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Erschienen in: Pediatric Nephrology 6/2022

06.09.2021 | Educational Review

Pediatric Onco-Nephrology: Time to Spread the Word-Part II: Long-Term Kidney Outcomes in Survivors of Childhood Malignancy and Malignancy after Kidney Transplant

verfasst von: Arwa Nada, Jennifer G Jetton

Erschienen in: Pediatric Nephrology | Ausgabe 6/2022

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Abstract

Onco-nephrology is a recent and evolving medical subspecialty devoted to the care of patients with kidney disease and unique kidney-related complications in the context of cancer and its treatments, recognizing that management of kidney disease as well as the cancer itself will improve survival and quality of life. While this area has received much attention in the adult medicine sphere, similar emphasis in the pediatric realm has not yet been realized. As in adults, kidney involvement in children with cancer extends beyond the time of initial diagnosis and treatment. Many interventions, such as chemotherapy, stem cell transplant, radiation, and nephrectomy, have long-term kidney effects, including the development of chronic kidney disease (CKD) with subsequent need for dialysis and/or kidney transplant. Thus, with the improved survival of children with malignancy comes the need for ongoing monitoring of kidney function and early mitigation of kidney-related comorbidities. In addition, children with kidney transplant are at higher risk of developing malignancies than their age-matched peers. Pediatric nephrologists thus need to be aware of issues related to cancer and its treatments as they impact their own patients. These facts emphasize the necessity of pediatric nephrologists and oncologists working closely together in managing these children and highlight the importance of bringing the onco-nephrology field to our growing list of pediatric nephrology subspecialties.
Literatur
1.
4.
Zurück zum Zitat Levey AS, Coresh J, Balk E, Kausz AT, Levin A, Steffes MW et al (2003) National Kidney Foundation practice guidelines for chronic kidney disease: evaluation, classification, and stratification. Ann Intern Med 139:137–147PubMedCrossRef Levey AS, Coresh J, Balk E, Kausz AT, Levin A, Steffes MW et al (2003) National Kidney Foundation practice guidelines for chronic kidney disease: evaluation, classification, and stratification. Ann Intern Med 139:137–147PubMedCrossRef
5.
Zurück zum Zitat Robison LL, Armstrong GT, Boice JD, Chow EJ, Davies SM, Donaldson SS et al (2009) The Childhood Cancer Survivor Study: a National Cancer Institute-supported resource for outcome and intervention research. J Clin Oncol 27:2308–2318PubMedPubMedCentralCrossRef Robison LL, Armstrong GT, Boice JD, Chow EJ, Davies SM, Donaldson SS et al (2009) The Childhood Cancer Survivor Study: a National Cancer Institute-supported resource for outcome and intervention research. J Clin Oncol 27:2308–2318PubMedPubMedCentralCrossRef
6.
Zurück zum Zitat Gutierrez-Millet V, Nieto J, Praga M, Usera G, Martinez MA, Morales JM (1986) Focal glomerulosclerosis and proteinuria in patients with solitary kidneys. Arch Intern Med 146:705–709PubMedCrossRef Gutierrez-Millet V, Nieto J, Praga M, Usera G, Martinez MA, Morales JM (1986) Focal glomerulosclerosis and proteinuria in patients with solitary kidneys. Arch Intern Med 146:705–709PubMedCrossRef
7.
Zurück zum Zitat Knijnenburg SL, Jaspers MW, van der Pal HJ, Schouten-van Meeteren AY, Bouts AH, Lieverst JA et al (2012) Renal dysfunction and elevated blood pressure in long-term childhood cancer survivors. Clin J Am Soc Nephrol 7:1416–1427PubMedPubMedCentralCrossRef Knijnenburg SL, Jaspers MW, van der Pal HJ, Schouten-van Meeteren AY, Bouts AH, Lieverst JA et al (2012) Renal dysfunction and elevated blood pressure in long-term childhood cancer survivors. Clin J Am Soc Nephrol 7:1416–1427PubMedPubMedCentralCrossRef
8.
Zurück zum Zitat Interiano RB, Delos Santos N, Huang S, Srivastava DK, Robison LL, Hudson MM et al (2015) Renal function in survivors of nonsyndromic Wilms tumor treated with unilateral radical nephrectomy. Cancer 121:2449–2456PubMedCrossRef Interiano RB, Delos Santos N, Huang S, Srivastava DK, Robison LL, Hudson MM et al (2015) Renal function in survivors of nonsyndromic Wilms tumor treated with unilateral radical nephrectomy. Cancer 121:2449–2456PubMedCrossRef
9.
Zurück zum Zitat de Graaf SS, van Gent H, Reitsma-Bierens WC, van Luyk WH, Dolsma WV, Postma A (1996) Renal function after unilateral nephrectomy for Wilms’ tumour: the influence of radiation therapy. Eur J Cancer 32A:465–469PubMedCrossRef de Graaf SS, van Gent H, Reitsma-Bierens WC, van Luyk WH, Dolsma WV, Postma A (1996) Renal function after unilateral nephrectomy for Wilms’ tumour: the influence of radiation therapy. Eur J Cancer 32A:465–469PubMedCrossRef
10.
Zurück zum Zitat Finklestein JZ, Norkool P, Green DM, Breslow N, D'Angio GJ (1993) Diastolic hypertension in Wilms’ tumor survivors: a late effect of treatment? A report from the National Wilms’ Tumor Study Group. Am J Clin Oncol 16:201–205PubMedCrossRef Finklestein JZ, Norkool P, Green DM, Breslow N, D'Angio GJ (1993) Diastolic hypertension in Wilms’ tumor survivors: a late effect of treatment? A report from the National Wilms’ Tumor Study Group. Am J Clin Oncol 16:201–205PubMedCrossRef
12.
Zurück zum Zitat Skinner R, Cotterill SJ, Stevens MC (2000) Risk factors for nephrotoxicity after ifosfamide treatment in children: a UKCCSG Late Effects Group study. United Kingdom Children's Cancer Study Group. Br J Cancer 82:1636–1645PubMedPubMedCentralCrossRef Skinner R, Cotterill SJ, Stevens MC (2000) Risk factors for nephrotoxicity after ifosfamide treatment in children: a UKCCSG Late Effects Group study. United Kingdom Children's Cancer Study Group. Br J Cancer 82:1636–1645PubMedPubMedCentralCrossRef
13.
Zurück zum Zitat Suarez A, McDowell H, Niaudet P, Comoy E, Flamant F (1991) Long-term follow-up of ifosfamide renal toxicity in children treated for malignant mesenchymal tumors: an International Society of Pediatric Oncology report. J Clin Oncol 9:2177–2182PubMedCrossRef Suarez A, McDowell H, Niaudet P, Comoy E, Flamant F (1991) Long-term follow-up of ifosfamide renal toxicity in children treated for malignant mesenchymal tumors: an International Society of Pediatric Oncology report. J Clin Oncol 9:2177–2182PubMedCrossRef
14.
