Erschienen in:
01.09.2004 | Oral presentation
Pharmacokinetic–pharmacodynamic modeling considering spinal and peripheral actions of nonsteroidal antiinflammatory drugs to optimize the treatment of inflammation-induced pain
verfasst von:
G Castañeda-Hernández, MI Ortiz, J Lozano-Cuenca, JE Torres-López, V Granados-Soto
Erschienen in:
Arthritis Research & Therapy
|
Sonderheft 3/2004
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Excerpt
It has been documented that nonsteroidal antiinflammatory drugs (NSAIDs) exhibit pharmacological actions at both the peripheral and central levels. However, the actual participation of the mechanisms of action elicited at different anatomical sites after systemic NSAID administration is not clear. To gain further knowledge on this issue, the aim of the present work is to study the pharmacodynamics and pharmacokinetics of diclofenac, a NSAID prototype, using an integrative approach. …