Skip to main content
Erschienen in: Indian Journal of Otolaryngology and Head & Neck Surgery 1/2019

14.05.2018 | Original Article

Oncological Outcomes Following Transoral CO2 Laser Microsurgery for T1 Glottic Cancer

verfasst von: Ankur Batra, A. Goyal, M. Goyal, S. Goel

Erschienen in: Indian Journal of Otolaryngology and Head & Neck Surgery | Sonderheft 1/2019

Einloggen, um Zugang zu erhalten

Abstract

The objective of this study is to analyze oncological outcomes for treatment of Tis and T1 glottic squamous cell carcinoma after transoral laser microsurgery. This study is retrospective analysis of previously untreated, suspected lesion of glottis, staged cT1a and cT1b squamous cell carcinoma in a tertiary care hospital and 53 patients were included in the study. End points for analysis were local control, overall and disease specific survival rates. The local control, ultimate local control with laser alone, 3-year overall survival, 3-year disease specific survival and organ preservation rates were 86.7, 90.5, 92.4, 98.1 and 98.1% respectively. The involvement of anterior commissure did not show any significant impact on local control or survival. TLM is safe and effective treatment of early glottis cancer, associated with less morbidity and a high percentage of local control, survival and organ preservation rates.
Literatur
1.
Zurück zum Zitat Mendenhall WM, Werning JW, Hinerman RW, Amdur RJ, Villaret DB (2004) Management of T1-T2 glottic carcinomas. Cancer 100(9):1786–1792CrossRef Mendenhall WM, Werning JW, Hinerman RW, Amdur RJ, Villaret DB (2004) Management of T1-T2 glottic carcinomas. Cancer 100(9):1786–1792CrossRef
2.
Zurück zum Zitat Hartl DM (2012) Evidence-based practice: management of glottic cancer. Otolaryngol Clin North Am 45:1143–1161CrossRef Hartl DM (2012) Evidence-based practice: management of glottic cancer. Otolaryngol Clin North Am 45:1143–1161CrossRef
3.
Zurück zum Zitat Strong MS (1975) Laser excision of carcinoma of the larynx. Laryngoscope 85(8):1286–1289CrossRef Strong MS (1975) Laser excision of carcinoma of the larynx. Laryngoscope 85(8):1286–1289CrossRef
4.
Zurück zum Zitat Strong MS, Jako GJ (1972) Laser surgery in the larynx. Early clinical experience with continuous CO2 laser. Ann Otol Rhinol Laryngol 81(6):791–798CrossRef Strong MS, Jako GJ (1972) Laser surgery in the larynx. Early clinical experience with continuous CO2 laser. Ann Otol Rhinol Laryngol 81(6):791–798CrossRef
5.
Zurück zum Zitat Succo G, Crosetti E, Bertolin A, Lucioni M, Caracciolo A, Panetta V et al (2016) Benefits and drawbacks of open partial horizontal laryngectomies, Part A: early- to intermediate-stage glottic carcinoma. Head Neck 38(Suppl 1):E333–E340CrossRef Succo G, Crosetti E, Bertolin A, Lucioni M, Caracciolo A, Panetta V et al (2016) Benefits and drawbacks of open partial horizontal laryngectomies, Part A: early- to intermediate-stage glottic carcinoma. Head Neck 38(Suppl 1):E333–E340CrossRef
6.
Zurück zum Zitat Mendenhall WM, Amdur RJ, Morris CG, Hinerman RW (2001) T1-T2N0 squamous cell carcinoma of the glottic larynx treated with radiation therapy. J Clin Oncol 19:4029–4036CrossRef Mendenhall WM, Amdur RJ, Morris CG, Hinerman RW (2001) T1-T2N0 squamous cell carcinoma of the glottic larynx treated with radiation therapy. J Clin Oncol 19:4029–4036CrossRef
7.
Zurück zum Zitat Remacle M, Van Haverbeke C, Eckel H, Bradley P, Chevalier D, Djukic V et al (2007) Proposal for revision of the European Laryngological Society classification of endoscopic cordectomies. Eur Arch Otorhinolaryngol 264(5):499–504CrossRef Remacle M, Van Haverbeke C, Eckel H, Bradley P, Chevalier D, Djukic V et al (2007) Proposal for revision of the European Laryngological Society classification of endoscopic cordectomies. Eur Arch Otorhinolaryngol 264(5):499–504CrossRef