Zurück zum Zitat Berrak SG, Pearson M, Berberoglu S, Ilhan IE, Jaffe N (2005) High-dose ifosfamide in relapsed pediatric osteosarcoma: therapeutic effects and renal toxicity. Pediatr Blood Cancer 44:215–219PubMedCrossRef Berrak SG, Pearson M, Berberoglu S, Ilhan IE, Jaffe N (2005) High-dose ifosfamide in relapsed pediatric osteosarcoma: therapeutic effects and renal toxicity. Pediatr Blood Cancer 44:215–219PubMedCrossRef
15.
Zurück zum Zitat Ho PT, Zimmerman K, Wexler LH, Blaney S, Jarosinski P, Weaver-McClure L et al (1995) A prospective evaluation of ifosfamide-related nephrotoxicity in children and young adults. Cancer 76:2557–2564PubMedCrossRef Ho PT, Zimmerman K, Wexler LH, Blaney S, Jarosinski P, Weaver-McClure L et al (1995) A prospective evaluation of ifosfamide-related nephrotoxicity in children and young adults. Cancer 76:2557–2564PubMedCrossRef
16.
Zurück zum Zitat Latcha S, Jaimes EA, Patil S, Glezerman IG, Mehta S, Flombaum CD (2016) Long-term renal outcomes after cisplatin treatment. Clin J Am Soc Nephrol 11:1173–1179PubMedPubMedCentralCrossRef Latcha S, Jaimes EA, Patil S, Glezerman IG, Mehta S, Flombaum CD (2016) Long-term renal outcomes after cisplatin treatment. Clin J Am Soc Nephrol 11:1173–1179PubMedPubMedCentralCrossRef
17.
Zurück zum Zitat Brock PR, Koliouskas DE, Barratt TM, Yeomans E, Pritchard J (1991) Partial reversibility of cisplatin nephrotoxicity in children. J Pediatr 118:531–534PubMedCrossRef Brock PR, Koliouskas DE, Barratt TM, Yeomans E, Pritchard J (1991) Partial reversibility of cisplatin nephrotoxicity in children. J Pediatr 118:531–534PubMedCrossRef
18.
Zurück zum Zitat McMahon KR, Harel-Sterling M, Pizzi M, Huynh L, Hessey E, Zappitelli M (2018) Long-term renal follow-up of children treated with cisplatin, carboplatin, or ifosfamide: a pilot study. Pediatr Nephrol 33:2311–2320PubMedCrossRef McMahon KR, Harel-Sterling M, Pizzi M, Huynh L, Hessey E, Zappitelli M (2018) Long-term renal follow-up of children treated with cisplatin, carboplatin, or ifosfamide: a pilot study. Pediatr Nephrol 33:2311–2320PubMedCrossRef
19.
Zurück zum Zitat Widemann BC, Balis FM, Kempf-Bielack B, Bielack S, Pratt CB, Ferrari S et al (2004) High-dose methotrexate-induced nephrotoxicity in patients with osteosarcoma. Cancer 100:2222–2232PubMedCrossRef Widemann BC, Balis FM, Kempf-Bielack B, Bielack S, Pratt CB, Ferrari S et al (2004) High-dose methotrexate-induced nephrotoxicity in patients with osteosarcoma. Cancer 100:2222–2232PubMedCrossRef
20.
Zurück zum Zitat Gronroos MH, Jahnukainen T, Mottonen M, Perkkio M, Irjala K, Salmi TT (2008) Long-term follow-up of renal function after high-dose methotrexate treatment in children. Pediatr Blood Cancer 51:535–539PubMedCrossRef Gronroos MH, Jahnukainen T, Mottonen M, Perkkio M, Irjala K, Salmi TT (2008) Long-term follow-up of renal function after high-dose methotrexate treatment in children. Pediatr Blood Cancer 51:535–539PubMedCrossRef
21.
Zurück zum Zitat Van Why SK, Friedman AL, Wei LJ, Hong R (1991) Renal insufficiency after bone marrow transplantation in children. Bone Marrow Transplant 7:383–388PubMed Van Why SK, Friedman AL, Wei LJ, Hong R (1991) Renal insufficiency after bone marrow transplantation in children. Bone Marrow Transplant 7:383–388PubMed
22.
Zurück zum Zitat Kist-van Holthe JE, van Zwet JM, Brand R, van Weel MH, Vossen JM, van der Heijden AJ (1998) Bone marrow transplantation in children: consequences for renal function shortly after and 1 year post-BMT. Bone Marrow Transplant 22:559–564PubMedCrossRef Kist-van Holthe JE, van Zwet JM, Brand R, van Weel MH, Vossen JM, van der Heijden AJ (1998) Bone marrow transplantation in children: consequences for renal function shortly after and 1 year post-BMT. Bone Marrow Transplant 22:559–564PubMedCrossRef
23.
Zurück zum Zitat Frisk P, Bratteby LE, Carlson K, Lonnerholm G (2002) Renal function after autologous bone marrow transplantation in children: a long-term prospective study. Bone Marrow Transplant 29:129–136PubMedCrossRef Frisk P, Bratteby LE, Carlson K, Lonnerholm G (2002) Renal function after autologous bone marrow transplantation in children: a long-term prospective study. Bone Marrow Transplant 29:129–136PubMedCrossRef
24.
Zurück zum Zitat Patzer L, Ringelmann F, Kentouche K, Fuchs D, Zintl F, Brandis M et al (2001) Renal function in long-term survivors of stem cell transplantation in childhood. A prospective trial. Bone Marrow Transplant 27:319–327PubMedCrossRef Patzer L, Ringelmann F, Kentouche K, Fuchs D, Zintl F, Brandis M et al (2001) Renal function in long-term survivors of stem cell transplantation in childhood. A prospective trial. Bone Marrow Transplant 27:319–327PubMedCrossRef
25.
Zurück zum Zitat Hoffmeister PA, Hingorani SR, Storer BE, Baker KS, Sanders JE (2010) Hypertension in long-term survivors of pediatric hematopoietic cell transplantation. Biol Blood Marrow Transpl 16:515–524CrossRef Hoffmeister PA, Hingorani SR, Storer BE, Baker KS, Sanders JE (2010) Hypertension in long-term survivors of pediatric hematopoietic cell transplantation. Biol Blood Marrow Transpl 16:515–524CrossRef
26.
Zurück zum Zitat Abboud I, Peraldi MN, Hingorani S (2012) Chronic kidney diseases in long-term survivors after allogeneic hematopoietic stem cell transplantation: monitoring and management guidelines. Semin Hematol 49:73–82PubMedCrossRef Abboud I, Peraldi MN, Hingorani S (2012) Chronic kidney diseases in long-term survivors after allogeneic hematopoietic stem cell transplantation: monitoring and management guidelines. Semin Hematol 49:73–82PubMedCrossRef
27.
Zurück zum Zitat Hingorani S, Gooley T, Pao E, Sandmaier B, McDonald G (2014) Urinary cytokines after HCT: evidence for renal inflammation in the pathogenesis of proteinuria and kidney disease. Bone Marrow Transplant 49:403–409PubMedCrossRef Hingorani S, Gooley T, Pao E, Sandmaier B, McDonald G (2014) Urinary cytokines after HCT: evidence for renal inflammation in the pathogenesis of proteinuria and kidney disease. Bone Marrow Transplant 49:403–409PubMedCrossRef
28.
