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Digestive Diseases and Sciences

Erschienen in:

01.08.2006 | Original Article

Nitric Oxide and Antioxidant Defense in Patients with Gastric Cancer

verfasst von: Yildiz Dincer, Tülay Akcay, Osman B. Tortum, Gülen Dogusoy

Erschienen in: Digestive Diseases and Sciences | Ausgabe 8/2006

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Abstract

In the present study, total nitrate and nitrite level (as end product of nitric oxide), superoxide dismutase activity, and glutathione peroxidase activity in leukocytes were determined in patients with gastric cancer, and the relationship between measured parameters and tumor grade were evaluated. Leukocyte nitrate and nitrite level was found to be increased and superoxide dismutase activity was found to be decreased in patients compared to controls. When the patient group was categorized, nitrate and nitrite level was found to be higher in patients with a high-grade tumor than in patients with a grade I tumor. We concluded that an increased level of leukocyte nitrate and nitrite is related to tumor grade in patients with gastric cancer; antioxidant activity is also impaired in these patients but it does not seem to be related to grade of tumor.

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Titel: Nitric Oxide and Antioxidant Defense in Patients with Gastric Cancer
verfasst von: Yildiz Dincer
Tülay Akcay
Osman B. Tortum
Gülen Dogusoy
Publikationsdatum: 01.08.2006
Verlag: Springer US
Erschienen in: Digestive Diseases and Sciences / Ausgabe 8/2006
Print ISSN: 0163-2116
Elektronische ISSN: 1573-2568
DOI: https://doi.org/10.1007/s10620-005-9021-0

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