Erschienen in:
01.11.2008
Neurochemical dementia diagnostics: assays in CSF and blood
verfasst von:
Piotr Lewczuk, Joachim Hornegger, Rüdiger Zimmermann, Markus Otto, Jens Wiltfang, Johannes Kornhuber
Erschienen in:
European Archives of Psychiatry and Clinical Neuroscience
|
Sonderheft 5/2008
Einloggen, um Zugang zu erhalten
Abstract
In this review, current neurochemical dementia diagnostics (NDD) procedures are presented with a focus on biomarkers in the cerebrospinal fluid (CSF) and blood: amyloid β peptides, tau protein, and its phosphorylated form (pTau). CSF analysis is an increasingly important tool for early and differential diagnosis of dementia syndromes. Although lumbar puncture is a mildly invasive procedure with a low incidence of complications, establishing blood assays capable of reliably measuring NDD biomarkers is an aim of several studies worldwide.