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Medical Molecular Morphology

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01.09.2013 | Review

Participation of aquaporin-1 in vascular changes and remodeling in cirrhotic liver

verfasst von: Hiroyoshi Iguchi, Masaya Oda, Hitoshi Yamazaki, Hiroaki Yokomori

Erschienen in: Medical Molecular Morphology | Ausgabe 3/2013

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Abstract

The pathophysiology of arterial capillary proliferation accompanying fibrosis in human cirrhosis remains unclear. However, evidence regarding the molecules participating in the pathophysiological process has been accumulating. Water channel proteins known as aquaporins (AQP)s, notably AQP-1, appear to be involved in the arterial capillary proliferation in the cirrhotic liver.

Rappaport AM (1980) Hepatic blood flow: morphologic aspects and physiologic regulation. Int Rev Physiol 21:1–63PubMed

Vollmar B, Menger MD (2009) The hepatic microcirculation: mechanistic contributions and therapeutic targets in liver injury and repair. Physiol Rev 89:1269–3393PubMedCrossRef

Iwakiri Y (2012) Endothelial dysfunction in the regulation of cirrhosis and portal hypertension. Liver Int 2012(32):199–213CrossRef

Aoki T, Imamura H, Kaneko J, Sakamoto Y, Matsuyama Y, Kokudo N, Sugawara Y, Makuuchi M (2005) Intraoperative direct measurement of hepatic arterial buffer response in patients with or without cirrhosis. Liver Transpl 11:684–691PubMedCrossRef

Nielsen S, Smith BL, Christensen EI, Agre P (1993) Distribution of the aquaporin CHIPS in secretary and resorptive epithelia and capillary endothelia. Proc Natl Acad Sci USA 90:7275–7279PubMedCrossRef

Matsuzaki T, Tajika Y, Ablimit A, Aoki T, Hagiwara H, Takata K (2004) Aquaporins in the digestive system. Med Electron Microsc 37:71–80PubMedCrossRef

Saadoun S, Papadopoulos MC, Chikuma MH, Verkman AS (2005) Impairment of angiogenesis and cell migration by targeted aquaporin-1 gene disruption. Nature 434:786–792PubMedCrossRef

Fernandez M, Semela D, Bruix J, Colle I, Pinzani M, Bosch J (2009) Angiogenesis in liver disease. J Hepatol 50:604–620PubMedCrossRef

Djonov V, Schmid M, Tschanz SA, Burri PH (2000) Intussusceptive angiogenesis: its role in embryonic vascular network formation. Circ Res 86:286–292PubMedCrossRef

10.

Semela D, Piguet AC, Kolev M, Schmitter K, Hlushchuk R, Djonov V, Stoupis C, Dufour JF (2007) Vascular remodeling and antitumoral effects of mTOR inhibition in a rat model of hepatocellular carcinoma. J Hepatol 46:840–848PubMedCrossRef

11.

Morales-Ruiz M, Jimenez W (2005) Neovascularization, angiogenesis and vascular remodeling in portal hypertension. In: Sanyal A, Shah V (eds) Portal Hypertension: Pathobiology, Evaluation, and Treatment. Humana Press, Totowa, pp 99–112CrossRef

12.

Fabris L, Cadamuro M, Libbrecht L, Raynaud P, Spirlì C, Fiorotto R, Okolicsanyi L, Lemaigre F, Strazzabosco M, Roskams T (2008) Epithelial expression of angiogenic growth factors modulate arterial vasculogenesis in human liver development. Hepatology 47:719–728PubMedCrossRef

13.

McCuskey RS, Reilly FD (1993) Hepatic microvasculature: dynamic structure and its regulation. Semin Liver Dis 13:1–12PubMedCrossRef

14.

Oda M, Nakamura M, Watanabe N, Ohya Y, Sekuzuka E, Tsukada N, Yonei Y, Komatsu H, Nagata H, Tsuchiya M (1983) Some dynamic aspects of hepatic microcirculation—demonstration of sinusoidal endothelial fenestrae as a possible regulatory factor. In: Tsuchiya M, Wayland M, Oda M, Okazaki I (eds) Intravital observation of organ microcirculation. Accepts medicaid, Amsterdam, pp 105–138

15.

Oda M, Han JY, Yokomori Y (2000) Local regulators of hepatic sinusoidal microcirculation: recent advances. Clin Hemorheol Microcirc 23:85–94PubMed

16.