Zurück zum Zitat Cohen EP (2000) Radiation nephropathy after bone marrow transplantation. Kidney Int 58:903–918PubMedCrossRef Cohen EP (2000) Radiation nephropathy after bone marrow transplantation. Kidney Int 58:903–918PubMedCrossRef
29.
Zurück zum Zitat Lawton CA, Cohen EP, Barber-Derus SW, Murray KJ, Ash RC, Casper JT et al (1991) Late renal dysfunction in adult survivors of bone marrow transplantation. Cancer 67:2795–2800PubMedCrossRef Lawton CA, Cohen EP, Barber-Derus SW, Murray KJ, Ash RC, Casper JT et al (1991) Late renal dysfunction in adult survivors of bone marrow transplantation. Cancer 67:2795–2800PubMedCrossRef
30.
Zurück zum Zitat Cohen EP, Lawton CA, Moulder JE (1995) Bone marrow transplant nephropathy: radiation nephritis revisited. Nephron 70:217–222PubMedCrossRef Cohen EP, Lawton CA, Moulder JE (1995) Bone marrow transplant nephropathy: radiation nephritis revisited. Nephron 70:217–222PubMedCrossRef
31.
Zurück zum Zitat Pettitt AR, Clark RE (1994) Thrombotic microangiopathy following bone marrow transplantation. Bone Marrow Transplant 14:495–504PubMed Pettitt AR, Clark RE (1994) Thrombotic microangiopathy following bone marrow transplantation. Bone Marrow Transplant 14:495–504PubMed
32.
Zurück zum Zitat Juckett M, Perry EH, Daniels BS, Weisdorf DJ (1991) Hemolytic uremic syndrome following bone marrow transplantation. Bone Marrow Transplant 7:405–409PubMed Juckett M, Perry EH, Daniels BS, Weisdorf DJ (1991) Hemolytic uremic syndrome following bone marrow transplantation. Bone Marrow Transplant 7:405–409PubMed
33.
Zurück zum Zitat Takatsuka H, Takemoto Y, Okamoto T, Fujimori Y, Tamura S, Wada H et al (1999) Thrombotic microangiopathy following allogeneic bone marrow transplantation. Bone Marrow Transplant 24:303–306PubMedCrossRef Takatsuka H, Takemoto Y, Okamoto T, Fujimori Y, Tamura S, Wada H et al (1999) Thrombotic microangiopathy following allogeneic bone marrow transplantation. Bone Marrow Transplant 24:303–306PubMedCrossRef
34.
Zurück zum Zitat Antignac C, Gubler MC, Leverger G, Broyer M, Habib R (1989) Delayed renal failure with extensive mesangiolysis following bone marrow transplantation. Kidney Int 35:1336–1344PubMedCrossRef Antignac C, Gubler MC, Leverger G, Broyer M, Habib R (1989) Delayed renal failure with extensive mesangiolysis following bone marrow transplantation. Kidney Int 35:1336–1344PubMedCrossRef
35.
Zurück zum Zitat El-Seisi S, Gupta R, Clase CM, Forrest DL, Milandinovic M, Couban S (2003) Renal pathology at autopsy in patients who died after hematopoietic stem cell transplantation. Biol Blood Marrow Transpl 9:683–688CrossRef El-Seisi S, Gupta R, Clase CM, Forrest DL, Milandinovic M, Couban S (2003) Renal pathology at autopsy in patients who died after hematopoietic stem cell transplantation. Biol Blood Marrow Transpl 9:683–688CrossRef
36.
Zurück zum Zitat Moulder JE, Fish BL, Cohen EP (1998) Radiation nephropathy is treatable with an angiotensin converting enzyme inhibitor or an angiotensin II type-1 (AT1) receptor antagonist. Radiother Oncol 46:307–315PubMedCrossRef Moulder JE, Fish BL, Cohen EP (1998) Radiation nephropathy is treatable with an angiotensin converting enzyme inhibitor or an angiotensin II type-1 (AT1) receptor antagonist. Radiother Oncol 46:307–315PubMedCrossRef
37.
Zurück zum Zitat Kemper MJ, Gungor T, Halter J, Schanz U, Neuhaus TJ (2007) Favorable long-term outcome of nephrotic syndrome after allogeneic hematopoietic stem cell transplantation. Clin Nephrol 67:5–11PubMedCrossRef Kemper MJ, Gungor T, Halter J, Schanz U, Neuhaus TJ (2007) Favorable long-term outcome of nephrotic syndrome after allogeneic hematopoietic stem cell transplantation. Clin Nephrol 67:5–11PubMedCrossRef
38.
Zurück zum Zitat Colombo AA, Rusconi C, Esposito C, Bernasconi P, Caldera D, Lazzarino M et al (2006) Nephrotic syndrome after allogeneic hematopoietic stem cell transplantation as a late complication of chronic graft-versus-host disease. Transplantation 81:1087–1092PubMedCrossRef Colombo AA, Rusconi C, Esposito C, Bernasconi P, Caldera D, Lazzarino M et al (2006) Nephrotic syndrome after allogeneic hematopoietic stem cell transplantation as a late complication of chronic graft-versus-host disease. Transplantation 81:1087–1092PubMedCrossRef
39.
Zurück zum Zitat Srinivasan R, Balow JE, Sabnis S, Lundqvist A, Igarashi T, Takahashi Y et al (2005) Nephrotic syndrome: an under-recognised immune-mediated complication of non-myeloablative allogeneic haematopoietic cell transplantation. Br J Haematol 131:74–79PubMedCrossRef Srinivasan R, Balow JE, Sabnis S, Lundqvist A, Igarashi T, Takahashi Y et al (2005) Nephrotic syndrome: an under-recognised immune-mediated complication of non-myeloablative allogeneic haematopoietic cell transplantation. Br J Haematol 131:74–79PubMedCrossRef
40.
Zurück zum Zitat Chien YH, Lin KH, Lee TY, Lu MY, Tsau YK (2000) Nephrotic syndrome in a bone marrow transplant recipient without chronic graft-versus-host disease. J Formos Med Assoc 99:503–506PubMed Chien YH, Lin KH, Lee TY, Lu MY, Tsau YK (2000) Nephrotic syndrome in a bone marrow transplant recipient without chronic graft-versus-host disease. J Formos Med Assoc 99:503–506PubMed
41.
Zurück zum Zitat Hiesse C, Goldschmidt E, Santelli G, Charpentier B, Machover D, Fries D (1988) Membranous nephropathy in a bone marrow transplant recipient. Am J Kidney Dis 11:188–191PubMedCrossRef Hiesse C, Goldschmidt E, Santelli G, Charpentier B, Machover D, Fries D (1988) Membranous nephropathy in a bone marrow transplant recipient. Am J Kidney Dis 11:188–191PubMedCrossRef
42.
Zurück zum Zitat Mathieson PW (2003) Immune dysregulation in minimal change nephropathy. Nephrol Dial Transplant 18(Suppl 6):vi26–vi29PubMed Mathieson PW (2003) Immune dysregulation in minimal change nephropathy. Nephrol Dial Transplant 18(Suppl 6):vi26–vi29PubMed
43.
