives. Biol Psychiatry 76:447–455CrossRefPubMedPubMedCentral

Nesvag R, Schaer M, Haukvik UK, Westlye LT, Rimol LM, Lange EH et al (2014) Reduced brain cortical folding in schizophrenia revealed in two independent samples. Schizophr Res 152:333–338CrossRefPubMed

Oldfield RC (1971) The assessment and analysis of handedness: the Edinburgh inventory. Neuropsychologia 9:97–113CrossRefPubMed

Overall JE, Gorham DR (1962) The brief psychiatric rating scale. Psychol Rep 10:799–812CrossRef

Palaniyappan L, Liddle PF (2012a) Aberrant cortical gyrification in schizophrenia: a surface-based morphometry study. J Psychiatry Neurosci: JPN. 37:399–406CrossRefPubMedPubMedCentral

Palaniyappan L, Liddle PF (2012b) Differential effects of surface area, gyrification and cortical thickness on voxel based morphometric deficits in schizophrenia. Neuroimage. 60:693–699CrossRefPubMed

Palaniyappan L, Liddle PF (2014) Diagnostic discontinuity in psychosis: a combined study of cortical gyrification and functional connectivity. Schizophr Bull 40:675–684CrossRefPubMedPubMedCentral

Qiu A, Adler M, Crocetti D, Miller MI, Mostofsky SH (2010) Basal ganglia shapes predict social, communication, and motor dysfunctions in boys with autism spectrum disorder. J Am Acad Child Adolesc Psychiatry. 49:539–551, 51 e1–51 e4

Raznahan A, Toro R, Daly E, Robertson D, Murphy C, Deeley Q et al (2010) Cortical anatomy in autism spectrum disorder: an in vivo MRI study on the effect of age. Cereb Cortex 20:1332–1340CrossRefPubMed

Rimol LM, Hartberg CB, Nesvag R, Fennema-Notestine C, Hagler DJ Jr, Pung CJ et al (2010) Cortical thickness and subcortical volumes in schizophrenia and bipolar disorder. Biol Psychiatry 68:41–50CrossRefPubMed

Rimol LM, Nesvag R, Hagler DJ Jr, Bergmann O, Fennema-Notestine C, Hartberg CB et al (2012) Cortical volume, surface area, and thickness in schizophrenia and bipolar disorder. Biol Psychiatry 71:552–560CrossRefPubMed

Rinehart NJ, Tonge BJ, Bradshaw JL, Iansek R, Enticott PG, McGinley J (2006) Gait function in high-functioning autism and Asperger’s disorder: evidence for basal-ganglia and cerebellar involvement? Eur Child Adolesc Psychiatry 15:256–264CrossRefPubMed

Rosas HD, Liu AK, Hersch S, Glessner M, Ferrante RJ, Salat DH et al (2002) Regional and progressive thinning of the cortical ribbon in Huntington’s disease. Neurology. 58:695–701CrossRefPubMed

Schaer M, Cuadra MB, Schmansky N, Fischl B, Thiran JP, Eliez S (2012) How to measure cortical folding from MR images: a step-by-step tutorial to compute local gyrification index. J Vis Exp: JoVE. doi:10.3791/3417 PubMedPubMedCentral

Schaer M, Ottet MC, Scariati E, Dukes D, Franchini M, Eliez S et al (2013) Decreased frontal gyrification correlates with altered connectivity in children with autism. Front Hum Neurosci 7:750CrossRefPubMedPubMedCentral

Schroder J, Niethammer R, Geider FJ, Reitz C, Binkert M, Jauss M et al (1991) Neurological soft signs in schizophrenia. Schizophr Res 6:25–30CrossRefPubMed

Schultz CC, Koch K, Wagner G, Roebel M, Nenadic I, Schachtzabel C et al (2010a) Complex pattern of cortical thinning in schizophrenia: results from an automated surface based analysis of cortical thickness. Psychiatry Res 182:134–140CrossRefPubMed

Schultz CC, Koch K, Wagner G, Roebel M, Schachtzabel C, Gaser C et al (2010b) Reduced cortical thickness in first episode schizophrenia. Schizophr Res 116:204–209CrossRefPubMed

Segonne F, Dale AM, Busa E, Glessner M, Salat D, Hahn HK et al (2004) A hybrid approach to the skull stripping problem in MRI. NeuroImage. 22:1060–1075CrossRefPubMed

Shaw P, Lerch J, Greenstein D, Sharp W, Clasen L, Evans A, Giedd J, Castellanos FX, Rapoport J. (2006) Longitudinal mapping of cortical thickness and clinical outcome in children and adolescents with attention-deficit/hyperactivity disorder. Arch Gen Psychiatry 63(5):540–549.