Bloch EH (1970) The termination of the hepatic arterioles and the functional unit of the liver as determined by microscopy of the living organ. Ann N Acad Sci 170:78–87CrossRef

17.

McCuskey RS (1970) A dynamic and static study of hepatic arterioles and hepatic sphincters. Am J Anat Rec 167:329–349CrossRef

18.

Suematsu M, Oda M, Suzuki H, Kaneko H, Watanabe N, Furusho T, Masushige S, Tsuchiya M (1993) Intravital and electron microscopic observation of Ito cells in rat hepatic microcirculation. Microvasc Res 46:28–42PubMedCrossRef

19.

Elias H, Petty D (1953) Terminal distribution of the hepatic artery. Anat Rec 116:9–77PubMedCrossRef

20.

Ekataksin W, Kaneda K (1999) Liver microvascular architecture: an insight into the pathophysiology of portal hypertension, Semi. Liver Dis 19:359–381CrossRef

21.

Oda M, Yokomori H, Han JY (2006) Regulatory mechanisms of hepatic microcirculatory hemodynamics: hepatic arterial system. Clin Hemorheol Microcirc 34:11–26PubMed

22.

Knisely MH, Harding F, Debacker H (1957) Hepatic sphincters. Science 125:1023–1026PubMedCrossRef

23.

Rhodin JAG (1967) The ultrastructure of mammalian arterioles and precapillary sphincters. J Ultrastruct Res 18:181–223PubMedCrossRef

24.

Rappaport AM, Black RG, Lucas CC, Ridout JH, Best CH (1966) Normal and pathologic microcirculation of the living mammalian liver. Rev Int Hepatol 16:813–828PubMed

25.

Rappaport AM, Schneiderman JH (1976) The function of the hepatic artery. Rev Physiol Biochem Pharmacol 76:129–175PubMedCrossRef

26.

Werner JA, Schünke M, Tillmann B (1987) Histochemical visualization of lymphatic capillaries in the rat: a comparison of methods demonstrated at the posterior pharyngeal surface. Arch Histol Jpn 50:505–514PubMedCrossRef

27.

Vollmar B, Siegmund S, Menger MD (1998) An intravital fluorescence microscopic study of hepatic microvascular and cellular derangements in developing cirrhosis in rats. Hepatology 27:1544–1553PubMedCrossRef

28.

Oda M, Han JY, Nakamura M (2000) Endothelial cell dysfunction in microvasculature: relevance to disease processes. Clin Hemorheol Microcirc 23:199–211PubMed

29.

Agre P (2004) Nobel Lecture. Aquaporin water channels. Biosci Rep 24:127–163PubMedCrossRef

30.

Verkman AS (2009) Aquaporins: translating bench research to human disease. J Exp Biol 212:1707–1715PubMedCrossRef

31.

Masyuk AI, LaRusso NF (2006) Aquaporins in the hepatobiliary system. Hepatology 43(2 Suppl 1):S75–S81PubMedCrossRef

32.

Portincasa P, Palasciano G, Svelto M, Calamita G (2008) Aquaporins in the hepatobiliary tract. Which, where and what they do in health and disease. Eur J Clin Invest 38:1–10PubMedCrossRef

33.

Swartz-Basile DA, Lu D, Basile DP, Graewin SJ, Al-Azzawi H, Kiely J, Mathur A, Yancey K, Pitt HA (2007) Leptin regulates gallbladder genes related to absorption and secretion. Am J Physiol Gastrointest Liver Physiol 293:G84–G90PubMedCrossRef

34.

Carreras FI, Gradilone SA, Mazzone A, Garcia F, Huang BQ, Ochoa JE, Tietz PS, Larusso NF, Calamita G, Marinelli RA (2003) Rat hepatocyte aquaporin-8 water channels are down-regulated in extrahepatic cholestasis. Hepatology 37:1026–1033PubMedCrossRef

35.

Calamita G, Ferri D, Gena P, Carreras FI, Liquori GE, Portincasa P, Marinelli RA, Svelto M (2008) Altered expression and distribution of aquaporin-9 in the liver of rat with obstructive extrahepatic cholestasis. Am J Physiol Gastrointest Liver Physiol 295:G682–G690PubMedCrossRef

36.

