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Aesthetic Plastic Surgery
Erschienen in: Aesthetic Plastic Surgery 5/2007

01.10.2007 | REVIEW

Nonsurgical Management of Hypertrophic Scars: Evidence-Based Therapies, Standard Practices, and Emerging Methods

verfasst von: Bishara S. Atiyeh

Erschienen in: Aesthetic Plastic Surgery | Ausgabe 5/2007

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Abstract

Hypertrophic scars, resulting from alterations in the normal processes of cutaneous wound healing, are characterized by proliferation of dermal tissue with excessive deposition of fibroblast-derived extracellular matrix proteins, especially collagen, over long periods, and by persistent inflammation and fibrosis. Hypertrophic scars are among the most common and frustrating problems after injury. As current aesthetic surgical techniques become more standardized and results more predictable, a fine scar may be the demarcating line between acceptable and unacceptable aesthetic results. However, hypertrophic scars remain notoriously difficult to eradicate because of the high recurrence rates and the incidence of side effects associated with available treatment methods. This review explores the various treatment methods for hypertrophic scarring described in the literature including evidence-based therapies, standard practices, and emerging methods, attempting to distinguish those with clearly proven efficiency from anecdotal reports about therapies of doubtful benefits while trying to differentiate between prophylactic measures and actual treatment methods. Unfortunately, the distinction between hypertrophic scar treatments and keloid treatments is not obvious in most reports, making it difficult to assess the efficacy of hypertrophic scar treatment.
Literatur
1.
Acikel C, Ergun O, Ulkur E, Servet E, Celikoz B (2005) Camouflage of self-inflicted razor blade incision scars with carbon dioxide laser resurfacing and thin skin grafting. Plast Reconstr Surg 116:798PubMedCrossRef
2.
Akita S, Akino K, Imaizumi T, Tanaka K, et al. (2006) The quality of pediatric burn scars is improved by early administration of basic fibroblast growth factor. J Burn Care Res 27:333PubMedCrossRef
3.
Allison KP, Kiernan MN, Waters RA, Clement RM (2003) Pulsed dye laser treatment of burn scars: Alleviation or irritation? Burns 29:207PubMedCrossRef
4.
Apfelberg DB, Maser MR, White DN, Lash H (1989) Failure of carbon dioxide laser excision of keloids. Lasers Surg Med 9:382CrossRefPubMed
5.
Alster T (2003) Laser scar revision: Comparison study of 585-nm pulsed-dye laser with and without intralesional corticosteroids. Dermatol Surg 29:25PubMed
6.
Alster TS (1997) Laser treatment of hypertrophic scars, keloids, and striae. Dermatol Clin 15:419PubMedCrossRef
7.
Alster TS, Handrick C (2000) Laser treatment of hypertrophic scars, keloids, and striae. Semin Cutan Med Surg 19:287PubMedCrossRef
8.
Alster TS, Nanni CA (1998) Pulsed-dye laser treatment of hypertrophic burn scars. Plast Reconstr Surg 102:2190PubMedCrossRef
9.
10.
Amicucci G, Schietroma M, Rossi M, Mazzotta C (2005) Silicone occlusive sheeting vs silicone cushion for the treatment of hypertrophic and keloid scars: A prospective randomized study. Ann Ital Chir 76:79PubMed
11.
Apikian M, Goodman G (2004) Intralesional 5-fluorouracil in the treatment of keloid scars. Australas J Dermatol 45:140PubMedCrossRef
12.
Asilian A, Darougheh A, Shariati F (2006) New combination of triamcinolone, 5-fluorouracil, and pulsed-dye laser for treatment of keloid and hypertrophic scars. Dermatol Surg 32:907PubMed
13.
Atiyeh BS, Al-Amm CA, El-Musa K (2003) Improved scar quality following primary and secondary healing of cutaneous wounds. Aesth Plast Surg 27:411CrossRef
14.
Atiyeh BS, Al-Amm CA, El-Musa KA, Sawwaf A, Dham R (2003) Scar quality and physiologic barrier function restoration following moist and moist exposed dressings of partial thickness wounds. Dematol Surg 29:14
15.
Atiyeh BS, Costagliola M, Hayek SN (2005) Keloid or hypertrophic scar: The controversy: Review of the Literature. Ann Plast Surg 54:676PubMedCrossRef
16.
Atiyeh BS, Ioannovich J, Al-Amm CA, El-Musa KA, Dham R (2002) Improving scar quality: A prospective clinical study. Aesth Plast Surg 26:470CrossRef
17.
Atkinson JA, McKenna KT, Barnett AG, McGrath DJ, Rudd MA (2005) Randomized, controlled trial to determine the efficacy of paper tape in preventing hypertrophic scar formation in surgical incisions that traverse Langer’s skin tension lines. Plast Reconstr Surg 116:1648PubMedCrossRef
18.
Baisch A, Riedel F (2006) Hyperplastic scars and keloids: Part I. Basics and prevention. HNO 54:893PubMedCrossRef
19.
Baum TM, Busuito MJ (1998) Use of a glycerin-based gel sheeting in scar management. Adv Wound Care 11:40PubMed
20.
Baumann LS, Spencer J (1999) The effects of topical vitamin E on the cosmetic appearance of scars. Dermatol Surg 25:311PubMedCrossRef
21.
22.
Behroozan DS, Goldberg LH, Dai T, Geronemus RG, Friedman PM (2006) Fractional photothermolysis for the treatment of surgical scars: A case report. J Cosmet Laser Ther 8:35PubMedCrossRef
23.