Zurück zum Zitat Rizzo JD, Wingard JR, Tichelli A, Lee SJ, Van Lint MT, Burns LJ et al (2006) Recommended screening and preventive practices for long-term survivors after hematopoietic cell transplantation: joint recommendations of the European Group for Blood and Marrow Transplantation, the Center for International Blood and Marrow Transplant Research, and the American Society of Blood and Marrow Transplantation. Biol Blood Marrow Transpl 12:138–151CrossRef Rizzo JD, Wingard JR, Tichelli A, Lee SJ, Van Lint MT, Burns LJ et al (2006) Recommended screening and preventive practices for long-term survivors after hematopoietic cell transplantation: joint recommendations of the European Group for Blood and Marrow Transplantation, the Center for International Blood and Marrow Transplant Research, and the American Society of Blood and Marrow Transplantation. Biol Blood Marrow Transpl 12:138–151CrossRef
44.
Zurück zum Zitat Cassady JR (1995) Clinical radiation nephropathy. Int J Radiat Oncol Biol Phys 31:1249–1256PubMedCrossRef Cassady JR (1995) Clinical radiation nephropathy. Int J Radiat Oncol Biol Phys 31:1249–1256PubMedCrossRef
46.
Zurück zum Zitat Bolling T, Schuck A, Pape H, Rube C, Meyer FM, Martini C et al (2007) Register for the evaluation of side effects after radiation in childhood and adolescence--first results. Klin Padiatr 219:139–145PubMedCrossRef Bolling T, Schuck A, Pape H, Rube C, Meyer FM, Martini C et al (2007) Register for the evaluation of side effects after radiation in childhood and adolescence--first results. Klin Padiatr 219:139–145PubMedCrossRef
47.
Zurück zum Zitat Carrie C, Thomas P (2008) The Pediatric Radiation Oncology Society (PROS): why? Int J Radiat Oncol Biol Phys 71:666PubMedCrossRef Carrie C, Thomas P (2008) The Pediatric Radiation Oncology Society (PROS): why? Int J Radiat Oncol Biol Phys 71:666PubMedCrossRef
48.
Zurück zum Zitat Ritchey ML, Green DM, Thomas PR, Smith GR, Haase G, Shochat S et al (1996) Renal failure in Wilms’ tumor patients: a report from the National Wilms’ Tumor Study Group. Med Pediatr Oncol 26:75–80PubMedCrossRef Ritchey ML, Green DM, Thomas PR, Smith GR, Haase G, Shochat S et al (1996) Renal failure in Wilms’ tumor patients: a report from the National Wilms’ Tumor Study Group. Med Pediatr Oncol 26:75–80PubMedCrossRef
49.
Zurück zum Zitat Mitus A, Tefft M, Fellers FX (1969) Long-term follow-up of renal functions of 108 children who underwent nephrectomy for malignant disease. Pediatrics 44:912–921PubMedCrossRef Mitus A, Tefft M, Fellers FX (1969) Long-term follow-up of renal functions of 108 children who underwent nephrectomy for malignant disease. Pediatrics 44:912–921PubMedCrossRef
50.
Zurück zum Zitat Krochak RJ, Baker DG (1986) Radiation nephritis. Clinical manifestations and pathophysiologic mechanisms. Urology 27:389–393PubMedCrossRef Krochak RJ, Baker DG (1986) Radiation nephritis. Clinical manifestations and pathophysiologic mechanisms. Urology 27:389–393PubMedCrossRef
52.
Zurück zum Zitat White DC (1976) The histopathologic basis for functional decrements in late radiation injury in diverse organs. Cancer 37(2 Suppl):1126–1143PubMedCrossRef White DC (1976) The histopathologic basis for functional decrements in late radiation injury in diverse organs. Cancer 37(2 Suppl):1126–1143PubMedCrossRef
53.
Zurück zum Zitat Choi KL, Bakris GL (2005) Hypertension treatment guidelines: practical implications. Semin Nephrol 25:198–209PubMedCrossRef Choi KL, Bakris GL (2005) Hypertension treatment guidelines: practical implications. Semin Nephrol 25:198–209PubMedCrossRef
54.
Zurück zum Zitat Batabyal P, Chapman JR, Wong G, Craig JC, Tong A (2012) Clinical practice guidelines on wait-listing for kidney transplantation: consistent and equitable? Transplantation 94:703–713PubMedCrossRef Batabyal P, Chapman JR, Wong G, Craig JC, Tong A (2012) Clinical practice guidelines on wait-listing for kidney transplantation: consistent and equitable? Transplantation 94:703–713PubMedCrossRef
55.
Zurück zum Zitat Chapman JR, Sheil AG, Disney AP (2001) Recurrence of cancer after renal transplantation. Transplant Proc 33:1830–1831PubMedCrossRef Chapman JR, Sheil AG, Disney AP (2001) Recurrence of cancer after renal transplantation. Transplant Proc 33:1830–1831PubMedCrossRef
56.
Zurück zum Zitat Penn I (1993) The effect of immunosuppression on pre-existing cancers. Transplantation 55:742–747PubMedCrossRef Penn I (1993) The effect of immunosuppression on pre-existing cancers. Transplantation 55:742–747PubMedCrossRef
57.
Zurück zum Zitat Engels EA, Pfeiffer RM, Fraumeni JF Jr, Kasiske BL, Israni AK, Snyder JJ et al (2011) Spectrum of cancer risk among US solid organ transplant recipients. JAMA 306:1891–1901PubMedPubMedCentralCrossRef Engels EA, Pfeiffer RM, Fraumeni JF Jr, Kasiske BL, Israni AK, Snyder JJ et al (2011) Spectrum of cancer risk among US solid organ transplant recipients. JAMA 306:1891–1901PubMedPubMedCentralCrossRef
58.
Zurück zum Zitat Collett D, Mumford L, Banner NR, Neuberger J, Watson C (2010) Comparison of the incidence of malignancy in recipients of different types of organ: a UK Registry audit. Am J Transplant 10:1889–1896PubMedCrossRef Collett D, Mumford L, Banner NR, Neuberger J, Watson C (2010) Comparison of the incidence of malignancy in recipients of different types of organ: a UK Registry audit. Am J Transplant 10:1889–1896PubMedCrossRef
59.
Zurück zum Zitat Samuel SM, Tonelli MA, Foster BJ, Alexander RT, Nettel-Aguirre A, Soo A et al (2011) Survival in pediatric dialysis and transplant patients. Clin J Am Soc Nephrol 6:1094–1099PubMedPubMedCentralCrossRef Samuel SM, Tonelli MA, Foster BJ, Alexander RT, Nettel-Aguirre A, Soo A et al (2011) Survival in pediatric dialysis and transplant patients. Clin J Am Soc Nephrol 6:1094–1099PubMedPubMedCentralCrossRef
60.
Zurück zum Zitat Tessari G, Naldi L, Boschiero L, Minetti E, Sandrini S, Nacchia F et al (2013) Incidence of primary and second cancers in renal transplant recipients: a multicenter cohort study. Am J Transplant 13:214–221PubMedCrossRef Tessari G, Naldi L, Boschiero L, Minetti E, Sandrini S, Nacchia F et al (2013) Incidence of primary and second cancers in renal transplant recipients: a multicenter cohort study. Am J Transplant 13:214–221PubMedCrossRef
61.
