Skip to main content
Erschienen in: Supportive Care in Cancer 3/2005

01.03.2005 | Original Article

Nutritional status of cancer patients and its relationship to function in an inpatient rehabilitation setting

verfasst von: Ying Guo, J. Lynn Palmer, Guddi Kaur, Susan Hainley, Beth Young, Eduardo Bruera

Erschienen in: Supportive Care in Cancer | Ausgabe 3/2005

Einloggen, um Zugang zu erhalten

Abstract

Background

Malnutrition is associated with prolonged hospitalization, lower survival rate, and various medical complications. However, little is known about malnutrition and its relationship with the functional status. We undertook this retrospective study to examine whether or not malnutrition affects rehabilitation outcome in patients who had undergone cancer rehabilitation.

Methods

We conducted a review of the charts of 30 consecutive cancer patients who had been admitted to the inpatient rehabilitation unit in a tertiary cancer center, from the beginning of March 2001 to the end of April 2001.

Results

The patients’ mean rehabilitation stay was 9 days and their mean age was 58 years (range 22–86 years). On rehabilitation admission, 15 of the patients (50%) had a below normal prealbumin (<18 mg/dl) level (95% confidence interval 31–69%), and on discharge 10 of the patients (33%) had a below normal prealbumin level (95% CI 17–54%). The serum prealbumin concentration level correlated with motor functional independence measure scores on admission. After inpatient rehabilitation, statistically significant gains in functional independence measure scores (P<0.0001) were obtained in patients with below normal admission prealbumin, as well as in those whose prealbumin levels were within the normal range; no statistically significant difference was found in functional gain between these two groups.