Bellew SG, Weiss MA, Weiss RA (2005) Comparison of intense pulsed light to 595-nm long-pulsed pulsed dye laser for treatment of hypertrophic surgical scars: A pilot study. J Drugs Dermatol 4:448PubMed
24.
Berman B, Dunan MR (1989) Short-term keloid treatment in vivo with human interferon α2b results in a selective and persistent normalization of keloid fibroblast collagen, glycosaminoglycan, and collagenase production in vitro. J Am Acad Dermatol 21:694PubMedCrossRef
25.
Berman B, Flores F (1999) Comparison of a silicone gel-filled cushion and silicon gel sheeting for the treatment of hypertrophic or keloid scars. Dermatol Surg 25:484PubMedCrossRef
26.
Berman B, Flores F (1997) Recurrence rates of excised keloids treated with postoperative triamcinolone acetonide injections or interferon alfa-2b injections. J Am Acad Dermatol 37:755PubMedCrossRef
27.
Berman B, Flores F (1998) The treatment of hypertrophic scars and keloids. Eur J Dermatol 8:591PubMed
28.
Beuth J, Hunzelmann N, Van Leendert R, Basten R, et al. (2006) Safety and efficacy of local administration of contractubex to hypertrophic scars in comparison to corticosteroid treatment: Results of a multicenter, comparative epidemiological cohort study in Germany. In Vivo 20:277PubMed
29.
Bock O, Schmid-Ott G, Malewski P, Mrowietz U (2006) Quality of life of patients with keloid and hypertrophic scarring. Arch Dermatol Res 297:433PubMedCrossRef
30.
Bombaro KM, Engrav LH, Carrougher GJ, Wiechman SA, et al. (2003) What is the prevalence of hypertrophic scarring following burns? Burns 29:299PubMedCrossRef
31.
Bonte F, Dumas M, Chaudagne C, Meybeck A (1995) Asiaticoside and madecassoside activity on human fibroblast type I and III collagen. Ann Pharm Franc 53:38PubMed
32.
Borgognoni L, Reali UM (1997) Intralesional hyaluronic acid treatment of pathological scars. Ann Plast Surg 38:308PubMedCrossRef
33.
Bosse JP, Papillon J, Frenette G, Dansereau J, et al. (1979) Clinical study of a new antikeloid agent. Ann Plast Surg 3:13PubMedCrossRef
34.
Boutli-Kasapidou F, Tsakiri A, Anagnostou E, Mourellou O (2005) Hypertrophic and keloidal scars: An approach to polytherapy. Int J Dermatol 44:324PubMedCrossRef
35.
Boyce DE, Bantick G, Murison MS (2000) The use of ADCON-T/N glycosaminoglycan gel in the revision of tethered scars. Br J Plast Surg 53:403PubMedCrossRef
36.
Branagan M, Chenery DH, Nicholson S (2000) Use of the infrared attenuated total reflectance spectroscopy for the in vivo measurement of hydration level and silicone distribution in the stratum corneum following skin coverage by polymeric dressings. Skin Pharmacol Appl Skin Physiol 13:157PubMedCrossRef
37.
Brissett AE, Sherris DA (2001) Scar contractures, hypertrophic scars, and keloids. Facial Plast Surg 17:263PubMedCrossRef
38.
Brown CA (2001) A comparison of the outcomes of two clinical audits of burn pressure garment satisfaction and compliance in Saudi Arabia. Burns 27:342PubMedCrossRef
39.
Burd A, Huang L (2005) Hypertrophic response and keloid diathesis: Two very different forms of scar. Plast Reconstr Surg 116:150ePubMedCrossRef
40.
Carney SA, Cason CG, Gowar JP, Stevenson JH, et al. (1994) Cica care gel sheeting in the management of hypertrophic scarring. Burns 20:163PubMedCrossRef
41.
Chan HH, Wong DS, Ho WS, Lam LK, Wei W (2004) The use of pulsed-dye laser for the prevention and treatment of hypertrophic scars in Chinese persons. Dermatol Surg 30:987PubMedCrossRef
42.
Chan KY, Lau CL, Adeeb SM, Somasundaram S, Nasir-Zahari M (2005) A randomized, placebo-controlled, double-blind, prospective clinical trial of silicone gel in prevention of hypertrophic scar development in median sternotomy wound. Plast Reconstr Surg 116:1013PubMedCrossRef
43.
Chang CC, Kuo YF, Chiu H, Lee JL, et al. (1995) Hydration, not silicone, modulates the effects of keratinocytes on fibroblasts. J Surg Res 59:705PubMedCrossRef
44.
Chang P, Laubenthal KN, Lewis RW, Rosenquist M, et al. (1995) Prospective, randomized study of the efficacy of pressure garment therapy in patients with burns. J Burn Care Rehabil 16:473PubMedCrossRef
45.
Chen MA, Davidson TM (2005) Scar management: Prevention and treatment strategies. Curr Opinion Otolaryngol Head Neck Surg 13:242CrossRef
46.
Cheng JCY, Evans JH, Leung KS, Clark JA, et al. (1984) Pressure therapy in the treatment of postburn hypertrophic scar: A clinical look into its usefulness and fallacies by pressure monitoring. Burns 10:154CrossRef
47.
Chowdri NA, Masarat M, Mattoo A, Darzi MA (1999) Keloids and hypertrophic scars: Results with intraoperative and serial postoperative corticosteroid injection therapy. Aust N Z J Surg 69:655PubMedCrossRef
48.