Zurück zum Zitat Debray D, Baudouin V, Lacaille F, Charbit M, Rivet C, Harambat J et al (2009) De novo malignancy after solid organ transplantation in children. Transplant Proc 41:674–675PubMedCrossRef Debray D, Baudouin V, Lacaille F, Charbit M, Rivet C, Harambat J et al (2009) De novo malignancy after solid organ transplantation in children. Transplant Proc 41:674–675PubMedCrossRef
62.
Zurück zum Zitat Simard JF, Baecklund E, Kinch A, Brattstrom C, Ingvar A, Molin D et al (2011) Pediatric organ transplantation and risk of premalignant and malignant tumors in Sweden. Am J Transplant 11:146–151PubMedCrossRef Simard JF, Baecklund E, Kinch A, Brattstrom C, Ingvar A, Molin D et al (2011) Pediatric organ transplantation and risk of premalignant and malignant tumors in Sweden. Am J Transplant 11:146–151PubMedCrossRef
63.
Zurück zum Zitat Ploos van Amstel S, Vogelzang JL, Starink MV, Jager KJ, Groothoff JW (2015) Long-term risk of cancer in survivors of pediatric ESRD. Clin J Am Soc Nephrol 10:2198–2204PubMedPubMedCentralCrossRef Ploos van Amstel S, Vogelzang JL, Starink MV, Jager KJ, Groothoff JW (2015) Long-term risk of cancer in survivors of pediatric ESRD. Clin J Am Soc Nephrol 10:2198–2204PubMedPubMedCentralCrossRef
64.
Zurück zum Zitat Mucha K, Foroncewicz B, Ziarkiewicz-Wroblewska B, Krawczyk M, Lerut J, Paczek L (2010) Post-transplant lymphoproliferative disorder in view of the new WHO classification: a more rational approach to a protean disease? Nephrol Dial Transplant 25:2089–2098PubMedCrossRef Mucha K, Foroncewicz B, Ziarkiewicz-Wroblewska B, Krawczyk M, Lerut J, Paczek L (2010) Post-transplant lymphoproliferative disorder in view of the new WHO classification: a more rational approach to a protean disease? Nephrol Dial Transplant 25:2089–2098PubMedCrossRef
65.
Zurück zum Zitat Caillard S, Dharnidharka V, Agodoa L, Bohen E, Abbott K (2005) Posttransplant lymphoproliferative disorders after renal transplantation in the United States in era of modern immunosuppression. Transplantation 80:1233–1243PubMedCrossRef Caillard S, Dharnidharka V, Agodoa L, Bohen E, Abbott K (2005) Posttransplant lymphoproliferative disorders after renal transplantation in the United States in era of modern immunosuppression. Transplantation 80:1233–1243PubMedCrossRef
66.
Zurück zum Zitat McDonald RA, Smith JM, Ho M, Lindblad R, Ikle D, Grimm P et al (2008) Incidence of PTLD in pediatric renal transplant recipients receiving basiliximab, calcineurin inhibitor, sirolimus and steroids. Am J Transplant 8:984–989PubMedCrossRef McDonald RA, Smith JM, Ho M, Lindblad R, Ikle D, Grimm P et al (2008) Incidence of PTLD in pediatric renal transplant recipients receiving basiliximab, calcineurin inhibitor, sirolimus and steroids. Am J Transplant 8:984–989PubMedCrossRef
67.
Zurück zum Zitat Haque T, Crawford DH (1998) Role of donor versus recipient type Epstein-Barr virus in post-transplant lymphoproliferative disorders. Springer Semin Immunopathol 20:375–387PubMedCrossRef Haque T, Crawford DH (1998) Role of donor versus recipient type Epstein-Barr virus in post-transplant lymphoproliferative disorders. Springer Semin Immunopathol 20:375–387PubMedCrossRef
68.
Zurück zum Zitat Quinlan SC, Pfeiffer RM, Morton LM, Engels EA (2011) Risk factors for early-onset and late-onset post-transplant lymphoproliferative disorder in kidney recipients in the United States. Am J Hematol 86:206–209PubMedPubMedCentralCrossRef Quinlan SC, Pfeiffer RM, Morton LM, Engels EA (2011) Risk factors for early-onset and late-onset post-transplant lymphoproliferative disorder in kidney recipients in the United States. Am J Hematol 86:206–209PubMedPubMedCentralCrossRef
69.
Zurück zum Zitat Schober T, Framke T, Kreipe H, Schulz TF, Grosshennig A, Hussein K et al (2013) Characteristics of early and late PTLD development in pediatric solid organ transplant recipients. Transplantation 95:240–246PubMedCrossRef Schober T, Framke T, Kreipe H, Schulz TF, Grosshennig A, Hussein K et al (2013) Characteristics of early and late PTLD development in pediatric solid organ transplant recipients. Transplantation 95:240–246PubMedCrossRef
70.
Zurück zum Zitat Hart A, Smith JM, Skeans MA, Gustafson SK, Stewart DE, Cherikh WS et al (2017) OPTN/SRTR 2015 Annual Data Report: kidney. Am J Transplant 17(Suppl 1):21–116PubMedPubMedCentralCrossRef Hart A, Smith JM, Skeans MA, Gustafson SK, Stewart DE, Cherikh WS et al (2017) OPTN/SRTR 2015 Annual Data Report: kidney. Am J Transplant 17(Suppl 1):21–116PubMedPubMedCentralCrossRef
71.
Zurück zum Zitat Dharnidharka VR (2010) Epidemiology of PTLD. In: VRGM D, Webber SA (eds) Post transplant lymphoproliferative disorders, vol 1. Springer-Verlag, Berlin-Heidelberg, pp 17–28CrossRef Dharnidharka VR (2010) Epidemiology of PTLD. In: VRGM D, Webber SA (eds) Post transplant lymphoproliferative disorders, vol 1. Springer-Verlag, Berlin-Heidelberg, pp 17–28CrossRef
72.
Zurück zum Zitat van der Molen AJ, Reimer P, Dekkers IA, Bongartz G, Bellin MF, Bertolotto M, Clement O, Heinz-Peer G, Stacul F, Webb JAW, Thomsen HS (2018) Post-contrast acute kidney injury. Part 2: risk stratification, role of hydration and other prophylactic measures, patients taking metformin and chronic dialysis patients : Recommendations for updated ESUR Contrast Medium Safety Committee guideline. Eur Radiol 28:2856–2869PubMedPubMedCentralCrossRef van der Molen AJ, Reimer P, Dekkers IA, Bongartz G, Bellin MF, Bertolotto M, Clement O, Heinz-Peer G, Stacul F, Webb JAW, Thomsen HS (2018) Post-contrast acute kidney injury. Part 2: risk stratification, role of hydration and other prophylactic measures, patients taking metformin and chronic dialysis patients : Recommendations for updated ESUR Contrast Medium Safety Committee guideline. Eur Radiol 28:2856–2869PubMedPubMedCentralCrossRef
73.
Zurück zum Zitat Allen UD, Preiksaitis JK, AST Infectious Diseases Community of Practice (2013) Epstein-Barr virus and posttransplant lymphoproliferative disorder in solid organ transplantation. Am J Transplant 13(Suppl 4):107–120PubMedCrossRef Allen UD, Preiksaitis JK, AST Infectious Diseases Community of Practice (2013) Epstein-Barr virus and posttransplant lymphoproliferative disorder in solid organ transplantation. Am J Transplant 13(Suppl 4):107–120PubMedCrossRef
74.