8.
Zurück zum Zitat Datta R, Sethi A, Singh S, Nilakantan A, Venkatesh MD (2011) Translation and validation of Voice Handicap Index in Hindi. J Laryngol Voice 1(1):12–17CrossRef Datta R, Sethi A, Singh S, Nilakantan A, Venkatesh MD (2011) Translation and validation of Voice Handicap Index in Hindi. J Laryngol Voice 1(1):12–17CrossRef
9.
Zurück zum Zitat Pfister DG, Laurie SA, Weinstein GS, Mendenhall WM, Adelstein DJ et al (2006) American Society of Clinical Oncology clinical practice guideline for the use of larynx-preservation strategies in the treatment of laryngeal cancer. J Clin Oncol 24(22):3693–3704CrossRef Pfister DG, Laurie SA, Weinstein GS, Mendenhall WM, Adelstein DJ et al (2006) American Society of Clinical Oncology clinical practice guideline for the use of larynx-preservation strategies in the treatment of laryngeal cancer. J Clin Oncol 24(22):3693–3704CrossRef
10.
Zurück zum Zitat Lee HS, Chun BG, Kim SW, Kim ST, Oh JH, Hong JC, Lee KD (2013) Transoral laser microsurgery for early glottic cancer as one-stage single-modality therapy. Laryngoscope 123(11):2670–2674CrossRef Lee HS, Chun BG, Kim SW, Kim ST, Oh JH, Hong JC, Lee KD (2013) Transoral laser microsurgery for early glottic cancer as one-stage single-modality therapy. Laryngoscope 123(11):2670–2674CrossRef
11.
Zurück zum Zitat Van Dijk BA, Gatta G, Capocaccia R, Pierannunzio D, Strojan P, Licitra L (2012) RARECARE Working Group. Rare cancers of the head and neck area in Europe. Eur J Cancer 48(6):783–796CrossRef Van Dijk BA, Gatta G, Capocaccia R, Pierannunzio D, Strojan P, Licitra L (2012) RARECARE Working Group. Rare cancers of the head and neck area in Europe. Eur J Cancer 48(6):783–796CrossRef
12.
Zurück zum Zitat Marur S, Forastiere AA (2008) Head and neck cancer: changing epidemiology, diagnosis, and treatment. Mayo Clin Proceed 83:489–501CrossRef Marur S, Forastiere AA (2008) Head and neck cancer: changing epidemiology, diagnosis, and treatment. Mayo Clin Proceed 83:489–501CrossRef
13.
Zurück zum Zitat Motta G, Esposito E, Motta S, Tartaro G, Testa D (2005) CO2 laser surgery in the treatment of glottic cancer. Head Neck 27(8):733CrossRef Motta G, Esposito E, Motta S, Tartaro G, Testa D (2005) CO2 laser surgery in the treatment of glottic cancer. Head Neck 27(8):733CrossRef
14.
Zurück zum Zitat Vilaseca-González I, Bernal-Sprekelsen M, Blanch-Alejandro JL, Moragas-Lluis M (2003) Complications in transoral CO2 laser surgery for carcinoma of the larynx and hypopharynx. Head Neck 25(5):382–388CrossRef Vilaseca-González I, Bernal-Sprekelsen M, Blanch-Alejandro JL, Moragas-Lluis M (2003) Complications in transoral CO2 laser surgery for carcinoma of the larynx and hypopharynx. Head Neck 25(5):382–388CrossRef
15.
Zurück zum Zitat Prgomet D, Bacić A, Prstacić R, Janjanin S (2013) Complications of endoscopic CO2 laser surgery for laryngeal cancer and concepts of their management. Coll Antropol 37(4):1373–1378PubMed Prgomet D, Bacić A, Prstacić R, Janjanin S (2013) Complications of endoscopic CO2 laser surgery for laryngeal cancer and concepts of their management. Coll Antropol 37(4):1373–1378PubMed
16.
Zurück zum Zitat Preuss SF, Cramer K, Klussmann JP, Eckel HE, Guntinas-Lichius O (2009) Transoral laser surgery for laryngeal cancer: outcome, complications and prognostic factors in 275 patients. Eur J Surg Oncol 35(3):235–240CrossRef Preuss SF, Cramer K, Klussmann JP, Eckel HE, Guntinas-Lichius O (2009) Transoral laser surgery for laryngeal cancer: outcome, complications and prognostic factors in 275 patients. Eur J Surg Oncol 35(3):235–240CrossRef