Chung VQ, Kelley L, Marra D, Jiang SB (2006) Onion extract gel versus petrolatum emollient on new surgical scars: A prospective double-blinded study. Dermatol Surg 32:193PubMed
49.
Collins J (1992) Pressure techniques for the prevention of hypertrophic scar. Clin Plast Surg 19:733
50.
Copcu E, Sivrioglu N, Oztan Y (2004) Combination of surgery and intralesional verapamil injection in the treatment of the keloid. J Burn Care Rehab 25:1CrossRef
51.
Costa AM, Peyrol S, Porto LC, Comparin JP, et al. (1999) Mechanical forces induce scar remodeling study in non–pressure-treated versus pressure-treated hypertrophic scars. Am J Pathol 155:1671PubMedPubMedCentralCrossRef
52.
Costagliola M, Rougé D, Gavroy JP, Ster F (1994) Quantitative and qualitative aspect of the vitro pressure test. 9ème Congrés de l’International Society for Burn Injury, Paris
53.
Cruz-Korchin NI (1996) Effectiveness of silicone sheets in the prevention of hypertrophic breast scars. Ann Plast Surg 37:345PubMedCrossRef
54.
Davey RB, Wallis KA, Bowering K (1991) Adhesive contact media: An update on graft fixation and burn scar management. Burns 17:313PubMedCrossRef
55.
De Cubber J (1998) A silicone elastomer manipulation technique for the production of medical devices. J Facial Somato Prosthetics 4:15
56.
De Cuyper C (2006) Permanent make-up: Indications and complications. Kosmet Med 27:56
57.
De Groot AC, Berretty PMJ, Ginkel GJW, den Henjst CW, et al. (1991) Allergic contact dermatitis from tocopheryl acetate in cosmetic creams. Contact Dermatitis 25:302PubMedCrossRef
58.
De Oliveira GV, Nunes TA, Magna LA, Cintra ML, et al. (2001) Silicone versus nonsilicone gel dressings: A controlled trial. Dermatol Surg 27:721PubMed
59.
Desmoulière A, Regard M, Darby I, Gabbiani G (1995) Apoptosis mediates the decrease in cellularity during the transition between granulation tissue and scar. Am J Pathol 146:56PubMedPubMedCentral
60.
Dinh Q, Veness M, Richards S (2004) Role of adjuvant radiotherapy in recurrent earlobe keloids. Australas J Dermatol 45:162PubMedCrossRef
61.
Dolynchuk KN, Ziesmann M, Serletti JM (1996) Topical putrescine (Fibrostat) in treatment of hypertrophic scars: Phase II study. Plast Reconstr Surg 97:117PubMedCrossRef
62.
Eberlein A, Schepler H, Spilker G, Altmeyer P, Hartmann B (2005) Erbium:YAG laser treatment of post-burn scars: Potentials and limitations. Burns 31:15PubMedCrossRef
63.
Espana A, Solano T, Quintanilla E (2001) Bleomycin in the treatment of keloids and hypertrophic scars by multiple needle punctures. Dermatol Surg 27:23–27PubMed
64.
Esselman PC, Thombs BD, Magyar-Russell G, Fauerbach JA (2006) Burn rehabilitation: State of the science. Am J Phys Med Rehabil 85:383PubMedCrossRef
65.
Feng X, Tan J, Pan Y, Wu Q, et al. (2006) Control of hypertrophic scar from inception by using xenogenic (porcine) acellular dermal matrix (ADM) to cover deep second-degree burn. Burns 32:293PubMedCrossRef
66.
Field T, Peck M, Hernandez-Rief M, Krugman S, et al. (2000) Postburn itching, pain, and psychological symptoms are reduced with massage therapy. J Burn Care Rehabil 21:189PubMedCrossRef
67.
Field T, Peck Krugman S, Tuchel T, Schanberg S, et al. (1998) Burn injuries benefit from massage therapy. J Burn Care Rehabil 19:241PubMedCrossRef
68.
Fitzpatrick RE (1999) Treatment of inflamed hypertrophic scars using intralesional 5-FU. Dermatol Surg 25:224PubMedCrossRef
69.
Fricke NB, Omnell ML, Dutcher KA, Hollender LG, Engrav LH (1999) Skeletal and dental disturbances in children after facial burns and pressure garment use: A 4 year follow up. J Burn Care Rehabil 20:239PubMedCrossRef
70.
Fulton JE Jr (1995) Silicone gel sheeting for the prevention and management of evolving hypertrophic and keloid scars. Dermatol Surg 21:947PubMed
71.
Gailloud-Matthieu MC, Raffoul W, Egloff DV (1999) Hypertrophic scars and keloids: Which therapeutic options today? Rev Med Suisse Romande 119:721PubMed
72.
George WM (1999) Linear lymphatic hypopigmentation after intralesional corticosteroid injection: Report of two cases. Cutis 64:61PubMed
73.
Gerasimenko MIu, Iusova ZhIu, Zenger VG, Kazantseva IA (2005) Differentiated approach to medicine phonophoresis in complex treatment of cicatrical deformations. Vestn Ross Akad Med Nauk 6:29PubMed
74.
Gerow FJ, Hardy SB, Spira M, Law SW (1963) Immersion treatment for burns: An experimental study. Surg Forum 14:32PubMed
75.
Ghahary A, Shen YJ, Scott PG, Tredget EE (1995) Immunolocalization of TGF-beta 1 in human hypertrophic scar and normal dermal tissues. Cytokine 7:184PubMedCrossRef
76.
Gibbons M, Zuker R, Brown M, Candlish S, et al. (1994) Experience with silastic gel sheeting in pediatric scarring. J Burn Care Rehabil 15:69PubMedCrossRef
77.
