Pelabresib (CPI-0610): An Exciting Novel Drug for the Treatment of Myelofibrosis
- 17.05.2023
Erschienen in:
- Verfasst von
- Guadalupe Ferreira Gomes
- Claire Harrison
- Erschienen in
- Current Hematologic Malignancy Reports | Ausgabe 4/2023
Abstract
Purpose of Review
Myelofibrosis (MF) is a myeloproliferative neoplasm characterized by bone marrow fibrosis, megakaryocyte atypia, and inflammatory cytokine overproduction, resulting in progressive cytopenias, splenomegaly, and high symptom burden. Current backbone of care includes JAK inhibitor (JAKi) therapy, which offers limited benefits and significant discontinuation rates. Targeting the epigenetic modifiers bromodomain and extra-terminal domain (BET) proteins is a novel approach for harnessing the expression of genes involved in critical oncogenic signalling pathways implicated in MF and other malignancies. Here, we review preclinical and clinical data on Pelabresib (CPI-0610), an investigational oral small-molecule potent BET-inhibitor being explored in MF.
Recent Findings
BET inhibition has been shown to target multiple MF driver mechanisms in preclinical studies, with synergistic results using combination therapy with JAKi. Pelabresib is currently being evaluated in the phase II MANIFEST study as monotherapy and in combination with ruxolitinib for MF. Interim data showed favourable responses in symptoms and spleen volume after 24 weeks of treatment, with correlated improvements in bone marrow fibrosis and mutant allele fraction reduction. Based on these encouraging results, the Phase III MANIFEST-2 study was initiated.
Summary
Pelabresib offers a much-needed innovative treatment approach for patients with MF, either as monotherapy or in combination with the current standard of care.
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- Titel
- Pelabresib (CPI-0610): An Exciting Novel Drug for the Treatment of Myelofibrosis
- Verfasst von
-
Guadalupe Ferreira Gomes
Claire Harrison
- Publikationsdatum
- 17.05.2023
- Verlag
- Springer US
- Erschienen in
-
Current Hematologic Malignancy Reports / Ausgabe 4/2023
Print ISSN: 1558-8211
Elektronische ISSN: 1558-822X - DOI
- https://doi.org/10.1007/s11899-023-00696-6
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