nach oben

Erschienen in:

01.03.2020

Physical exercise effects on metastasis: a systematic review and meta-analysis in animal cancer models

verfasst von: Cecilia Rincón-Castanedo, Javier S. Morales, Asunción Martín-Ruiz, Pedro L. Valenzuela, Manuel Ramírez, Alejandro Santos-Lozano, Alejandro Lucia, Carmen Fiuza-Luces

Erschienen in: Cancer and Metastasis Reviews | Ausgabe 1/2020

Einloggen, um Zugang zu erhalten

Abstract

Physical exercise is considered a well-tolerated adjuvant therapy to mitigate cancer-related side effects, but its impact on metastasis is unclear. The present systematic review and meta-analysis aimed to summarize the evidence on the effects of exercise on metastasis in animal cancer models. A systematic search was conducted to identify controlled studies in animals analyzing the impact of exercise interventions on any marker of metastasis incidence or severity. The pooled mean differences (PMD) were calculated for those endpoints for which a minimum of three studies used the same assessment method. We also calculated the pooled odds ratio (OR) of metastases. Twenty-six articles were included in the systematic review, of which 12 could be meta-analyzed. Exercise training in murine cancer models did not significantly modify the number of metastatic foci (PMD = − 3.18; 95% confidence interval [CI] − 8.32, 1.97; p = 0.23), the weight of metastatic tumors (PMD = − 0.03; 95% CI − 0.10, 0.04; p = 0.41), or the risk of developing metastasis (OR = 0.64; 95% CI 0.10, 4.12; p = 0.64). These findings suggest that exercise has no overall influence on any marker of cancer metastasis incidence or severity in animal models. However, the wide methodological heterogeneity observed between studies might be taken into account and the potential exercise effects on metastasis development remain to be determined in pediatric tumors.

Nur mit Berechtigung zugänglich

Steeg, P. S. (2016). Targeting metastasis. Nature Reviews Cancer, 16, 201–218. https://doi.org/10.1038/nrc.2016.25.CrossRefPubMedPubMedCentral

Lambert, A. W., Pattabiraman, D. R., & Weinberg, R. A. (2017). Emerging biological principles of metastasis. Cell, 168, 670–691. https://doi.org/10.1016/j.cell.2016.11.037.CrossRefPubMedPubMedCentral

Nguyen, D. X., Bos, P. D., & Massagué, J. (2009). Metastasis: from dissemination to organ-specific colonization. Nature Reviews Cancer, 9, 274–284. https://doi.org/10.1038/nrc2622.CrossRefPubMed

Massagué, J., & Obenauf, A. C. (2016). Metastatic colonization by circulating tumour cells. Nature, 529, 298–306. https://doi.org/10.1038/nature17038.CrossRefPubMedPubMedCentral

Pedersen, L., Christensen, J. F., & Hojman, P. (2015). Effects of exercise on tumor physiology and metabolism. Cancer Journal, 21, 111–116. https://doi.org/10.1097/PPO.0000000000000096.CrossRef

Chen, Y. J., Li, X. X., Ma, H. K., Zhang, X., Wang, B. W., Guo, T. T., et al. (2019). Exercise training for improving patient-reported outcomes in patients with advanced-stage cancer: a systematic review and meta-analysis. Journal of Pain and Symptom Management. https://doi.org/10.1016/j.jpainsymman.2019.09.010.

Schmitz, K. H., Courneya, K. S., Matthews, C., Demark-Wahnefried, W., Galvão, D. A., Pinto, B. M., Irwin, M. L., Wolin, K. Y., Segal, R. J., Lucia, A., Schneider, C. M., von Gruenigen, V., Schwartz, A. L., & American College of Sports Medicine. (2010). American College of Sports Medicine American College of Sports Medicine roundtable on exercise guidelines for cancer survivors. Medicine & Science in Sports & Exercise, 42, 1409–1426. https://doi.org/10.1249/MSS.0b013e3181e0c112.CrossRef

Morales, J. S., Santana-Sosa, E., Santos-Lozano, A., Baño-Rodrigo, A., Valenzuela, P. L., Rincón-Castanedo, C., et al. (2019). Inhospital exercise benefits in childhood cancer: a prospective cohort study. Scandinavian Journal of Medicine and Science in Sports. https://doi.org/10.1111/sms.13545.