Conclusion

Our study showed that a large number of cancer rehabilitation patients had malnutrition. Nevertheless, functional gain was achieved in all patients after rehabilitation, whether or not malnutrition was present. We conclude that malnourished patients should still be considered candidates for rehabilitation.
Literatur
1.
Zurück zum Zitat Aisner J, Hiponia D, Conley B, et al (1995) Combined modalities in the treatment of head and neck cancers. Semin Oncol 22 [3 Suppl 6]:28–34 Aisner J, Hiponia D, Conley B, et al (1995) Combined modalities in the treatment of head and neck cancers. Semin Oncol 22 [3 Suppl 6]:28–34
2.
Zurück zum Zitat Ardies CM (2002) Exercise, cachexia, and cancer therapy: a molecular rationale. Nutr Cancer 42:143–157CrossRefPubMed Ardies CM (2002) Exercise, cachexia, and cancer therapy: a molecular rationale. Nutr Cancer 42:143–157CrossRefPubMed
3.
Zurück zum Zitat Beck FK, Rosenthal TC (2002) Pre-albumin: a marker for nutritional evaluation. Am Fam Physician 65:1575–1578PubMed Beck FK, Rosenthal TC (2002) Pre-albumin: a marker for nutritional evaluation. Am Fam Physician 65:1575–1578PubMed
5.
Zurück zum Zitat Breitbart W, Rosenfeld B, Pessin H, et al (2000) Depression, hopelessness, and desire for hastened death in terminally ill patients with cancer. JAMA 284:2907–2911CrossRefPubMed Breitbart W, Rosenfeld B, Pessin H, et al (2000) Depression, hopelessness, and desire for hastened death in terminally ill patients with cancer. JAMA 284:2907–2911CrossRefPubMed
6.
Zurück zum Zitat Briassoulis G, Zavras N, Hatzis T (2001) Malnutrition, nutritional indices, and early enteral feeding in critically ill children. Nutrition 17:548–557CrossRefPubMed Briassoulis G, Zavras N, Hatzis T (2001) Malnutrition, nutritional indices, and early enteral feeding in critically ill children. Nutrition 17:548–557CrossRefPubMed
7.
8.
Zurück zum Zitat Cozzaglio L, Balzola F, Cosentino F, et al (1997) Outcome of cancer patients receiving home parenteral nutrition. Italian Society of Parenteral and Enteral Nutrition (SINPE). JPEN J Parenter Enteral Nutr 21:339–342PubMed Cozzaglio L, Balzola F, Cosentino F, et al (1997) Outcome of cancer patients receiving home parenteral nutrition. Italian Society of Parenteral and Enteral Nutrition (SINPE). JPEN J Parenter Enteral Nutr 21:339–342PubMed
9.
Zurück zum Zitat Crogan NL, Pasvogel A (2003) The influence of protein-calorie malnutrition on quality of life in nursing homes. J Gerontol A Biol Sci Med Sci 58:159–164PubMed Crogan NL, Pasvogel A (2003) The influence of protein-calorie malnutrition on quality of life in nursing homes. J Gerontol A Biol Sci Med Sci 58:159–164PubMed
10.
Zurück zum Zitat Elhasid R, Laor A, Lischinsky S, et al (1999) Nutritional status of children with solid tumors. Cancer 86:119–125CrossRefPubMed Elhasid R, Laor A, Lischinsky S, et al (1999) Nutritional status of children with solid tumors. Cancer 86:119–125CrossRefPubMed
11.
Zurück zum Zitat Granger CV (1998) The emerging science of functional assessment: our tool for outcomes analysis. Arch Phys Med Rehabil 79:235–240CrossRefPubMed Granger CV (1998) The emerging science of functional assessment: our tool for outcomes analysis. Arch Phys Med Rehabil 79:235–240CrossRefPubMed
12.
Zurück zum Zitat Hamilton BB, Laughlin JA, Granger CV, et al (1991) Interrater agreement of the seven level Functional Independence Measure (FIM). Arch Phys Med Rehabil 71:790 Hamilton BB, Laughlin JA, Granger CV, et al (1991) Interrater agreement of the seven level Functional Independence Measure (FIM). Arch Phys Med Rehabil 71:790
13.
Zurück zum Zitat Hamilton BB, Deutsch A, Russell C, et al (1999) Relation of disability costs to function: spinal cord injury. Arch Phys Med Rehabil 80:385–391CrossRefPubMed Hamilton BB, Deutsch A, Russell C, et al (1999) Relation of disability costs to function: spinal cord injury. Arch Phys Med Rehabil 80:385–391CrossRefPubMed
14.
Zurück zum Zitat Humphreys J, de la Maza P, Hirsch S, et al (2002) Muscle strength as a predictor of loss of functional status in hospitalized patients. Nutrition 18:616–620CrossRefPubMed Humphreys J, de la Maza P, Hirsch S, et al (2002) Muscle strength as a predictor of loss of functional status in hospitalized patients. Nutrition 18:616–620CrossRefPubMed
15.
Zurück zum Zitat Karnofsky DA, Abelmann WH, Craver LF, et al (1948) The use of nitrogen mustards in the palliative treatment of carcinoma. Cancer 1:634–656 Karnofsky DA, Abelmann WH, Craver LF, et al (1948) The use of nitrogen mustards in the palliative treatment of carcinoma. Cancer 1:634–656
16.