Zurück zum Zitat Al-Mansour Z, Nelson BP, Evens AM (2013) Post-transplant lymphoproliferative disease (PTLD): risk factors, diagnosis, and current treatment strategies. Curr Hematol Malig Rep 8:173–183PubMedPubMedCentralCrossRef Al-Mansour Z, Nelson BP, Evens AM (2013) Post-transplant lymphoproliferative disease (PTLD): risk factors, diagnosis, and current treatment strategies. Curr Hematol Malig Rep 8:173–183PubMedPubMedCentralCrossRef
75.
Zurück zum Zitat Bingler MA, Feingold B, Miller SA, Quivers E, Michaels MG, Green M et al (2008) Chronic high Epstein-Barr viral load state and risk for late-onset posttransplant lymphoproliferative disease/lymphoma in children. Am J Transplant 8:442–445PubMedCrossRef Bingler MA, Feingold B, Miller SA, Quivers E, Michaels MG, Green M et al (2008) Chronic high Epstein-Barr viral load state and risk for late-onset posttransplant lymphoproliferative disease/lymphoma in children. Am J Transplant 8:442–445PubMedCrossRef
76.
Zurück zum Zitat Dharnidharka VR, Sullivan EK, Stablein DM, Tejani AH, Harmon WE, North American Pediatric Renal Transplant Cooperative Study (2001) Risk factors for posttransplant lymphoproliferative disorder (PTLD) in pediatric kidney transplantation: a report of the North American Pediatric Renal Transplant Cooperative Study (NAPRTCS). Transplantation 71:1065–1068PubMedCrossRef Dharnidharka VR, Sullivan EK, Stablein DM, Tejani AH, Harmon WE, North American Pediatric Renal Transplant Cooperative Study (2001) Risk factors for posttransplant lymphoproliferative disorder (PTLD) in pediatric kidney transplantation: a report of the North American Pediatric Renal Transplant Cooperative Study (NAPRTCS). Transplantation 71:1065–1068PubMedCrossRef
77.
Zurück zum Zitat Mathew T, Kreis H, Friend P (2004) Two-year incidence of malignancy in sirolimus-treated renal transplant recipients: results from five multicenter studies. Clin Transpl 18:446–449CrossRef Mathew T, Kreis H, Friend P (2004) Two-year incidence of malignancy in sirolimus-treated renal transplant recipients: results from five multicenter studies. Clin Transpl 18:446–449CrossRef
78.
Zurück zum Zitat Kahan BD, Yakupoglu YK, Schoenberg L, Knight RJ, Katz SM, Lai D et al (2005) Low incidence of malignancy among sirolimus/cyclosporine-treated renal transplant recipients. Transplantation 80:749–758PubMedCrossRef Kahan BD, Yakupoglu YK, Schoenberg L, Knight RJ, Katz SM, Lai D et al (2005) Low incidence of malignancy among sirolimus/cyclosporine-treated renal transplant recipients. Transplantation 80:749–758PubMedCrossRef
79.
Zurück zum Zitat Kirk AD, Cherikh WS, Ring M, Burke G, Kaufman D, Knechtle SJ et al (2007) Dissociation of depletional induction and posttransplant lymphoproliferative disease in kidney recipients treated with alemtuzumab. Am J Transplant 7:2619–2625PubMedPubMedCentralCrossRef Kirk AD, Cherikh WS, Ring M, Burke G, Kaufman D, Knechtle SJ et al (2007) Dissociation of depletional induction and posttransplant lymphoproliferative disease in kidney recipients treated with alemtuzumab. Am J Transplant 7:2619–2625PubMedPubMedCentralCrossRef
80.
Zurück zum Zitat Cherikh WS, Kauffman HM, McBride MA, Maghirang J, Swinnen LJ, Hanto DW (2003) Association of the type of induction immunosuppression with posttransplant lymphoproliferative disorder, graft survival, and patient survival after primary kidney transplantation. Transplantation 76:1289–1293PubMedCrossRef Cherikh WS, Kauffman HM, McBride MA, Maghirang J, Swinnen LJ, Hanto DW (2003) Association of the type of induction immunosuppression with posttransplant lymphoproliferative disorder, graft survival, and patient survival after primary kidney transplantation. Transplantation 76:1289–1293PubMedCrossRef
81.
Zurück zum Zitat Funch DP, Ko HH, Travasso J, Brady J, Kew CE 2nd, Nalesnik MA et al (2005) Posttransplant lymphoproliferative disorder among renal transplant patients in relation to the use of mycophenolate mofetil. Transplantation 80:1174–1180PubMedCrossRef Funch DP, Ko HH, Travasso J, Brady J, Kew CE 2nd, Nalesnik MA et al (2005) Posttransplant lymphoproliferative disorder among renal transplant patients in relation to the use of mycophenolate mofetil. Transplantation 80:1174–1180PubMedCrossRef
82.
83.
Zurück zum Zitat Bustami RT, Ojo AO, Wolfe RA, Merion RM, Bennett WM, McDiarmid SV et al (2004) Immunosuppression and the risk of post-transplant malignancy among cadaveric first kidney transplant recipients. Am J Transplant 4:87–93PubMedCrossRef Bustami RT, Ojo AO, Wolfe RA, Merion RM, Bennett WM, McDiarmid SV et al (2004) Immunosuppression and the risk of post-transplant malignancy among cadaveric first kidney transplant recipients. Am J Transplant 4:87–93PubMedCrossRef
84.
Zurück zum Zitat Opelz G, Henderson R (1993) Incidence of non-Hodgkin lymphoma in kidney and heart transplant recipients. Lancet 342:1514–1516PubMedCrossRef Opelz G, Henderson R (1993) Incidence of non-Hodgkin lymphoma in kidney and heart transplant recipients. Lancet 342:1514–1516PubMedCrossRef
85.
Zurück zum Zitat Grinyo J, Charpentier B, Pestana JM, Vanrenterghem Y, Vincenti F, Reyes-Acevedo R et al (2010) An integrated safety profile analysis of belatacept in kidney transplant recipients. Transplantation 90:1521–1527PubMedCrossRef Grinyo J, Charpentier B, Pestana JM, Vanrenterghem Y, Vincenti F, Reyes-Acevedo R et al (2010) An integrated safety profile analysis of belatacept in kidney transplant recipients. Transplantation 90:1521–1527PubMedCrossRef
86.
Zurück zum Zitat Kidney Disease: Improving Global Outcomes Transplant Work Group (2009) KDIGO clinical practice guideline for the care of kidney transplant recipients. Am J Transplant 9(Suppl 3):S1–S155 Kidney Disease: Improving Global Outcomes Transplant Work Group (2009) KDIGO clinical practice guideline for the care of kidney transplant recipients. Am J Transplant 9(Suppl 3):S1–S155
87.
Zurück zum Zitat Kasiske BL, Vazquez MA, Harmon WE, Brown RS, Danovitch GM, Gaston RS et al (2000) Recommendations for the outpatient surveillance of renal transplant recipients. American Society of Transplantation. J Am Soc Nephrol 11(Suppl 15):S1–S86 Kasiske BL, Vazquez MA, Harmon WE, Brown RS, Danovitch GM, Gaston RS et al (2000) Recommendations for the outpatient surveillance of renal transplant recipients. American Society of Transplantation. J Am Soc Nephrol 11(Suppl 15):S1–S86
88.