17.
Zurück zum Zitat Cabanillas R, Rodrigo JP, Llorente JL, Suárez V, Ortega P, Suárez C (2004) Functional outcomes of transoral laser surgery of supraglottic carcinoma compared with a transcervical approach. Head Neck 26(8):653–659CrossRef Cabanillas R, Rodrigo JP, Llorente JL, Suárez V, Ortega P, Suárez C (2004) Functional outcomes of transoral laser surgery of supraglottic carcinoma compared with a transcervical approach. Head Neck 26(8):653–659CrossRef
18.
Zurück zum Zitat Peretti G, Piazza C, Cocco D, De Benedetto L, Del Bon F, Redaelli De Zinis LO et al (2010) Transoral CO(2) laser treatment for T(is)-T(3) glottic cancer: the University of Brescia experience on 595 patients. Head Neck 32(8):977–983CrossRef Peretti G, Piazza C, Cocco D, De Benedetto L, Del Bon F, Redaelli De Zinis LO et al (2010) Transoral CO(2) laser treatment for T(is)-T(3) glottic cancer: the University of Brescia experience on 595 patients. Head Neck 32(8):977–983CrossRef
19.
Zurück zum Zitat Crespo AN, Chone CT, Gripp FM, Spina AL, Altemani A (2006) Role of margin status in recurrence after CO2 laser endoscopic resection of early glottic cancer. Acta Otolaryngol 126:306–310CrossRef Crespo AN, Chone CT, Gripp FM, Spina AL, Altemani A (2006) Role of margin status in recurrence after CO2 laser endoscopic resection of early glottic cancer. Acta Otolaryngol 126:306–310CrossRef
20.
Zurück zum Zitat Manola M, Moscillo L, Costa G, Barillari U, Lo Sito S, Mastella A et al (2008) Conservative laser microsurgery for T1 glottic carcinoma. Auris Nasus Larynx 35(1):141–147CrossRef Manola M, Moscillo L, Costa G, Barillari U, Lo Sito S, Mastella A et al (2008) Conservative laser microsurgery for T1 glottic carcinoma. Auris Nasus Larynx 35(1):141–147CrossRef
21.
Zurück zum Zitat Sigston E, de Mones E, Babin E, Hans S, Hartl DM, Clement P et al (2006) Early-stage glottic cancer: oncological results and margins in laser cordectomy. Arch Otolaryngol Head Neck Surg 132(2):147–152CrossRef Sigston E, de Mones E, Babin E, Hans S, Hartl DM, Clement P et al (2006) Early-stage glottic cancer: oncological results and margins in laser cordectomy. Arch Otolaryngol Head Neck Surg 132(2):147–152CrossRef
22.
Zurück zum Zitat Jeong WJ, Kim H, Ahn JC, Sung MW, Kim KH, Ahn SH (2012) Serial endoscopic analysis of the glottis following laser cordectomy: from an oncological perspective. Lasers Med Sci 27:1025–1031CrossRef Jeong WJ, Kim H, Ahn JC, Sung MW, Kim KH, Ahn SH (2012) Serial endoscopic analysis of the glottis following laser cordectomy: from an oncological perspective. Lasers Med Sci 27:1025–1031CrossRef
23.
Zurück zum Zitat Pearson BW, Salassa JR (2003) Transoral laser microresection for cancer of the larynx involving the anterior commissure. Laryngoscope 113:1104–1112CrossRef Pearson BW, Salassa JR (2003) Transoral laser microresection for cancer of the larynx involving the anterior commissure. Laryngoscope 113:1104–1112CrossRef
24.
Zurück zum Zitat Hartl DM, de Mones E, Hans S, Janot F, Brasnu D (2007) Treatment of earlystage glottic cancer by transoral laser resection. Ann Otol Rhinol Laryngol 116:832–836CrossRef Hartl DM, de Mones E, Hans S, Janot F, Brasnu D (2007) Treatment of earlystage glottic cancer by transoral laser resection. Ann Otol Rhinol Laryngol 116:832–836CrossRef
25.