Shaw P, Lerch JP, Pruessner JC, Taylor KN, Rose AB, Greenstein D, Clasen L, Evans A, Rapoport JL, Giedd JN. (2007) Cortical morphology in children and adolescents with different apolipoprotein E gene polymorphisms: an observational study. Lancet Neurol 6(6):494–500

Sled JG, Zijdenbos AP, Evans AC (1998) A nonparametric method for automatic correction of intensity nonuniformity in MRI data. IEEE Trans Med Imaging 17:87–97CrossRefPubMed

Strauss JS, Carpenter WT Jr (1974) The prediction of outcome in schizophrenia. II. Relationships between predictor and outcome variables: a report from the WHO international pilot study of schizophrenia. Arch Gen Psychiatry 31:37–42CrossRefPubMed

Tani P, Lindberg N, Appelberg B, Nieminen-von Wendt T, von Wendt L, Porkka-Heiskanen T (2006) Clinical neurological abnormalities in young adults with Asperger syndrome. Psychiatry Clin Neurosci 60:253–255CrossRefPubMed

Teixeira S, Machado S, Velasques B, Sanfim A, Minc D, Peressutti C et al (2014) Integrative parietal cortex processes: neurological and psychiatric aspects. J Neurol Sci 338:12–22CrossRefPubMed

Thomann PA, Wustenberg T, Santos VD, Bachmann S, Essig M, Schroder J (2009) Neurological soft signs and brain morphology in first-episode schizophrenia. Psychol Med 39:371–379CrossRefPubMed

Wallace GL, Robustelli B, Dankner N, Kenworthy L, Giedd JN, Martin A (2013) Increased gyrification, but comparable surface area in adolescents with autism spectrum disorders. Brain. 136:1956–1967CrossRefPubMedPubMedCentral

Weiß RH (2006) CFT 20-R Grundintelligenztest Skala 2—Revision. Hogrefe, Göttingen

Wheeler AL, Voineskos AN (2014) A review of structural neuroimaging in schizophrenia: from connectivity to connectomics. Front Hum Neurosci 8:653CrossRefPubMedPubMedCentral

Whyatt C, Craig C (2013) Sensory-motor problems in Autism. Front Integr Neurosci 7:51CrossRefPubMedPubMedCentral

Wittchen HU, Wunderlich U, Gruschwitz S, Zaudig M (1997a) SKID-I: Strukturiertes klinisches Interview für DSM-IV. Hogrefe, Göttingen

Wittchen HU, Wunderlich U, Gruschwitz S, Zaudig M (1997b) SKID-I: Strukturiertes klinisches Interview für DSM-IV. Hogrefe, Göttingen

Woodbury-Smith MR, Robinson J, Wheelwright S, Baron-Cohen S (2005) Screening adults for Asperger Syndrome using the AQ: a preliminary study of its diagnostic validity in clinical practice. J Autism Dev Disord 35:331–335CrossRefPubMed

Zhao Q, Li Z, Huang J, Yan C, Dazzan P, Pantelis C et al (2014) Neurological soft signs are not “soft” in brain structure and functional networks: evidence from ALE meta-analysis. Schizophr Bull. 40(3):626–641CrossRefPubMedPubMedCentral

Zielinski BA, Prigge MB, Nielsen JA, Froehlich AL, Abildskov TJ, Anderson JS et al (2014) Longitudinal changes in cortical thickness in autism and typical development. Brain. 137:1799–1812CrossRefPubMedPubMedCentral

Titel: Neuroanatomical Markers of Neurological Soft Signs in Recent-Onset Schizophrenia and Asperger-Syndrome
verfasst von: Dusan Hirjak
Robert C. Wolf
Isa Paternoga
Katharina M. Kubera
Anne K. Thomann
Bram Stieltjes
Klaus H. Maier-Hein
Philipp A. Thomann
Publikationsdatum: 26.12.2015
Verlag: Springer US
Erschienen in: Brain Topography / Ausgabe 3/2016
Print ISSN: 0896-0267
Elektronische ISSN: 1573-6792
DOI: https://doi.org/10.1007/s10548-015-0468-9

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