nach oben

Erschienen in:

14.03.2018 | Case Report

Oral Manifestation of Lymphomatoid Granulomatosis

verfasst von: Alessandro Antônio Costa Pereira, Christian Barros Ferreira, João Adolfo Costa Hanemann, Livia Maris Ribeiro Paranaiba, Patricia Peres Iucif Pereira, Carla Isabelly Rodrigues-Fernandes, Celeste Sánchez-Romero, Oslei Paes de Almeida, Felipe Paiva Fonseca

Erschienen in: Head and Neck Pathology | Ausgabe 2/2019

Einloggen, um Zugang zu erhalten

Abstract

Lymphomatoid granulomatosis (LYG) is a rare B-cell lymphoproliferative disorder driven by Esptein–Barr virus (EBV) that most commonly affects the lungs, although extra pulmonary sites like the central nervous system, skin, liver and kidney can also be involved. It is microscopically characterized by an angiocentric and angiodestructive growth pattern, predominantly composed by small T-cells, although a smaller population of atypical large B-cells is considered the true neoplastic component. Oral cavity involvement of LYG has rarely been described and the diagnosis of this neoplasm is very difficult. The aim of this report is to present a rare case of LYG affecting an 86-year-old female patient that was diagnosed due to an extensive, ulcerated and painful oral lesion affecting the hard palate. Detailed microscopic evaluation together with a large immunohistochemical study were necessary to achieve the correct diagnosis of LYG.

Szumera-Ciećkiewicz A, Gałązka K, Szpor J, Rymkiewicz G, Jesionek-Kupnicka D, Gruchała A, Ziarkiewicz-Wróblewska B, Poniatowska-Broniek G, Demczuk S, Prochorec-Sobieszek M. Distribution of lymphomas im Poland according to World Health Organization classification: analysis of 11718 cases from National Histopathological Lymphoma Register project—the Polish Lymphoma Research Group study. Int J Clin Exp Pathol. 2014;7(6):3280–6.PubMedPubMedCentral

Kemp S, Gallagher G, Kabani S, Noonan V, O’Hara C. Oral non-Hodgkin lymphoma: review of the literature and World Health Organization classification with reference to 40 cases. Oral Surg Oral Med Oral Pathol Oral Radiol Oral Endod. 2008;105:194–201.CrossRef

Bhattacharyya I, Chehal HK, Cohen DM, Al-Quran SZ. Primary diffuse large B-cell lymphoma of the oral cavity: germinal center classification. Head Neck Pathol. 2010;4:181–91.CrossRefPubMedPubMedCentral

Triantafilidou K, Dimitrakopoulos J, Iordanidis F, Gkagkalis A. Extranodal non-Hodgkin lymphomas of the oral cavity and maxillofacial region: a clinical study of 58 cases and review of the literature. J Oral Maxillofac Surg. 2012;70:2776–85.CrossRef

Roschewski M, Staudt LM, Wilson WH. Diffuse large B-cell lymphoma—treatment approaches in the molecular era. Nat Rev Clin Oncol. 2014;11:12–23.CrossRefPubMed

Deng D, Wang Y, Liu W, Qian Y. Oral and maxillofacial non-Hodgkin lymphomas—case report with review of literature. Medicine. 2017;96(35):1–9.CrossRef

Kolokotronis A, Konstantinou N, Christakis I, Papadimitriou P, Matiakis A, Zaraboukas T, Antoniades D. Localized B-cell non-Hodgkin’s lymphoma of oral cavity and maxillofacial region: a clinical study. Oral Surg Oral Med Oral Pathol Oral Radiol Oral Endod. 2005;99:303–10.CrossRef

Swerdlow SH, Campo E, Pileri SA, Harris NL, Stein H, Siebert R, Advani R, Ghielmini M, Salles GA, Zelenetz AD, Jaffe ES. The 2016 revision of the World Health Organization classification of lymphoid neoplasms. Blood. 2016;127(20):2375–90.CrossRefPubMedPubMedCentral

Hsi ED. 2016 WHO Classification update—What’s new un lymphoid neoplasms. Int J Lab Hematol. 2017;39:14–22.CrossRefPubMed

10.