Zurück zum Zitat Rucci L, Romagnoli P, Scala J (2010) CO2 laser therapy in Tis and T1 glottic cancer: indications and results. Head Neck 32:392–398PubMed Rucci L, Romagnoli P, Scala J (2010) CO2 laser therapy in Tis and T1 glottic cancer: indications and results. Head Neck 32:392–398PubMed
26.
Zurück zum Zitat Rucci L, Bocciolini C, Romagnoli P, Olofsson J (2003) Risk factors and prognosis of anterior commissure versus posterior commissure T1-T2 glottic cancer. Ann Otol Rhinol Laryngol 112:223–229CrossRef Rucci L, Bocciolini C, Romagnoli P, Olofsson J (2003) Risk factors and prognosis of anterior commissure versus posterior commissure T1-T2 glottic cancer. Ann Otol Rhinol Laryngol 112:223–229CrossRef
27.
Zurück zum Zitat Steiner W, Ambrosch P, Rödel RM, Kron M (2004) Impact of anterior commissure involvement on local control of early glottic carcinoma treated by laser microresection. Laryngoscope 114:1485–1491CrossRef Steiner W, Ambrosch P, Rödel RM, Kron M (2004) Impact of anterior commissure involvement on local control of early glottic carcinoma treated by laser microresection. Laryngoscope 114:1485–1491CrossRef
28.
Zurück zum Zitat Cömert E, Tunçel Ü, Dizman A, Güney YY (2014) Comparison of early oncological results of diode laser surgery with radiotherapy for early glottic carcinoma. Otolaryngol Head Neck Surg 150:818–823CrossRef Cömert E, Tunçel Ü, Dizman A, Güney YY (2014) Comparison of early oncological results of diode laser surgery with radiotherapy for early glottic carcinoma. Otolaryngol Head Neck Surg 150:818–823CrossRef
29.
Zurück zum Zitat Hakeem AH, Tubachi J, Pradhan SA (2013) Significance of anterior commissure involvement in early glottic squamous cell carcinoma treated with trans-oral CO2 laser microsurgery. Laryngoscope 123(8):1912–1917CrossRef Hakeem AH, Tubachi J, Pradhan SA (2013) Significance of anterior commissure involvement in early glottic squamous cell carcinoma treated with trans-oral CO2 laser microsurgery. Laryngoscope 123(8):1912–1917CrossRef
30.
Zurück zum Zitat Mortuaire G, Francois J, Wiel E, Chevalier D (2006) Local recurrence after CO2 laser cordectomy for early glottic carcinoma. Laryngoscope 116(1):101–105CrossRef Mortuaire G, Francois J, Wiel E, Chevalier D (2006) Local recurrence after CO2 laser cordectomy for early glottic carcinoma. Laryngoscope 116(1):101–105CrossRef
31.
Zurück zum Zitat Fang TJ, Courey MS, Liao CT, Yen TC, Li HY (2013) Frozen margin analysis as a prognosis predictor in early glottic cancer by laser cordectomy. Laryngoscope 123:1490–1495CrossRef Fang TJ, Courey MS, Liao CT, Yen TC, Li HY (2013) Frozen margin analysis as a prognosis predictor in early glottic cancer by laser cordectomy. Laryngoscope 123:1490–1495CrossRef
32.
Zurück zum Zitat Ansarin M, Santoro L, Cattaneo A, Massaro MA, Calabrese L, Giugliano G et al (2009) Laser surgery for early glottic cancer: impact of margin status on local control and organ preservation. Arch Otolaryngol Head Neck Surg 135(4):385–390CrossRef Ansarin M, Santoro L, Cattaneo A, Massaro MA, Calabrese L, Giugliano G et al (2009) Laser surgery for early glottic cancer: impact of margin status on local control and organ preservation. Arch Otolaryngol Head Neck Surg 135(4):385–390CrossRef
33.
Zurück zum Zitat Jackel MC, Ambrosch P, Martin A, Steiner W (2007) Impact of re-resection for inadequate margins on the prognosis of upper aerodigestive tract cancer treated by laser microsurgery. Laryngoscope 117:350–356CrossRef Jackel MC, Ambrosch P, Martin A, Steiner W (2007) Impact of re-resection for inadequate margins on the prognosis of upper aerodigestive tract cancer treated by laser microsurgery. Laryngoscope 117:350–356CrossRef
