nach oben

European Archives of Oto-Rhino-Laryngology

Erschienen in:

31.10.2018 | Rhinology

Olfactory bulbus volume and olfactory sulcus depth in psychotic patients and patients with anxiety disorder/depression

verfasst von: Neşe Asal, Nuray Bayar Muluk, Mikail Inal, Mehmet Hamdi Şahan, Adil Doğan, Sadiye Visal Buturak

Erschienen in: European Archives of Oto-Rhino-Laryngology | Ausgabe 12/2018

Einloggen, um Zugang zu erhalten

Abstract

Objectives

In the present study, we investigated olfactory bulb (OB) volume and olfactory sulcus (OS) depth of the psychotic patients (predominantly schizophrenia) and patients with anxiety disorder/depression.

Methods

This study was conducted retrospectively. Group 1 consisted of 30 psychotic patients (predominantly schizophrenia) (19 males and 11 females). Group 2 consisted of 37 patients with anxiety disorder/depression (10 males, 27 females). Group 3 consisted of 30 non-psychotic and non-anxiety disorder/depression subjects (9 males and 21 females). OB volume and OS depth measurements were performed on Cranial MRI.

Results

OB volume (right and left) of the psychotic; and anxiety disorder/depression groups were significantly lower than those of the control group (p_adjusted < 0.0175). OS depth (Left) value of anxiety disorder/depression group was significantly lower than those of the control group (p_adjusted < 0.0175). In psychotic and anxiety disorder/depression groups, left OS depth values were significantly lower than those of the right side (p < 0.05). In each of the males and females of the anxiety disorder/depression group, left OS depth values were significantly lower than those of the right side (p < 0.05). In psychotic group, OS depth (left) values get lower in older patients (p < 0.05).

Conclusion

Decreased OB volume in the psychotic patients and decreased OB volume and OS depth in anxiety disorder/depression patients were detected. Lower OB volume and OS depth are related to the olfactory loss/or olfactory impairment. Physicians should be aware of the olfactory deficits in psychotic patients (mainly schizophrenia) and patients with anxiety disorder/depression. When reduced OB volume is detected on MRI, psychosis, schizophrenia or depression should also be kept in mind and the patients should be evaluated in detail for these diseases.

Atanasova B, Graux J, El Hage W, Hommet C, Camus V, Belzung C (2008) Olfaction: a potential cognitive marker of psychiatric disorders. Neurosci Biobehav Rev 32(7):1315–1325CrossRef

Moberg PJ, Agrin R, Gur RE, Gur RC, Turetsky BI, Doty RL (1999) Olfactory dysfunction in schizophrenia: a qualitative and quantitative review. Neuropsychopharmacology 21:325–340CrossRef

Rupp CI, Fleischhacker WW, Kemmler G et al (2005) Olfactory functions and volumetric measures of orbitofrontal and limbic regions in schizophrenia. Schizophr Res 74:149–161CrossRef

Rupp CI, Fleischhacker WW, Kemmler G et al (2005) Various bilateral olfactory deficits in male patients with schizophrenia. Schizophr Bull 31:155–165CrossRef

Sirota P, Davidson B, Mosheva T, Benhatov R, Zohar J, Gross-Isseroff R (1999) Increased olfactory sensitivity in first episode psychosis and the effect of neuroleptic treatment on olfactory sensitivity in schizophrenia. Psychiatry Res 86:143–153CrossRef

Kopala L, Clark C (1990) Implications of olfactory agnosia for understanding sex differences in schizophrenia. Schizophr Bull 16:255–261CrossRef

Serby MJ, Larson PM, Kalstein D (1990) Olfactory senses in psychosis. Biol Psychiat 28:829–830

Pause BM, Miranda A, Goder R, Aldenhoff JB, Ferstl R (2001) Reduced olfactory performance in patients with major depression. J Psychiatr Res 35:271–277CrossRef

Lombion-Pouthier S, Vandel P, Nezelof S, Haffen E, Millot JL (2006) Odor perception in patients with mood disorders. J Affect Disord 90:187–191CrossRef

10.

Pollatos O, Albrecht J, Kopietz R et al (2007) Reduced olfactory sensitivity in subjectsbwith depressive symptoms. J Affect Disord 102:101–108CrossRef

11.

Clepce M, Gossler A, Reich K, Kornhuber J, Thuerauf N (2010) The relation between depression, anhedonia and olfactory hedonic estimates—a pilotstudy in major depression. Neurosci Lett 471(3):139–143CrossRef

12.

