Skip to main content
Hauptrubriken
CME Facharzt-Training Webinare Zeitschriften Bücher e.Medpedia Podcast
Service
Jobbörse Info & Hilfe
Fachgebiete
Anästhesiologie Allgemeinmedizin Arbeitsmedizin Augenheilkunde Chirurgie Dermatologie Gynäkologie und Geburtshilfe HNO Innere Medizin Kardiologie Neurologie Onkologie und Hämatologie Orthopädie und Unfallchirurgie Pädiatrie Pathologie Psychiatrie Radiologie Rechtsmedizin Urologie Zahnmedizin
Themen
Typ-2-Diabetes und Adipositas Klimawandel und Gesundheit Neues aus dem Markt COVID-19 Praxis und Beruf Seltene Erkrankungen GOÄ & EBM Panorama
Sammlungen
Kasuistiken Algorithmen & Infografiken Blickdiagnosen Arthropedia FlapFinder (für Dermatochirurgen) Videos Kongressberichterstattung Medizin für Apothekerinnen und Apotheker Für Ärztinnen und Ärzte in Weiterbildung Für Medizinstudierende

Live-Webinar "Urologie und Sexualmedizin in der Praxis"

Häufige urologisch-sexualmedizinische Themen in der Praxis sind das Thema des MMW-Webinars am 5. Juni von 17.30 bis 19 Uhr. Konkret geht es um die Frage, wann bei Harnwegsinfektionen auf Antibiotika verzichtet werden kann, und um ein Update zur Therapie von Libido- und Potenzstörungen des Mannes. Der dritte Vortrag behandelt sexuell übertragbare Krankheiten. Stellen Sie Ihre Fragen an die Experten und sammeln Sie 2 CME-Punkte. Jetzt gleich anmelden!
Erweiterte Suche
Anmelden
nach oben
Current Urology Reports
Erschienen in: Current Urology Reports 11/2016

01.11.2016 | Men’s Health (A Dabaja, Section Editor)

Overview of Dietary Supplements in Prostate Cancer

verfasst von: Aline Yacoubian, Rana Abu Dargham, Raja B. Khauli, Bassel G. Bachir