Morales, J. S., Valenzuela, P. L., Rincón-Castanedo, C., Takken, T., Fiuza-Luces, C., Santos-Lozano, A., & Lucia, A. (2018). Exercise training in childhood cancer: a systematic review and meta-analysis of randomized controlled trials. Cancer Treatment Reviews, 70, 154–167. https://doi.org/10.1016/j.ctrv.2018.08.012.CrossRefPubMed

10.

Fiuza-Luces, C., Padilla, J. R., Soares-Miranda, L., Santana-Sosa, E., Quiroga, J. V., Santos-Lozano, A., Pareja-Galeano, H., Sanchis-Gomar, F., Lorenzo-González, R., Verde, Z., López-Mojares, L. M., Lassaletta, A., Fleck, S. J., Pérez, M., Pérez-Martínez, A., & Lucia, A. (2017). Exercise intervention in pediatric patients with solid tumors: the physical activity in pediatric cancer trial. Medicine & Science in Sports & Exercise, 49, 223–230. https://doi.org/10.1249/MSS.0000000000001094.CrossRef

11.

Schmitz, K. H., Campbell, A. M., Stuiver, M. M., Pinto, B. M., Schwartz, A. L., Morris, G. S., Ligibel, J. A., Cheville, A., Galvão, D. A., Alfano, C. M., Patel, A. V., Hue, T., Gerber, L. H., Sallis, R., Gusani, N. J., Stout, N. L., Chan, L., Flowers, F., Doyle, C., Helmrich, S., Bain, W., Sokolof, J., Winters-Stone, K. M., Campbell, K. L., & Matthews, C. E. (2019). Exercise is medicine in oncology: engaging clinicians to help patients move through cancer. CA: a Cancer Journal for Clinicians, 69, 468–484. https://doi.org/10.3322/caac.21579.CrossRef

12.

Dai, J. Y., Wang, B., Wang, X., Cheng, A., Kolb, S., Stanford, J. L., & Wright, J. L. (2019). Vigorous physical activity is associated with lower risk of metastatic-lethal progression in prostate cancer and hypomethylation in the CRACR2A gene. Cancer Epidemiology, Biomarkers & Prevention, 28, 258–264. https://doi.org/10.1158/1055-9965.EPI-18-0622.CrossRef

13.

Guercio, B. J., Zhang, S., Ou, F. S., Venook, A. P., Niedzwiecki, D., Lenz, H. J., Innocenti, F., O’Neil, B. H., Shaw, J. E., Polite, B. N., Hochster, H. S., Atkins, J. N., Goldberg, R. M., Sato, K., Ng, K., van Blarigan, E., Mayer, R. J., Blanke, C. D., O'Reilly, E. M., Fuchs, C. S., & Meyerhardt, J. A. (2019). Associations of physical activity with survival and progression in metastatic colorectal cancer: results from Cancer and Leukemia Group B (Alliance)/SWOG 80405. Journal of Clinical Oncology, 37, 2620–2631. https://doi.org/10.1200/JCO.19.01019.CrossRefPubMedPubMedCentral

14.

Brown, J. C., Rhim, A. D., Manning, S. L., Brennan, L., Mansour, A. I., Rustgi, A. K., Damjanov, N., Troxel, A. B., Rickels, M. R., Ky, B., Zemel, B. S., Courneya, K. S., & Schmitz, K. H. (2018). Effects of exercise on circulating tumor cells among patients with resected stage I-III colon cancer. PLoS One, 13, e0204875. https://doi.org/10.1371/journal.pone.0204875.CrossRefPubMedPubMedCentral

15.

Jinnah, A. H., Zacks, B. C., Gwam, C. U., & Kerr, B. A. (2018). Emerging and established models of bone metastasis. Cancers (Basel), 10. https://doi.org/10.3390/cancers10060176.

16.

Ashcraft, K. A., Peace, R. M., Betof, A. S., Dewhirst, M. W., & Jones, L. W. (2016). Efficacy and mechanisms of aerobic exercise on cancer initiation, progression, and metastasis: a critical systematic review of in vivo preclinical data. Cancer Research, 76, 4032–4050. https://doi.org/10.1158/0008-5472.CAN-16-0887.CrossRefPubMedPubMedCentral

17.

Ruiz-Casado, A., Martín-Ruiz, A., Pérez, L. M., Provencio, M., Fiuza-Luces, C., & Lucia, A. (2017). Exercise and the hallmarks of cancer. Trends in Cancer, 3, 423–441. https://doi.org/10.1016/j.trecan.2017.04.007.CrossRefPubMed

18.