American Psychiatric Association (1994) Diagnostic and statistical manual of mental disorders, 4th edn. American Psychiatric Association, Washington, DC

13.

Thierry P, Duprez A, Rombaux P (2010) Imaging the olfactory tract. Eur J Radiol 74:288–298CrossRef

14.

Buschhüter D, Smitka M, Puschmann S et al (2008) Correlation between olfactory bulb volume and olfactory function. Neuroimage 42:498–502CrossRef

15.

Kopala L, Good K, Martzke J, Hurwitz T (1995) Olfactory deficits in schizophrenia are not a function of task complexity. Schizophr Res 17:195–199CrossRef

16.

Croy I, Nordin S, Hummel T (2014) Olfactory disorders and quality of life—an updated review. Chem Senses 39(3):185–194CrossRef

17.

Negoias S, Croy I, Gerber J, Puschmann S, Petrowski K, Joraschky P (2010) Reduced olfactory bulb volume and olfactory sensitivity in patients with acute major depression. Neuroscience 169(1):415–421CrossRef

18.

Yuan T, Hou G, Arias-Carrion O (2015) Chronic stress impacts on olfactory system. CNS Neurol Disord Drug Targets 14:486–491CrossRef

19.

Kohli P, Soler ZM, Nguyen SA, Muus JS, Schlosser RJ (2016) The association between olfaction and depression: a systematic review. Chem Senses 41(6):479–486CrossRef

20.

Buschhuter D, Smitka M, Puschmann S et al (2008) Correlation between olfactory bulb volume and olfactory function. Neuroimage 42(2):498–502CrossRef

21.

Rottstaedt F, Weidner K, Strauß T et al (2017) Size matters—the olfactory bulb as a marker for depression. J Affect Disord 229:193–198CrossRef

22.

Croy I, Hummel T. Olfaction as a marker for depression. J Neurol. 264(4):631–638CrossRef

23.

Takahashi T, Nishikawa Y, Yücel M et al (2016) Olfactory sulcus morphology in patients with current and past major depression. Psychiatry Res Neuroimaging 255:60–65CrossRef

24.

Rottstädt F, Han P, Weidner K et al (2018) Reduced olfactory bulb volume in depression—a structural moderator analysis. Hum Brain Mapp 39(6):2573–2582CrossRef

25.

Turetsky BI, Moberg PJ, Yousem DM, Doty RL, Arnold SE, Gur RE (2000) Reduced olfactory bulb volume in patients with schizophrenia. Am J Psychiatry 157:828–830CrossRef

26.

Takahashi T, Nakamura Y, Nakamura K,et al (2013) Altered depth of the olfactory sulcus in first-episode schizophrenia. Prog Neuropsychopharmacol Biol Psychiatry 40:167–172CrossRef

27.

Hummel T, Damm M, Vent J et al (2003) Depth of olfactory sulcus and olfactory function. Brain Res 975:85–89CrossRef

28.

Doty RL, Brugger WE, Jurs PC, Orndorff MA, Snyder PJ, Lowry LD (1978) Intranasal trigeminal stimulation from odorous volatiles: psychometric responses from anosmic and normal humans. Physiol Behav 20:175–185CrossRef

29.

Brand G, Millot JL, Henquell D (2001) Complexity of olfactory lateralization processes revealed by functional imaging: a review. Neurosci Biobehav Rev 25:159–166CrossRef

30.

Royet JP, Plailly J, Delon-Martin C, Kareken DA, Segebarth C (2003) fMRI of emotional responses to odors: influence of hedonic valence and judgment, handedness, and gender. NeuroImage 20:713–728CrossRef

31.

Pause BM, Raack N, Sojka B, Goder R, Aldenhoff JB, Roman Ferstl R (2003) Convergent and divergent effects of odors and emotions in depression. Psychophysiology 40:209–225CrossRef

32.

Kopala LC, Clark C, Hurwitz T (1993) Olfactory deficits in neuroleptic naive patients with schizophrenia. Schizophr Res 8:245–250CrossRef

33.

Kopala LC, Good K, Honer WG (1995) Olfactory identification ability in pre- and postmenopausal women with schizophrenia. Biol Psychiat 38:57–63CrossRef

34.

Cohen AS, Brown LA, Auster TL (2012) Olfaction, “olfiction,” and the schizophrenia-spectrum: an updated meta-analysis on identification and acuity. Schizophr Res 135(1–3):152–157CrossRef

35.

