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Clinical and Translational Oncology

Erschienen in:

01.03.2013 | EDUCATIONAL SERIES – BLUE SERIES

Novel insight into the role of GAPDH playing in tumor

verfasst von: Chunmei Guo, Shuqing Liu, Ming-Zhong Sun

Erschienen in: Clinical and Translational Oncology | Ausgabe 3/2013

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Abstract

The role of glyceraldehyde-3-phosphate dehydrogenase (GAPDH) being consistently regarded as the main housekeeping gene and reference gene/protein for expression quantification in tumors has been gradually questioned and challenged by accumulated experiment evidence. The current review notified that the GAPDH expression was deregulated in lung cancer, renal cancer, breast cancer, gastric cancer, glioma, liver cancer, colorectal cancer, melanoma, prostatic cancer, pancreatic cancer and bladder cancer. Interestingly, GAPDH was commonly up-regulated in a variety of types of cancer, which was revealed to be potentially required for the cancer cell growth and tumor formation. The relevant mechanisms were also discussed in current review. This work might provide useful insights for future studies on GAPDH in tumors.

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Titel: Novel insight into the role of GAPDH playing in tumor
verfasst von: Chunmei Guo
Shuqing Liu
Ming-Zhong Sun
Publikationsdatum: 01.03.2013
Verlag: Springer Milan
Erschienen in: Clinical and Translational Oncology / Ausgabe 3/2013
Print ISSN: 1699-048X
Elektronische ISSN: 1699-3055
DOI: https://doi.org/10.1007/s12094-012-0924-x

Springer Medizin

Novel insight into the role of GAPDH playing in tumor

Abstract

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