Erschienen in:
17.02.2022 | Neurotrauma (D. Sandsmark, Section Editor)
Neuromodulation Treatments for Mild Traumatic Brain Injury and Post-concussive Symptoms
verfasst von:
Adriano Mollica, Rachel Greben, Chika Oriuwa, Shan H. Siddiqi, Matthew J. Burke
Erschienen in:
Current Neurology and Neuroscience Reports
|
Ausgabe 3/2022
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Abstract
Purpose of Review
Mild traumatic brain injury (mTBI) can result in prolonged post-concussive symptoms (e.g., depression, headaches, cognitive impairment) that are debilitating and difficult to treat. This article reviews recent research on neuromodulation for mTBI.
Recent Findings
Transcranial magnetic stimulation (TMS) is the most studied neuromodulation approach for mTBI (four studies for depression, four for headache, one for cognitive impairment, and two for global post-concussive symptoms) with promising results for post-concussive depression and headache. Transcranial direct current stimulation (tDCS) has also been evaluated (one study for post-traumatic headache, and three for cognitive impairment), with more mixed results overall.
Summary
TMS appears to be a potentially promising neuromodulation treatment strategy for post-concussive symptoms; however, integration into clinical practice will require larger sham-controlled randomized trials with longer and more consistent follow-up periods. Future studies should also explore new stimulation protocols, personalized approaches, and the role of placebo effects.