nach oben

Metabolic Brain Disease

Erschienen in:

01.06.2015 | Research Article

Neuroprotective activity of hydroponic Teucrium polium following bilateral ovariectomy

verfasst von: K. V. Simonyan, V. A. Chavushyan

Erschienen in: Metabolic Brain Disease | Ausgabe 3/2015

Einloggen, um Zugang zu erhalten

Abstract

Ovariectomy is known as “surgical menopause” with decreased levels of estrogen in female rodents. Its reported risks and adverse effects include cognitive impairment. The action of hydroponic Teucrium polium on nucleus basalis of Meynert (bnM) neurons following 6 weeks of ovariectomy was carried out. The analysis of spike activity was observed by on-line selection and the use of a software package. Early and late tetanic, − posttetanic potentiation and depression of neurons to high frequency stimulation of hippocampus were studied. The complex averaged peri-event time and frequency histograms were constructed. The histochemical study of the activity of Са²⁺-dependent acid phosphatase was observed. In conditions of hydroponic Teucrium polium administration, positive changes in neurons and gain of metabolism leading to cellular survival were revealed. The administration of Teucrium polium elicited neurodegenerative changes in bnM.

Anukulthanakorn K, Malaivijitnond S, Kitahashi T, Jaroenporn S, Parhar I (2013) Molecular events during the induction of neurodegeneration and memory loss in estrogen-deficient rats. Gen Comp Endocrinol 181:316–323CrossRefPubMed

Chavushyan V, Simonyan K, Galstyan H (2010) Toxicity studies of Teucrium polium lamiaceae growing in nature and in culture. The Second International symposium “Biopharma 2010: from science to industry” May 17–20 Armenia. -Yerevan 2010.- P.11, 45

Craig MC, Brammer M, Maki PM, Fletcher PC, Daly EM, Rymer J, Giampietro V, Picchioni M, Stahl D, Murphy DG (2010) The interactive effect of acute ovarian suppression and the cholinergic system on visuospatial working memory in young women. Psychoneuroendocrinology 7:987–1000CrossRef

D’Abrosca B, Pacifico S, Scognamiglio M, D’Angelo G, Galasso S, Monaco P, Fiorentino A (2013) A new acylated flavone glycoside with antioxidant and radical scavenging activities from Teucrium polium leaves. Nat Prod Res 4–5:356–363CrossRef

Dajas F, Rivera-Megret F, Blasina F, Arredondo F, Abin-Carriquiry JA, Costa G, Echeverry C, Lafon L, Heizen H, Ferreira M, Morquio A (2003) Neuroprotection by flavonoids. Braz J Med Biol Res 12:1613–1620CrossRef

Dajas F, Andrés AC, Florencia A, Carolina E, Felicia RM (2013) Neuroprotective actions of flavones and flavonols: mechanisms and relationship to flavonoid structural features. Cent Nerv Syst Agents Med Chem 1:30–35CrossRef

Decker MW, McGaugh JL (1991) The role of interactions between the cholinergic system and other neuromodulatory systems in learning and memory. Synapse 2:151–168CrossRef

Doi A, Ishibashi H, Jinno S, Kosaka T, Akaike N (2002) Presynaptic inhibition of GABAergic miniature currents by metabotropic glutamate receptor in the rat CNS. Neuroscience 2:299–311CrossRef

Giovannini MG, Rakovska A, Benton RS, Pazzagli M, Bianchi L, Pepeu G (2001) Effects of novelty and habituation on acetylcholine, GABA, and glutamate release from the frontal cortex and hippocampus of freely moving rats. Neuroscience 1:43–53CrossRef

Hernandez I, Delgado JL, Díaz J, Quesada T, Teruel MJG, Carmen-Llanos M, Carbonell LF (2000) 17β-Estradiol prevents oxidative stress and decreases blood pressure in ovariectomized rats. Am J Physiol 279:R1599–R1605

Howes MJR, Perry NSL, Houghton PJ (2003) Plants with traditional uses and activities relevant to the management of Alzheimer’s disease and other cognitive disorders. Phytother Res 17:1–18CrossRefPubMed

