Erschienen in:
01.03.2012 | Letter to the Editor
Patterns of BCR breakpoints in patients with coexisting inv(16)(p13.1q22) and t(9;22)(q34;q11.2)
verfasst von:
Daniel Bustamante, Kathryn R. Chan, David R. Czuchlewski, A. Amir Al Saadi
Erschienen in:
International Journal of Hematology
|
Ausgabe 3/2012
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Excerpt
We read with great interest “Coexistence of inversion 16 and the Philadelphia chromosome comprising P190 BCR/ABL in chronic myeloid leukemia blast crisis” by Ninomiya et al. [
1]. As the authors note, their case represents the first reported usage of the minor
BCR breakpoint in the setting of chronic myelogenous leukemia (CML) in myeloid blast phase with a concomitant inv(16)(p13.1q22). All previously investigated similar cases show usage of the major
BCR breakpoint, while all investigated cases of de novo acute myeloid leukemia (AML) with coexisting inv(16)(p13.1q22) and t(9;22)(q34;q11.2) use the minor
BCR breakpoint. Indeed, this pattern is reinforced by several patients described in the literature but not listed in the authors’ Table 1 “Summary of reported cases of Ph+ myeloid leukemia with inv(16)” [
2‐
4]. …