Gilman TH (2003) Silicone sheet for treatment and prevention of hypertrophic scar: A new proposal for the mechanism of efficacy. Wound Rep Reg 11:235–236CrossRef
78.
Giele HP, Liddiard K, Currie K, Wood FM (1997) Direct measurement of cutaneous pressures generated by pressure garments. Burns 23:137PubMedCrossRef
79.
Giele H, Liddiard K, Booth K, Wood F (1998) Anatomical variations in pressures generated by pressure garments. Plast Reconstr Surg 101:399PubMedCrossRef
80.
Giugliano G, Pasquali D, Notaro A, Brongo S, et al. (2003) Verapamil inhibits interleukin-6 and vascular endothelial growth factor production in primary cultures of keloid fibroblasts. Br J Plast Surg 56:804PubMedCrossRef
81.
Gold MH (1994) A controlled clinical trail of topical silicone gel sheeting in the treatment of hypertrophic scars and keloids. J Am Acad Dermatol 30:506PubMedCrossRef
82.
Gold MH, Foster TD, Adair MA, Burlison K, Lewis T (2001) Prevention of hypertrophic scars and keloids by the prophylactic use of topical silicone gel sheets following a surgical procedure in an office setting. Dermatol Surg 27:641PubMed
83.
Gopinath D, Ahmed MR, Gomathi K (2004) Dermal wound healing processes with curcumin induced collagen films. Biomaterials 25:1911PubMedCrossRef
84.
Govindarajan R, Vijayakumar M, Rao C, Shirwaikar A, et al. (2004) Healing potential of Anogeissus latifolia for dermal wounds in rats. Acta Pharm 54:331PubMed
85.
Hamanova H, Broz L (2002) Topigel in the treatment of hypertrophic scars after burn injuries. Acta Chir Plast 44:18PubMed
86.
Hambleton J, Shakespeare P, Pratt B (1992) The progress of hypertrophic scars monitored by ultrasound measurements of thickness. Burns 18:301PubMedCrossRef
87.
Hanasono MM, Lum J, Carroll LA, Mikulec AA, Koch RJ (2004) The effect of silicone gel on basic fibroblast growth factor levels in fibroblast cell culture. Arch Facial Plast Surg 6:88PubMedCrossRef
88.
Har-Shai Y, Amar M, Sabo E (2003) Intralesional cryotherapy for enhancing the involution of hypertrophic scars and keloids. Plast Reconstr Surg 111:1841PubMedCrossRef
89.
Har-Shai Y, Lindenbaum E, Tendler M, Gamliel-Lazarovich A, et al. (1999) Negatively charged static electricity stimulation as a possible mechanism for enhancing the involution of hypertrophic and keloid scars. Isr Med Assoc J 1:203PubMed
90.
Harumi M, Miyuki N, Hideo M, Kiyokazu K (2001) Effects of clothing pressure exerted on a trunk on heart rate, blood pressure, skin blood flow, and respiratory function. J Textile Mach Soc Jpn 54:57CrossRef
91.
Havlik RJ (1997) Vitamin E and wound healing: Safety and efficacy reports. Plast Reconstr Surg 100:1901PubMedCrossRef
92.
Hirshowitz B, Ullmann Y, Har-Shai Y, Vilenski A, Peled IJ (1993) Silicone occlusive sheeting (SOS) in the management of hypertrophic scarring, including the possible mode of action of silicone, by static electricity. Eur J Plast Surg 16:5CrossRef
93.
Ho WS, Ying SY, Chan PC, Chan HH (2006) Use of onion extract, heparin, allantoin gel in prevention of scarring in Chinese patients having laser removal of tattoos: A prospective randomized controlled trial. Dermatol Surg 32:891PubMed
94.
Holme SA, Beattie PE, Fleming CJ (2002) Cosmetic camouflage advice improves quality of life. Br J Dermatol 147:946PubMedCrossRef
95.
Hulsbergen-Henning JP, Roskam Y, van Gemert MJ (1986) Treatment of keloids and hypertrophic scars with an argon laser. Lasers Surg Med 6:72PubMedCrossRef
96.
Hubbard M, Masters IB, Williams GR, Chang AB (2000) Severe obstructive sleep apnea secondary to pressure garments used in the treatment of hypertrophic burn scars. Eur Respir J 16:1205PubMedCrossRef
97.
Jackson BA, Shelton AJ, McDaniel DH (1999) Pilot study evaluating topical onion extract as treatment for postsurgical scars. Dermatol Surg 25:267PubMedCrossRef
98.
Jaros E, Priborsky J, Klein L (1999) Treatment of keloids and hypertrophic scars with cryotherapy. Acta Medica (Hradec Kralove) Suppl 42:61
99.
Jenkins M, Alexander JW, Mac Millian BG (1986) Failure of topical steroids and vitamin E to reduce postoperative scar formation following reconstructive surgery. J Burn Care Rehabil 7:309PubMedCrossRef
100.
Johnson J, Greenspan B, Gorga D, Nagler W, Goodwin C (1994) Compliance with pressure garment use in burn rehabilitation. J Burn Care Rehabil 15:181CrossRef
101.
Jurjus A, Atiyeh BS, Abdallah IM, Jurjus RA, et al. Pharmacological modulation of wound healing in experimental burns. Burns 2007 in press
102.
Kang N, Sivakumar B, Sanders R, Nduka C, Gault D (2006) Intralesional injections of collagenase are ineffective in the treatment of keloid and hypertrophic scars. J Plast Reconstr Aesthet Surg 59:693PubMedCrossRef
103.