Betof, A. S., Dewhirst, M. W., & Jones, L. W. (2013). Effects and potential mechanisms of exercise training on cancer progression: a translational perspective. Brain, Behavior, and Immunity, 30, S75–S87. https://doi.org/10.1016/j.bbi.2012.05.001.CrossRefPubMed

19.

Moher, D., Shamseer, L., Clarke, M., Ghersi, D., Liberati, A., Petticrew, M., Shekelle, P., Stewart, L. A., & PRISMA-P Group. (2015). Preferred reporting items for systematic review and meta-analysis protocols (PRISMA-P) 2015 statement. Systematic Reviews, 4, 1. https://doi.org/10.1186/2046-4053-4-1.CrossRefPubMedPubMedCentral

20.

Goh, J., Tsai, J., Bammler, T. K., Farin, F. M., Endicott, E., & Ladiges, W. C. (2013). Exercise training in transgenic mice is associated with attenuation of early breast cancer growth in a dose-dependent manner. PLoS One, 8, e80123. https://doi.org/10.1371/journal.pone.0080123.CrossRefPubMedPubMedCentral

21.

Hooijmans, C. R., Rovers, M. M., de Vries, R. B. M., Leenaars, M., Ritskes-Hoitinga, M., & Langendam, M. W. (2014). SYRCLE’s risk of bias tool for animal studies. BMC Medical Research Methodology, 14, 43. https://doi.org/10.1186/1471-2288-14-43.CrossRefPubMedPubMedCentral

22.

Bax, L., Yu, L. M., Ikeda, N., Tsuruta, H., & Moons, K. G. M. (2006). Development and validation of MIX: comprehensive free software for meta-analysis of causal research data. BMC Medical Research Methodology, 6, 50. https://doi.org/10.1186/1471-2288-6-50.CrossRefPubMedPubMedCentral

23.

Smeda, M., Przyborowski, K., Proniewski, B., Zakrzewska, A., Kaczor, D., Stojak, M., Buczek, E., Nieckarz, Z., Zoladz, J. A., Wietrzyk, J., & Chlopicki, S. (2017). Breast cancer pulmonary metastasis is increased in mice undertaking spontaneous physical training in the running wheel; a call for revising beneficial effects of exercise on cancer progression. American Journal of Cancer Research, 7, 1926–1936.PubMedPubMedCentral

24.

MacNeil, B., & Hoffman-Goetz, L. (1993). Exercise training and tumour metastasis in mice: influence of time of exercise onset. Anticancer Research, 13, 2085–2088.PubMed

25.

Hoffmann-Goetz, L., MacNeil, B., & Arumugam, Y. (1994). Tissue distribution of radiolabelled tumor cells in wheel exercised and sedentary mice. International Journal of Sports Medicine, 15, 249–253.CrossRef

26.

Jadeski, L., & Hoffman-Goetz, L. (1996). Exercise and in vivo natural cytotoxicity against tumour cells of varying metastatic capacity. Clinical & Experimental Metastasis, 14, 138–144.CrossRef

27.

Jee, H., Chang, J. E., & Yang, E. J. (2016). Positive prehabilitative effect of intense treadmill exercise for ameliorating cancer cachexia symptoms in a mouse model. Journal of Cancer, 7, 2378–2387. https://doi.org/10.7150/jca.17162.CrossRefPubMedPubMedCentral

28.

Tsai, M. S., Kuo, M. L., Chang, C. C., & Wu, Y. T. (2013). The effects of exercise training on levels of vascular endothelial growth factor in tumor-bearing mice. Cancer Biomarkers, 13, 307–313. https://doi.org/10.3233/CBM-130359.CrossRefPubMed

29.

Uhlenbruck, G., & Order, U. (1991). Can endurance sports stimulate immune mechanisms against cancer and metastasis? International Journal of Sports Medicine, 12(Suppl 1), S63–S68. https://doi.org/10.1055/s-2007-1024753.CrossRefPubMed

30.

MacNeil, B., & Hoffman-Goetz, L. (1993). Effect of exercise on natural cytotoxicity and pulmonary tumor metastases in mice. Medicine & Science in Sports & Exercise, 25, 922–928.CrossRef

31.

Murphy, E. A., Davis, J. M., Brown, A. S., Carmichael, M. D., Mayer, E. P., & Ghaffar, A. (2004). Effects of moderate exercise and oat beta-glucan on lung tumor metastases and macrophage antitumor cytotoxicity. Journal of Applied Physiology, 97, 955–959. https://doi.org/10.1152/japplphysiol.00252.2004.CrossRefPubMed

32.