Good KP, Sullivan RL (2015) Olfactory function in psychotic disorders: Insights from neuroimaging studies. World J Psychiatr 5(2):210–221CrossRef

36.

Brewer WJ, Pantelis C, Anderson V et al (2001) Stability of olfactory identification deficits in neuroleptic-naive patients with first-episode psychosis. Am J Psychiatry 158:107–115CrossRef

37.

Good KP, Whitehorn D, Rui Q, Milliken H, Kopala LC (2006) Olfactory identification deficits in first-episode psychosis may predict patients at risk for persistent negative and disorganized or cognitive symptoms. Am J Psychiatry 163: 932–933CrossRef

38.

Good KP, Tibbo P, Milliken H et al (2010) An investigation of a possible relationship between olfactory identification deficits at first episode and fouryear outcomes in patients with psychosis. Schizophr Res 124:60–65CrossRef

39.

Kopala LC, Good KP, Honer WG (1994) Olfactory hallucinations and olfactory identification ability in patients with schizophrenia and other psychiatric disorders. Schizophr Res 12:205–211CrossRef

40.

Stedman TJ, Clair AL (1998) Neuropsychological, neurological and symptom correlates of impaired olfactory identification in schizophrenia. Schizophr Res 32:23–30CrossRef

41.

Brewer WJ, Edwards J, Anderson V, Robinson T, Pantelis C (1996) Neuropsychological, olfactory, and hygiene deficits in men with negative symptom schizophrenia. Biol Psychiat 40:1021–1031CrossRef

42.

Malaspina D, Coleman E (2003) Olfaction and social drive in schizophrenia. Arch Gen Psychiatry 60:578–584CrossRef

43.

Deems DA, Doty RL, Settle RG et al (1991) Smell and taste disorders, a study of 750 patients from the University of Pennsylvania Smell and Taste Center. Arch Otolaryngol Head Neck Surg 117:519–528CrossRef

44.

Wilson DA, Chapuis J, Sullivan RM (2015) Cortical olfactory anatomy and physiology. Handbook of olfaction and gustation, 3rd edn. Wiley, Hoboken, pp 209–223CrossRef

Titel: Olfactory bulbus volume and olfactory sulcus depth in psychotic patients and patients with anxiety disorder/depression
verfasst von: Neşe Asal
Nuray Bayar Muluk
Mikail Inal
Mehmet Hamdi Şahan
Adil Doğan
Sadiye Visal Buturak
Publikationsdatum: 31.10.2018
Verlag: Springer Berlin Heidelberg
Erschienen in: European Archives of Oto-Rhino-Laryngology / Ausgabe 12/2018
Print ISSN: 0937-4477
Elektronische ISSN: 1434-4726
DOI: https://doi.org/10.1007/s00405-018-5187-x

Neu im Fachgebiet HNO

16.04.2024 | HNO-Chirurgie | Nachrichten

Update HNO

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert – ganz bequem per eMail.

Newsletter bestellen

Springer Medizin

Olfactory bulbus volume and olfactory sulcus depth in psychotic patients and patients with anxiety disorder/depression

Abstract

Objectives

Methods

Results

Conclusion

Neu im Fachgebiet HNO

HNO-Op. auch mit über 90?

Intrakapsuläre Tonsillektomie gewinnt an Boden

Bilateraler Hörsturz hat eine schlechte Prognose

„Nur wer sich gut aufgehoben fühlt, kann auch für Patientensicherheit sorgen“

Update HNO

Springer Medizin

Abstract

Objectives

Methods

Results

Conclusion

Bitte loggen Sie sich ein, um Zugang zu diesem Inhalt zu erhalten

Weitere Artikel der Ausgabe 12/2018

The protective effect of metformin against the noise-induced hearing loss

Angulation of the ossified stylohyoid complex and Eagle syndrome

Long-term functional voice outcomes after thyroidectomy, and effect of endotracheal intubation on voice

Novel three-dimensional image system for endoscopic ear surgery

Does endoscopic stapedotomy increase hearing restoration rates comparing to microscopic? A systematic review and meta-analysis

The effect of “xanthan gum-based fluid thickener” on hydration, swallowing functions and nutritional status in total maxillectomy patients

Neu im Fachgebiet HNO

HNO-Op. auch mit über 90?

Intrakapsuläre Tonsillektomie gewinnt an Boden

Bilateraler Hörsturz hat eine schlechte Prognose

„Nur wer sich gut aufgehoben fühlt, kann auch für Patientensicherheit sorgen“

Update HNO