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02.03.2020 | Proceeding of the North American Society of Head and Neck Pathology Companion Meeting, March 1, 2020, Los Angeles, California

Noninvasive Follicular Thyroid Neoplasm with Papillary-Like Nuclear Features (NIFTP): An Update

verfasst von: Bin Xu, Ronald A. Ghossein

Erschienen in: Head and Neck Pathology | Ausgabe 2/2020

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Abstract

Based on evidence accumulated over the past three decades showing that noninvasive encapsulated follicular variant of papillary thyroid carcinoma has an indolent clinical behavior and a RAS-like molecular profile similar to follicular adenoma, the Endocrine Pathology Society working group in 2016 proposed to rename this entity as “noninvasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP)” in order to eliminate the term “carcinoma” from the diagnosis. It is a major evidence-based attempt initiated by an international group of endocrine pathologists to tackle the epidemic of thyroid cancer overdiagnosis and overtreatment. However, its creation and continuous existence are not without controversies. NIFTP has sparked a wave of follow up studies aiming to decipher the exact nature of this new entity. In this review, we summarize the rationale, diagnostic criteria, controversies and subsequent changes to the NIFTP concept, and their impact on patient care and pathology practice.

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Titel: Noninvasive Follicular Thyroid Neoplasm with Papillary-Like Nuclear Features (NIFTP): An Update
verfasst von: Bin Xu
Ronald A. Ghossein
Publikationsdatum: 02.03.2020
Verlag: Springer US
Erschienen in: Head and Neck Pathology / Ausgabe 2/2020
Elektronische ISSN: 1936-0568
DOI: https://doi.org/10.1007/s12105-019-01124-z

Springer Medizin

Noninvasive Follicular Thyroid Neoplasm with Papillary-Like Nuclear Features (NIFTP): An Update

Abstract

Neu im Fachgebiet Pathologie

Molekularpathologische Untersuchungen im Wandel der Zeit

Vergleichende Pathologie in der onkologischen Forschung

Gastrointestinale Stromatumoren

Personalisierte Medizin in der Onkologie

Springer Medizin

Abstract

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