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11.09.2017 | Case Report

Neurological and multiple organ involvement due to Paracoccidioides brasiliensis and HIV co-infection diagnosed at autopsy

verfasst von: Sergio Monteiro de Almeida, Thiago H. Roza, Gabriel L.O. Salvador, João C.B. França, Luine Rosele Renaud Vidal, Meri Bordignon Nogueira, Lubomira Veronica Oliva, Luis Fernando Bleggi Torres, Lucia Helena de Noronha

Erschienen in: Journal of NeuroVirology | Ausgabe 6/2017

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Abstract

Paracoccidioidomycosis (PCM), caused by Paracoccidioides brasiliensis, is the most prevalent systemic mycosis among immunocompetent patients in Latin America; it is rare in immunocompromised patients. The estimated frequency of central nervous system (CNS) involvement in the HIV/PCM population was 2.5%. We report a case of HIV/P. brasiliensis co-infection, with neurological (NPCM) and multiple organ involvement, indicating a diagnosis of AIDS. PCM diagnosis was established during the autopsy. This is the first described case of HIV/P. brasiliensis co-infection with CNS involvement diagnosed at autopsy. In conclusion, the diagnosis of NPCM is challenging, and it must be considered in the differential diagnosis in HIV-positive patients who reside in or have visited areas in which the condition is endemic and who present with neurological symptoms.

Almeida SM, Queiroz-Telles F, Doi EM, Ono M, Werneck LC (2002) Anti-gp43 antibodies in the cerebrospinal fluid of patients with central nervous system involvement by paracoccidioidomycosis. Am J Clin Pathol 118:864–868CrossRefPubMed

Almeida SM, Queiroz-Telles F, Teive HAG, Ribeiro CEL, Werneck LC (2004) Central nervous system paracoccidioidomycosis: clinical features and laboratorial findings. J Inf Secur 48:193–198

Bellissimo-Rodrigues F, Vitali LH, Martinez R (2010) Serological diagnosis of paracoccidioidomycosis in HIV-coinfected patients. Mem Inst Oswaldo Cruz 105:904–907CrossRefPubMed

Benard G, Duarte AJ (2000) Paracoccidioidomycosis: a model for evaluation of the effects of human immunodeficiency virus infection on the natural history of endemic tropical diseases. Clin Infect Dis 31:1032–1039CrossRefPubMed

Buitrago MJ, Merino P, Puente S, Gomez-Lopez A, Arribi A, Zancopé-Oliveira RM, Gutierrez MC, Rodriguez-Tudela JL, Cuenca-Estrella M (2009) Utility of real-time PCR for the detection of Paracoccidioides brasiliensis DNA in the diagnosis of imported paracoccidioidomycosis. Med Mycol 47:879–882CrossRefPubMed

Colombo AL, Junior GT, Lotfi CJ, Lima FO, Levi DS, Accerturi CA (1989) Paracoccidioidomicose disseminada em pacientes com AIDS (achado de necropsia) [abstract] In: Program and abstracts of the 26th Congresso da Sociedade Brasileira de Medicina Tropical (São Paulo). São Paulo: Sociedade Brasileira de Medicina Tropical [in Portuguese]

de Almeida SM (2005) Central nervous system paracoccidioidomycosis: an overview. Braz J Infect Dis 9:126–133CrossRefPubMed

de Almeida SM, Roza TH (2017) HIV immune recovery inflammatory syndrome and central nervous system paracoccidioidomycosis. Mycopathologia 182:393–396CrossRefPubMed

Finamor LP, Muccioli C, Martins MC, Rizzo LV, Belfort R (2002) Ocular and central nervous system paracoccidioidomycosis in a pregnant woman with acquired immunodeficiency syndrome. Am J Ophthalmol 134:456–459CrossRefPubMed

Goldani LZ, Sugar AM (1995) Paracoccidioidomycosis and AIDS: an overview. Clin Infect Dis 21:1275–1281CrossRefPubMed

Guimarães JCA, Bortoliero AI, Bonametti AM, de Pauli DS, Baldy JLS, Passos JN, Takata PK (1991) Infecção oportunista do sistema nervoso central por Paracoccidioides brasiliensis: relato do caso [abstract no 114]. Rev Soc Bras Med Trop 24(suppl II):30-1

Lorenzoni PJ, Chang MR, Paniago AMM, Salgado PR (2002) Meningite paracoccidioidomicótica: relato de caso. Arq Neuropsiquiatr 60:1015–1018CrossRefPubMed

Morejón KM, Machado AA, Martinez R (2009) Paracoccidioidomycosis in patients infected with and not infected with human immunodeficiency virus: a case-control study. Am J Trop Med Hyg 80:359–366PubMed

Nobrega de Almeida J, Del Negro GM, Grenfell RC, Vidal MS, Thomaz DY, de Figueiredo DS, Bagagli E, Juliano L, Benard G (2015) Matrix-assisted laser desorption ionization-time of flight mass spectrometry for differentiation of the dimorphic fungal species Paracoccidioides brasiliensis and Paracoccidioides lutzii. J Clin Microbiol 53:1383–1386CrossRefPubMedPubMedCentral

Pedroso VSP, Vilela MC, Pedroso ERP, Teixeira AL (2009) Paracoccidioidomycosis compromising the central nervous system: a systematic review of the literature. Rev Soc Bras Med Trop 42(6):691–697CrossRefPubMed

Restrepo A (1978) Paracoccidioidomicosis. Acta Med Colomb 3:33–66

Shikanai-Yasuda MA, Telles Filho FQ, Mendes RP, Colombo AL, Moretti ML, Grupo de Consultores do Consenso em Paracoccidioidomicose (2006) Consenso em paracoccidioidomicose. Rev Soc Bras Med Trop 39:297–310CrossRefPubMed

Silva-Vergara ML, Teixeira AC, Curi VGM, Costa Júnior JC, Vanunce R, Carmo WM, Silva MR (2003) Paracoccidioidomycosis associated with human immunodeficiency virus infection. Report of 10 cases. Med Mycol 41:259–263CrossRefPubMed

Silva-Vergara ML, Rocha IH, Vasconcelos RR, Maltos AL, de Freitas NF, de Almeida Silva Teixeira L, Mora DJ (2014) Central nervous system paracoccidioidomycosis in an AIDS patient: case report. Mycopathologia 177:137–141CrossRefPubMed

Titel: Neurological and multiple organ involvement due to Paracoccidioides brasiliensis and HIV co-infection diagnosed at autopsy
verfasst von: Sergio Monteiro de Almeida
Thiago H. Roza
Gabriel L.O. Salvador
João C.B. França
Luine Rosele Renaud Vidal
Meri Bordignon Nogueira
Lubomira Veronica Oliva
Luis Fernando Bleggi Torres
Lucia Helena de Noronha
Publikationsdatum: 11.09.2017
Verlag: Springer International Publishing
Erschienen in: Journal of NeuroVirology / Ausgabe 6/2017
Print ISSN: 1355-0284
Elektronische ISSN: 1538-2443
DOI: https://doi.org/10.1007/s13365-017-0577-1

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Neurological and multiple organ involvement due to Paracoccidioides brasiliensis and HIV co-infection diagnosed at autopsy

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