34.
Zurück zum Zitat Michel J, Fakhry N, Duflo S, Lagier A, Mancini J, Dessi P et al (2011) Prognostic value of the status of resection margins after endoscopic laser cordectomy for T1a glottic carcinoma. Eur Ann Otorhinolaryngol Head Neck Dis 128(6):297–300CrossRef Michel J, Fakhry N, Duflo S, Lagier A, Mancini J, Dessi P et al (2011) Prognostic value of the status of resection margins after endoscopic laser cordectomy for T1a glottic carcinoma. Eur Ann Otorhinolaryngol Head Neck Dis 128(6):297–300CrossRef
35.
Zurück zum Zitat Brøndbo K, Fridrich K, Boysen M (2007) Laser surgery of T1a glottic carcinomas; significance of resection margins. Eur Arch Otorhinolaryngol 264:627–630CrossRef Brøndbo K, Fridrich K, Boysen M (2007) Laser surgery of T1a glottic carcinomas; significance of resection margins. Eur Arch Otorhinolaryngol 264:627–630CrossRef
36.
Zurück zum Zitat Lucioni M, Bertolin A, D’Ascanio L, Rizzotto G (2012) Margin photocoagulation in laser surgery for early glottic cancer: impact on disease local control. Otolaryngol Head Neck Surg 146:600–605CrossRef Lucioni M, Bertolin A, D’Ascanio L, Rizzotto G (2012) Margin photocoagulation in laser surgery for early glottic cancer: impact on disease local control. Otolaryngol Head Neck Surg 146:600–605CrossRef
37.
Zurück zum Zitat Galli A, Giordano L, Sarandria D, Di Santo D, Bussi M (2016) Oncological and complication assessment of CO2 laser-assisted endoscopic surgery for T1-T2 glottic tumours: clinical experience. Acta Otorhinolaryngol Ital 36(3):167–173PubMedPubMedCentral Galli A, Giordano L, Sarandria D, Di Santo D, Bussi M (2016) Oncological and complication assessment of CO2 laser-assisted endoscopic surgery for T1-T2 glottic tumours: clinical experience. Acta Otorhinolaryngol Ital 36(3):167–173PubMedPubMedCentral
38.
Zurück zum Zitat Bradley PJ, Mackenzie K, Wight R, Pracy P, Paleri V, ENT-UK Head & Neck Group (2009) Consensus statement on management in the UK: transoral laser assisted microsurgical resection of early glottic cancer. Clin Otolaryngol 344:367–373CrossRef Bradley PJ, Mackenzie K, Wight R, Pracy P, Paleri V, ENT-UK Head & Neck Group (2009) Consensus statement on management in the UK: transoral laser assisted microsurgical resection of early glottic cancer. Clin Otolaryngol 344:367–373CrossRef
39.
Zurück zum Zitat Lee HS, Kim JS, Kim SW, Noh WJ, Kim YJ, Oh D, Hong JC, Lee KD (2016) Voice outcome according to surgical extent of transoral laser microsurgery for T1 glottic carcinoma. Laryngoscope 126(9):2051–2056CrossRef Lee HS, Kim JS, Kim SW, Noh WJ, Kim YJ, Oh D, Hong JC, Lee KD (2016) Voice outcome according to surgical extent of transoral laser microsurgery for T1 glottic carcinoma. Laryngoscope 126(9):2051–2056CrossRef
40.
Zurück zum Zitat Chu PY, Hsu YB, Lee TL, Fu S, Wang LM, Kao YC (2012) Longitudinal analysis of voice quality in patients with early glottic cancer after transoral laser microsurgery. Head Neck 34(9):1294–1298CrossRef Chu PY, Hsu YB, Lee TL, Fu S, Wang LM, Kao YC (2012) Longitudinal analysis of voice quality in patients with early glottic cancer after transoral laser microsurgery. Head Neck 34(9):1294–1298CrossRef
Metadaten
Titel
Oncological Outcomes Following Transoral CO2 Laser Microsurgery for T1 Glottic Cancer
verfasst von
Ankur Batra
A. Goyal
M. Goyal
S. Goel
Publikationsdatum
14.05.2018
Verlag
Springer India
Erschienen in
Indian Journal of Otolaryngology and Head & Neck Surgery / Ausgabe Sonderheft 1/2019
Print ISSN: 2231-3796
Elektronische ISSN: 0973-7707
DOI
https://doi.org/10.1007/s12070-018-1394-4