Erschienen in: Current Urology Reports | Ausgabe 11/2016

Einloggen, um Zugang zu erhalten

Abstract

Prostate cancer is a key health concern for men with its etiology still under investigation. Recently, the role of dietary supplements has been noted to have a major inhibitory effect on prostate cancer and numerous studies have been conducted in this regard. This review provides a summary on numerous recent studies conducted in this field. Some of the studies reviewed revealed a protective role for supplements, and others showed no correlation while some even had an adverse effect. The mechanism of how these supplements act on the prostate is still not clear. Further studies are warranted especially for supplements that have been shown to have a potential inhibitory role in prostate cancer.
Literatur
1.
2.
Westerlund A, Steineck G, Balter K, Stattin P, Gronberg H, Hedelin M. Dietary supplement use patterns in men with prostate cancer: the Cancer Prostate Sweden study. Ann oncol : off j Eur Soc Med Oncol / ESMO. 2011;22(4):967–72.CrossRef
3.
Boon H, Westlake K, Stewart M, Gray R, Fleshner N, Gavin A, et al. Use of complementary/alternative medicine by men diagnosed with prostate cancer: prevalence and characteristics. Urology. 2003;62(5):849–53.CrossRefPubMed
4.
Velicer CM, Ulrich CM. Vitamin and mineral supplement use among US adults after cancer diagnosis: a systematic review. J Clin Oncol Off J Am Soc Clin Oncol. 2008;26(4):665–73.CrossRef
5.
6.••
7.
Nyame YA, Murphy AB, Bowen DK, Jordan G, Batai K, Dixon M, et al. Associations between serum vitamin D and adverse pathology in men undergoing radical prostatectomy. J Clin Oncol Off J Am Soc Clin Oncol. 2016;34(12):1345–9.CrossRef
8.
Marshall DT, Savage SJ, Garrett-Mayer E, Keane TE, Hollis BW, Horst RL, et al. Vitamin D3 supplementation at 4000 international units per day for 1 year results in a decrease of positive cores at repeat biopsy in subjects with low-risk prostate cancer under active surveillance. J Clin Endocrinol Metab. 2012;97(7):2315–24.CrossRefPubMedPubMedCentral
9.
Shui IM, Mucci LA, Kraft P, Tamimi RM, Lindstrom S, Penney KL, et al. Vitamin D-related genetic variation, plasma vitamin D, and risk of lethal prostate cancer: a prospective nested case-control study. J Natl Cancer Inst. 2012;104(9):690–9.CrossRefPubMedPubMedCentral
10.
Kristal AR, Till C, Song X, Tangen CM, Goodman PJ, Neuhauser ML, et al. Plasma vitamin D and prostate cancer risk: results from the Selenium and Vitamin E Cancer Prevention Trial. Cancer Epidemiol Biomark Prev Publ Am Assoc Cancer Res Am Soc Prev Oncol. 2014;23(8):1494–504.CrossRef
11.
Lippman SM, Goodman PJ, Klein EA, Parnes HL, Thompson Jr IM, Kristal AR, et al. Designing the Selenium and Vitamin E Cancer Prevention Trial (SELECT). J Natl Cancer Inst. 2005;97(2):94–102.CrossRefPubMed
12.
Schenk JM, Till CA, Tangen CM, Goodman PJ, Song X, Torkko KC, et al. Serum 25-hydroxyvitamin D concentrations and risk of prostate cancer: results from the Prostate Cancer Prevention Trial. Cancer Epidemiol Biomark Prev Publ Am Assoc Cancer Res Am Soc Prev Oncol. 2014;23(8):1484–93.CrossRef
13.
Coltman Jr CA, Thompson Jr IM, Feigl P. Prostate Cancer Prevention Trial (PCPT) update. Eur Urol. 1999;35(5–6):544–7.CrossRefPubMed
14.•
Albanes D, Mondul AM, Yu K, Parisi D, Horst RL, Virtamo J, et al. Serum 25-hydroxy vitamin D and prostate cancer risk in a large nested case-control study. Cancer Epidemiol Biomark Prev Publ Am Assoc Cancer Res Am Soc Prev Oncol. 2011;20(9):1850–60. This was a nested case-control study within the Alpha-Tocopherol, Beta-Carotene Cancer Prevention Study with 1000 cases and 1000 controls. Men who had higher serum 25(OH)D were at greater risk for developing prostate cancer, but there was no evidence for men with low vitamin D status. CrossRef
15.
The ATBC Cancer Prevention Study Group. The effect of vitamin E and beta carotene on the incidence of lung cancer and other cancers in male smokers. N Engl J Med. 1994;330:1029–35.
16.
Mondul AM, Watters JL, Mannisto S, Weinstein SJ, Snyder K, Virtamo J, et al. Serum retinol and risk of prostate cancer. Am J Epidemiol. 2011;173(7):813–21.CrossRefPubMedPubMedCentral
17.
Schenk JM, Riboli E, Chatterjee N, Leitzmann MF, Ahn J, Albanes D, et al. Serum retinol and prostate cancer risk: a nested case-control study in the prostate, lung, colorectal, and ovarian cancer screening trial. Cancer Epidemiol Biomark Prev Publ Am Assoc Cancer Res Am Soc Prev Oncol. 2009;18(4):1227–31.CrossRef
18.
Roswall N, Larsen SB, Friis S, Outzen M, Olsen A, Christensen J, et al. Micronutrient intake and risk of prostate cancer in a cohort of middle-aged, Danish men. Cancer Causes Control CCC. 2013;24(6):1129–35.CrossRefPubMed
19.
