Erschienen in:
01.10.2009 | Invited Paper
Neuropsychological sequelae and quality of life following treatment of posterior fossa ependymomas in children
verfasst von:
Constantinos Charalambides, Argyris Dinopoulos, Spyros Sgouros
Erschienen in:
Child's Nervous System
|
Ausgabe 10/2009
Einloggen, um Zugang zu erhalten
Abstract
Introduction
Modern treatment of posterior fossa ependymomas in children has improved the overall survival, but as more children live longer, the neuropsychological problems that they endure as result of the disease and its treatment become more the focus of attention.
Material
Early problems such as cerebellar mutism appear to be related to surgery and do not seem to be influenced in their incidence or outcome by the otherwise beneficial effect of oncological treatment. Indeed, the cause of cerebellar mutism is still elusive. While it was originally believed to be totally reversible, it is increasingly realized that it may be related to more complex delayed neuropsychological problems. Late problems such as the cerebellar cognitive affective syndrome are increasingly being recognized. The deleterious effect of both surgery and radiotherapy that is commonly administered afterwards is now well appreciated.
Conclusion
Careful neuropsychological assessment of these children and early intervention will maximize chances for recovery and improvement of academic functions and quality of life issues.