Zurück zum Zitat Green M, Reyes J, Webber S, Rowe D (2001) The role of antiviral and immunoglobulin therapy in the prevention of Epstein-Barr virus infection and post-transplant lymphoproliferative disease following solid organ transplantation. Transpl Infect Dis 3:97–103PubMedCrossRef Green M, Reyes J, Webber S, Rowe D (2001) The role of antiviral and immunoglobulin therapy in the prevention of Epstein-Barr virus infection and post-transplant lymphoproliferative disease following solid organ transplantation. Transpl Infect Dis 3:97–103PubMedCrossRef
89.
Zurück zum Zitat Hocker B, Bohm S, Fickenscher H, Kusters U, Schnitzler P, Pohl M et al (2012) (Val-)Ganciclovir prophylaxis reduces Epstein-Barr virus primary infection in pediatric renal transplantation. Transpl Int 25:723–731PubMedCrossRef Hocker B, Bohm S, Fickenscher H, Kusters U, Schnitzler P, Pohl M et al (2012) (Val-)Ganciclovir prophylaxis reduces Epstein-Barr virus primary infection in pediatric renal transplantation. Transpl Int 25:723–731PubMedCrossRef
90.
Zurück zum Zitat Funch DP, Walker AM, Schneider G, Ziyadeh NJ, Pescovitz MD (2005) Ganciclovir and acyclovir reduce the risk of post-transplant lymphoproliferative disorder in renal transplant recipients. Am J Transplant 5:2894–2900PubMedCrossRef Funch DP, Walker AM, Schneider G, Ziyadeh NJ, Pescovitz MD (2005) Ganciclovir and acyclovir reduce the risk of post-transplant lymphoproliferative disorder in renal transplant recipients. Am J Transplant 5:2894–2900PubMedCrossRef
91.
Zurück zum Zitat Meng Q, Hagemeier SR, Fingeroth JD, Gershburg E, Pagano JS, Kenney SC (2010) The Epstein-Barr virus (EBV)-encoded protein kinase, EBV-PK, but not the thymidine kinase (EBV-TK), is required for ganciclovir and acyclovir inhibition of lytic viral production. J Virol 84:4534–4542PubMedPubMedCentralCrossRef Meng Q, Hagemeier SR, Fingeroth JD, Gershburg E, Pagano JS, Kenney SC (2010) The Epstein-Barr virus (EBV)-encoded protein kinase, EBV-PK, but not the thymidine kinase (EBV-TK), is required for ganciclovir and acyclovir inhibition of lytic viral production. J Virol 84:4534–4542PubMedPubMedCentralCrossRef
92.
Zurück zum Zitat Green M, Michaels MG, Katz BZ, Burroughs M, Gerber D, Shneider BL et al (2006) CMV-IVIG for prevention of Epstein Barr virus disease and posttransplant lymphoproliferative disease in pediatric liver transplant recipients. Am J Transplant 6:1906–1912PubMedCrossRef Green M, Michaels MG, Katz BZ, Burroughs M, Gerber D, Shneider BL et al (2006) CMV-IVIG for prevention of Epstein Barr virus disease and posttransplant lymphoproliferative disease in pediatric liver transplant recipients. Am J Transplant 6:1906–1912PubMedCrossRef
93.
Zurück zum Zitat AlDabbagh MA, Gitman MR, Kumar D, Humar A, Rotstein C, Husain S (2017) The role of antiviral prophylaxis for the prevention of Epstein-Barr virus-associated posttransplant lymphoproliferative disease in solid organ transplant recipients: a systematic review. Am J Transplant 17:770–781PubMedCrossRef AlDabbagh MA, Gitman MR, Kumar D, Humar A, Rotstein C, Husain S (2017) The role of antiviral prophylaxis for the prevention of Epstein-Barr virus-associated posttransplant lymphoproliferative disease in solid organ transplant recipients: a systematic review. Am J Transplant 17:770–781PubMedCrossRef
94.
Zurück zum Zitat Rees L, Tizard EJ, Morgan AJ, Cubitt WD, Finerty S, Oyewole-Eletu TA et al (2009) A phase I trial of Epstein-Barr virus gp350 vaccine for children with chronic kidney disease awaiting transplantation. Transplantation 88:1025–1029PubMedCrossRef Rees L, Tizard EJ, Morgan AJ, Cubitt WD, Finerty S, Oyewole-Eletu TA et al (2009) A phase I trial of Epstein-Barr virus gp350 vaccine for children with chronic kidney disease awaiting transplantation. Transplantation 88:1025–1029PubMedCrossRef
95.
Zurück zum Zitat Tsai DE, Hardy CL, Tomaszewski JE, Kotloff RM, Oltoff KM, Somer BG et al (2001) Reduction in immunosuppression as initial therapy for posttransplant lymphoproliferative disorder: analysis of prognostic variables and long-term follow-up of 42 adult patients. Transplantation 71:1076–1088PubMedCrossRef Tsai DE, Hardy CL, Tomaszewski JE, Kotloff RM, Oltoff KM, Somer BG et al (2001) Reduction in immunosuppression as initial therapy for posttransplant lymphoproliferative disorder: analysis of prognostic variables and long-term follow-up of 42 adult patients. Transplantation 71:1076–1088PubMedCrossRef
96.
Zurück zum Zitat Reshef R, Vardhanabhuti S, Luskin MR, Heitjan DF, Hadjiliadis D, Goral S et al (2011) Reduction of immunosuppression as initial therapy for posttransplantation lymphoproliferative disorder (bigstar). Am J Transplant 11:336–347PubMedPubMedCentralCrossRef Reshef R, Vardhanabhuti S, Luskin MR, Heitjan DF, Hadjiliadis D, Goral S et al (2011) Reduction of immunosuppression as initial therapy for posttransplantation lymphoproliferative disorder (bigstar). Am J Transplant 11:336–347PubMedPubMedCentralCrossRef
97.
Zurück zum Zitat Dharnidharka VR, Martz KL, Stablein DM, Benfield MR (2011) Improved survival with recent post-transplant lymphoproliferative disorder (PTLD) in children with kidney transplants. Am J Transplant 11:751–758PubMedCrossRef Dharnidharka VR, Martz KL, Stablein DM, Benfield MR (2011) Improved survival with recent post-transplant lymphoproliferative disorder (PTLD) in children with kidney transplants. Am J Transplant 11:751–758PubMedCrossRef
98.
Zurück zum Zitat Choquet S, Trappe R, Leblond V, Jager U, Davi F, Oertel S (2007) CHOP-21 for the treatment of post-transplant lymphoproliferative disorders (PTLD) following solid organ transplantation. Haematologica 92:273–274PubMedCrossRef Choquet S, Trappe R, Leblond V, Jager U, Davi F, Oertel S (2007) CHOP-21 for the treatment of post-transplant lymphoproliferative disorders (PTLD) following solid organ transplantation. Haematologica 92:273–274PubMedCrossRef
99.