Gaziano JM, Glynn RJ, Christen WG, Kurth T, Belanger C, Macfadyen J, et al. Vitamins E and C in the prevention of prostate and total cancer in men: the Physicians’ Health Study II randomized controlled trial. JAMA. 2009;301(1):52–62.CrossRefPubMed
20.
Bidoli E, Talamini R, Zucchetto A, Bosetti C, Negri E, Lenardon O, et al. Dietary vitamins E and C and prostate cancer risk. Acta Oncol. 2009;48(6):890–4.CrossRefPubMed
21.
Ledesma MC, Jung-Hynes B, Schmit TL, Kumar R, Mukhtar H, Ahmad N. Selenium and vitamin E for prostate cancer: post-SELECT (Selenium and Vitamin E Cancer Prevention Trial) status. Mol Med. 2011;17(1–2):134–43.PubMed
22.
Wright ME, Weinstein SJ, Lawson KA, Albanes D, Subar AF, Dixon LB, et al. Supplemental and dietary vitamin E intakes and risk of prostate cancer in a large prospective study. Cancer Epidemiol Biomark Prev Publ Am Assoc Cancer Res Am Soc Prev Oncol. 2007;16(6):1128–35.CrossRef
23.
Heinonen OP, Albanes D, Virtamo J, Taylor PR, Huttunen JK, Hartman AM, et al. Prostate cancer and supplementation with alpha-tocopherol and beta-carotene: incidence and mortality in a controlled trial. J Natl Cancer Inst. 1998;90(6):440–6.CrossRefPubMed
24.
Peters U, Littman AJ, Kristal AR, Patterson RE, Potter JD, White E. Vitamin E and selenium supplementation and risk of prostate cancer in the Vitamins and lifestyle (VITAL) study cohort. Cancer Causes Control CCC. 2008;19(1):75–87.CrossRefPubMed
25.
Rodriguez C, Jacobs EJ, Mondul AM, Calle EE, McCullough ML, Thun MJ. Vitamin E supplements and risk of prostate cancer in U.S. men. Cancer Epidemiol Biomark Prev Publ Am Assoc Cancer Res Am Soc Prev Oncol. 2004;13(3):378–82.
26.
Kristal AR, Till C, Platz EA, Song X, King IB, Neuhouser ML, et al. Serum lycopene concentration and prostate cancer risk: results from the Prostate Cancer Prevention Trial. Cancer Epidemiol Biomark Prev Publ Am Assoc Cancer Res Am Soc Prev Oncol. 2011;20(4):638–46.CrossRef
27.
Kirsh VA, Mayne ST, Peters U, Chatterjee N, Leitzmann MF, Dixon LB, et al. A prospective study of lycopene and tomato product intake and risk of prostate cancer. Cancer Epidemiol Biomark Prev Publ Am Assoc Cancer Res Am Soc Prev Oncol. 2006;15(1):92–8.CrossRef
28.
Zu K, Mucci L, Rosner BA, Clinton SK, Loda M, Stampfer MJ, et al. Dietary lycopene, angiogenesis, and prostate cancer: a prospective study in the prostate-specific antigen era. J Natl Cancer Inst. 2014;106(2):djt430.CrossRefPubMedPubMedCentral
29.
Ming DS, Pham S, Deb S, Chin MY, Kharmate G, Adomat H, et al. Pomegranate extracts impact the androgen biosynthesis pathways in prostate cancer models in vitro and in vivo. J Steroid Biochem Mol Biol. 2014;143:19–28.CrossRefPubMed
30.
Paller CJ, Ye X, Wozniak PJ, Gillespie BK, Sieber PR, Greengold RH, et al. A randomized phase II study of pomegranate extract for men with rising PSA following initial therapy for localized prostate cancer. Prostate Cancer Prostatic Dis. 2013;16(1):50–5.CrossRefPubMed
31.
Pantuck AJ, Leppert JT, Zomorodian N, Aronson W, Hong J, Barnard RJ, et al. Phase II study of pomegranate juice for men with rising prostate-specific antigen following surgery or radiation for prostate cancer. Clin cancer res off j Am Assoc Cancer Res. 2006;12(13):4018–26.CrossRef
32.
Steinbrecher A, Meplan C, Hesketh J, Schomburg L, Endermann T, Jansen E, et al. Effects of selenium status and polymorphisms in selenoprotein genes on prostate cancer risk in a prospective study of European men. J Clin Oncol Off J Am Soc Clin OncolCancer Epidemiol Biomark Prev Publ Am Assoc Cancer Res Am Soc Prev Oncol. 2010;19(11):2958–68.
33.•
Kenfield SA, Van Blarigan EL, DuPre N, Stampfer MJ ELG, Chan JM. Selenium supplementation and prostate cancer mortality. J Natl Cancer Inst. 2015;107(1):360. This is a study which prospectively followed 4459 men initially diagnosed with non-metastatic prostate cancer in the Health Professionals Follow-Up Study were followed up to check for selenium consumption after diagnosis. Men who took selenium supplementation of 140 or more μg/day after diagnosis of non-metastatic prostate cancer were at elevated risk for mortality from prostate cancer mortality. CrossRefPubMed
34.
Gann PH, Deaton RJ, Rueter EE, van Breemen RB, Nonn L, Macias V, et al. A Phase II Randomized Trial of Lycopene-Rich Tomato Extract Among Men with High-Grade Prostatic Intraepithelial Neoplasia. Nutr Cancer. 2015;67(7):1104–12.CrossRefPubMedPubMedCentral
Metadaten
Titel
Overview of Dietary Supplements in Prostate Cancer
verfasst von
Aline Yacoubian
Rana Abu Dargham
Raja B. Khauli
Bassel G. Bachir
Publikationsdatum
01.11.2016
Verlag
Springer US
Erschienen in
Current Urology Reports / Ausgabe 11/2016
Print ISSN: 1527-2737
Elektronische ISSN: 1534-6285
DOI
https://doi.org/10.1007/s11934-016-0637-8