Kapoor M, Howard R, Hall I, Appleton I (2004) Effects of epicatechin gallate on wound healing and scar formation in a full thickness incisional wound healing model in rats. Am J Pathol 165:299PubMedPubMedCentralCrossRef
104.
Katz BE (1995) Silicone gel sheeting in scar therapy. Cutis 56:65PubMed
105.
Khoosal D, Goldman RD (2006) Vitamin E for treating children’s scars: Does it help reduce scarring? Can Family Physician 52:855
106.
Kono T, Ercocen AR, Nakazawa H, Nozaki M (2005) Treatment of hypertrophic scars using a long-pulsed dye laser with cryogen-spray cooling. Ann Plast Surg 54:487PubMedCrossRef
107.
Kopp J, Wang GY, Kulmburg P, Schultze-Mosgau S, et al. (2004) Accelerated wound healing by in vivo application of keratinocytes overexpressing KGF. Mol Ther 10:86PubMedCrossRef
108.
Kosaka M (2004) The current therapy and prevention of hypertrophic scars and keloids. Skin Res 3:628
109.
Kosaka M, Kamiishi H (2001) New concept of balloon-compression wear for the treatment of keloids and hypertrophic scars. Plast Reconstr Surg 108:1454PubMedCrossRef
110.
Kuhn MA, Moffit MR, Smith PD, Lyle WG, et al. (2001) Silicone sheeting decreases fibroblast activity and downregulates TGFbeta2 in hypertrophic scar model. Int J Surg Invest 2:467
111.
Larrabee WF Jr, East CA, Jaffe HS, Stephenson C, Petrson KE (1990) Intralesional interferon [gamma] treatment for keloids and hypertrophic scars. Arch Otolaryngol Head Neck Surg 116:1159PubMedCrossRef
112.
Larson DL, Abston S, Evans EB, Dobrkovsky M, Linares HA (1971) Techniques for decreasing scar formation and contractures in the burned patient. J Trauma 11:807PubMedCrossRef
113.
Larson DL, Abston S, Willis B, Linares HA, et al. (1974) Contracture and scar formation in the burned patient. Clin Plast Surg 1:653PubMed
114.
Lebwohl M (2000) From the literature: Intralesional 5-FU in the treatment of hypertrophic scars and keloids: Clinical experience. J Am Acad Dermatol 42:677PubMedCrossRef
115.
Lee DK, Serkin AL (2004) Carbon dioxide laser and Apligraf for a painful plantar hypertrophic scar. J Am Podiatr Med Assoc 94:61PubMedCrossRef
116.
Lee JP, Jalili RB, Tredget EE, Demare JR, Ghahary A (2005) Antifibrogenic effects of liposome-encapsulated IFN-alpha2b cream on skin wounds in a fibrotic rabbit ear model. J Interferon Cytokine Res 25:627PubMedCrossRef
117.
Lee SM, Ngim CK, Chan YY, Ho MJ (1996) A comparison of Sil-K and Epiderm in scar management. Burns 22:483PubMedCrossRef
118.
LeVier RR, Harrison MC, Cook RR, Lane TH (1993) What is silicone? Plast Reconstr Surg 92:163PubMed
119.
Leung K, Cheng J, Ma G, Clark J, Leung P (1984) Complications of pressure therapy for postburn hypertrophic scar. Burns 10:434CrossRef
120.
Leung PC, Ng M (1980) Pressure therapy for hypertrophic scars resulting from burns. Burns 6:244CrossRef
121.
Leung P, Ng M (1980) Pressure treatment for hypertrophic scars resulting from burns. Burns 6:244CrossRef
122.
123.
Linares HA, Larson DL, Willis-Galstaun BA (1993) Historical notes on the use of pressure in the treatment of hypertrophic scars or keloids. Burns 19:17PubMedCrossRef
124.
Loladze M, Alibegashvili M, Turmanidze TS, Iashvili B, et al. (2005) Use of bilidase for the treatment of experimental hypertrophic postburn cicatrices. Bull Exp Biol Med 139:98PubMedCrossRef
125.
Lu L, Saulis AS, Liu WR, Roy NK, et al. (2005) The temporal effects of anti-TGF-beta1, -2, and -3 monoclonal antibody on wound healing and hypertrophic scar formation. J Am College Surg 201:391CrossRef
126.
127.
Macintyre L, Baird M (2006) Pressure garments for use in the treatment of hypertrophic scars: A review of the problems associated with their use. Burns 32:10PubMedCrossRef
128.
Magliaro A, Gianfaldoni R, Cervadoro G (1999) Treatment of burn scars with a gel based on allantoin and sulfomucopolysaccharides. G Ital Dermatol Venereol 134:153
129.
Majan JI (2006) Evaluation of a self-adherent soft silicone dressing for the treatment of hypertrophic postoperative scars. J Wound Care 15:193PubMedCrossRef
130.
Malaker K, Vijayraghavan K, Hodson I, Al Yafi T (2004) Retrospective analysis of treatment of unresectable keloid with primary radiation over 25 years. Clin Oncol (R Coll Radiol) 16:290CrossRef
131.
Malick MH, Carr JA (1980) Flexible elastomer molds in burn scar control. Am J Occup Ther 34:603PubMedCrossRef
132.
Manuskiatti W, Fitzpatrick RE (2002) Treatment response of keloidal and hypertrophic sternotomy scars: Comparison among intralesional corticosteroid, 5-fluorouracil, and 585-nm flashlamp-pumped pulsed-dye laser treatments. Arch Dermatol 138:1149PubMedCrossRef
133.