Hu Y, Hou TT, Zhang QY, Xin HL, Zheng HC, Rahman K, Qin LP (2007) Evaluation of the estrogenic activity of the constituents in the fruits of Vitex rotundifolia L. for the potential treatment of premenstrual syndrome. J Pharm Pharmacol 9:1307–1312CrossRef

Ibrahim NA, Shalaby AS, Farag RS, Elbaroty GS, Nofal SM, Hassan EM (2008) Gynecological efficacy and chemical investigation of Vitex agnus-castus L. fruits growing in Egypt. Nat Prod Res 6:537–546CrossRef

Jang S, Dilger RN, Johnson RW (2010) Luteolin inhibits microglia and alters hippocampal-dependent spatial working memory in aged mice. J Nutr 10:1892–1898CrossRef

Johnston GA (2005) GABA(A) receptor channel pharmacology. Curr Pharm Des 15:1867–1885CrossRef

Kadifkova-Panovska T, Kulevanova S, Stefova M (2005) In vitro antioxidant activity of some Teucrium species (Lamiaceae). Acta Pharm 55:207–214PubMed

Kawai H, ZagoW BDK (2002) Nicotinic alpha 7 receptor clusters on hippocampal GABAergic neurons: regulation by synaptic activity and neurotrophins. J Neurosci 22:7903–7912PubMed

Koo KA, Sung SH, Park JH, Kim SH, Lee KY, Kim YC (2005) In vitro neuroprotective activities of phenylethanoid glycosides from Callicarpa dichotoma. Planta Med 8:778–780CrossRef

Larson J, Lynch G, Games D, Seubert P (1999) Alterations in synaptic transmission and long-term potentiation in hippocampal slices from young and aged PDAPP mice. Brain Res 1–2:23–35CrossRef

Liu R, Gao M, Qiang GF, Zhang TT, Lan X, Ying J, Du GH (2009) The anti-amnesic effects of luteolin against amyloid beta(25–35) peptide-induced toxicity in mice involve the protection of neurovascular unit. Neuroscience 4:1232–1243CrossRef

Liu L, Su Y, Yang W, Xiao M, Gao J, Hu G (2010) Disruption of neuronal-glial-vascular units in the hippocampus of ovariectomized mice injected with D-galactose. Neuroscience 2:596–608CrossRef

Liu R, Zhang T, Yang H, Lan X, Ying J, Du G (2011) The flavonoid apigenin protects brain neurovascular coupling against amyloid-β25-35-induced toxicity in mice. J Alzheimers Dis 1:85–100

Losi G, Puia G, Garzon G, de Vuono MC, Baraldi M (2004) Apigenin modulates GABAergic and glutamatergic transmission in cultured cortical neurons. Eur J Pharmacol 1–2:41–46CrossRef

Lozada AF, Wang X, Gounko NV, Massey KA, Duan J, Liu Z, Berg DK (2012a) Glutamatergic synapse formation is promoted by a7-con-taining nicotinic acetylcholine receptors. J Neurosci 32:7651–7661CrossRefPubMedCentralPubMed

Lozada AF, Wang X, Gounko NV, Massey KA, Duan J, Liu Z, Berg DK (2012b) Induction of dendritic spines by b2-containing nicotinic receptors. J Neurosci 32:8391–8400CrossRefPubMedCentralPubMed

Luine V, Frankfurt M (2012) Interactions between estradiol, BDNF and dendritic spines in promoting memory. Neuroscience 239:34–45CrossRefPubMedCentralPubMed

Meliksetyan IB (2007) A revelation Са2+−dependent acidic phosphatase in cellular structions of the rat brain. Morphology (s-t Peterburg) 2:77–80

Meng Y, Wang R, Yang F, Ji ZJ, Fang L, Sheng SL (2010) Amyloid precursor protein 17-mer peptide ameliorates hippocampal neurodegeneration in ovariectomized rats. Neurosci Lett 3:173–177CrossRef

Navarrete M, Perea G, Maglio L, Pastor J, García de Sola R, Araque A (2013) Astrocyte Calcium Signal and Gliotransmission in Human Brain Tissue. Cereb Cortex 5:1240–1246CrossRef

