Patterns of medication use and factors associated with antibiotic use among adult fever patients at Singapore primary care clinics

Antimicrobial resistance (AMR) is a public health problem of global importance. The recent O’Neill review on AMR, commissioned by the government of the United Kingdom, suggests that the death toll from antimicrobial-resistant infections could exceed 10 million annually by 2050, surpassing mortality from cancer [1]. Antibiotic use is associated with AMR. [2] A systematic review by Costelloe and colleagues showed that the greater the number or duration of antibiotics prescribed in previous 12 months, the greater the likelihood of isolating drug-resistant bacteria [3]. Thus, it is important to optimize the use of antibiotics in humans and animals. This was also a particular focus of the O’Neill review and a key recommendation in the 2015 World Health Organization (WHO) Global Action Plan on AMR. [1, 4] Understanding levels and determinants of antibiotic use is critical to inform guidelines on optimal antibiotic use. Previous studies from the United States and the Netherlands reported excessive and inappropriate use of antibiotics in primary care [5, 6]. In Hong Kong, level of antibiotic use in primary care was generally similar to other developed settings with relatively lower number of antibiotics used among patients with upper respiratory tract infections [7]. In Singapore, much focus has been given to antibiotic usage patterns in hospital settings while data on antibiotic usage in primary care are lacking [8, 9]. In this paper, we report antibiotic usage patterns and factors associated with antibiotic usage among adult fever patients presenting to primary care clinics in Singapore.

We analyzed data from 1884 adult AFI patients enrolled in the EDEN study between December 2007 and February 2013. The mean age of patients was 36.7 years (SD, 14.7), 1235 (66%) were male, and 958 (51%) were Chinese. Most patients (74.3%) lived in public housing. Average body temperature at initial presentation was 38.2 °C, median duration of illness was 5 days (IQR, 3–7), and 759 (40%) patients satisfied the WHO definition of ILI. Less than 5% of AFI patients were known to have diabetes; other comorbidities (i.e. malignancy, and ischemic heart disease) were uncommon (<1%) (Table 1).

Overall, 309 (16%) patients used antibiotics, ranging from 5 to 31% across 5 polyclinics. OTC medication was used by 56% of patients, and included use of analgesics (309, 16%), cough medicines (608, 32%) and cold remedies (378, 20%). Figure 1 presents the use of antibiotics and over-the-counter medication over time. A marked drop in the percentage of patients who used antibiotics occurred in 2010, with a reduction of 40% from the mean for the entire study period in the second quarter of 2010. This coincided with increased use of OTC medication. This effect was only temporary and was reversed from 2011 onwards.

Among AFI patients, 94% reported two or more symptoms at the initial presentation. Headache (69%), muscle pain (64%), and loss of appetite (54%) were the three most commonly reported symptoms. Vomiting, diarrhea, swollen lymph nodes, rashes, and bleeding were each reported by fewer than 10% of patients (Fig. 2).

In multivariable analysis, factors associated with increased odds of antibiotic use, after adjusting for age, gender, recruiting polyclinic, and year of enrolment, included living in landed property compared to public housing (OR = 1.73; 95% CI: 1.06–2.80); having a body mass index (BMI) below 18.5 kg/m² (OR = 1.87; 95% CI: 1.19–2.93), and elevated WBC count (OR = 1.98; 95% CI: 1.42–2.78). Persistence of symptoms at 2–3 days from initial presentation was also associated with increased odds of antibiotic use; adjusted OR (95% CI) for categories of 1, 2, 3, and ≥4 persisting symptoms were 2.00 (1.38–2.92), 2.67 (1.80–3.97), 4.26 (2.73–6.64), and 2.79 (1.84–4.24) respectively (Table 2).

In a sub-group analysis of patients who met the WHO definition of ILI, after adjusting for age, gender, recruiting polyclinic, and year of enrolment, an elevated WBC count at initial presentation (OR = 1.97; 95% CI: 1.17–3.33), and persistence of symptoms at 2–3 days from initial presentation [(OR = 1.42; 95% CI: 0.79–2.57), (OR = 2.30; 95% CI: 1.23–4.30), (OR = 5.12; 95% CI: 2.67–9.83), and (OR = 2.28; 95% CI: 1.24–4.19) for categories of 1, 2, 3 and ≥4 persisting symptoms respectively] were associated with higher odds of antibiotic usage (Table 3).