Murthy SL, Hitchcock MA, Endicott-Yazdani TR, Watson JT, Krause JR. Epstein–Barr virus-positive diffuse large B-cell lymphoma. In Baylor University Medical Center Proceedings; 2017. p. 443–444.

11.

Cargini P, Civica M, Sollima L, Di Cola E, Pontecorvi E, Cutilli T. Oral lymphomatoid granulomatosis, the first sign of a “rare disease”: a case report. J Med Case Rep. 2014;8(152):1–5.

12.

Higashi Y, Yoshioka T, Kwai K, Fujii K, Yoshimitsu M, Kusuyama J, Shima K, Tanimoto A, Kanekura T. Lymphomatoid granulomatosis initially presenting as ulcerated subcutaneous and muscle lesions without pulmonary involvement. J Dermatol. 2017;44(5):e107–e108.CrossRefPubMed

13.

Mosqueda-Taylor A, Meneses-Garcia A, Zarate-Osorno A, Rivera LMRG, Ochoa-Carrillo FJ, Mohar-Betancourt A. Angiocentric lymphomas of the palate: clinico-pathological considerations in 12 cases. J Oral Pathol Med 1997;26:93–7.CrossRefPubMed

14.

Roschewski M, Wilson WH. Lymphomatoid granulomatosis. Cancer J. 2012;18:469–74.CrossRefPubMed

15.

Katzenstein ALA, Doxtader E, Narendra S. Lymphomatoid granulomatosis—insights gained over 4 decades. Am J Surg Pathol. 2010;34:e35–e38.CrossRefPubMed

16.

Rysgaard CD, Stone MS. Lymphomatoid granulomatosis presenting with cutaneous involvement: a case report and review of the literature. J Cutan Pathol. 2015;42:188–93.CrossRefPubMed

17.

Bartosik W, Raza A, Kalimuthu S, Fabre A. Pulmonary lymphomatoid granulomatosis mimicking lung cancer. Interact CardioVasc Thorac Surg. 2012;14(5):662–4.CrossRefPubMedPubMedCentral

18.

Hadid W, Rifai D, David O, Sadikot RT. A woman in her 40 s with AIDS and lung mass. Chest. 2014;145(1):173–7.CrossRefPubMed

19.

Jaffe ES. Lymphoid lesions of the head and neck: a model of lymphocyte homing and lymphomagenesis. Mod Pathol. 2002;15(3):255–63.CrossRefPubMed

20.

Song JY, Pittaluga S, Dunleavy K, Grant N, White T, Jiang L, Davies-Hill T, Raffeld M, Wilson WH, Jaffe ES. Lymphomatoid granulomatosis—a single institute experience. Pathologic findings and clinical correlations. Am J Surg Pathol. 2015;39:141–56.CrossRefPubMedPubMedCentral

21.

Pittaluga S, Wilson WH, Jaffe ES. Lymphomatoid granulomatosis. In: Swerdlow SH, Campo E, Harris NL, editors. WHO classification of tumours of the haematopoietic and lymphoid tissues. Vol. 4. Lyon: IARC; 2008. p. 247–9.

22.

Diez JSJ, Hernández-Pérez B, De Paula JMP, Ortega EO. Granulomatosis linfomatoidea: caso clínico de uma enfermedad infrecuente com uma presentación infrecuente. Revista Clínica Española. 2000;200(8):461–3.CrossRef

23.

Shanti RB, Torres-Cabala CA, Jaffe ES, Wilson WH, Brahim JS. Lymphomatoid granulomatosis with involvement of the hard palate: a case report. J Oral Maxillofac Surg. 2008;66:2161–3.CrossRefPubMedPubMedCentral

24.

Torrelo A, Martin M, Rocamoral A, Allegue F, Ledo A. Lymphomatoid granulomatosis presenting as angioedema. Postgrad Med J. 1992;68:366–8.CrossRefPubMedPubMedCentral

25.

