Erschienen in:
Open Access
01.12.2018 | Commentary
Phenotypic testicular abnormalities and pubertal development in boys with McCune-Albright syndrome
verfasst von:
Tommaso Aversa, Giuseppina Zirilli, Domenico Corica, Filippo De Luca, Malgorzata Wasniewska
Erschienen in:
Italian Journal of Pediatrics
|
Ausgabe 1/2018
Abstract
Aim of this survey is to review the few available literature data on pathophysiologic and clinical aspects of pubertal development in boys with McCune-Albright syndrome (MAS). On the basis of such analysis, we concluded that:
1) peripheral precocious puberty (PPP) is significantly more infrequent in boys than in girls; 2) the most common testicular abnormality at MAS presentation is macroorchidism, that may be either monolateral or bilateral; 3) macroorchidism is not always associated with clinical and biochemical evidence of PPP; 4) testicular microlothiasis is distinctly more frequent in boys with MAS than in those without MAS; 5) the available therapeutic schedules have to be adopted already at MAS presentation only in the cases with PPP.