Pedersen, L., Idorn, M., Olofsson, G. H., Lauenborg, B., Nookaew, I., Hansen, R. H., Johannesen, H. H., Becker, J. C., Pedersen, K. S., Dethlefsen, C., Nielsen, J., Gehl, J., Pedersen, B. K., Thor Straten, P., & Hojman, P. (2016). Voluntary running suppresses tumor growth through epinephrine- and IL-6-dependent NK cell mobilization and redistribution. Cell Metabolism, 23, 554–562. https://doi.org/10.1016/j.cmet.2016.01.011.CrossRefPubMed

33.

Alvarado, A., Gil da Costa, R. M., Faustino-Rocha, A. I., Ferreira, R., Lopes, C., Oliveira, P. A., & Colaço, B. (2017). Effects of exercise training on breast cancer metastasis in a rat model. International Journal of Experimental Pathology, 98, 40–46. https://doi.org/10.1111/iep.12225.CrossRefPubMedPubMedCentral

34.

Hoffman-Goetz, L., May, K. M., & Arumugam, Y. (1994). Exercise training and mouse mammary tumour metastasis. Anticancer Research, 14, 2627–2631.PubMed

35.

Higgins, K. A., Park, D., Lee, G. Y., Curran, W. J., & Deng, X. (2014). Exercise-induced lung cancer regression: mechanistic findings from a mouse model. Cancer, 120, 3302–3310. https://doi.org/10.1002/cncr.28878.CrossRefPubMedPubMedCentral

36.

Assi, M., Kenawi, M., Ropars, M., & Rébillard, A. (2017). Interleukin-6, C/EBP-β and PPAR-γ expression correlates with intramuscular liposarcoma growth in mice: the impact of voluntary physical activity levels. Biochemical and Biophysical Research Communications, 490, 1026–1032. https://doi.org/10.1016/j.bbrc.2017.06.158.CrossRefPubMed

37.

Zhang, Q. B., Zhang, B. H., Zhang, K. Z., Meng, X. T., Jia, Q. A., Zhang, Q. B., Bu, Y., Zhu, X. D., Ma, D. N., Ye, B. G., Zhang, N., Ren, Z. G., Sun, H. C., & Tang, Z. Y. (2016). Moderate swimming suppressed the growth and metastasis of the transplanted liver cancer in mice model: with reference to nervous system. Oncogene, 35, 4122–4131. https://doi.org/10.1038/onc.2015.484.CrossRefPubMed

38.

Zhang, Q. B., Meng, X. T., Jia, Q. A., Bu, Y., Ren, Z. G., Zhang, B. H., & Tang, Z. Y. (2016). Herbal compound songyou yin and moderate swimming suppress growth and metastasis of liver cancer by enhancing immune function. Integrative Cancer Therapies, 15, 368–375. https://doi.org/10.1177/1534735415622011.CrossRefPubMed

39.

Wolff, G., Davidson, S. J., Wrobel, J. K., & Toborek, M. (2015). Exercise maintains blood-brain barrier integrity during early stages of brain metastasis formation. Biochemical and Biophysical Research Communications, 463, 811–817. https://doi.org/10.1016/j.bbrc.2015.04.153.CrossRefPubMedPubMedCentral

40.

Hoffman-Goetz, L., MacNeil, B., Arumugam, Y., & Randall Simpson, J. (1992). Differential effects of exercise and housing condition on murine natural killer cell activity and tumor growth. International Journal of Sports Medicine, 13, 167–171. https://doi.org/10.1055/s-2007-1021250.CrossRefPubMed

41.

Colbert, L. H., Westerlind, K. C., Perkins, S. N., Haines, D. C., Berrigan, D., Donehower, L. A., Fuchs-Young, R., & Hursting, S. D. (2009). Exercise effects on tumorigenesis in a p53-deficient mouse model of breast cancer. Medicine & Science in Sports & Exercise, 41, 1597–1605. https://doi.org/10.1249/MSS.0b013e31819f1f05.CrossRef

42.

Bryner, R., Riggs, D., Donley, D., White, J., Ullrich, I., Lamm, D., et al. (1998). Effects of voluntary running wheel exercise on the growth and metastasis of transplanted prostate cancer in rats. Journal of Exercise Physiology Online, 1, 1–9.

43.

Yan, L., & Demars, L. C. (2011). Effects of non-motorized voluntary running on experimental and spontaneous metastasis in mice. Anticancer Research, 31, 3337–3344.PubMed

44.