Weitere Artikel der Sonderheft 1/2019

Indian Journal of Otolaryngology and Head & Neck Surgery 1/2019 Zur Ausgabe

Akuter Schwindel: Wann lohnt sich eine MRT?

28.04.2024 Schwindel Nachrichten

Akuter Schwindel stellt oft eine diagnostische Herausforderung dar. Wie nützlich dabei eine MRT ist, hat eine Studie aus Finnland untersucht. Immerhin einer von sechs Patienten wurde mit akutem ischämischem Schlaganfall diagnostiziert.

Bei schweren Reaktionen auf Insektenstiche empfiehlt sich eine spezifische Immuntherapie

Insektenstiche sind bei Erwachsenen die häufigsten Auslöser einer Anaphylaxie. Einen wirksamen Schutz vor schweren anaphylaktischen Reaktionen bietet die allergenspezifische Immuntherapie. Jedoch kommt sie noch viel zu selten zum Einsatz.

HNO-Op. auch mit über 90?

16.04.2024 HNO-Chirurgie Nachrichten

Mit Blick auf das Risiko für Komplikationen nach elektiven Eingriffen im HNO-Bereich scheint das Alter der Patienten kein ausschlaggebender Faktor zu sein. Entscheidend ist offenbar, wie fit die Betroffenen tatsächlich sind.

Intrakapsuläre Tonsillektomie gewinnt an Boden

16.04.2024 Tonsillektomie Nachrichten

Gegenüber der vollständigen Entfernung der Gaumenmandeln hat die intrakapsuläre Tonsillektomie einige Vorteile, wie HNO-Fachleute aus den USA hervorheben. Sie haben die aktuelle Literatur zu dem Verfahren gesichtet.

Update HNO

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert – ganz bequem per eMail.