Kuriyama H, Shimomura I, Kishida K, Kondo H, Furuyama N, Nishizawa H, Maeda N, Matsuda M, Nagaretani H, Kihara S, Nakamura T, Tochino Y, Funahashi T, Matsuzawa Y (2002) Coordinated regulation of fat-specific and liver-specific glycerol channels, aquaporin adipose and aquaporin 9. Diabetes 51:2915–2921PubMedCrossRef

37.

Nielsen S, Kwon TH, Frokiaer J, Agre P (2007) Regulation and dysregulation of aquaporins in water balance disorders. J Intern Med 261:53–64PubMedCrossRef

38.

Fujita N, Ishikawa SE, Sasaki S, Fujisawa G, Fushimi K, Marumo F, Saito T (1995) Role of water channel AQP-CD in water retention in SIADH and cirrhotic rats. Am J Physiol 269:F926–F931PubMed

39.

Claria J, Jimenez W, Arroyo V, Guarner F, Lopez C, La Villa G, López C, Asbert M, Castro A, Gaya J, Rivera F, Rodés J (1989) Blockade of the hydroosmotic effect of vasopressin normalizes water excretion in cirrhotic rats. Gastroenterology 97:1294–1299PubMed

40.

Rojek AM, Skowronski MT, Fuchtbauer EM, Fuchtbauer AC, Fenton RA, Agre P, Frøkiaer J, Nielsen S (2007) Defective glycerol metabolism in aquaporin 9 (AQP9) knockout mice. Proc Natl Acad Sci USA 104:3609–3614PubMedCrossRef

41.

Chiappini F, Barrier A, Saffroy R, Domart MC, Dagues N, Azoulay D, Azoulay D, Sebagh M, Franc B, Chevalier S, Debuire B, Dudoit S, Lemoine A (2006) Exploration of global gene expression in human liver steatosis by high-density oligonucleotide microarray. Lab Invest 86:154–165PubMedCrossRef

42.

Calamita G, Portincasa P (2007) Present and future therapeutic strategies in non-alcoholic fatty liver disease. Expert Opin Ther Targets 11:1231–1249PubMedCrossRef

43.

Aishima S, Kuroda Y, Nishihara Y, Taguchi K, Iguchi T, Taketomi A, Maehara Y, Tsuneyoshi M (2007) Down-regulation of aquaporin-1 in intrahepatic cholangiocarcinoma is related to tumor progression and mucin expression. Hum Pathol 38:1819–1825PubMedCrossRef

44.

Papadopoulos MC, Saadoun S, Verkman AS (2008) Aquaporins and cell migration. Pflugers Arch 456:693–700PubMedCrossRef

45.

Verkman AS, Hara-Chikuma M, Papadopoulos MC (2008) Aquaporins: new players in cancer biology. J Mol Med 86:523–529PubMedCrossRef

46.

Yokomori H, Oda M, Yoshimura K, Watanabe S, Hibi T (2010) Aberrant expressions of aquaporin-1 in association with capillarized sinusoidal endothelial cells in cirrhotic rat liver. Med Mol Morphol 43:6–12PubMedCrossRef

47.

Huebert RC, Vasdev MM, Shergill U, Das A, Huang BQ, Charlton MR, LaRusso NF, Shah VH (2010) Aquaporin-1 facilitates angiogenic invasion in the pathological neovasculature that accompanies cirrhosis. Hepatology 52:238–248PubMedCrossRef

48.

Braet F, Wisse E (2002) Structural and functional aspects of liver sinusoidal endothelial cell fenestrae: a review. Comp Hepatol 23:1–17CrossRef

49.

Rippe B, Rosengren BI, Carlsson O, Venturoli D (2002) Transendothelial transport: the vesicle controversy. J Vasc Res 39:375–390PubMedCrossRef

50.

Yokomori H (2008) New insights in the dynamics of sinusoidal endothelial fenestrae in liver sinusoidal endothelial cells. Med Mol Morphol 41:1–4PubMedCrossRef

51.

Rosmorduc O, Wendum D, Corpechot C, Galy B, Sebbagh N, Raleigh J, Housset C, Poupon R (1999) Hepatocellular hypoxia-induced vascular endothelial growth factor expression and angiogenesis in experimental biliary cirrhosis. Am J Pathol 1555:1065–1073CrossRef

52.

Kaneko K, Yagui K, Tanaka A, Yoshihara K, Ishikawa K, Takahashi K, Bujo H, Sakurai K, Saito Y (2008) Aquaporin 1 is required for hypoxia-inducible angiogenesis in human retinal vascular endothelial cells. Microvas Res 75:297–301CrossRef

53.