Martin A (1996) The use of antioxidants in healing. Dermatol Surg 22:156PubMed
134.
McCraw JB, McCraw JA, McMellin A, Bettencourt N (1999) Prevention of unfavorable scars using early pulse-dye laser treatments: A preliminary report. Ann Plast Surg 42:7PubMedCrossRef
135.
Meier K, Nanney LB (2006) Emerging new drugs for scar reduction. Expert Opin Emerging Drugs 11:39CrossRef
136.
Meshkinpour A, Ghasri P, Pope K, Lyubovitsky JG, et al. (2005) Treatment of hypertrophic scars and keloids with a radiofrequency device: A study of collagen effects. Lasers Surg Med 37:343PubMedCrossRef
137.
Miller J, Hardy SB, Spira M (1965) Treatment of burns of the hand with silicone dressing and early motion: Preliminary report. J Bone Joint Surg 47:938PubMed
138.
Miller MC, Nanchahal J (2005) Advances in the modulation of cutaneous wound healing and scarring. BioDrugs 19:363PubMedCrossRef
139.
Mizutani H, Yoshida T, Nouchi N, Hamanaka H, Shimizu M (1999) Topical tocoretinate improved hypertrophic scar, skin sclerosis in systemic sclerosis, and morphea. J Dermatol 26:11–17PubMedCrossRef
140.
Murison M, James W (2006) Preliminary evaluation of the efficacy of Dermatix silicone gel in the reduction of scar elevation and pigmentation. J Plast Reconstr Aesthetic Surg 59:437CrossRef
141.
Musgrave M, Umraw N, Fish J, Gomez M, et al. (2002) The effect of silicone gel sheets on perfusion of hypertrophic burn scars. J Burn Care Rehab 23:208CrossRef
142.
Mustoe TA, Cooter RD, Gold MH, Hobbs FD, et al. (2002) International clinical recommendations on scar management. Plast Reconstr Surg 110:560PubMedCrossRef
143.
Mutalik S (2005) Treatment of keloids and hypertrophic scars. Indian J Dermatol Venereol Leprol 71:3PubMedCrossRef
144.
Nachbar F, Korting HC (1995) The role of vitamin E in normal and damaged skin. J Mol Med 73:7PubMedCrossRef
145.
Naeini FF, Najafian J, Ahmadpour K (2006) Bleomycin tattooing as a promising therapeutic modality in large keloids and hypertrophic scars. Dermatol Surg 32:1023PubMed
146.
Nakaoka H, Miyauchi S, Miki Y (1995) Proliferating activity of dermal fibroblasts in keloids and hypertrophic scars. Acta Derm Venereol 75:102PubMed
147.
Nedelec B, Ghahary A, Scott P, Tredget E (2000) Control of wound contraction: Basic and clinical features. Hand Clin 16:289PubMed
148.
Niessen F, Spauwen P, Robinson P, Fidler V, Kon M (1998) The use of silicone occlusive sheeting (Sil-K) and silicone occlusive gel (Epiderm) in the prevention of hypertrophic scar formation. Plast Reconstr Surg 102:1962PubMedCrossRef
149.
Niessen FB, Spauwen PHM, Schalkwijk J, Kon M (1999) On the nature of hypertrophic scars and keloids: A review. Plast Reconstr Surg 104:1435PubMedCrossRef
150.
Nikkonen MM, Pitkanen JM, Al-Qattan MM (2001) Problems associated with the use of silicone gel sheeting for hypertrophic scars in the hot climate of Saudi Arabia. Burns 27:498PubMedCrossRef
151.
Norris JE (1991) The effect of carbon dioxide laser surgery on the recurrence of keloids. Plast Reconstr Surg 87:44PubMedCrossRef
152.
Norris JEC (1995) Superficial X-ray therapy in keloid management: A retrospective study of 24 cases and literature review. Plast Reconstr Surg 95:1051PubMedCrossRef
153.
154.
O’Brien L, Pandit A (2006) Silicon gel sheeting for preventing and treating hypertrophic and keloid scars. Cochrane Database Syst Rev 25(1):CD003826
155.
Ogawa R, Mitsuhashi K, Hyakusoku H, Miyashita T (2003) Postoperative electron-beam irradiation therapy for keloids and hypertrophic scars: Retrospective study of 147 cases followed for more than 18 months. Plast Reconstr Surg 111:547PubMedCrossRef
156.
Panin G, Strumia R, Ursini F (2004) Topical alpha-tocopherol acetate in the bulk phase: Eight years of experience in skin treatment. Ann N Y Acad Sci 1031:443PubMedCrossRef
157.
Patino O, Novick C, Merlo A, Benaim F (1999) Massage in hypertrophic scars. J Burn Care Rehabil 20:268PubMed
158.
Patterson RP, Fisher SV (1979) The accuracy of electrical transducers for the measurement of pressure applied to the skin. IEEE Trans Biomed Eng 26:450PubMedCrossRef
159.
Peacock EE, Madden JW, Trier WC (1970) Biologic basis for treatment of keloids and hypertrophic scar. South Med J 63:755PubMedCrossRef
160.
Pekins K, Davey RB, Wallis KA (1982) Silicone gel: A new treatment for burn scars and contractures. Burns 9:201CrossRef
161.
Phan TT, Lim IJ, Chan SY, Tan EK, et al. (2004) Signaling in keloid-derived fibroblasts by quercetin/smad signaling in keloid-derived fibroblasts by quercetin: Implications for the treatment of excessive scars. J Trauma 57:1032PubMedCrossRef
162.