Weitere Artikel der Ausgabe 11/2016

Current Urology Reports 11/2016 Zur Ausgabe

Lower Urinary Tract Symptoms & Voiding Dysfunction (H Goldman and G Badlani, Section Editors)

Post-Sling Urinary Retention in Women

INVITED COMMENTARY

Newly Proposed Prognostic Grade Group System for Prostate Cancer: Genesis, Utility and its Implications in Clinical Practice

Men’s Health (A Dabaja, Section Editor)

Urinary Catheterization: a Paradigm Shift in Difficult Urinary Catheterization

INVITED COMMENTARY

Influences of the Results from STRIVE Trial on the Combination Androgen Depletion Therapy for Advanced Prostate Cancer

Lower Urinary Tract Symptoms & Voiding Dysfunction (H Goldman and G Badlani, Section Editors)

Minimally Invasive Sacrocolpopexy: How to Avoid Short- and Long-Term Complications

Lower Urinary Tract Symptoms & Voiding Dysfunction (H Goldman and G Badlani, Section Editors)

Specific Tips for General Controversies in Sacral Neuromodulation

Neu im Fachgebiet Urologie

Mit dem Seitenschneider gegen das Reißverschluss-Malheur

03.06.2024 Urologische Notfallmedizin Nachrichten

Wer ihn je erlebt hat, wird ihn nicht vergessen: den Schmerz, den die beim Öffnen oder Schließen des Reißverschlusses am Hosenschlitz eingeklemmte Haut am Penis oder Skrotum verursacht. Eine neue Methode für rasche Abhilfe hat ein US-Team getestet.

Patrone im Penis bringt Urologen in Gefahr

30.05.2024 Operationen am Penis Nachrichten

In Lebensgefahr brachte ein junger Mann nicht nur sich selbst, sondern auch das urologische Team, das ihm zu Hilfe kam: Er hatte sich zur Selbstbefriedigung eine scharfe Patrone in die Harnröhre gesteckt.

15% bedauern gewählte Blasenkrebs-Therapie

29.05.2024 Urothelkarzinom Nachrichten

Ob Patienten und Patientinnen mit neu diagnostiziertem Blasenkrebs ein Jahr später Bedauern über die Therapieentscheidung empfinden, wird einer Studie aus England zufolge von der Radikalität und dem Erfolg des Eingriffs beeinflusst.

Costims – das nächste heiße Ding in der Krebstherapie?

28.05.2024 Onkologische Immuntherapie Nachrichten

„Kalte“ Tumoren werden heiß – CD28-kostimulatorische Antikörper sollen dies ermöglichen. Am besten könnten diese in Kombination mit BiTEs und Checkpointhemmern wirken. Erste klinische Studien laufen bereits.

Update Urologie

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.

Newsletter bestellen
Bildnachweise