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Current Oncology Reports

Erschienen in:

01.11.2019 | Melanoma (RJ Sullivan, Section Editor)

Novel Immunotherapy Combinations

verfasst von: Babar Bashir, Melissa A. Wilson

Erschienen in: Current Oncology Reports | Ausgabe 11/2019

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Abstract

Purpose of Review

The last decade witnessed an explosion in immunotherapeutic agent approvals for various malignancies. The success of immune checkpoint inhibitors (CTLA-4 and PD-1/PD-L1) in melanoma quickly sprung to other cancer types and are considered the emerging face of oncology.

Recent Findings

Antibodies to CTLA-4 were first to enter the field, quickly followed by PD-1/PD-L1 inhibitors. Combination anti-CTLA4 and anti-PD-1/PD-L1 therapies were investigated, and after demonstrating improved responses, rapidly gained approval. Certain tumor types previously considered non-immunogenic also demonstrated durable responses which has been a remarkable discovery. However, not all tumor types respond to immunotherapies and it is widely recognized that tumor-specific immune inflammatory status predicts the best responders. Ongoing translational work indicates specific upregulation in additional immune checkpoints that circumvent response to anti-CTLA4 and anti-PD-1/PD-L1 antibodies.

Summary

Here, we provide a comprehensive review of promising therapies on the horizon with unique combinations designed to overcome resistance or expand the pool of treatment responders.

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Titel: Novel Immunotherapy Combinations
verfasst von: Babar Bashir
Melissa A. Wilson
Publikationsdatum: 01.11.2019
Verlag: Springer US
Erschienen in: Current Oncology Reports / Ausgabe 11/2019
Print ISSN: 1523-3790
Elektronische ISSN: 1534-6269
DOI: https://doi.org/10.1007/s11912-019-0851-x

Die Highlights vom Kongress des American College of Cardiology 2024

Springer Medizin

Novel Immunotherapy Combinations

Abstract

Purpose of Review

Recent Findings

Summary

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Die Highlights vom Kongress des American College of Cardiology 2024

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Abstract

Purpose of Review

Recent Findings

Summary

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