Davis, J. M., Kohut, M. L., Jackson, D. A., Colbert, L. H., Mayer, E. P., & Ghaffar, A. (1998). Exercise effects on lung tumor metastases and in vitro alveolar macrophage antitumor cytotoxicity. American Journal of Physiology, 274, R1454–R1459. https://doi.org/10.1152/ajpregu.1998.274.5.R1454.CrossRefPubMed

45.

MacNeil, B., & Hoffman-Goetz, L. (1993). Chronic exercise enhances in vivo and in vitro cytotoxic mechanisms of natural immunity in mice. Journal of Applied Physiology, 74, 388–395. https://doi.org/10.1152/jappl.1993.74.1.388.CrossRefPubMed

46.

Khori, V., Amani Shalamzari, S., Isanejad, A., Alizadeh, A. M., Alizadeh, S., Khodayari, S., Khodayari, H., Shahbazi, S., Zahedi, A., Sohanaki, H., Khaniki, M., Mahdian, R., Saffari, M., & Fayad, R. (2015). Effects of exercise training together with tamoxifen in reducing mammary tumor burden in mice: possible underlying pathway of miR-21. European Journal of Pharmacology, 765, 179–187. https://doi.org/10.1016/j.ejphar.2015.08.031.CrossRefPubMed

47.

Jones, L. W., Antonelli, J., Masko, E. M., Broadwater, G., Lascola, C. D., Fels, D., Dewhirst, M. W., Dyck, J. R., Nagendran, J., Flores, C. T., Betof, A. S., Nelson, E. R., Pollak, M., Dash, R. C., Young, M. E., & Freedland, S. J. (2012). Exercise modulation of the host-tumor interaction in an orthotopic model of murine prostate cancer. Journal of Applied Physiology, 113, 263–272. https://doi.org/10.1152/japplphysiol.01575.2011.CrossRefPubMedPubMedCentral

48.

Garzia, L., Kijima, N., Morrissy, A. S., De Antonellis, P., Guerreiro-Stucklin, A., Holgado, B. L., et al. (2018). A hematogenous route for medulloblastoma leptomeningeal metastases. Cell, 172, 1050–1062.e14. https://doi.org/10.1016/j.cell.2018.01.038.CrossRefPubMedPubMedCentral

49.

McTiernan, A. (2008). Mechanisms linking physical activity with cancer. Nature Reviews Cancer, 8, 205–211. https://doi.org/10.1038/nrc2325.CrossRefPubMed

50.

Theriau, C. F., Shpilberg, Y., Riddell, M. C., & Connor, M. K. (2016). Voluntary physical activity abolishes the proliferative tumor growth microenvironment created by adipose tissue in animals fed a high fat diet. Journal of Applied Physiology, 121, 139–153. https://doi.org/10.1152/japplphysiol.00862.2015.CrossRefPubMedPubMedCentral

51.

Bianco, T. M., Abdalla, D. R., Desidério, C. S., Thys, S., Simoens, C., Bogers, J. P., Murta, E. F. C., & Michelin, M. A. (2017). The influence of physical activity in the anti-tumor immune response in experimental breast tumor. Immunology Letters, 190, 148–158. https://doi.org/10.1016/j.imlet.2017.08.007.CrossRefPubMed

52.

Koelwyn, G. J., Quail, D. F., Zhang, X., White, R. M., & Jones, L. W. (2017). Exercise-dependent regulation of the tumour microenvironment. Nature Reviews Cancer, 17, 620–632. https://doi.org/10.1038/nrc.2017.78.CrossRefPubMed

53.

Jones, L. W., Fels, D. R., West, M., Allen, J. D., Broadwater, G., Barry, W. T., Wilke, L. G., Masko, E., Douglas, P. S., Dash, R. C., Povsic, T. J., Peppercorn, J., Marcom, P. K., Blackwell, K. L., Kimmick, G., Turkington, T. G., & Dewhirst, M. W. (2013). Modulation of circulating angiogenic factors and tumor biology by aerobic training in breast cancer patients receiving neoadjuvant chemotherapy. Cancer Prevention Research, 6, 925–937. https://doi.org/10.1158/1940-6207.CAPR-12-0416.CrossRefPubMed

54.

Pearson, M. J., & Smart, N. A. (2017). Aerobic training intensity for improved endothelial function in heart failure patients: a systematic review and meta-analysis. Cardiology Research and Practice, 2017, 2450202. https://doi.org/10.1155/2017/2450202.CrossRefPubMedPubMedCentral

55.

