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European Archives of Oto-Rhino-Laryngology

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01.03.2016 | Review Article

Paraneoplastic syndromes in patients with laryngeal neuroendocrine carcinomas: clinical manifestations and prognostic significance

verfasst von: Alfio Ferlito, Alessandra Rinaldo, Justin A. Bishop, Jennifer L. Hunt, Vincent Vander Poorten, Michelle D. Williams, Asterios Triantafyllou, Kenneth O. Devaney, Douglas R. Gnepp, Kimihide Kusafuka, Gyorgy B. Halmos, William H. Westra, Robert P. Takes, Lester D. R. Thompson

Erschienen in: European Archives of Oto-Rhino-Laryngology | Ausgabe 3/2016

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Abstract

Paraneoplastic syndromes are associated with a variety of malignant neoplasms and are systemic and non-metastatic manifestations that develop in a minority of cancer patients. This review examines all published cases of paraneoplastic syndromes associated with neuroendocrine carcinomas of the larynx. There are a total of ten patients reported with paraneoplastic syndromes associated with laryngeal neuroendocrine carcinomas in the literature. Of these, nine died and the tenth is alive with liver metastases. There were five cases of small-cell neuroendocrine carcinoma, four cases of moderately differentiated neuroendocrine carcinoma, and one case of well-differentiated neuroendocrine carcinoma associated with paraneoplastic syndromes. As these syndromes have significant clinical relevance, physicians should be aware of the possible presence of paraneoplastic syndromes in the diagnostic process of patients with neuroendocrine carcinoma of the larynx.

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Titel: Paraneoplastic syndromes in patients with laryngeal neuroendocrine carcinomas: clinical manifestations and prognostic significance
verfasst von: Alfio Ferlito
Alessandra Rinaldo
Justin A. Bishop
Jennifer L. Hunt
Vincent Vander Poorten
Michelle D. Williams
Asterios Triantafyllou
Kenneth O. Devaney
Douglas R. Gnepp
Kimihide Kusafuka
Gyorgy B. Halmos
William H. Westra
Robert P. Takes
Lester D. R. Thompson
Publikationsdatum: 01.03.2016
Verlag: Springer Berlin Heidelberg
Erschienen in: European Archives of Oto-Rhino-Laryngology / Ausgabe 3/2016
Print ISSN: 0937-4477
Elektronische ISSN: 1434-4726
DOI: https://doi.org/10.1007/s00405-014-3351-5

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Paraneoplastic syndromes in patients with laryngeal neuroendocrine carcinomas: clinical manifestations and prognostic significance

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