Orhan I, Aslan M (2009) Appraisal of scopolamine-induced antiamnesic effect in mice and in vitro antiacetylcholinesterase and antioxidant activities of some traditionally used Lamiaceae plants. J Ethnopharmacol 122:327–332CrossRefPubMed

Perry N, Court G, Bidet N et al (1996) Cholinergic activities of European herbs and potential for dementia therapy. J Geriatr Psychiatry 11:1063–1069CrossRef

Pesavento E, Capsoni S, Domenici L, Cattaneo A (2002) Acute cholinergic rescue of synaptic plasticity in the neurodegenerating cortex of anti-nerve-growth-factor mice. Eur J Neurosci 6:1030–1036CrossRef

Ping SE, Trieu J, Wlodek ME, Barrett GL (2008) Effects of estrogen on basal forebrain cholinergic neurons and spatial learning. J Neurosci Res 7:1588–1598CrossRef

Proestos C, Sereli D, Komaitis M (2006) Determination of phenolic compounds in aromatic plants by RP-HPLC and GC-MS. Food Chem 95:44–52CrossRef

Rapkin AJ, Akopians AL (2012) Pathophysiology of premenstrual syndrome and premenstrual dysphoric disorder. Menopause Int 2:52–59

Rezai-Zadeh K, Ehrhart J, Bai Y, Sanberg PR, Bickford P, Tan J, Shytle RD (2009) Apigenin and luteolin modulate microglial activation via inhibition of STAT1-induced CD40 expression. J Neuroinflammation 5:41CrossRef

Rissman RA, De Blas AL, Armstrong DM (2007) GABAA receptors in aging and Alzheimer’s disease. J Neurochem 103:1285–1292CrossRefPubMed

Role LW, Berg DK (1996) Nicotinic receptors in the development and modulation of CNS synapses. Neuron 16:1077–1085CrossRefPubMed

Takata N, Mishima T, Hisatsune C, Nagai T, Ebisui E, Mikoshiba K, Hirase H (2011) Astrocyte calcium signaling transforms cholinergic modulation to cortical plasticity in vivo. J Neurosci 31:18155–18165CrossRefPubMed

Tsai FS, Peng WH, Wang WH, Wu CR, Hsieh CC, Lin YT, Feng IC, Hsieh MT (2007) Effects of luteolin on learning acquisition in rats: involvement of the central cholinergic system. Life Sci 18:1692–1698CrossRef

Taupin P (2009) Apigenin and related compounds stimulate adult neurogenesis. Mars, Inc., the Salk Institute for Biological Studies. Expert Opin Ther Pat 4: 523–527

Unal D, Halici Z, Altunkaynak Z, Keles ON, Oral E, Unal B (2012) A new hypothesis about neuronal degeneration appeared after a rat model of menopause. Neurodegener Dis 1:25–30CrossRef

Wenk GL (1984) Pharmacological manipulations of the substantia innominata-cortical cholinergic pathway. Neurosci Lett 1:99–103CrossRef

Wenk H, Bigl V, Meyer U (1980) Cholinergic projections from magnocellular nuclei of the basal forebrain to cortical areas in rats. Brain Res 2:295–316CrossRefPubMed

Xu XW, Shi C, He ZQ, Ma CM, Chen WH, Shen YP, Guo Q, Shen CJ, Xu J (2008) Effects of phytoestrogen on mitochondrial structure and function of hippocampal CA1 region of ovariectomized rats. Cell Mol Neurobiol 6:875–886CrossRef

Xu SL, Bi CW, Choi RC, Zhu KY, Miernisha A, Dong TT, Tsim KW (2013) Flavonoids induce the synthesis and secretion of neurotrophic factors in cultured rat astrocytes: a signaling response mediated by estrogen receptor. Evid Based Complement Alternat Med 2013:127075PubMedCentralPubMed

Yenkoyan K, Safaryan K, Chavushyan V, Meliksetyan I, Navasardyan G, Sarkissian J, Galoyan A, Aghajanov M (2011) Neuroprotective action of proline-rich polypeptide-1 in β-amyloid induced neurodegeneration in rats. Brain Res Bull 86:262–271CrossRefPubMed