Echevarria M, Munoz-Cabello AM, Sanchez-Silva R, Toledo-Aral JJ, Lopez-Barneo J (2007) Development of cytosolic hypoxia and HIF stabilization are facilitated by aquaporin 1 expression. J Biol Chem 282:30207–30215PubMedCrossRef

54.

Yokomori H, Oda M, Yoshimura K, Kaneko F, Hibi T (2011) Aquaporin-1 associated with hepatic arterial capillary proliferation on hepatic sinusoid in human cirrhotic liver. Liver Int 31:1554–1564PubMedCrossRef

55.

Masyuk TV, Erik L, Ritman EL, LaRusso NF (2003) Hepatic artery and portal vein remodeling in rat liver. Vascular response to selective cholangiocyte proliferation. Am J Pathol 162:1175–1182

56.

Kono N, Nakanuma Y (1992) Ultrastructural and immunohistochemical studies of the intrahepatic peribiliary capillary plexus in normal livers and extrahepatic biliary obstruction in human beings. Hepatology 15:411–418PubMedCrossRef

57.

Gaudio E, Onori P, Pannarale L, Alvaro D (1996) Hepatic microcirculation and peribiliary plexus in experimental biliary cirrhosis: a morphological study. Gastroenterology 111:1118–1124PubMedCrossRef

58.

Gouw A, van den Heuvel M, Boot M, Slooff M, Poppema S, de Jong K (2006) Dynamics of the vascular profile of the finer branches of the biliary tree in normal and diseased human livers. J Hepatol 45:393–400PubMedCrossRef

59.

Roberts SK, Yano M, Ueno Y, Pham L, Alpini G, Agre P, LaRusso NF (1994) Cholangiocytes express the aquaporin CHIP and transport water via a channel-mediated mechanism. Proc Natl Acad Sci USA 91: 13009–13013

60.

Tamai K, Fukushima K, Ueno Y, Moritoki Y, Yamagiwa Y, Kanno N, Jefferson D, Shimosegawa T (2006) Differential expressions of aquaporin proteins in human cholestatic liver diseases. Hepatol Res 34:99–103PubMedCrossRef

61.

Medina J, Sanz-Cameno P, García-Buey L, Martín-Vílchez S, López-Cabrera M, Moreno-Otero R (2005) Evidence of angiogenesis in primary biliary cirrhosis: an immunohistochemical descriptive study. J Hepatol 42:124–131PubMedCrossRef

62.

Yokomori H, Oda M, Hibi T (2008) Aquaporin-1 demonstrates arterial capillary proliferation and hepatic sinusoidal transformation related to portal hypertension in primary biliary cirrhosis. 108th Digestive Disease Week (DDW) San Diego, USA. Gastroenterology 134: 1571A

63.

Tugues S, Fernandez-Varo G, Munoz-Luque J, Ros J, Arroyo V, Rodes J, Friedman SL, Carmeliet P, Jiménez W, Morales-Ruiz M (2007) Antiangiogenic treatment with sunitinib ameliorates inflammatory infiltrate, fibrosis, and portal pressure in cirrhotic rats. Hepatology 46:1919–1926PubMedCrossRef

64.

Morishita Y et al (2005) Disruption of aquaporin-11 produces polycystic kidneys following vacuolization of the proximal tubule. Mol Cell Biol 25:7770–7779PubMedCrossRef

Titel: Participation of aquaporin-1 in vascular changes and remodeling in cirrhotic liver
verfasst von: Hiroyoshi Iguchi
Masaya Oda
Hitoshi Yamazaki
Hiroaki Yokomori
Publikationsdatum: 01.09.2013
Verlag: Springer Japan
Erschienen in: Medical Molecular Morphology / Ausgabe 3/2013
Print ISSN: 1860-1480
Elektronische ISSN: 1860-1499
DOI: https://doi.org/10.1007/s00795-013-0039-7

Springer Medizin

Participation of aquaporin-1 in vascular changes and remodeling in cirrhotic liver

Abstract

Neu im Fachgebiet Pathologie

Molekularpathologische Untersuchungen im Wandel der Zeit

Vergleichende Pathologie in der onkologischen Forschung

Gastrointestinale Stromatumoren

Personalisierte Medizin in der Onkologie

Springer Medizin

Abstract

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