Poveda A, Campech M, Gavroy JP, Ster F (1998) Le massage «en brûlure»: Formes topographiques et chronologiques. 18 Congrés de la Société Française d’Etude et de Traitement de la Brûlure, SFETB, Saint Gervais
163.
164.
Quinn KJ, Evans JH, Courtney JM, Gaylor JD, Reid WH (1985) Nonpressure treatment of hypertrophic scars. Burns Incl Therm Inj 12:102PubMedCrossRef
165.
Rawlins JM, Lam WL, Karoo RO, Naylor IL, Sharpe DT (2006) Pentoxifylline inhibits mature burn scar fibroblasts in culture. Burns 32:42PubMedCrossRef
166.
Rayner K (2000) The use of pressure therapy to treat hypertrophic scarring. J Wound Care 9:151PubMedCrossRef
167.
Reid WH, Evans JH, Naismith RS, Tully AE, Sherwin S (1987) Hypertrophic scarring and pressure therapy. Burns 13:S29CrossRef
168.
Reno F, Sabbatini M, Stella M, Magliacani G, Cannas M (2005) Effect of in vitro mechanical compression on Epilysin (matrix metalloproteinase-28) expression in hypertrophic scars. Wound Repair Regen 13:255PubMedCrossRef
169.
Reiken SR, Wolfort SF, Berthiaume F, Compton C, et al. (1997) Control of hypertrophic scar growth using selective photothermolysis. Lasers Surg Med 21:7PubMedCrossRef
170.
Reiffel RS (1995) Prevention of hypertrophic scars by long-term paper tape application. Plast Reconstr Surg 96:1715PubMedCrossRef
171.
Remlinger KA (2003) Cutaneous reactions to chemotherapy drugs: The art of consultation. Arch Dermatol 139:77PubMedCrossRef
172.
Reno F, Grazianetti P, Cannas M (2001) Effects of mechanical compression on hypertrophic scars: Prostaglandin E2 release. Burns 27:215PubMedCrossRef
173.
Reno F, Sabbatini M, Lombardi F, Stella M, et al. (2003) In vitro mechanical compression induces apoptosis and regulates cytokines release in hypertrophic scars. Wound Rep Reg 11:331CrossRef
174.
Ricketts CH, Martin L, Faria DT, Saed GM, Fivenson DP (1996) Cytokine mRNA changes during the treatment of hypertrophic scars with silicone and nonsilicone gel dressings. Dermatol Surg 22:955PubMed
175.
Rockwell WB, Cohen IK, Ehrlich HP (1989) Keloids and hypertrophic scars: A comprehensive review. Plast Reconstr Surg 84:827PubMedCrossRef
176.
177.
Rose MP, Deitch EA (1985) The clinical use of a tubular compression bandage, Tubigrip, for burn-scar therapy: A critical analysis. Burns 12:58CrossRef
178.
Roseborough IE, Grevious MA, Lee RC (2004) Prevention and treatment of excessive dermal scarring. J Natl Med Assoc 96:108PubMedPubMedCentral
179.
Rusciani L, Rossi G, Bono R (1993) Use of cryotherapy in the treatment of keloids. J Dermatol Surg Oncol 19:529PubMedCrossRef
180.
Sanders KW, Gage-White L, Stucker FJ (2005) Topical mitomycin C in the prevention of keloid scar recurrence. Arch Facial Plast Surg 7:172PubMedCrossRef
181.
Saray Y, Gulec AT (2005) Treatment of keloids and hypertrophic scars with dermojet injections of bleomycin: A preliminary study. Int J Dermatol 44:777PubMedCrossRef
182.
Saulis A, Mogford JH, Mustoe TA (2002) Effect of Mederma on hypertrophic scarring in the rabbit ear model. Plast Reconstr Surg 110:177PubMedCrossRef
183.
Sawada Y, Urushidate S, Nihei Y (1998) Hydration and occlusive treatment of a sutured wound. Ann Plast Surg 41:508PubMedCrossRef
184.
Sawada Y, Sone K (1990) Treatment of scars and keloids with a cream containing silicone oil. Br J Plast Surg 43:683PubMedCrossRef
185.
Sawada Y, Sone K (1992) Hydration and occlusion treatment for hypertrophic scars and keloids. Br J Plast Surg 45:599PubMedCrossRef
186.
Schmidt A, Gassmueller J, Hughes-Formella B, Bielfeldt S (2001) Treating hypertrophic scars for 12 or 24 hours with a self-adhesive hydroactive polyurethane dressing. J Wound Care 10:149PubMedCrossRef
187.
Schultze-Mosgau S, Blaese MA, Grabenbauer G, Wehrhan F, et al. (2004) Smad-3 and Smad-7 expression following anti-transforming growth factor beta 1 (TGFbeta1)-treatment in irradiated rat tissue. Radiother Oncol 70:249PubMedCrossRef
188.
Shakespeare PG, van Reeterghem L (1985) Some observations on the surface structure of collagen in hypertrophic scars. Burns 11:175CrossRef
189.
Sheridan RL, MacMillan K, Donelan M, Choucair R, et al. (1997) Tunable dye laser neovessel ablation as an adjunct to the management of hypertrophic scarring in burned children: Pilot trial to establish safety. J Burn Care Rehabil 18:317PubMedCrossRef
190.
Sherris DA, Larrabee WF Jr, Murakami CS (1995) Management of scar contractures, hypertrophic scars, and keloids. Otolaryngol Clin North Am 28:1057PubMed
191.