Zurück zum Zitat Keith RA, Granger CV, Hamilton BB, et al (1987) The Functional Independence Measure: a new tool for rehabilitation. In: Eisenberg MG, Grzesiak RC (eds) Advances in clinical rehabilitation. Springer, New York, pp 6–18 Keith RA, Granger CV, Hamilton BB, et al (1987) The Functional Independence Measure: a new tool for rehabilitation. In: Eisenberg MG, Grzesiak RC (eds) Advances in clinical rehabilitation. Springer, New York, pp 6–18
17.
Zurück zum Zitat Kidd D, Stewart G, Baldry J, et al (1995) The Functional Independence Measure: a comparative validity and reliability study. Disabil Rehabil 17:10–14PubMed Kidd D, Stewart G, Baldry J, et al (1995) The Functional Independence Measure: a comparative validity and reliability study. Disabil Rehabil 17:10–14PubMed
18.
Zurück zum Zitat Kretser AJ, Voss T, Kerr WW, et al (2003) Effects of two models of nutritional intervention on homebound older adults at nutritional risk. J Am Diet Assoc 103:329–336CrossRefPubMed Kretser AJ, Voss T, Kerr WW, et al (2003) Effects of two models of nutritional intervention on homebound older adults at nutritional risk. J Am Diet Assoc 103:329–336CrossRefPubMed
19.
Zurück zum Zitat Kurugol Z, Egemen A, Cetingul N, et al (1997) Early determination of nutritional problems in pediatric cancer patients. Turk J Pediatr 39:325–334PubMed Kurugol Z, Egemen A, Cetingul N, et al (1997) Early determination of nutritional problems in pediatric cancer patients. Turk J Pediatr 39:325–334PubMed
20.
Zurück zum Zitat Lai SL, Perng RP (1998) Impact of nutritional status on the survival of lung cancer patients. Chin Med J (Engl) 61:134–140 Lai SL, Perng RP (1998) Impact of nutritional status on the survival of lung cancer patients. Chin Med J (Engl) 61:134–140
21.
Zurück zum Zitat Mears E (1996) Outcomes of continuous process improvement of a nutritional care program incorporating serum pre-albumin measurements. Nutrition 12:479–484CrossRefPubMed Mears E (1996) Outcomes of continuous process improvement of a nutritional care program incorporating serum pre-albumin measurements. Nutrition 12:479–484CrossRefPubMed
22.
Zurück zum Zitat Mittman N, Avram MM, Oo KK, et al (2001) Serum pre-albumin predicts survival in hemodialysis and peritoneal dialysis: 10 years of prospective observation. Am J Kidney Dis 38:1358–1364PubMed Mittman N, Avram MM, Oo KK, et al (2001) Serum pre-albumin predicts survival in hemodialysis and peritoneal dialysis: 10 years of prospective observation. Am J Kidney Dis 38:1358–1364PubMed
23.
Zurück zum Zitat Nelson ME, Layne JE, Bernstein MJ, et al (2004) The effects of multidimensional home-based exercise on functional performance in elderly people. J Gerontol A Biol Sci Med Sci 59:154–160PubMed Nelson ME, Layne JE, Bernstein MJ, et al (2004) The effects of multidimensional home-based exercise on functional performance in elderly people. J Gerontol A Biol Sci Med Sci 59:154–160PubMed
24.
Zurück zum Zitat Nucci M, Anaissie EJ, Queiroz-Telles F, et al (2003) Outcome predictors of 84 patients with hematologic malignancies and Fusarium infection. Cancer 98:315–319CrossRefPubMed Nucci M, Anaissie EJ, Queiroz-Telles F, et al (2003) Outcome predictors of 84 patients with hematologic malignancies and Fusarium infection. Cancer 98:315–319CrossRefPubMed
25.
Zurück zum Zitat Ollenschlager G, Viell B, Thomas W, et al (1991) Tumor anorexia: causes, assessment, treatment. Recent Results Cancer Res 121:249–259PubMed Ollenschlager G, Viell B, Thomas W, et al (1991) Tumor anorexia: causes, assessment, treatment. Recent Results Cancer Res 121:249–259PubMed
26.
Zurück zum Zitat Ottery FD (1995) Supportive nutrition to prevent cachexia and improve quality of life. Semin Oncol 22 [2 Suppl 3]:98–111 Ottery FD (1995) Supportive nutrition to prevent cachexia and improve quality of life. Semin Oncol 22 [2 Suppl 3]:98–111
27.
Zurück zum Zitat Pallicino P, Snyder W, Granger C (1992) The NIH Stroke Scale and the FIM in stroke rehabilitation. Stroke 23:919 Pallicino P, Snyder W, Granger C (1992) The NIH Stroke Scale and the FIM in stroke rehabilitation. Stroke 23:919
28.
Zurück zum Zitat Payette H, Boutier V, Coulombe C, et al (2002) Benefits of nutritional supplementation in free-living, frail, undernourished elderly people: a prospective randomized community trial. J Am Diet Assoc 102:1088–1095CrossRefPubMed Payette H, Boutier V, Coulombe C, et al (2002) Benefits of nutritional supplementation in free-living, frail, undernourished elderly people: a prospective randomized community trial. J Am Diet Assoc 102:1088–1095CrossRefPubMed
29.