Youdim KA, Qaiser MZ, Begley DJ, Rice-Evans CA, Abbott NJ (2004) Flavonoid permeability across an in situ model of the blood–brain barrier. Free Radic Biol Med 36:592–604CrossRefPubMed

Zhao L, Mao Z, Brinton RD (2009) A select combination of clinically relevant phytoestrogens enhances estrogen receptor beta-binding selectivity and neuroprotective activities in vitro and in vivo. Endocrinology 2:770–783CrossRef

Zhao L, Wang JL, Liu R, Li XX, Li JF, Zhang L (2013) Neuroprotective, anti-amyloidogenic and neurotrophic effects of apigenin in an Alzheimer’s disease mouse model. Molecules 8:9949–9965CrossRef

Zhu R, Ge B, Yang B, Chen K, Wen Y, Zhou J, Han G, Cheng G, Zhai Y (2012) Study on estrogenic effect of genistein and apigenin in vitro. Zhongguo Zhong Yao Za Zhi 15:2317–2322

Titel: Neuroprotective activity of hydroponic Teucrium polium following bilateral ovariectomy
verfasst von: K. V. Simonyan
V. A. Chavushyan
Publikationsdatum: 01.06.2015
Verlag: Springer US
Erschienen in: Metabolic Brain Disease / Ausgabe 3/2015
Print ISSN: 0885-7490
Elektronische ISSN: 1573-7365
DOI: https://doi.org/10.1007/s11011-014-9640-2

Leitlinien kompakt für die Neurologie

Mit medbee Pocketcards sicher entscheiden.

^{Seit 2022 gehört die medbee GmbH zum Springer Medizin Verlag}

Kostenlos registrieren

Neu im Fachgebiet Neurologie

Niedriger diastolischer Blutdruck erhöht Risiko für schwere kardiovaskuläre Komplikationen

25.04.2024 Hypotonie Nachrichten

Wenn unter einer medikamentösen Hochdrucktherapie der diastolische Blutdruck in den Keller geht, steigt das Risiko für schwere kardiovaskuläre Ereignisse: Darauf deutet eine Sekundäranalyse der SPRINT-Studie hin.

Frühe Alzheimertherapie lohnt sich

25.04.2024 AAN-Jahrestagung 2024 Nachrichten

Ist die Tau-Last noch gering, scheint der Vorteil von Lecanemab besonders groß zu sein. Und beginnen Erkrankte verzögert mit der Behandlung, erreichen sie nicht mehr die kognitive Leistung wie bei einem früheren Start. Darauf deuten neue Analysen der Phase-3-Studie Clarity AD.

Viel Bewegung in der Parkinsonforschung

25.04.2024 Parkinson-Krankheit Nachrichten

Neue arznei- und zellbasierte Ansätze, Frühdiagnose mit Bewegungssensoren, Rückenmarkstimulation gegen Gehblockaden – in der Parkinsonforschung tut sich einiges. Auf dem Deutschen Parkinsonkongress ging es auch viel um technische Innovationen.

Demenzkranke durch Antipsychotika vielfach gefährdet

23.04.2024 Demenz Nachrichten

Wenn Demenzkranke aufgrund von Symptomen wie Agitation oder Aggressivität mit Antipsychotika behandelt werden, sind damit offenbar noch mehr Risiken verbunden als bislang angenommen.

Update Neurologie

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.

Newsletter bestellen

Springer Medizin

Abstract

Bitte loggen Sie sich ein, um Zugang zu diesem Inhalt zu erhalten

Weitere Artikel der Ausgabe 3/2015

Role of neurotrophin in the taste system following gustatory nerve injury

Induction of DJ-1 protects neuronal cells from isoflurane induced neurotoxicity

Dipeptidyl-peptidase IV (DPP-IV) inhibitor delays tolerance to anxiolytic effect of ethanol and withdrawal-induced anxiety in rats

Chronic exercise prevents repeated restraint stress-provoked enhancement of immobility in forced swimming test in ovariectomized mice

Using saccades to diagnose covert hepatic encephalopathy