Shmoilov AM, Rudenskaya GN, Isaev VA, Baydakov AV, et al. (2006) A comparative study of collagenase complex and new homogeneous collagenase preparations for scar treatment. J Drug Deliv Sci Technol 16:285CrossRef
192.
Silfen R, Amir A, Hauben DJ, Calderon S (2001) Effect of facial pressure garments for burn injury in adult patients after orthodontic treatment. Burns 27:409CrossRefPubMed
193.
Slemp AE, Kirschner RE (2006) Keloids and scars: A review of keloids and scars, their pathogenesis, risk factors, and management. Curr Opin Pedatr 18:396CrossRef
194.
Smeets L, Grandjean F-X, Nickers P, Deleuze J-P, et al. (2006) How I treat fibroproliferative scars. Rev Med Liege 61:11PubMed
195.
So K, Umraw N, Scott J, Campbell K, et al. (2003) Effects of enhanced patient education on compliance with silicone gel sheeting and burn scar outcome: A randomized prospective study. J Burn Care Rehabil 24:411PubMedCrossRef
196.
Sproat JE, Dalcin A, Weitauer N, Roberts RS (1992) Hypertrophic sternal scars: Silicone gel sheeting versus kenalog injection treatment. Plast Reconstr Surg 90:988PubMedCrossRef
197.
Staley MJ, Richard RL (1997) Use of pressure to treat hypertrophic burn scars. Adv Wound Care 10:44PubMed
198.
Stewart R, Bhagwanjee AM, Mbakaza Y, Binase T (2000) Pressure garment adherence in adult patients with burn injuries: An analysis of patient and clinician perceptions. Am J Occup Ther 54:598PubMedCrossRef
199.
Su CW, Alizadeh K, Boddie A, Lee RC (1998) The problem scar. Clin Plast Surg 25:451PubMed
200.
Suetak T, Sasai S, Zhen YX, Tagami H (2000) Effects of silicone gel sheet on the stratum corneum hydration. Br J Plast Surg 53:503PubMedCrossRef
201.
Sumitra M, Manikandau P, Suguna L (2005) Efficacy of Butea monosperma on dermal wounds in rats. Int J Biochem Cell Biol 37:566PubMedCrossRef
202.
Tredget EE, Nedelec B, Scott PG, Ghahary A (1997) Hypertrophic scars, keloids, and contractures: The cellular and molecular basis for therapy. Surg Clin North Am 77:701PubMedCrossRef
203.
Tredget EE, Shankowsky HA, Pannu R, Nedelec B, et al. (1998) Transforming growth factor-beta in thermally injured patients with hypertrophic scars: Effects of interferon alpha-2b. Plast Reconstr Surg 102:1317PubMedCrossRef
204.
Tredget EE, Wang R, Shen Q, Scott PG, Ghahary A (2000) Transforming growth factor-beta mRNA and protein in hypertrophic scar tissues and fibroblasts: Antagonism by IFN-alpha and IFN-gamma in vitro and in vivo. J Interferon Cytokine Res 20:143PubMedCrossRef
205.
Tsubota A, Chayama K, Ikeda K, Yasuji A, et al. (1994) Factors predictive of response to interferon-alpha therapy in hepatitis C virus infection. Hepatology 19:1080CrossRef
206.
Tuan T, Nichter LS (1998) The molecular basis of keloid and hypertrophic scar formation. Mol Med Today 1:19CrossRef
207.
Urioste SS, Arndt KA, Dover JS (1999) Keloids and hypertrophic scars: Review and treatment strategies. Semin Cutan Med Surg 18:159PubMedCrossRef
208.
Van den Kerckhove E, Stappaerts K, Boeckx W, Van den Hof B, et al. (2001) Silicones in the rehabilitation of burns: A review and overview. Burns 27:205PubMedCrossRef
209.
Van den Kerckhove E, Stappaerts K, Fieuws S, Laperre J, et al. (2005) The assessment of erythema and thickness on burn related scars during pressure garment therapy as a preventive measure for hypertrophic scarring. Burns 31:696PubMedCrossRef
210.
Ward RS (1991) Pressure therapy for the control of hypertrophic scar formation after burn injury: A history and review. J Burn Care Rehabil 12:257PubMedCrossRef
211.
Widgerow AD, Chait LA, Stals R, Stals PJ (2000) New innovations in scar management. Aesth Plast Surg 24:227CrossRef
212.
Wu J-X, Liu Q-S, Zhou X-L, Qin W, et al. (2005) Primary observation of therapeutic effect of collagenase on hypertrophic scar. Chin J Clin Rehab 38:168
213.
214.
Yii NW, Frame JD (1996) Evaluation of cynthaskin and topical steroid in the treatment of hypertrophic scars and keloids. Eur J Plast Surg 19:162CrossRef
215.
Yosipovitch G, Widijanti Sugeng M, Goon A (2001) A comparison of the combined effect of cryotherapy and corticosteroid injections versus corticosteroids and cryotherapy on keloids: A controlled study. J Dermatol Treat 12:87CrossRef
216.
Ziegler UE (2004) International clinical recommendations on scar management. Zentralbl. Chir 129:296PubMedCrossRef
Metadaten
Titel
Nonsurgical Management of Hypertrophic Scars: Evidence-Based Therapies, Standard Practices, and Emerging Methods
verfasst von
Bishara S. Atiyeh
Publikationsdatum
01.10.2007
Erschienen in
Aesthetic Plastic Surgery / Ausgabe 5/2007
Print ISSN: 0364-216X
Elektronische ISSN: 1432-5241
DOI
https://doi.org/10.1007/s00266-006-0253-y

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