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01.03.2009 | Original Article

Partially Hydrolyzed Guar Gum Attenuates the Severity of Pouchitis in a Rat Model of Ileal J Pouch-Anal Anastomosis

verfasst von: Koray Atila, Cem Terzi, Aras Emre Canda, Serpil Tanriverdi Akhisaroglu, Hatice Sanli Avci, Sulen Sarioglu, Gulgun Oktay, Zeynep Gulay

Erschienen in: Digestive Diseases and Sciences | Ausgabe 3/2009

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Abstract

We aimed to evaluate the efficacy of treatment with partially hydrolyzed guar gum (PHGG) using a rat model of ileal pouch-anal anastomosis and pouchitis. In the J pouch groups, tissue myeloperoxidase activities were significantly higher than native myeloperoxidase activities (P = 0.020; P = 0.015; P = 0.004, respectively). A statistically significant difference in total histological score was detected in the J pouch + 5% dextran sulfate sodium (DSS) group, compared to the J pouch control and the J pouch + 5% DSS + PHGG groups (P < 0.01 and P < 0.01, respectively). There was a significant overgrowth of aerobes and anaerobes in the J pouch + 5% DSS group. This study demonstrated that rectal administration of PHGG attenuates the severity of pouchitis in a rat model. In conclusion, PHGG may be an additional therapeutic strategy for the treatment of pouchitis.

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Titel: Partially Hydrolyzed Guar Gum Attenuates the Severity of Pouchitis in a Rat Model of Ileal J Pouch-Anal Anastomosis
verfasst von: Koray Atila
Cem Terzi
Aras Emre Canda
Serpil Tanriverdi Akhisaroglu
Hatice Sanli Avci
Sulen Sarioglu
Gulgun Oktay
Zeynep Gulay
Publikationsdatum: 01.03.2009
Verlag: Springer US
Erschienen in: Digestive Diseases and Sciences / Ausgabe 3/2009
Print ISSN: 0163-2116
Elektronische ISSN: 1573-2568
DOI: https://doi.org/10.1007/s10620-008-0377-9

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Partially Hydrolyzed Guar Gum Attenuates the Severity of Pouchitis in a Rat Model of Ileal J Pouch-Anal Anastomosis

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