Zurück zum Zitat Potter MA, Luxton G (1999) Pre-albumin measurement as a screening tool for protein calorie malnutrition in emergency hospital admissions: a pilot study. Clin Invest Med 22:44–52PubMed Potter MA, Luxton G (1999) Pre-albumin measurement as a screening tool for protein calorie malnutrition in emergency hospital admissions: a pilot study. Clin Invest Med 22:44–52PubMed
30.
Zurück zum Zitat Sabers SR, Kokal JE, Girardi JC, et al (1999) Evaluation of consultation-based rehabilitation for hospitalized cancer patients with functional impairment. Mayo Clinic Proc 74:855–861 Sabers SR, Kokal JE, Girardi JC, et al (1999) Evaluation of consultation-based rehabilitation for hospitalized cancer patients with functional impairment. Mayo Clinic Proc 74:855–861
31.
Zurück zum Zitat Scott C, Sause WT, Byhardt R, et al (1997) Recursive partitioning analysis of 1592 patients on four Radiation Therapy Oncology Group studies in inoperable non-small cell lung cancer. Lung Cancer 17 [Suppl 1]:S59–74 Scott C, Sause WT, Byhardt R, et al (1997) Recursive partitioning analysis of 1592 patients on four Radiation Therapy Oncology Group studies in inoperable non-small cell lung cancer. Lung Cancer 17 [Suppl 1]:S59–74
32.
Zurück zum Zitat Smale BF, Mullen JL, Buzby GP, et al (1981) The efficacy of nutritional assessment and support in cancer surgery. Cancer 47:2375–2381PubMed Smale BF, Mullen JL, Buzby GP, et al (1981) The efficacy of nutritional assessment and support in cancer surgery. Cancer 47:2375–2381PubMed
33.
Zurück zum Zitat Stafford RS, Cyr PL (1997) The impact of cancer on the physical function of the elderly and their utilization of health care. Cancer 80:1973–1980CrossRefPubMed Stafford RS, Cyr PL (1997) The impact of cancer on the physical function of the elderly and their utilization of health care. Cancer 80:1973–1980CrossRefPubMed
34.
Zurück zum Zitat Stineman MG, Fiedler RC, Granger CV, et al (1998) Functional task benchmarks for stroke rehabilitation. Arch Phys Med Rehabil 79:497–504CrossRefPubMed Stineman MG, Fiedler RC, Granger CV, et al (1998) Functional task benchmarks for stroke rehabilitation. Arch Phys Med Rehabil 79:497–504CrossRefPubMed
35.
Zurück zum Zitat Strasser F, Bruera ED (2002) Update on anorexia and cachexia. Hematol Oncol Clin North Am 16:589–617PubMed Strasser F, Bruera ED (2002) Update on anorexia and cachexia. Hematol Oncol Clin North Am 16:589–617PubMed
36.
Zurück zum Zitat Tchekmedyian NS (1999) Nutritional support and quality of life. In: Heber D, Blackburn GL, Go VLW, et al (eds) Nutritional oncology. Academic Press, San Diego, pp 587–592 Tchekmedyian NS (1999) Nutritional support and quality of life. In: Heber D, Blackburn GL, Go VLW, et al (eds) Nutritional oncology. Academic Press, San Diego, pp 587–592
37.
Zurück zum Zitat Thiel HJ, Fietkau R, Sauer R (1988) Malnutrition and the role of nutritional support for radiation therapy patients. Recent Results Cancer Res 108:205–226PubMed Thiel HJ, Fietkau R, Sauer R (1988) Malnutrition and the role of nutritional support for radiation therapy patients. Recent Results Cancer Res 108:205–226PubMed
39.
Zurück zum Zitat Wouters-Wesseling W, Van Hooijdonk C, Wagenaar L, et al (2003) The effect of a liquid nutrition supplement on body composition and physical functioning in elderly people. Clin Nutr 22:371–377CrossRefPubMed Wouters-Wesseling W, Van Hooijdonk C, Wagenaar L, et al (2003) The effect of a liquid nutrition supplement on body composition and physical functioning in elderly people. Clin Nutr 22:371–377CrossRefPubMed
40.
Zurück zum Zitat Yoshioka H (1994) Rehabilitation for the terminal cancer patient. Am J Phys Med Rehabil 73:199–206PubMed Yoshioka H (1994) Rehabilitation for the terminal cancer patient. Am J Phys Med Rehabil 73:199–206PubMed
41.
Zurück zum Zitat Zogbaum AT (1996) Enteral feedings are associated with improved adherence to radiation treatment prescription and weight maintenance in head and neck cancer patients (abstract). J Am Diet Assoc 96:A-35 Zogbaum AT (1996) Enteral feedings are associated with improved adherence to radiation treatment prescription and weight maintenance in head and neck cancer patients (abstract). J Am Diet Assoc 96:A-35
Metadaten
Titel
Nutritional status of cancer patients and its relationship to function in an inpatient rehabilitation setting
verfasst von
Ying Guo
J. Lynn Palmer
Guddi Kaur
Susan Hainley
Beth Young
Eduardo Bruera
Publikationsdatum
01.03.2005
Verlag
Springer-Verlag
Erschienen in
Supportive Care in Cancer / Ausgabe 3/2005
Print ISSN: 0941-4355
Elektronische ISSN: 1433-7339
DOI
https://doi.org/10.1007/s00520-004-0680-8