Alinari L, Pant S, McNamara K, Kalmar JR, Marsh W, Allen CM, Baiocchi RA. Lymphomatoid granulomatosis presenting with gingival involvement in an imune competente elderly male. Head Neck Pathol. 2012;6:496–501.CrossRefPubMedPubMedCentral

26.

Cabane J, Godeau P, Chomette G, Auriol M, Szpirglass H, Raphae M. Granulomatose lymphomatoïde buccale. Rev Med Interne. 1990;11:69–72.CrossRefPubMed

27.

Ammannagari N, Srivali N, Price C, Ungprasert P, Leonardo J. Lymphomatoid granulomatosis masquerading as pneumonia. Ann Hematol. 2013;92:981–3.CrossRefPubMed

28.

Eminger LA, Hall LD, Hesterman KS, Heymann WR. Epstein–Barr virus: dermatologic associations and implications—Part II. Associated lymphoproliferative disorders and solid tumors. J Am Acad Dermatol. 2015;72:21–34.CrossRefPubMed

29.

Castillo JJ, Beltran BE, Miranda RN, Young KH, Chavez JC, Sotomayor EM. EBV-positive diffuse large B-cell lymphoma of the elderly: 2016 update on diagnosis, risk-stratification, and management. Am J Hematol. 2016;91(5):529–37.CrossRefPubMed

30.

Jung KH, Sung HJ, Lee JH, Lee KY, Shin JS, Kim KM, Kim YS, Shin C, Kim JH. A case of pulmonary lymphomatoid granulomatosis successfully treated by combination chemotherapy with Rituximab. Chemotherapy. 2009;55:386–90.CrossRefPubMed

31.

Gangar P, Venkatarajan S. Granulomatous lymphoproliferative disorders—granulomatous slack skin and Lymphomatoid granulomatosis. Dermatol Clin. 2015;33:489–96.CrossRefPubMed

Titel: Oral Manifestation of Lymphomatoid Granulomatosis
verfasst von: Alessandro Antônio Costa Pereira
Christian Barros Ferreira
João Adolfo Costa Hanemann
Livia Maris Ribeiro Paranaiba
Patricia Peres Iucif Pereira
Carla Isabelly Rodrigues-Fernandes
Celeste Sánchez-Romero
Oslei Paes de Almeida
Felipe Paiva Fonseca
Publikationsdatum: 14.03.2018
Verlag: Springer US
Erschienen in: Head and Neck Pathology / Ausgabe 2/2019
Elektronische ISSN: 1936-0568
DOI: https://doi.org/10.1007/s12105-018-0910-x

Springer Medizin

Oral Manifestation of Lymphomatoid Granulomatosis

Abstract

Neu im Fachgebiet Pathologie

Molekularpathologische Untersuchungen im Wandel der Zeit

Vergleichende Pathologie in der onkologischen Forschung

Gastrointestinale Stromatumoren

Personalisierte Medizin in der Onkologie

Springer Medizin

Abstract

Bitte loggen Sie sich ein, um Zugang zu diesem Inhalt zu erhalten

Weitere Artikel der Ausgabe 2/2019

Kaposi Sarcoma of the Ear in HIV-Negative Patients

Demographic, Clinical and Histopathological Features of Oral Neural Neoplasms: A Retrospective Study

Sporadic Minute Pharyngeal Xanthomas Detected Incidentally During Esophagogastroduodenoscopy: A Case Series

An Autopsy Report of an Adenoid Cystic Carcinoma Arising in the Trachea

Fetal Type Rhabdomyoma of the Soft Palate in an Adult Patient: Report of One Case and Review of the Literature

Measuring Depth of Invasion in Early Squamous Cell Carcinoma of the Oral Tongue: Positive Deep Margin, Extratumoral Perineural Invasion, and Other Challenges

Neu im Fachgebiet Pathologie

Molekularpathologische Untersuchungen im Wandel der Zeit

Vergleichende Pathologie in der onkologischen Forschung

Gastrointestinale Stromatumoren

Personalisierte Medizin in der Onkologie