Zurück zum Zitat Gross TG, Bucuvalas JC, Park JR, Greiner TC, Hinrich SH, Kaufman SS et al (2005) Low-dose chemotherapy for Epstein-Barr virus-positive post-transplantation lymphoproliferative disease in children after solid organ transplantation. J Clin Oncol 23:6481–6488PubMedCrossRef Gross TG, Bucuvalas JC, Park JR, Greiner TC, Hinrich SH, Kaufman SS et al (2005) Low-dose chemotherapy for Epstein-Barr virus-positive post-transplantation lymphoproliferative disease in children after solid organ transplantation. J Clin Oncol 23:6481–6488PubMedCrossRef
100.
Zurück zum Zitat Gross TG, Orjuela MA, Perkins SL, Park JR, Lynch JC, Cairo MS et al (2012) Low-dose chemotherapy and rituximab for posttransplant lymphoproliferative disease (PTLD): a Children’s Oncology Group Report. Am J Transplant 12:3069–3075PubMedPubMedCentralCrossRef Gross TG, Orjuela MA, Perkins SL, Park JR, Lynch JC, Cairo MS et al (2012) Low-dose chemotherapy and rituximab for posttransplant lymphoproliferative disease (PTLD): a Children’s Oncology Group Report. Am J Transplant 12:3069–3075PubMedPubMedCentralCrossRef
101.
Zurück zum Zitat Manez R, Breinig MK, Linden P, Kusne S, Torre-Cisneros J, Wilson J et al (1994) Factors associated with the development of post-transplant lymphoproliferative disease (PTLD) in Epstein-Barr virus (EBV)-seronegative adult liver transplant recipients. Transpl Int 7(Suppl 1):S235–S237PubMedCrossRef Manez R, Breinig MK, Linden P, Kusne S, Torre-Cisneros J, Wilson J et al (1994) Factors associated with the development of post-transplant lymphoproliferative disease (PTLD) in Epstein-Barr virus (EBV)-seronegative adult liver transplant recipients. Transpl Int 7(Suppl 1):S235–S237PubMedCrossRef
102.
Zurück zum Zitat Penn I (1986) Cancers of the anogenital region in renal transplant recipients. Analysis of 65 cases. Cancer 58:611–616PubMedCrossRef Penn I (1986) Cancers of the anogenital region in renal transplant recipients. Analysis of 65 cases. Cancer 58:611–616PubMedCrossRef
103.
Zurück zum Zitat Arends MJ, Benton EC, McLaren KM, Stark LA, Hunter JA, Bird CC (1997) Renal allograft recipients with high susceptibility to cutaneous malignancy have an increased prevalence of human papillomavirus DNA in skin tumours and a greater risk of anogenital malignancy. Br J Cancer 75:722–728PubMedPubMedCentralCrossRef Arends MJ, Benton EC, McLaren KM, Stark LA, Hunter JA, Bird CC (1997) Renal allograft recipients with high susceptibility to cutaneous malignancy have an increased prevalence of human papillomavirus DNA in skin tumours and a greater risk of anogenital malignancy. Br J Cancer 75:722–728PubMedPubMedCentralCrossRef
104.
Zurück zum Zitat Hartevelt MM, Bavinck JN, Kootte AM, Vermeer BJ, Vandenbroucke JP (1990) Incidence of skin cancer after renal transplantation in The Netherlands. Transplantation 49:506–509PubMedCrossRef Hartevelt MM, Bavinck JN, Kootte AM, Vermeer BJ, Vandenbroucke JP (1990) Incidence of skin cancer after renal transplantation in The Netherlands. Transplantation 49:506–509PubMedCrossRef
105.
Zurück zum Zitat Mullen DL, Silverberg SG, Penn I, Hammond WS (1976) Squamous cell carcinoma of the skin and lip in renal homograft recipients. Cancer 37:729–734PubMedCrossRef Mullen DL, Silverberg SG, Penn I, Hammond WS (1976) Squamous cell carcinoma of the skin and lip in renal homograft recipients. Cancer 37:729–734PubMedCrossRef
106.
Zurück zum Zitat Blohme I, Brynger H (1985) Malignant disease in renal transplant patients. Transplantation 39:23–25PubMed Blohme I, Brynger H (1985) Malignant disease in renal transplant patients. Transplantation 39:23–25PubMed
107.
Zurück zum Zitat Penn I (1993) Neoplastic complications of transplantation. Semin Respir Infect 8:233–239PubMed Penn I (1993) Neoplastic complications of transplantation. Semin Respir Infect 8:233–239PubMed
108.
Zurück zum Zitat Smith JM, Martz K, McDonald RA, Harmon WE (2013) Solid tumors following kidney transplantation in children. Pediatr Transplant 17:726–730PubMedCrossRef Smith JM, Martz K, McDonald RA, Harmon WE (2013) Solid tumors following kidney transplantation in children. Pediatr Transplant 17:726–730PubMedCrossRef
109.
Zurück zum Zitat Penn I (1995) Primary kidney tumors before and after renal transplantation. Transplantation 59:480–485 Penn I (1995) Primary kidney tumors before and after renal transplantation. Transplantation 59:480–485
110.
Zurück zum Zitat Williams JC, Merguerian PA, Schned AR, Morrison PM (1995) Acquired renal cystic disease and renal cell carcinoma in an allograft kidney. J Urol 153:395–396PubMedCrossRef Williams JC, Merguerian PA, Schned AR, Morrison PM (1995) Acquired renal cystic disease and renal cell carcinoma in an allograft kidney. J Urol 153:395–396PubMedCrossRef
111.
Zurück zum Zitat Baker R, Jardine A, Andrews P (2011) Renal Association Clinical Practice Guideline on post-operative care of the kidney transplant recipient. Nephron Clin Pract 118(Suppl 1):c311–c347PubMedCrossRef Baker R, Jardine A, Andrews P (2011) Renal Association Clinical Practice Guideline on post-operative care of the kidney transplant recipient. Nephron Clin Pract 118(Suppl 1):c311–c347PubMedCrossRef
112.
Zurück zum Zitat EBPG, Expert Group on Renal Transplantation (2002) European best practice guidelines for renal transplantation. Section IV: Long-term management of the transplant recipient. IV.6.3. Cancer risk after renal transplantation. Solid organ cancers: prevention and treatment. Nephrol Dial Transplant 17(Suppl 4):32–34-36 EBPG, Expert Group on Renal Transplantation (2002) European best practice guidelines for renal transplantation. Section IV: Long-term management of the transplant recipient. IV.6.3. Cancer risk after renal transplantation. Solid organ cancers: prevention and treatment. Nephrol Dial Transplant 17(Suppl 4):32–34-36
Metadaten
Titel
Pediatric Onco-Nephrology: Time to Spread the Word-Part II: Long-Term Kidney Outcomes in Survivors of Childhood Malignancy and Malignancy after Kidney Transplant
verfasst von
Arwa Nada
Jennifer G Jetton
Publikationsdatum
06.09.2021
Verlag
Springer Berlin Heidelberg
Erschienen in
Pediatric Nephrology / Ausgabe 6/2022
Print ISSN: 0931-041X
Elektronische ISSN: 1432-198X
DOI
https://doi.org/10.1007/s00467-021-05172-y

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