Weitere Artikel der Ausgabe 3/2005

Supportive Care in Cancer 3/2005 Zur Ausgabe

Erhöhtes Risiko fürs Herz unter Checkpointhemmer-Therapie

28.05.2024 Nebenwirkungen der Krebstherapie Nachrichten

Kardiotoxische Nebenwirkungen einer Therapie mit Immuncheckpointhemmern mögen selten sein – wenn sie aber auftreten, wird es für Patienten oft lebensgefährlich. Voruntersuchung und Monitoring sind daher obligat.

Costims – das nächste heiße Ding in der Krebstherapie?

28.05.2024 Onkologische Immuntherapie Nachrichten

„Kalte“ Tumoren werden heiß – CD28-kostimulatorische Antikörper sollen dies ermöglichen. Am besten könnten diese in Kombination mit BiTEs und Checkpointhemmern wirken. Erste klinische Studien laufen bereits.

Perioperative Checkpointhemmer-Therapie verbessert NSCLC-Prognose

28.05.2024 NSCLC Nachrichten

Eine perioperative Therapie mit Nivolumab reduziert das Risiko für Rezidive und Todesfälle bei operablem NSCLC im Vergleich zu einer alleinigen neoadjuvanten Chemotherapie um über 40%. Darauf deuten die Resultate der Phase-3-Studie CheckMate 77T.

Positiver FIT: Die Ursache liegt nicht immer im Dickdarm

27.05.2024 Blut im Stuhl Nachrichten

Immunchemischer Stuhltest positiv, Koloskopie negativ – in solchen Fällen kann die Blutungsquelle auch weiter proximal sitzen. Ein Forschungsteam hat nachgesehen, wie häufig und in welchen Lokalisationen das der Fall ist.

Update Onkologie

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.