We conducted a secondary data analysis, and assessed antibiotic use among adult fever patients in primary care setting, and factors associated with elevated antibiotic use. We found that overall 16% of adult AFI patients reported antibiotic use, although there was considerable variation between polyclinics. Factors that are likely to indicate higher socioeconomic status, and factors that are risk factors of a severe illness were associated with higher odds of antibiotic use.

Our estimates of antibiotic usage are difficult to compare to other settings, as previous studies have reported antibiotic usage or prescription overall, rather than specifically in adult fever patients. A Malaysian study by Ab Rahman and colleagues showed that 24% of adults were prescribed antibiotic in primary care clinics [13]. A survey conducted in Indonesia reported that an overall 21% patients attending public primary care centers consumed antibiotic [14]. In the United States, antibiotic prescription was reported in 10% of overall ambulatory visits [15].

Our study shows that patients living in a landed property were more likely to use antibiotics. In Singapore, landed properties (such as terrace houses, semi-detached houses, and bungalows) are likely to be related to higher socioeconomic status [16]. A possible explanation to our finding is that patients of higher socioeconomic status were more likely to expect an antibiotic prescription from physicians. This is consistent with the findings of a study from the United States [17].

Having low BMI and persisting symptoms at 2–3 days from the initial presentation were associated with a higher odds of antibiotic usage. Prescribing clinicians may perceive these as risk factors for more severe or longer-lasting illness, or secondary infection [18‐20], and may be more likely to prescribe antibiotics to these patients [6, 21].

Fever patients with elevated WBC count at initial presentation were more likely to use antibiotics. A similar association was also observed in the subgroup of patients with ILI. A high WBC count might indicate a bacterial infection, and thus the likelihood of antibiotic prescription. Studies from Switzerland and China found that more antibiotic use among fever patients was assoiated with higher WBC count [22, 23].

Our data indicate that antibiotic use decreased markedly in late 2009 and 2010, during which time the use of OTC medications increased. This coincided with the period following the epidemic of influenza A H1N1, which was introduced into Singapore in May 2009 and peaked in the latter part of 2009 and early 2010 [24]. The reduction in antibiotic use during this period could be due to heightened awareness among primary care physicians of the H1N1 pandemic. A similar phenomenon was reported in a study by Hebert and colleagues, in which lower antibiotic prescribing was observed during a pandemic period of febrile respiratory illness in the metropolitan Chicago area. [25] Although this pattern of reduced antibiotic usage was reversed in 2011, it suggests that considerable reductions in antibiotic prescription are possible in primary care.

The EDEN study was primarily designed to assess Dengue virus infection patterns, and antibiotic use was self-reported by the participants. Data on prescription, type, dosage and timing of antibiotic use were not available. Certain respiratory symptoms, such as cough, were not systematically recorded, and may have led to an underestimation of ILI.

Among fever patients in Singapore, approximately 80% of primary care consultations take place at private institutions [11]. The EDEN study did not sample patients visiting private practitioners. Patients accessing public primary care services are likely to differ from those using private services. For example, there were notable differences between patients in our data and the general population: 50% of patients were Chinese and 72% lived in HDB flats compared to 74% and 82% of the general population, respectively [26, 27]. In addition, antibiotic prescription and usage patterns among patients using primary care services in the private sector may be different to those in the public sector. A Malaysian study reported higher antibiotic prescription among healthcare providers in the private sector compared to those in the public sector [13]. Inclusion of private healthcare providers in research studies is important to gain a comprehensive picture of antibiotic usage in primary care.

Our study provides insights on antibiotic usage among adult patients presenting to primary care clinics with febrile illness, and suggests that high socio-economic status, and risk factors of a severe illness, that is, low BMI and persistence of initial symptoms, are associated with higher antibiotic use. Further work to understand trends of antibiotic use, both in the public and private sectors, as well as factors that influence patient expectation and physician prescribing of antibiotics is important, in order to identify opportunities to rationalize antibiotic use and develop policies for optimal antibiotic use in primary care.