Hojman, P., Gehl, J., Christensen, J. F., & Pedersen, B. K. (2018). Molecular mechanisms linking exercise to cancer prevention and treatment. Cell Metabolism, 27, 10–21. https://doi.org/10.1016/j.cmet.2017.09.015.CrossRefPubMed

56.

Goetz, J. G. (2018). Metastases go with the flow. Science, 362, 999–1000. https://doi.org/10.1126/science.aat9100.CrossRefPubMed

57.

Shachar, S. S., Williams, G. R., Muss, H. B., & Nishijima, T. F. (2016). Prognostic value of sarcopenia in adults with solid tumours: a meta-analysis and systematic review. European Journal of Cancer, 57, 58–67. https://doi.org/10.1016/j.ejca.2015.12.030.CrossRefPubMed

58.

Wolin, K. Y., Ruiz, J. R., Tuchman, H., & Lucia, A. (2010). Exercise in adult and pediatric hematological cancer survivors: an intervention review. Leukemia, 24, 1113–1120. https://doi.org/10.1038/leu.2010.54.CrossRefPubMed

59.

Pei, Y., Moore, C. E., Wang, J., Tewari, A. K., Eroshkin, A., Cho, Y. J., Witt, H., Korshunov, A., Read, T. A., Sun, J. L., Schmitt, E. M., Miller, C. R., Buckley, A. F., McLendon, R., Westbrook, T. F., Northcott, P. A., Taylor, M. D., Pfister, S. M., Febbo, P. G., & Wechsler-Reya, R. J. (2012). An animal model of MYC-driven medulloblastoma. Cancer Cell, 21, 155–167. https://doi.org/10.1016/j.ccr.2011.12.021.CrossRefPubMedPubMedCentral

60.

Weiss, W. A., Aldape, K., Mohapatra, G., Feuerstein, B. G., & Bishop, J. M. (1997). Targeted expression of MYCN causes neuroblastoma in transgenic mice. EMBO Journal, 16, 2985–2995. https://doi.org/10.1093/emboj/16.11.2985.CrossRefPubMed

61.

Sweet-Cordero, E. A., & Biegel, J. A. (2019). The genomic landscape of pediatric cancers: implications for diagnosis and treatment. Science, 363, 1170–1175. https://doi.org/10.1126/science.aaw3535.CrossRefPubMed

Titel: Physical exercise effects on metastasis: a systematic review and meta-analysis in animal cancer models
verfasst von: Cecilia Rincón-Castanedo
Javier S. Morales
Asunción Martín-Ruiz
Pedro L. Valenzuela
Manuel Ramírez
Alejandro Santos-Lozano
Alejandro Lucia
Carmen Fiuza-Luces
Publikationsdatum: 01.03.2020
Verlag: Springer US
Erschienen in: Cancer and Metastasis Reviews / Ausgabe 1/2020
Print ISSN: 0167-7659
Elektronische ISSN: 1573-7233
DOI: https://doi.org/10.1007/s10555-020-09851-4

Neu im Fachgebiet Onkologie

25.04.2024 | Nierenkarzinom | Nachrichten

Springer Medizin

Physical exercise effects on metastasis: a systematic review and meta-analysis in animal cancer models

Abstract

Neu im Fachgebiet Onkologie

Adjuvante Immuntherapie verlängert Leben bei RCC

Alectinib verbessert krankheitsfreies Überleben bei ALK-positivem NSCLC

Bei Senioren mit Prostatakarzinom auf Anämie achten!

ICI-Therapie in der Schwangerschaft wird gut toleriert

Update Onkologie

Springer Medizin

Abstract

Bitte loggen Sie sich ein, um Zugang zu diesem Inhalt zu erhalten

Weitere Artikel der Ausgabe 1/2020

Involvement of the central nervous system in acute lymphoblastic leukemia: opinions on molecular mechanisms and clinical implications based on recent data

Clinical research tools in pediatric oncology: challenges and opportunities

A systematic approach to the endocrine care of survivors of pediatric hematopoietic stem cell transplantation

The genomics of acute myeloid leukemia in children

Drug repurposing towards targeting cancer stem cells in pediatric brain tumors

Pediatric hemispheric high-grade glioma: targeting the future

Neu im Fachgebiet Onkologie

Adjuvante Immuntherapie verlängert Leben bei RCC

Alectinib verbessert krankheitsfreies Überleben bei ALK-positivem NSCLC

Bei Senioren mit Prostatakarzinom auf Anämie achten!

ICI-Therapie in der Schwangerschaft wird gut toleriert

Update Onkologie